Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups
Identifieur interne : 001653 ( Pmc/Curation ); précédent : 001652; suivant : 001654Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups
Auteurs : G. M. Leung [République populaire de Chine, États-Unis] ; W. W. Lim [République populaire de Chine] ; L.-M. Ho [République populaire de Chine] ; T.-H. Lam [République populaire de Chine] ; A. C. Ghani [Royaume-Uni] ; C. A. Donnelly [Royaume-Uni] ; C. Fraser [Royaume-Uni] ; S. Riley [Royaume-Uni] ; N. M. Ferguson [Royaume-Uni] ; R. M. Anderson [Royaume-Uni] ; A. J. Hedley [République populaire de Chine]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2005.
Abstract
We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0·10% [95% confidence interval (CI) 0·02–0·18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0·23%, 95% CI 0·02–0·45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0·16%, 95% CI 0–0·37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0·050%, 95% CI 0–0·15) than single test protocols (0·20%, 95% CI 0·06–0·34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.
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DOI: 10.1017/S0950268805004826
PubMed: 16490123
PubMed Central: 2870380
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Hedley</name><affiliation wicri:level="1"><nlm:aff id="aff001">Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16490123</idno><idno type="pmc">2870380</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870380</idno><idno type="RBID">PMC:2870380</idno><idno type="doi">10.1017/S0950268805004826</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001653</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001653</idno><idno type="wicri:Area/Pmc/Curation">001653</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups</title><author><name sortKey="Leung, G M" sort="Leung, G M" uniqKey="Leung G" first="G. M." last="Leung">G. M. Leung</name><affiliation wicri:level="1"><nlm:aff id="aff001">Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002">Takemi Program, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Takemi Program, Harvard School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Lim, W W" sort="Lim, W W" uniqKey="Lim W" first="W. W." last="Lim">W. W. Lim</name><affiliation wicri:level="1"><nlm:aff id="aff003">Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ho, L M" sort="Ho, L M" uniqKey="Ho L" first="L.-M." last="Ho">L.-M. Ho</name><affiliation wicri:level="1"><nlm:aff id="aff001">Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Lam, T H" sort="Lam, T H" uniqKey="Lam T" first="T.-H." last="Lam">T.-H. Lam</name><affiliation wicri:level="1"><nlm:aff id="aff001">Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ghani, A C" sort="Ghani, A C" uniqKey="Ghani A" first="A. C." last="Ghani">A. C. Ghani</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Donnelly, C A" sort="Donnelly, C A" uniqKey="Donnelly C" first="C. A." last="Donnelly">C. A. Donnelly</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Fraser, C" sort="Fraser, C" uniqKey="Fraser C" first="C." last="Fraser">C. Fraser</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Riley, S" sort="Riley, S" uniqKey="Riley S" first="S." last="Riley">S. Riley</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Ferguson, N M" sort="Ferguson, N M" uniqKey="Ferguson N" first="N. M." last="Ferguson">N. M. Ferguson</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Anderson, R M" sort="Anderson, R M" uniqKey="Anderson R" first="R. M." last="Anderson">R. M. Anderson</name><affiliation wicri:level="1"><nlm:aff id="aff004">Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London</wicri:regionArea></affiliation></author><author><name sortKey="Hedley, A J" sort="Hedley, A J" uniqKey="Hedley A" first="A. J." last="Hedley">A. J. Hedley</name><affiliation wicri:level="1"><nlm:aff id="aff001">Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea></affiliation></author></analytic><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p>We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0·10% [95% confidence interval (CI) 0·02–0·18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0·23%, 95% CI 0·02–0·45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0·16%, 95% CI 0–0·37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0·050%, 95% CI 0–0·15) than single test protocols (0·20%, 95% CI 0·06–0·34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.</p></div></front></TEI><pmc article-type="review-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Epidemiol Infect</journal-id><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Epidemiology and Infection</journal-title><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16490123</article-id><article-id pub-id-type="pmc">2870380</article-id><article-id pub-id-type="doi">10.1017/S0950268805004826</article-id><article-id pub-id-type="pii">S0950268805004826</article-id><article-id pub-id-type="publisher-id">00482</article-id><article-categories><subj-group subj-group-type="heading"><subject>Systematic Review</subject></subj-group></article-categories><title-group><article-title>Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups</article-title><alt-title alt-title-type="left-running">G. M. Leung and others</alt-title><alt-title alt-title-type="right-running">Seroprevalence of IgG antibodies to SARS-coronavirus</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>LEUNG</surname><given-names>G. M.</given-names></name><xref ref-type="aff" rid="aff001">1</xref><xref ref-type="aff" rid="aff002">2</xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author"><name><surname>LIM</surname><given-names>W. W.</given-names></name><xref ref-type="aff" rid="aff003">3</xref></contrib><contrib contrib-type="author"><name><surname>HO</surname><given-names>L.-M.</given-names></name><xref ref-type="aff" rid="aff001">1</xref></contrib><contrib contrib-type="author"><name><surname>LAM</surname><given-names>T.-H.</given-names></name><xref ref-type="aff" rid="aff001">1</xref></contrib><contrib contrib-type="author"><name><surname>GHANI</surname><given-names>A. C.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>DONNELLY</surname><given-names>C. A.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>FRASER</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>RILEY</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>FERGUSON</surname><given-names>N. M.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>ANDERSON</surname><given-names>R. M.</given-names></name><xref ref-type="aff" rid="aff004">4</xref></contrib><contrib contrib-type="author"><name><surname>HEDLEY</surname><given-names>A. J.</given-names></name><xref ref-type="aff" rid="aff001">1</xref></contrib></contrib-group><aff id="aff001"><label>1</label>Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, China</aff><aff id="aff002"><label>2</label>Takemi Program, Harvard School of Public Health, Boston, MA, USA</aff><aff id="aff003"><label>3</label>Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong, China</aff><aff id="aff004"><label>4</label>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, University of London, St Mary’s Campus, Norfolk Place, London, UK</aff><author-notes><corresp id="cor001"><label>*</label>Author for correspondence: Dr G. M. Leung, Department of Community Medicine, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China. (Email: <email xlink:href="gmleung@hkucc.hk">gmleung@hkucc.hk</email>)</corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>22</day><month>7</month><year>2005</year></pub-date><volume>134</volume><issue>2</issue><fpage>211</fpage><lpage>221</lpage><history><date date-type="accepted"><day>21</day><month>4</month><year>2005</year></date></history><copyright-statement>© Cambridge University Press 2005</copyright-statement><copyright-year>2005</copyright-year><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="S0950268805004826a.pdf"></self-uri><abstract abstract-type="normal"><title>SUMMARY</title><p>We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0·10% [95% confidence interval (CI) 0·02–0·18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0·23%, 95% CI 0·02–0·45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0·16%, 95% CI 0–0·37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0·050%, 95% CI 0–0·15) than single test protocols (0·20%, 95% CI 0·06–0·34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.</p></abstract><counts><page-count count="11"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>dispart</meta-name><meta-value>Systematic Review</meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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