Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3
Identifieur interne : 001580 ( Pmc/Curation ); précédent : 001579; suivant : 001581Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3
Auteurs : Hui Hui Wong [République populaire de Chine, Singapour] ; To Sing Fung [République populaire de Chine] ; Shouguo Fang [Singapour, République populaire de Chine] ; Mei Huang [Singapour] ; My Tra Le [Singapour] ; Ding Xiang Liu [République populaire de Chine, Singapour]Source :
- Virology [ 0042-6822 ] ; 2017.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) is an inefficient inducer of interferon (IFN) response. It expresses various proteins that effectively circumvent IFN production at different levels via distinct mechanisms. Through the construction of recombinant IBV expressing proteins 8a, 8b and 8ab encoded by SARS-CoV ORF8, we demonstrate that expression of 8b and 8ab enables the corresponding recombinant viruses to partially overcome the inhibitory actions of IFN activation to achieve higher replication efficiencies in cells. We also found that proteins 8b and 8ab could physically interact with IRF3. Overexpression of 8b and 8ab resulted in the reduction of poly (I:C)-induced IRF3 dimerization and inhibition of the IFN-β signaling pathway. This counteracting effect was partially mediated by protein 8b/8ab-induced degradation of IRF3 in a ubiquitin-proteasome-dependent manner. Taken together, we propose that SARS-CoV may exploit the unique functions of proteins 8b and 8ab as novel mechanisms to overcome the effect of IFN response during virus infection.
Url:
DOI: 10.1016/j.virol.2017.12.028
PubMed: 29294448
PubMed Central: 7112132
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sort="Fang, Shouguo" uniqKey="Fang S" first="Shouguo" last="Fang">Shouguo Fang</name><affiliation wicri:level="1"><nlm:aff id="aff0015">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Agricultural School, Yangtze University, 266 Jingmilu, Jingzhou City, Hubei Province 434025, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Agricultural School, Yangtze University, 266 Jingmilu, Jingzhou City, Hubei Province 434025</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Mei" sort="Huang, Mei" uniqKey="Huang M" first="Mei" last="Huang">Mei Huang</name><affiliation wicri:level="1"><nlm:aff id="aff0015">School of 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510642, Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</wicri:regionArea></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:aff id="aff0005">South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Fang, Shouguo" sort="Fang, Shouguo" uniqKey="Fang S" first="Shouguo" last="Fang">Shouguo Fang</name><affiliation wicri:level="1"><nlm:aff id="aff0015">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Agricultural School, Yangtze University, 266 Jingmilu, Jingzhou City, Hubei Province 434025, China.</nlm:aff><country xml:lang="fr" 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Molecular and Cell Biology, 61 Biopolis Drive, Proteos</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Ding Xiang" sort="Liu, Ding Xiang" uniqKey="Liu D" first="Ding Xiang" last="Liu">Ding Xiang Liu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551</wicri:regionArea></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome coronavirus (SARS-CoV) is an inefficient inducer of interferon (IFN) response. It expresses various proteins that effectively circumvent IFN production at different levels via distinct mechanisms. Through the construction of recombinant IBV expressing proteins 8a, 8b and 8ab encoded by SARS-CoV ORF8, we demonstrate that expression of 8b and 8ab enables the corresponding recombinant viruses to partially overcome the inhibitory actions of IFN activation to achieve higher replication efficiencies in cells. We also found that proteins 8b and 8ab could physically interact with IRF3. Overexpression of 8b and 8ab resulted in the reduction of poly (I:C)-induced IRF3 dimerization and inhibition of the IFN-β signaling pathway. This counteracting effect was partially mediated by protein 8b/8ab-induced degradation of IRF3 in a ubiquitin-proteasome-dependent manner. Taken together, we propose that SARS-CoV may exploit the unique functions of proteins 8b and 8ab as novel mechanisms to overcome the effect of IFN response during virus infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anderson, R A" uniqKey="Anderson R">R.A. Anderson</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author><author><name sortKey="Gompels, U A" uniqKey="Gompels U">U.A. Gompels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bibeau Poirier, A" uniqKey="Bibeau Poirier A">A. Bibeau-Poirier</name></author><author><name sortKey="Gravel, S P" uniqKey="Gravel S">S.-P. Gravel</name></author><author><name sortKey="Clement, J F" uniqKey="Clement J">J.-F. Clément</name></author><author><name sortKey="Rolland, S" uniqKey="Rolland S">S. Rolland</name></author><author><name sortKey="Rodier, G" uniqKey="Rodier G">G. Rodier</name></author><author><name sortKey="Coulombe, P" uniqKey="Coulombe P">P. Coulombe</name></author><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author><author><name sortKey="Grandvaux, N" uniqKey="Grandvaux N">N. Grandvaux</name></author><author><name sortKey="Meloche, S" uniqKey="Meloche S">S. Meloche</name></author><author><name sortKey="Servant, M J" uniqKey="Servant M">M.J. Servant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, C Y" uniqKey="Chen C">C.Y. Chen</name></author><author><name sortKey="Ping, Y H" uniqKey="Ping Y">Y.H. Ping</name></author><author><name sortKey="Lee, H C" uniqKey="Lee H">H.C. Lee</name></author><author><name sortKey="Chen, K H" uniqKey="Chen K">K.H. Chen</name></author><author><name sortKey="Lee, Y M" uniqKey="Lee Y">Y.M. Lee</name></author><author><name sortKey="Chan, Y J" uniqKey="Chan Y">Y.J. Chan</name></author><author><name sortKey="Lien, T C" uniqKey="Lien T">T.C. Lien</name></author><author><name sortKey="Jap, T S" uniqKey="Jap T">T.S. Jap</name></author><author><name sortKey="Lin, C H" uniqKey="Lin C">C.H. Lin</name></author><author><name sortKey="Kao, L S" uniqKey="Kao L">L.S. Kao</name></author><author><name sortKey="Chen, Y M A" uniqKey="Chen Y">Y.M.A. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Rijnbrand, R" uniqKey="Rijnbrand R">R. Rijnbrand</name></author><author><name sortKey="Jangra, R K" uniqKey="Jangra R">R.K. Jangra</name></author><author><name sortKey="Devaraj, S G" uniqKey="Devaraj S">S.G. Devaraj</name></author><author><name sortKey="Qu, L" uniqKey="Qu L">L. Qu</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y. Ma</name></author><author><name sortKey="Lemon, S M" uniqKey="Lemon S">S.M. Lemon</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. Dediego</name></author><author><name sortKey="Pewe, L" uniqKey="Pewe L">L. Pewe</name></author><author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name></author><author><name sortKey="Rejas, M T" uniqKey="Rejas M">M.T. Rejas</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devaraj, S G" uniqKey="Devaraj S">S.G. Devaraj</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Tseng, M" uniqKey="Tseng M">M. Tseng</name></author><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name></author><author><name sortKey="Tseng, C T K" uniqKey="Tseng C">C.-T.K. Tseng</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z. Ding</name></author><author><name sortKey="Fang, L" uniqKey="Fang L">L. Fang</name></author><author><name sortKey="Jing, H" uniqKey="Jing H">H. Jing</name></author><author><name sortKey="Zeng, S" uniqKey="Zeng S">S. Zeng</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Luo, R" uniqKey="Luo R">R. Luo</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Xiao, S" uniqKey="Xiao S">S. Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, S" uniqKey="Fang S">S. Fang</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B. Chen</name></author><author><name sortKey="Tay, F P L" uniqKey="Tay F">F.P.L. Tay</name></author><author><name sortKey="Ng, B S" uniqKey="Ng B">B.S. Ng</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitzgerald, K A" uniqKey="Fitzgerald K">K.A. Fitzgerald</name></author><author><name sortKey="Mcwhirter, S M" uniqKey="Mcwhirter S">S.M. McWhirter</name></author><author><name sortKey="Faia, K L" uniqKey="Faia K">K.L. Faia</name></author><author><name sortKey="Rowe, D C" uniqKey="Rowe D">D.C. Rowe</name></author><author><name sortKey="Latz, E" uniqKey="Latz E">E. Latz</name></author><author><name sortKey="Golenbock, D T" uniqKey="Golenbock D">D.T. Golenbock</name></author><author><name sortKey="Coyle, A J" uniqKey="Coyle A">A.J. Coyle</name></author><author><name sortKey="Liao, S M" uniqKey="Liao S">S.-M. Liao</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T. Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Kopecky Bromberg, S A" uniqKey="Kopecky Bromberg S">S.A. Kopecky-Bromberg</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodbourn, S" uniqKey="Goodbourn S">S. Goodbourn</name></author><author><name sortKey="Didcock, L" uniqKey="Didcock L">L. Didcock</name></author><author><name sortKey="Randall, R E" uniqKey="Randall R">R.E. Randall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grandvaux, N" uniqKey="Grandvaux N">N. Grandvaux</name></author><author><name sortKey="Servant, M J" uniqKey="Servant M">M.J. Servant</name></author><author><name sortKey="Tenoever, B" uniqKey="Tenoever B">B. tenOever</name></author><author><name sortKey="Sen, G C" uniqKey="Sen G">G.C. Sen</name></author><author><name sortKey="Balachandran, S" uniqKey="Balachandran S">S. Balachandran</name></author><author><name sortKey="Barber, G N" uniqKey="Barber G">G.N. Barber</name></author><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Zhuang, Z" uniqKey="Zhuang Z">Z. Zhuang</name></author><author><name sortKey="Cheung, C" uniqKey="Cheung C">C. Cheung</name></author><author><name sortKey="Luo, S" uniqKey="Luo S">S. Luo</name></author><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgs, R" uniqKey="Higgs R">R. Higgs</name></author><author><name sortKey="Jefferies, C A" uniqKey="Jefferies C">C.A. Jefferies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgs, R" uniqKey="Higgs R">R. Higgs</name></author><author><name sortKey="Ni Gabhann, J" uniqKey="Ni Gabhann J">J. Ní Gabhann</name></author><author><name sortKey="Ben Larbi, N" uniqKey="Ben Larbi N">N. Ben Larbi</name></author><author><name sortKey="Breen, E P" uniqKey="Breen E">E.P. Breen</name></author><author><name sortKey="Fitzgerald, K A" uniqKey="Fitzgerald K">K.A. Fitzgerald</name></author><author><name sortKey="Jefferies, C A" uniqKey="Jefferies C">C.A. Jefferies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jimenez Guarde O, J M" uniqKey="Jimenez Guarde O J">J.M. Jimenez-Guardeño</name></author><author><name sortKey="Regla Nava, J A" uniqKey="Regla Nava J">J.A. Regla-Nava</name></author><author><name sortKey="Nieto Torres, J L" uniqKey="Nieto Torres J">J.L. Nieto-Torres</name></author><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name></author><author><name sortKey="Casta O Rodriguez, C" uniqKey="Casta O Rodriguez C">C. Castaño-Rodriguez</name></author><author><name sortKey="Fernandez Delgado, R" uniqKey="Fernandez Delgado R">R. Fernandez-Delgado</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W. Kamitani</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K. Lokugamage</name></author><author><name sortKey="Ikegami, T" uniqKey="Ikegami T">T. Ikegami</name></author><author><name sortKey="Ito, N" uniqKey="Ito N">N. Ito</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H. Kubo</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keng, C T" uniqKey="Keng C">C.-T. Keng</name></author><author><name sortKey="Akerstrom, S" uniqKey="Akerstrom S">S. Akerström</name></author><author><name sortKey="Leung, C S W" uniqKey="Leung C">C.S.-W. Leung</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author><author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name></author><author><name sortKey="Mirazimi, A" uniqKey="Mirazimi A">A. Mirazimi</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.-J. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keng, C T" uniqKey="Keng C">C.-T. Keng</name></author><author><name sortKey="Choi, Y W" uniqKey="Choi Y">Y.-W. Choi</name></author><author><name sortKey="Welkers, M R A" uniqKey="Welkers M">M.R.A. Welkers</name></author><author><name sortKey="Chan, D Z L" uniqKey="Chan D">D.Z.L. Chan</name></author><author><name sortKey="Shen, S" uniqKey="Shen S">S. Shen</name></author><author><name sortKey="Gee Lim, S" uniqKey="Gee Lim S">S. Gee Lim</name></author><author><name sortKey="Hong, W" uniqKey="Hong W">W. Hong</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.-J. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kopecky Bromberg, S A" uniqKey="Kopecky Bromberg S">S.A. Kopecky-Bromberg</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martínez-Sobrido</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Baric, R A" uniqKey="Baric R">R.A. Baric</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubota, T" uniqKey="Kubota T">T. Kubota</name></author><author><name sortKey="Matsuoka, M" uniqKey="Matsuoka M">M. Matsuoka</name></author><author><name sortKey="Chang, T H" uniqKey="Chang T">T.-H. Chang</name></author><author><name sortKey="Tailor, P" uniqKey="Tailor P">P. Tailor</name></author><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T. Sasaki</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M. Tashiro</name></author><author><name sortKey="Kato, A" uniqKey="Kato A">A. Kato</name></author><author><name sortKey="Ozato, K" uniqKey="Ozato K">K. Ozato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumagai, Y" uniqKey="Kumagai Y">Y. Kumagai</name></author><author><name sortKey="Takeuchi, O" uniqKey="Takeuchi O">O. Takeuchi</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, H" uniqKey="Kumar H">H. Kumar</name></author><author><name sortKey="Kawai, T" uniqKey="Kawai T">T. Kawai</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, H" uniqKey="Kumar H">H. Kumar</name></author><author><name sortKey="Kawai, T" uniqKey="Kawai T">T. Kawai</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K P" uniqKey="Lau S">S.K.P. Lau</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Luk, H K H" uniqKey="Luk H">H.K.H. Luk</name></author><author><name sortKey="Yang, W H" uniqKey="Yang W">W.-H. Yang</name></author><author><name sortKey="Li, K S M" uniqKey="Li K">K.S.M. Li</name></author><author><name sortKey="Zhang, Y Z" uniqKey="Zhang Y">Y.-Z. Zhang</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Song, Z Z" uniqKey="Song Z">Z.-Z. Song</name></author><author><name sortKey="Chow, W N" uniqKey="Chow W">W.-N. Chow</name></author><author><name sortKey="Fan, R Y Y" uniqKey="Fan R">R.Y.Y. Fan</name></author><author><name sortKey="Ahmed, S S" uniqKey="Ahmed S">S.S. Ahmed</name></author><author><name sortKey="Yeung, H C" uniqKey="Yeung H">H.C. Yeung</name></author><author><name sortKey="Lam, C S F" uniqKey="Lam C">C.S.F. Lam</name></author><author><name sortKey="Cai, J P" uniqKey="Cai J">J.-P. Cai</name></author><author><name sortKey="Wong, S S Y" uniqKey="Wong S">S.S.Y. Wong</name></author><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Zhang, H L" uniqKey="Zhang H">H.-L. Zhang</name></author><author><name sortKey="Woo, P C Y" uniqKey="Woo P">P.C.Y. Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, P Y P" uniqKey="Law P">P.Y.P. Law</name></author><author><name sortKey="Liu, Y M" uniqKey="Liu Y">Y.-M. Liu</name></author><author><name sortKey="Geng, H" uniqKey="Geng H">H. Geng</name></author><author><name sortKey="Kwan, K H" uniqKey="Kwan K">K.H. Kwan</name></author><author><name sortKey="Waye, M M Y" uniqKey="Waye M">M.M.-Y. Waye</name></author><author><name sortKey="Ho, Y Y" uniqKey="Ho Y">Y.-Y. Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le, T M" uniqKey="Le T">T.M. Le</name></author><author><name sortKey="Wong, H H" uniqKey="Wong H">H.H. Wong</name></author><author><name sortKey="Tay, F P L" uniqKey="Tay F">F.P.L. Tay</name></author><author><name sortKey="Fang, S" uniqKey="Fang S">S. Fang</name></author><author><name sortKey="Keng, C T" uniqKey="Keng C">C.-T. Keng</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F Q" uniqKey="Li F">F.Q. Li</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H. Xiao</name></author><author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, K P" uniqKey="Lim K">K.P. Lim</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Y X" uniqKey="Lim Y">Y.X. Lim</name></author><author><name sortKey="Ng, Y L" uniqKey="Ng Y">Y.L. Ng</name></author><author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Heylbroeck, C" uniqKey="Heylbroeck C">C. Heylbroeck</name></author><author><name sortKey="Pitha, P M" uniqKey="Pitha P">P.M. Pitha</name></author><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Mamane, Y" uniqKey="Mamane Y">Y. Mamane</name></author><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author><author><name sortKey="Inglis, S C" uniqKey="Inglis S">S.C. Inglis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author><author><name sortKey="Inglis, S C" uniqKey="Inglis S">S.C. Inglis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author><author><name sortKey="Fung, T S" uniqKey="Fung T">T.S. Fung</name></author><author><name sortKey="Chong, K K L" uniqKey="Chong K">K.K.L. Chong</name></author><author><name sortKey="Shukla, A" uniqKey="Shukla A">A. Shukla</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y C" uniqKey="Liu Y">Y.-C. Liu</name></author><author><name sortKey="Penninger, J" uniqKey="Penninger J">J. Penninger</name></author><author><name sortKey="Karin, M" uniqKey="Karin M">M. Karin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loo, Y M" uniqKey="Loo Y">Y.-M. Loo</name></author><author><name sortKey="Fornek, J" uniqKey="Fornek J">J. Fornek</name></author><author><name sortKey="Crochet, N" uniqKey="Crochet N">N. Crochet</name></author><author><name sortKey="Bajwa, G" uniqKey="Bajwa G">G. Bajwa</name></author><author><name sortKey="Perwitasari, O" uniqKey="Perwitasari O">O. Perwitasari</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author><author><name sortKey="Gill, M A" uniqKey="Gill M">M.A. Gill</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. García-Sastre</name></author><author><name sortKey="Katze, M G" uniqKey="Katze M">M.G. Katze</name></author><author><name sortKey="Gale, M" uniqKey="Gale M">M. Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Pan, J" uniqKey="Pan J">J. Pan</name></author><author><name sortKey="Tao, J" uniqKey="Tao J">J. Tao</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lui, P Y" uniqKey="Lui P">P.-Y. Lui</name></author><author><name sortKey="Wong, L Y R" uniqKey="Wong L">L.-Y.R. Wong</name></author><author><name sortKey="Fung, C L" uniqKey="Fung C">C.-L. Fung</name></author><author><name sortKey="Siu, K L" uniqKey="Siu K">K.-L. Siu</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M.-L. Yeung</name></author><author><name sortKey="Yuen, K S" uniqKey="Yuen K">K.-S. Yuen</name></author><author><name sortKey="Chan, C P" uniqKey="Chan C">C.-P. Chan</name></author><author><name sortKey="Woo, P C Y" uniqKey="Woo P">P.C.-Y. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D.-Y. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author><author><name sortKey="Jones, S J M" uniqKey="Jones S">S.J.M. Jones</name></author><author><name sortKey="Astell, C R" uniqKey="Astell C">C.R. Astell</name></author><author><name sortKey="Holt, R A" uniqKey="Holt R">R.A. Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A. Brooks-Wilson</name></author><author><name sortKey="Butterfield, Y S N" uniqKey="Butterfield Y">Y.S.N. Butterfield</name></author><author><name sortKey="Khattra, J" uniqKey="Khattra J">J. Khattra</name></author><author><name sortKey="Asano, J K" uniqKey="Asano J">J.K. Asano</name></author><author><name sortKey="Barber, S A" uniqKey="Barber S">S.A. Barber</name></author><author><name sortKey="Chan, S Y" uniqKey="Chan S">S.Y. Chan</name></author><author><name sortKey="Cloutier, A" uniqKey="Cloutier A">A. Cloutier</name></author><author><name sortKey="Coughlin, S M" uniqKey="Coughlin S">S.M. Coughlin</name></author><author><name sortKey="Freeman, D" uniqKey="Freeman D">D. Freeman</name></author><author><name sortKey="Girn, N" uniqKey="Girn N">N. Girn</name></author><author><name sortKey="Griffith, O L" uniqKey="Griffith O">O.L. Griffith</name></author><author><name sortKey="Leach, S R" uniqKey="Leach S">S.R. Leach</name></author><author><name sortKey="Mayo, M" uniqKey="Mayo M">M. Mayo</name></author><author><name sortKey="Mcdonald, H" uniqKey="Mcdonald H">H. McDonald</name></author><author><name sortKey="Montgomery, S B" uniqKey="Montgomery S">S.B. Montgomery</name></author><author><name sortKey="Pandoh, P K" uniqKey="Pandoh P">P.K. Pandoh</name></author><author><name sortKey="Petrescu, A S" uniqKey="Petrescu A">A.S. Petrescu</name></author><author><name sortKey="Robertson, A G" uniqKey="Robertson A">A.G. Robertson</name></author><author><name sortKey="Schein, J E" uniqKey="Schein J">J.E. Schein</name></author><author><name sortKey="Siddiqui, A" uniqKey="Siddiqui A">A. Siddiqui</name></author><author><name sortKey="Smailus, D E" uniqKey="Smailus D">D.E. Smailus</name></author><author><name sortKey="Stott, J M" uniqKey="Stott J">J.M. Stott</name></author><author><name sortKey="Yang, G S" uniqKey="Yang G">G.S. Yang</name></author><author><name sortKey="Plummer, F" uniqKey="Plummer F">F. Plummer</name></author><author><name sortKey="Andonov, A" uniqKey="Andonov A">A. Andonov</name></author><author><name sortKey="Artsob, H" uniqKey="Artsob H">H. Artsob</name></author><author><name sortKey="Bastien, N" uniqKey="Bastien N">N. Bastien</name></author><author><name sortKey="Bernard, K" uniqKey="Bernard K">K. Bernard</name></author><author><name sortKey="Booth, T F" uniqKey="Booth T">T.F. Booth</name></author><author><name sortKey="Bowness, D" uniqKey="Bowness D">D. Bowness</name></author><author><name sortKey="Czub, M" uniqKey="Czub M">M. Czub</name></author><author><name sortKey="Drebot, M" uniqKey="Drebot M">M. Drebot</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L. Fernando</name></author><author><name sortKey="Flick, R" uniqKey="Flick R">R. Flick</name></author><author><name sortKey="Garbutt, M" uniqKey="Garbutt M">M. Garbutt</name></author><author><name sortKey="Gray, M" uniqKey="Gray M">M. Gray</name></author><author><name sortKey="Grolla, A" uniqKey="Grolla A">A. Grolla</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S. Jones</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name></author><author><name sortKey="Meyers, A" uniqKey="Meyers A">A. Meyers</name></author><author><name sortKey="Kabani, A" uniqKey="Kabani A">A. Kabani</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Normand, S" uniqKey="Normand S">S. Normand</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U. Stroher</name></author><author><name sortKey="Tipples, G A" uniqKey="Tipples G">G.A. Tipples</name></author><author><name sortKey="Tyler, S" uniqKey="Tyler S">S. Tyler</name></author><author><name sortKey="Vogrig, R" uniqKey="Vogrig R">R. Vogrig</name></author><author><name sortKey="Ward, D" uniqKey="Ward D">D. Ward</name></author><author><name sortKey="Watson, B" uniqKey="Watson B">B. Watson</name></author><author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C. Brunham</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M. Krajden</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M. Petric</name></author><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name></author><author><name sortKey="Upton, C" uniqKey="Upton C">C. Upton</name></author><author><name sortKey="Roper, R L" uniqKey="Roper R">R.L. Roper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, K" uniqKey="Matthews K">K. Matthews</name></author><author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A. Schäfer</name></author><author><name sortKey="Pham, A" uniqKey="Pham A">A. Pham</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minakshi, R" uniqKey="Minakshi R">R. Minakshi</name></author><author><name sortKey="Padhan, K" uniqKey="Padhan K">K. Padhan</name></author><author><name sortKey="Rani, M" uniqKey="Rani M">M. Rani</name></author><author><name sortKey="Khan, N" uniqKey="Khan N">N. Khan</name></author><author><name sortKey="Ahmad, F" uniqKey="Ahmad F">F. Ahmad</name></author><author><name sortKey="Jameel, S" uniqKey="Jameel S">S. Jameel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K. Lokugamage</name></author><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W. Kamitani</name></author><author><name sortKey="Ikegami, T" uniqKey="Ikegami T">T. Ikegami</name></author><author><name sortKey="Tseng, C T K" uniqKey="Tseng C">C.-T.K. Tseng</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onomoto, K" uniqKey="Onomoto K">K. Onomoto</name></author><author><name sortKey="Yoneyama, M" uniqKey="Yoneyama M">M. Yoneyama</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M. Oostra</name></author><author><name sortKey="De Haan, C A M" uniqKey="De Haan C">C.A.M. de Haan</name></author><author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P.J.M. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ran, Y" uniqKey="Ran Y">Y. Ran</name></author><author><name sortKey="Liu, T T" uniqKey="Liu T">T.-T. Liu</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author><author><name sortKey="Li, S" uniqKey="Li S">S. Li</name></author><author><name sortKey="Mao, A P" uniqKey="Mao A">A.-P. Mao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Liu, L J" uniqKey="Liu L">L.-J. Liu</name></author><author><name sortKey="Cheng, J K" uniqKey="Cheng J">J.-K. Cheng</name></author><author><name sortKey="Shu, H B" uniqKey="Shu H">H.-B. Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saira, K" uniqKey="Saira K">K. Saira</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jones, C" uniqKey="Jones C">C. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saitoh, T" uniqKey="Saitoh T">T. Saitoh</name></author><author><name sortKey="Tun Kyi, A" uniqKey="Tun Kyi A">A. Tun-Kyi</name></author><author><name sortKey="Ryo, A" uniqKey="Ryo A">A. Ryo</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Finn, G" uniqKey="Finn G">G. Finn</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N. Yamamoto</name></author><author><name sortKey="Lu, K P" uniqKey="Lu K">K.P. Lu</name></author><author><name sortKey="Yamaoka, S" uniqKey="Yamaoka S">S. Yamaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sen, A" uniqKey="Sen A">A. Sen</name></author><author><name sortKey="Feng, N" uniqKey="Feng N">N. Feng</name></author><author><name sortKey="Ettayebi, K" uniqKey="Ettayebi K">K. Ettayebi</name></author><author><name sortKey="Hardy, M E" uniqKey="Hardy M">M.E. Hardy</name></author><author><name sortKey="Greenberg, H B" uniqKey="Greenberg H">H.B. Greenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Fang, S G" uniqKey="Fang S">S.G. Fang</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B. Chen</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Tay, F P L" uniqKey="Tay F">F.P.L. Tay</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siu, K L" uniqKey="Siu K">K.-L. Siu</name></author><author><name sortKey="Kok, K H" uniqKey="Kok K">K.-H. Kok</name></author><author><name sortKey="Ng, M H J" uniqKey="Ng M">M.-H.J. Ng</name></author><author><name sortKey="Poon, V K M" uniqKey="Poon V">V.K.M. Poon</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.-J. Zheng</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D.-Y. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siu, K L" uniqKey="Siu K">K.-L. Siu</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M.L. Yeung</name></author><author><name sortKey="Kok, K H" uniqKey="Kok K">K.-H. Kok</name></author><author><name sortKey="Yuen, K S" uniqKey="Yuen K">K.-S. Yuen</name></author><author><name sortKey="Kew, C" uniqKey="Kew C">C. Kew</name></author><author><name sortKey="Lui, P Y" uniqKey="Lui P">P.-Y. Lui</name></author><author><name sortKey="Chan, C P" uniqKey="Chan C">C.-P. Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H. Tse</name></author><author><name sortKey="Woo, P C Y" uniqKey="Woo P">P.C.Y. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D.-Y. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiegel, M" uniqKey="Spiegel M">M. Spiegel</name></author><author><name sortKey="Pichlmair, A" uniqKey="Pichlmair A">A. Pichlmair</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martínez-Sobrido</name></author><author><name sortKey="Cros, J" uniqKey="Cros J">J. Cros</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. García-Sastre</name></author><author><name sortKey="Haller, O" uniqKey="Haller O">O. Haller</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiegel, M" uniqKey="Spiegel M">M. Spiegel</name></author><author><name sortKey="Pichlmair, A" uniqKey="Pichlmair A">A. Pichlmair</name></author><author><name sortKey="Muhlberger, E" uniqKey="Muhlberger E">E. Mühlberger</name></author><author><name sortKey="Haller, O" uniqKey="Haller O">O. Haller</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stetson, D B" uniqKey="Stetson D">D.B. Stetson</name></author><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R. Medzhitov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suhara, W" uniqKey="Suhara W">W. Suhara</name></author><author><name sortKey="Yoneyama, M" uniqKey="Yoneyama M">M. Yoneyama</name></author><author><name sortKey="Kitabayashi, I" uniqKey="Kitabayashi I">I. Kitabayashi</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, S C" uniqKey="Sung S">S.C. Sung</name></author><author><name sortKey="Chao, C Y" uniqKey="Chao C">C.Y. Chao</name></author><author><name sortKey="Jeng, K S" uniqKey="Jeng K">K.S. Jeng</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Lai, M" uniqKey="Lai M">M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Y W" uniqKey="Tan Y">Y.W. Tan</name></author><author><name sortKey="Fang, S" uniqKey="Fang S">S. Fang</name></author><author><name sortKey="Fan, H" uniqKey="Fan H">H. Fan</name></author><author><name sortKey="Lescar, J" uniqKey="Lescar J">J. Lescar</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T. Taniguchi</name></author><author><name sortKey="Ogasawara, K" uniqKey="Ogasawara K">K. Ogasawara</name></author><author><name sortKey="Takaoka, A" uniqKey="Takaoka A">A. Takaoka</name></author><author><name sortKey="Tanaka, N" uniqKey="Tanaka N">N. Tanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thanos, D" uniqKey="Thanos D">D. Thanos</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T. Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Versteeg, G A" uniqKey="Versteeg G">G.A. Versteeg</name></author><author><name sortKey="Bredenbeek, P J" uniqKey="Bredenbeek P">P.J. Bredenbeek</name></author><author><name sortKey="Van Den Worm, S H E" uniqKey="Van Den Worm S">S.H.E. van den Worm</name></author><author><name sortKey="Spaan, W J M" uniqKey="Spaan W">W.J.M. Spaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G. Wang</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Zheng, D" uniqKey="Zheng D">D. Zheng</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wathelet, M G" uniqKey="Wathelet M">M.G. Wathelet</name></author><author><name sortKey="Orr, M" uniqKey="Orr M">M. Orr</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author><author><name sortKey="Kochs, G" uniqKey="Kochs G">G. Kochs</name></author><author><name sortKey="Haller, O" uniqKey="Haller O">O. Haller</name></author><author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P. Staeheli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Ye, F" uniqKey="Ye F">F. Ye</name></author><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z. Zhao</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Roberts, R S" uniqKey="Roberts R">R.S. Roberts</name></author><author><name sortKey="Sims, A C" uniqKey="Sims A">A.C. Sims</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author><author><name sortKey="Sparks, J" uniqKey="Sparks J">J. Sparks</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author><author><name sortKey="Davis, N" uniqKey="Davis N">N. Davis</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author><author><name sortKey="Tian, Y" uniqKey="Tian Y">Y. Tian</name></author><author><name sortKey="Wang, R P" uniqKey="Wang R">R.-P. Wang</name></author><author><name sortKey="Gao, D" uniqKey="Gao D">D. Gao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Diao, F C" uniqKey="Diao F">F.-C. Diao</name></author><author><name sortKey="Chen, D Y" uniqKey="Chen D">D.-Y. Chen</name></author><author><name sortKey="Zhai, Z H" uniqKey="Zhai Z">Z.-H. Zhai</name></author><author><name sortKey="Shu, H B" uniqKey="Shu H">H.-B. Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Shi, K" uniqKey="Shi K">K. Shi</name></author><author><name sortKey="Yoo, D" uniqKey="Yoo D">D. Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="He, M L" uniqKey="He M">M.-L. He</name></author><author><name sortKey="Wong, K L" uniqKey="Wong K">K.-L. Wong</name></author><author><name sortKey="Lum, C T" uniqKey="Lum C">C.T. Lum</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Lin, M C M" uniqKey="Lin M">M.C.M. Lin</name></author><author><name sortKey="Kung, H F" uniqKey="Kung H">H.-F. Kung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y. Zhong</name></author><author><name sortKey="Tan, Y W" uniqKey="Tan Y">Y.W. Tan</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn><publisher><publisher-name>Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29294448</article-id><article-id pub-id-type="pmc">7112132</article-id><article-id pub-id-type="publisher-id">S0042-6822(17)30442-7</article-id><article-id pub-id-type="doi">10.1016/j.virol.2017.12.028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Wong</surname><given-names>Hui Hui</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0010"><name><surname>Fung</surname><given-names>To Sing</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0015"><name><surname>Fang</surname><given-names>Shouguo</given-names></name><xref rid="aff0015" ref-type="aff">c</xref><xref rid="aff0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au0020"><name><surname>Huang</surname><given-names>Mei</given-names></name><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0025"><name><surname>Le</surname><given-names>My Tra</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0030"><name><surname>Liu</surname><given-names>Ding Xiang</given-names></name><email>dxliu0001@163.com</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0015" ref-type="aff">c</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China</aff><aff id="aff0010"><label>b</label>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore</aff><aff id="aff0015"><label>c</label>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore</aff><aff id="aff0020"><label>d</label>Agricultural School, Yangtze University, 266 Jingmilu, Jingzhou City, Hubei Province 434025, China.</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author at: South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China. <email>dxliu0001@163.com</email></corresp><fn id="fn1"><label>1</label><p id="ntp0005">Equal contribution.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>12</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2017</year></pub-date><volume>515</volume><fpage>165</fpage><lpage>175</lpage><history><date date-type="received"><day>10</day><month>11</month><year>2017</year></date><date date-type="rev-recd"><day>22</day><month>12</month><year>2017</year></date><date date-type="accepted"><day>25</day><month>12</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 Elsevier Inc.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0010"><p>Severe acute respiratory syndrome coronavirus (SARS-CoV) is an inefficient inducer of interferon (IFN) response. It expresses various proteins that effectively circumvent IFN production at different levels via distinct mechanisms. Through the construction of recombinant IBV expressing proteins 8a, 8b and 8ab encoded by SARS-CoV ORF8, we demonstrate that expression of 8b and 8ab enables the corresponding recombinant viruses to partially overcome the inhibitory actions of IFN activation to achieve higher replication efficiencies in cells. We also found that proteins 8b and 8ab could physically interact with IRF3. Overexpression of 8b and 8ab resulted in the reduction of poly (I:C)-induced IRF3 dimerization and inhibition of the IFN-β signaling pathway. This counteracting effect was partially mediated by protein 8b/8ab-induced degradation of IRF3 in a ubiquitin-proteasome-dependent manner. Taken together, we propose that SARS-CoV may exploit the unique functions of proteins 8b and 8ab as novel mechanisms to overcome the effect of IFN response during virus infection.</p></abstract><abstract abstract-type="author-highlights" id="ab0015"><title>Highlights</title><p><list list-type="simple" id="li0005"><list-item id="u0005"><label>•</label><p id="p0005">Recombinant IBV expressing SARS-CoV protein 8b or 8ab replicates better than wild type in cells pre-treated with poly(I:C).</p></list-item><list-item id="u0010"><label>•</label><p id="p0010">8b interacts with the IAD domain of IRF3.</p></list-item><list-item id="u0015"><label>•</label><p id="p0015">Overexpression of 8b or 8ab reduces poly(I:C)-induced IRF3 dimerization and interferon induction.</p></list-item><list-item id="u0020"><label>•</label><p id="p0020">8b and 8ab induce degradation of IRF3 in a ubiquitin-proteasome-dependent manner.</p></list-item><list-item id="u0025"><label>•</label><p id="p0025">8b and 8ab suppress interferon response induced by constitutively active IRF3.</p></list-item></list></p></abstract><kwd-group id="keys0005"><title>Keywords</title><kwd>IFN antagonist</kwd><kwd>IRF3</kwd><kwd>SARS-CoV</kwd><kwd>ORF8</kwd><kwd>Ubiquitin-dependent degradation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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