Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel
Identifieur interne : 001349 ( Pmc/Curation ); précédent : 001348; suivant : 001350Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel
Auteurs : Shelan Liu [République populaire de Chine] ; Ta-Chien Chan [Taïwan] ; Yu-Tseng Chu [Taïwan] ; Joseph Tsung-Shu Wu [Taïwan, Malawi] ; Xingyi Geng [République populaire de Chine] ; Na Zhao [République populaire de Chine] ; Wei Cheng [République populaire de Chine] ; Enfu Chen [République populaire de Chine] ; Chwan-Chuen King [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP. The epidemiological findings showed that the mean age of MERS-HCP and total MERS cases were 40 (24~74) and 49 (2~90) years, respectively, much older than those in SARS [SARS-HCP: 35 (21~68) years,
Url:
DOI: 10.1371/journal.pone.0149988
PubMed: 26930074
PubMed Central: 4773072
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id="aff002"><addr-line>Center for Geographic Information Science, Research Center for Humanities and Social Science, Academia Sinica, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Geographic Information Science, Research Center for Humanities and Social Science, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Chu, Yu Tseng" sort="Chu, Yu Tseng" uniqKey="Chu Y" first="Yu-Tseng" last="Chu">Yu-Tseng Chu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Institute of Statistical 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International, Malawi Office and Mzuzu University, Mzuzu City</wicri:regionArea></affiliation></author><author><name sortKey="Geng, Xingyi" sort="Geng, Xingyi" uniqKey="Geng X" first="Xingyi" last="Geng">Xingyi Geng</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Na" sort="Zhao, Na" uniqKey="Zhao N" first="Na" last="Zhao">Na Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Wei" sort="Cheng, Wei" uniqKey="Cheng W" first="Wei" last="Cheng">Wei Cheng</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Enfu" sort="Chen, Enfu" uniqKey="Chen E" first="Enfu" last="Chen">Enfu Chen</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province</wicri:regionArea></affiliation></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 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last="Liu">Shelan Liu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Ta Chien" sort="Chan, Ta Chien" uniqKey="Chan T" first="Ta-Chien" last="Chan">Ta-Chien Chan</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Center for Geographic Information Science, Research Center for Humanities and Social Science, Academia Sinica, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Geographic Information Science, Research Center for Humanities and Social Science, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Chu, Yu Tseng" sort="Chu, Yu Tseng" uniqKey="Chu Y" first="Yu-Tseng" last="Chu">Yu-Tseng Chu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Institute of Statistical Science, Academia Sinica, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Statistical Science, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Joseph Tsung Shu" sort="Wu, Joseph Tsung Shu" uniqKey="Wu J" first="Joseph Tsung-Shu" last="Wu">Joseph Tsung-Shu Wu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Luke International, Malawi Office and Mzuzu University, Mzuzu City, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Luke International, Malawi Office and Mzuzu University, Mzuzu City</wicri:regionArea></affiliation></author><author><name sortKey="Geng, Xingyi" sort="Geng, Xingyi" uniqKey="Geng X" first="Xingyi" last="Geng">Xingyi Geng</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Na" sort="Zhao, Na" uniqKey="Zhao N" first="Na" last="Zhao">Na Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Wei" sort="Cheng, Wei" uniqKey="Cheng W" first="Wei" last="Cheng">Wei Cheng</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Enfu" sort="Chen, Enfu" uniqKey="Chen E" first="Enfu" last="Chen">Enfu Chen</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province</wicri:regionArea></affiliation></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP. The epidemiological findings showed that the mean age of MERS-HCP and total MERS cases were 40 (24~74) and 49 (2~90) years, respectively, much older than those in SARS [SARS-HCP: 35 (21~68) years, <italic>p =</italic> 0.006; total SARS: 42 (0~94) years, <italic>p =</italic> 0.0002]. The case fatality rates (CFR) was much lower in MERS-HCP [7.03% (9/128)] or SARS-HCP [12.24% (12/98)] than the MERS-non-HCP [36.96% (34/92), <italic>p<0</italic>.<italic>001</italic>] or SARS-non-HCP [24.50% (61/249), <italic>p<0</italic>.<italic>001</italic>], however, no difference was found between MERS-HCP and SARS-HCP [<italic>p = 0</italic>.<italic>181</italic>]. In terms of clinical period, the days from onset to death [13 (4~17) vs 14.5 (0~52), <italic>p</italic> = 0.045] and to discharge [11 (5~24) vs 24 (0~74), <italic>p =</italic> 0.010] and be hospitalized days [9.5 (3~22) vs 22 (0~69), <italic>p</italic> = 0.040] were much shorter in MERS-HCP than SARS-HCP. Similarly, days from onset to confirmation were shorter in MERS-HCP than MERS-non-HCP [6 (1~14) vs 10 (1~21), <italic>p =</italic> 0.044]. In conclusion, the severity of MERS-HCP and SARS-HCP was lower than that of MERS-non-HCP and SARS-non-HCP due to younger age and early confirmation in HCP groups. However, no statistical difference was found in MERS-HCP and SARS-HCP. Thus, prevention of nosocomial infections involving both novel Coronavirus is crucially important to protect HCP.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mcnabb, Sj" uniqKey="Mcnabb S">SJ McNabb</name></author><author><name sortKey="Shaikh, A" uniqKey="Shaikh A">A Shaikh</name></author><author><name sortKey="Heymann, Dl" uniqKey="Heymann D">DL Heymann</name></author><author><name sortKey="Mccloskey, B" uniqKey="Mccloskey B">B McCloskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Brown, Cs" 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Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomersall, Cd" uniqKey="Gomersall C">CD Gomersall</name></author><author><name sortKey="Joynt, Gm" uniqKey="Joynt G">GM Joynt</name></author><author><name sortKey="Ho, Om" uniqKey="Ho O">OM Ho</name></author><author><name sortKey="Ip, M" uniqKey="Ip M">M Ip</name></author><author><name sortKey="Yap, F" uniqKey="Yap F">F Yap</name></author><author><name sortKey="Derrick, Jl" uniqKey="Derrick J">JL Derrick</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26930074</article-id><article-id pub-id-type="pmc">4773072</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0149988</article-id><article-id pub-id-type="publisher-id">PONE-D-15-46268</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Viral Diseases</subject><subj-group><subject>SARS</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Coronaviruses</subject><subj-group><subject>SARS coronavirus</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical microbiology</subject><subj-group><subject>Microbial pathogens</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Coronaviruses</subject><subj-group><subject>SARS coronavirus</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and health sciences</subject><subj-group><subject>Pathology and laboratory medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial pathogens</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Coronaviruses</subject><subj-group><subject>SARS coronavirus</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Coronaviruses</subject><subj-group><subject>SARS coronavirus</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pulmonology</subject><subj-group><subject>Respiratory Infections</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Geographical Locations</subject><subj-group><subject>Asia</subject><subj-group><subject>Taiwan</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Coronaviruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Coronaviruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Coronaviruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Coronaviruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Infectious Disease Control</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Population Biology</subject><subj-group><subject>Population Dynamics</subject><subj-group><subject>Geographic Distribution</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and places</subject><subj-group><subject>Geographical locations</subject><subj-group><subject>Asia</subject><subj-group><subject>Saudi Arabia</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel</article-title><alt-title alt-title-type="running-head">MERS and SARS among Healthcare Personnel</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Liu</surname><given-names>Shelan</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Chan</surname><given-names>Ta-Chien</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Yu-Tseng</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Joseph Tsung-Shu</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Geng</surname><given-names>Xingyi</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Na</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Enfu</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>King</surname><given-names>Chwan-Chuen</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Center for Geographic Information Science, Research Center for Humanities and Social Science, Academia Sinica, Taipei, Taiwan</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Institute of Statistical Science, Academia Sinica, Taipei, Taiwan</addr-line></aff><aff id="aff005"><label>5</label><addr-line>Luke International, Malawi Office and Mzuzu University, Mzuzu City, Malawi</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province, China</addr-line></aff><aff id="aff007"><label>7</label><addr-line>National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Chan</surname><given-names>Renee W.Y.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>The Chinese University of Hong Kong, HONG KONG</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: SLL CCK. Performed the experiments: SLL TCC YTC JTSW. Analyzed the data: TCC YTC JTSW. Contributed reagents/materials/analysis tools: XYG NZ WC EFC. Wrote the paper: SLL.</p></fn><corresp id="cor001">* E-mail: <email>liushelan@126.com</email> (SLL); <email>chwanchuen@gmail.com</email> (CCK)</corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>3</issue><elocation-id>e0149988</elocation-id><history><date date-type="received"><day>21</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>7</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Liu et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Liu et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0149988.pdf"></self-uri><abstract><p>The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP. The epidemiological findings showed that the mean age of MERS-HCP and total MERS cases were 40 (24~74) and 49 (2~90) years, respectively, much older than those in SARS [SARS-HCP: 35 (21~68) years, <italic>p =</italic> 0.006; total SARS: 42 (0~94) years, <italic>p =</italic> 0.0002]. The case fatality rates (CFR) was much lower in MERS-HCP [7.03% (9/128)] or SARS-HCP [12.24% (12/98)] than the MERS-non-HCP [36.96% (34/92), <italic>p<0</italic>.<italic>001</italic>] or SARS-non-HCP [24.50% (61/249), <italic>p<0</italic>.<italic>001</italic>], however, no difference was found between MERS-HCP and SARS-HCP [<italic>p = 0</italic>.<italic>181</italic>]. In terms of clinical period, the days from onset to death [13 (4~17) vs 14.5 (0~52), <italic>p</italic> = 0.045] and to discharge [11 (5~24) vs 24 (0~74), <italic>p =</italic> 0.010] and be hospitalized days [9.5 (3~22) vs 22 (0~69), <italic>p</italic> = 0.040] were much shorter in MERS-HCP than SARS-HCP. Similarly, days from onset to confirmation were shorter in MERS-HCP than MERS-non-HCP [6 (1~14) vs 10 (1~21), <italic>p =</italic> 0.044]. In conclusion, the severity of MERS-HCP and SARS-HCP was lower than that of MERS-non-HCP and SARS-non-HCP due to younger age and early confirmation in HCP groups. However, no statistical difference was found in MERS-HCP and SARS-HCP. Thus, prevention of nosocomial infections involving both novel Coronavirus is crucially important to protect HCP.</p></abstract><funding-group><funding-statement>This study was supported by the Taiwan Science Foundation (NSF Grant #92-2751-B-002-020-Y).</funding-statement></funding-group><counts><fig-count count="4"></fig-count><table-count count="3"></table-count><page-count count="16"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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