Multiple organ infection and the pathogenesis of SARS
Identifieur interne : 001135 ( Pmc/Curation ); précédent : 001134; suivant : 001136Multiple organ infection and the pathogenesis of SARS
Auteurs : Jiang Gu [République populaire de Chine, États-Unis] ; Encong Gong [République populaire de Chine] ; Bo Zhang [République populaire de Chine] ; Jie Zheng [République populaire de Chine] ; Zifen Gao [République populaire de Chine] ; Yanfeng Zhong [République populaire de Chine] ; Wanzhong Zou [République populaire de Chine] ; Jun Zhan [République populaire de Chine] ; Shenglan Wang [République populaire de Chine] ; Zhigang Xie [République populaire de Chine] ; Hui Zhuang [République populaire de Chine] ; Bingquan Wu [République populaire de Chine] ; Haohao Zhong [République populaire de Chine] ; Hongquan Shao [République populaire de Chine] ; Weigang Fang [République populaire de Chine] ; Dongshia Gao [République populaire de Chine] ; Fei Pei [République populaire de Chine] ; Xingwang Li ; Zhongpin He ; Danzhen Xu ; Xeying Shi [République populaire de Chine] ; Virginia M. Anderson [États-Unis] ; Anthony S.-Y. LeongSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2005.
Abstract
After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.
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DOI: 10.1084/jem.20050828
PubMed: 16043521
PubMed Central: 2213088
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Xingwang Li<affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff5">Hunter Area Pathology Services and Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia 2310</nlm:aff><wicri:noCountry code="subfield">Australia 2310</wicri:noCountry></affiliation>Le document en format XML
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type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Wu, Bingquan" sort="Wu, Bingquan" uniqKey="Wu B" first="Bingquan" last="Wu">Bingquan Wu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhong, Haohao" sort="Zhong, Haohao" uniqKey="Zhong H" first="Haohao" last="Zhong">Haohao Zhong</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Shao, Hongquan" sort="Shao, Hongquan" uniqKey="Shao H" first="Hongquan" last="Shao">Hongquan Shao</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Fang, Weigang" sort="Fang, Weigang" uniqKey="Fang W" first="Weigang" last="Fang">Weigang Fang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Gao, Dongshia" sort="Gao, Dongshia" uniqKey="Gao D" first="Dongshia" last="Gao">Dongshia Gao</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Pei, Fei" sort="Pei, Fei" uniqKey="Pei F" first="Fei" last="Pei">Fei Pei</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="He, Zhongpin" sort="He, Zhongpin" uniqKey="He Z" first="Zhongpin" last="He">Zhongpin He</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Danzhen" sort="Xu, Danzhen" uniqKey="Xu D" first="Danzhen" last="Xu">Danzhen Xu</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="Shi, Xeying" sort="Shi, Xeying" uniqKey="Shi X" first="Xeying" last="Shi">Xeying Shi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Anderson, Virginia M" sort="Anderson, Virginia M" uniqKey="Anderson V" first="Virginia M." last="Anderson">Virginia M. Anderson</name><affiliation wicri:level="2"><nlm:aff id="aff4">State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>State University of New York Health Science Center at Brooklyn, Brooklyn</wicri:cityArea></affiliation></author><author><name sortKey="Leong, Anthony S Y" sort="Leong, Anthony S Y" uniqKey="Leong A" first="Anthony S.-Y." last="Leong">Anthony S.-Y. Leong</name><affiliation><nlm:aff id="aff5">Hunter Area Pathology Services and Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia 2310</nlm:aff><wicri:noCountry code="subfield">Australia 2310</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16043521</idno><idno type="pmc">2213088</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213088</idno><idno type="RBID">PMC:2213088</idno><idno type="doi">10.1084/jem.20050828</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001135</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001135</idno><idno type="wicri:Area/Pmc/Curation">001135</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multiple organ infection and the pathogenesis of SARS</title><author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>State University of New York Health Science Center at Brooklyn, Brooklyn</wicri:cityArea></affiliation></author><author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhang, Bo" sort="Zhang, Bo" uniqKey="Zhang B" first="Bo" last="Zhang">Bo Zhang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Gao, Zifen" sort="Gao, Zifen" uniqKey="Gao Z" first="Zifen" last="Gao">Zifen Gao</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhong, Yanfeng" sort="Zhong, Yanfeng" uniqKey="Zhong Y" first="Yanfeng" last="Zhong">Yanfeng Zhong</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zou, Wanzhong" sort="Zou, Wanzhong" uniqKey="Zou W" first="Wanzhong" last="Zou">Wanzhong Zou</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhan, Jun" sort="Zhan, Jun" uniqKey="Zhan J" first="Jun" last="Zhan">Jun Zhan</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Wang, Shenglan" sort="Wang, Shenglan" uniqKey="Wang S" first="Shenglan" last="Wang">Shenglan Wang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Xie, Zhigang" sort="Xie, Zhigang" uniqKey="Xie Z" first="Zhigang" last="Xie">Zhigang Xie</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Wu, Bingquan" sort="Wu, Bingquan" uniqKey="Wu B" first="Bingquan" last="Wu">Bingquan Wu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Zhong, Haohao" sort="Zhong, Haohao" uniqKey="Zhong H" first="Haohao" last="Zhong">Haohao Zhong</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Shao, Hongquan" sort="Shao, Hongquan" uniqKey="Shao H" first="Hongquan" last="Shao">Hongquan Shao</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Fang, Weigang" sort="Fang, Weigang" uniqKey="Fang W" first="Weigang" last="Fang">Weigang Fang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Gao, Dongshia" sort="Gao, Dongshia" uniqKey="Gao D" first="Dongshia" last="Gao">Dongshia Gao</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Pei, Fei" sort="Pei, Fei" uniqKey="Pei F" first="Fei" last="Pei">Fei Pei</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="He, Zhongpin" sort="He, Zhongpin" uniqKey="He Z" first="Zhongpin" last="He">Zhongpin He</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Danzhen" sort="Xu, Danzhen" uniqKey="Xu D" first="Danzhen" last="Xu">Danzhen Xu</name><affiliation><nlm:aff id="aff3">Beijing Ditan Hospital, Beijing, China 100011</nlm:aff><wicri:noCountry code="subfield">China 100011</wicri:noCountry></affiliation></author><author><name sortKey="Shi, Xeying" sort="Shi, Xeying" uniqKey="Shi X" first="Xeying" last="Shi">Xeying Shi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Pathology, Peking University, Beijing, China 100083</nlm:aff><orgName type="university">Université de Pékin</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Anderson, Virginia M" sort="Anderson, Virginia M" uniqKey="Anderson V" first="Virginia M." last="Anderson">Virginia M. Anderson</name><affiliation wicri:level="2"><nlm:aff id="aff4">State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>State University of New York Health Science Center at Brooklyn, Brooklyn</wicri:cityArea></affiliation></author><author><name sortKey="Leong, Anthony S Y" sort="Leong, Anthony S Y" uniqKey="Leong A" first="Anthony S.-Y." last="Leong">Anthony S.-Y. Leong</name><affiliation><nlm:aff id="aff5">Hunter Area Pathology Services and Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia 2310</nlm:aff><wicri:noCountry code="subfield">Australia 2310</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id><journal-id journal-id-type="iso-abbrev">J. Exp. Med</journal-id><journal-title-group><journal-title>The Journal of Experimental Medicine</journal-title></journal-title-group><issn pub-type="ppub">0022-1007</issn><issn pub-type="epub">1540-9538</issn><publisher><publisher-name>The Rockefeller University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16043521</article-id><article-id pub-id-type="pmc">2213088</article-id><article-id pub-id-type="publisher-id">20050828</article-id><article-id pub-id-type="doi">10.1084/jem.20050828</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Multiple organ infection and the pathogenesis of SARS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Jiang</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Encong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Zifen</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Yanfeng</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Wanzhong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhan</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Shenglan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Zhigang</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhuang</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Bingquan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Haohao</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shao</surname><given-names>Hongquan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fang</surname><given-names>Weigang</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Dongshia</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pei</surname><given-names>Fei</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Xingwang</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Zhongpin</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Danzhen</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Xeying</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Virginia M.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Leong</surname><given-names>Anthony S.-Y.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Pathology, Peking University, Beijing, China 100083</aff><aff id="aff2"><label>2</label>Department of Microbiology, Peking University, Beijing, China 100083</aff><aff id="aff3"><label>3</label>Beijing Ditan Hospital, Beijing, China 100011</aff><aff id="aff4"><label>4</label>State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203</aff><aff id="aff5"><label>5</label>Hunter Area Pathology Services and Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia 2310</aff><author-notes><fn><p>CORRESPONDENCE Jiang Gu: <email>jgu@privatedoctor.org</email></p></fn></author-notes><pub-date pub-type="ppub"><day>1</day><month>8</month><year>2005</year></pub-date><volume>202</volume><issue>3</issue><fpage>415</fpage><lpage>424</lpage><history><date date-type="received"><day>25</day><month>4</month><year>2005</year></date><date date-type="accepted"><day>16</day><month>6</month><year>2005</year></date></history><permissions><copyright-statement>Copyright © 2005, The Rockefeller University Press</copyright-statement><license license-type="openaccess"><license-p>This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see <ext-link ext-link-type="uri" xlink:href="http://www.rupress.org/terms">http://www.rupress.org/terms</ext-link>). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/">http://creativecommons.org/licenses/by-nc-sa/4.0/</ext-link>).</license-p></license></permissions><abstract><p>After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.</p></abstract></article-meta><notes><fn-group><fn><p>Abbreviations used: CoV, coronavirus; EM, electron microscopy; LM, light microscopy; SARS, severe acute respiratory syndrome.</p></fn></fn-group></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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