A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China
Identifieur interne : 000F04 ( Pmc/Curation ); précédent : 000F03; suivant : 000F05A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China
Auteurs : Xiao-Yan Che ; Biao Di ; Guo-Ping Zhao ; Ya-Di Wang ; Li-Wen Qiu ; Wei Hao ; Ming Wang ; Peng-Zhe Qin ; Yu-Fei Liu ; Kwok-Hong Chan ; Vincent C. C. Cheng ; Kwok-Yung YuenSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2006.
Abstract
An asymptomatic case of severe acute respiratory syndrome (SARS) occurred early in 2004, during a community outbreak of SARS in Guangzhou, China. This was the first time that a case of asymptomatic SARS was noted in an individual with antigenemia and seroconversion. The asymptomatic case patient and the second index case patient with SARS in the 2003–2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses. Epidemiological information and laboratory findings suggested that the findings for the patient with asymptomatic infection, together with the findings from previously reported serological analyses of handlers of wild animals and the 4 index case patients from the 2004 community outbreak, reflected a likely intermediate phase of animal-to-human transmission of infection, rather than a case of human-to-human transmission. This intermediate phase may be a critical stage for virus evolution and disease prevention.
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DOI: 10.1086/504943
PubMed: 16758408
PubMed Central: 7108013
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Cheng</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16758408</idno><idno type="pmc">7108013</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108013</idno><idno type="RBID">PMC:7108013</idno><idno type="doi">10.1086/504943</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000F04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F04</idno><idno type="wicri:Area/Pmc/Curation">000F04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China</title><author><name sortKey="Che, Xiao Yan" sort="Che, Xiao Yan" uniqKey="Che X" first="Xiao-Yan" last="Che">Xiao-Yan Che</name><affiliation><nlm:aff id="aff1"><institution>Center of Laboratory, Zhujiang Hospital, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Di, Biao" sort="Di, Biao" uniqKey="Di B" first="Biao" last="Di">Biao Di</name><affiliation><nlm:aff id="aff2"><institution>Center for Disease Control and Prevention of Guangzhou</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhao, Guo Ping" sort="Zhao, Guo Ping" uniqKey="Zhao G" first="Guo-Ping" last="Zhao">Guo-Ping Zhao</name><affiliation><nlm:aff id="aff3"><institution>Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai</institution>,<addr-line>Shanghai</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Ya Di" sort="Wang, Ya Di" uniqKey="Wang Y" first="Ya-Di" last="Wang">Ya-Di Wang</name><affiliation><nlm:aff id="aff1"><institution>Center of Laboratory, Zhujiang Hospital, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qiu, Li Wen" sort="Qiu, Li Wen" uniqKey="Qiu L" first="Li-Wen" last="Qiu">Li-Wen Qiu</name><affiliation><nlm:aff id="aff1"><institution>Center of Laboratory, Zhujiang Hospital, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hao, Wei" sort="Hao, Wei" uniqKey="Hao W" first="Wei" last="Hao">Wei Hao</name><affiliation><nlm:aff id="aff1"><institution>Center of Laboratory, Zhujiang Hospital, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation><nlm:aff id="aff2"><institution>Center for Disease Control and Prevention of Guangzhou</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qin, Peng Zhe" sort="Qin, Peng Zhe" uniqKey="Qin P" first="Peng-Zhe" last="Qin">Peng-Zhe Qin</name><affiliation><nlm:aff id="aff2"><institution>Center for Disease Control and Prevention of Guangzhou</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Liu, Yu Fei" sort="Liu, Yu Fei" uniqKey="Liu Y" first="Yu-Fei" last="Liu">Yu-Fei Liu</name><affiliation><nlm:aff id="aff2"><institution>Center for Disease Control and Prevention of Guangzhou</institution>,<addr-line>Guangzhou</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Kwok Hong" sort="Chan, Kwok Hong" uniqKey="Chan K" first="Kwok-Hong" last="Chan">Kwok-Hong Chan</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation><nlm:aff id="aff4"><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>An asymptomatic case of severe acute respiratory syndrome (SARS) occurred early in 2004, during a community outbreak of SARS in Guangzhou, China. This was the first time that a case of asymptomatic SARS was noted in an individual with antigenemia and seroconversion. The asymptomatic case patient and the second index case patient with SARS in the 2003–2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses. Epidemiological information and laboratory findings suggested that the findings for the patient with asymptomatic infection, together with the findings from previously reported serological analyses of handlers of wild animals and the 4 index case patients from the 2004 community outbreak, reflected a likely intermediate phase of animal-to-human transmission of infection, rather than a case of human-to-human transmission. This intermediate phase may be a critical stage for virus evolution and disease prevention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liang, Gd" uniqKey="Liang G">GD Liang</name></author><author><name sortKey="Chen, Qx" uniqKey="Chen Q">QX Chen</name></author><author><name sortKey="Xu, Jg" uniqKey="Xu J">JG Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Hd" uniqKey="Song H">HD Song</name></author><author><name sortKey="Tu, Cc" uniqKey="Tu C">CC Tu</name></author><author><name sortKey="Zhang, Gw" uniqKey="Zhang G">GW Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Yan, My" uniqKey="Yan M">MY Yan</name></author><author><name sortKey="Xu, Hf" uniqKey="Xu H">HF Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author><author><name sortKey="Hao, W" uniqKey="Hao W">W Hao</name></author><author><name sortKey="Wang, Yd" uniqKey="Wang Y">YD Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author><author><name sortKey="Qiu, Lw" uniqKey="Qiu L">LW Qiu</name></author><author><name sortKey="Pan, Yx" uniqKey="Pan Y">YX Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Yh" uniqKey="Li Y">YH Li</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Liu, Xe" uniqKey="Liu X">XE Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, Hy" uniqKey="Mo H">HY Mo</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Ren, Xl" uniqKey="Ren X">XL Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wq" uniqKey="Chen W">WQ Chen</name></author><author><name sortKey="Lu, Cy" uniqKey="Lu C">CY Lu</name></author><author><name sortKey="Wong, Tw" uniqKey="Wong T">TW Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Q" uniqKey="He Q">Q He</name></author><author><name sortKey="Manopo, I" uniqKey="Manopo I">I Manopo</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author><author><name sortKey="Qiu, Lw" uniqKey="Qiu L">LW Qiu</name></author><author><name sortKey="Liao, Zy" uniqKey="Liao Z">ZY Liao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewkowich, Ip" uniqKey="Lewkowich I">IP Lewkowich</name></author><author><name sortKey="Campbell, Jd" uniqKey="Campbell J">JD Campbell</name></author><author><name sortKey="Hayglass, Kt" uniqKey="Hayglass K">KT HayGlass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stohr</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilder Smith, A" uniqKey="Wilder Smith A">A Wilder-Smith</name></author><author><name sortKey="Teleman, Md" uniqKey="Teleman M">MD Teleman</name></author><author><name sortKey="Heng, Bh" uniqKey="Heng B">BH Heng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Ky" uniqKey="Ho K">KY Ho</name></author><author><name sortKey="Singh, Ks" uniqKey="Singh K">KS Singh</name></author><author><name sortKey="Habib, Ag" uniqKey="Habib A">AG Habib</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>The University of Chicago Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16758408</article-id><article-id pub-id-type="pmc">7108013</article-id><article-id pub-id-type="doi">10.1086/504943</article-id><article-categories><subj-group subj-group-type="heading"><subject>Electronic Articles</subject><subj-group subj-group-type="category-toc-heading"><subject>Major Article</subject></subj-group></subj-group></article-categories><title-group><article-title>A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Che</surname><given-names>Xiao-yan</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref><pmc-comment>linche@pub.guangzhou.gd.cn </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Di</surname><given-names>Biao</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Guo-ping</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="cor2"></xref><pmc-comment>gpzhao@sibs.ac.cn </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ya-di</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Qiu</surname><given-names>Li-wen</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hao</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ming</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Qin</surname><given-names>Peng-zhe</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yu-fei</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Kwok-hong</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Vincent C. C.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Kwok-yung</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Center of Laboratory, Zhujiang Hospital, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line></aff><aff id="aff2"><label>2</label><institution>Center for Disease Control and Prevention of Guangzhou</institution>,<addr-line>Guangzhou</addr-line></aff><aff id="aff3"><label>3</label><institution>Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai</institution>,<addr-line>Shanghai</addr-line></aff><aff id="aff4"><label>4</label><institution>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</institution>,<addr-line>People's Republic of China</addr-line></aff><author-notes><corresp id="cor1">Reprints or correspondence: Dr. Xiao-yan Che, Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People's Republic of China (<email>linche@pub.guangzhou.gd.cn</email>);</corresp><corresp id="cor2">Dr. Guo-ping Zhao, Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, People's Republic of China (<email>gpzhao@sibs.ac.cn</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>7</month><year>2006</year></pub-date><pub-date pub-type="epub" iso-8601-date="2006-07-01"><day>1</day><month>7</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2006</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>43</volume><issue>1</issue><fpage>e1</fpage><lpage>e5</lpage><history><date date-type="received"><day>30</day><month>6</month><year>2005</year></date><date date-type="rev-recd"><day>18</day><month>3</month><year>2006</year></date></history><permissions><copyright-statement>© 2006 by the Infectious Diseases Society of America</copyright-statement><copyright-year>2006</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="43-1-e1.pdf"></self-uri><abstract><title>Abstract</title><p>An asymptomatic case of severe acute respiratory syndrome (SARS) occurred early in 2004, during a community outbreak of SARS in Guangzhou, China. This was the first time that a case of asymptomatic SARS was noted in an individual with antigenemia and seroconversion. The asymptomatic case patient and the second index case patient with SARS in the 2003–2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses. Epidemiological information and laboratory findings suggested that the findings for the patient with asymptomatic infection, together with the findings from previously reported serological analyses of handlers of wild animals and the 4 index case patients from the 2004 community outbreak, reflected a likely intermediate phase of animal-to-human transmission of infection, rather than a case of human-to-human transmission. This intermediate phase may be a critical stage for virus evolution and disease prevention.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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