Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
Identifieur interne : 000E95 ( Pmc/Curation ); précédent : 000E94; suivant : 000E96Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
Auteurs : Zheng Zhang [République populaire de Chine] ; Dongping Xu [République populaire de Chine] ; Yonggang Li [République populaire de Chine] ; Lei Jin [République populaire de Chine] ; Ming Shi [République populaire de Chine] ; Min Wang [République populaire de Chine] ; Xianzhi Zhou [République populaire de Chine] ; Hao Wu [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; Fu-Sheng Wang [République populaire de Chine]Source :
- Clinical Immunology (Orlando, Fla.) [ 1521-6616 ] ; 2005.
Abstract
In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5–7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.
Url:
DOI: 10.1016/j.clim.2005.04.015
PubMed: 15964242
PubMed Central: 7106242
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E95
Links to Exploration step
PMC:7106242Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome</title><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yonggang" sort="Li, Yonggang" uniqKey="Li Y" first="Yonggang" last="Li">Yonggang Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Ming" sort="Shi, Ming" uniqKey="Shi M" first="Ming" last="Shi">Ming Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xianzhi" sort="Zhou, Xianzhi" uniqKey="Zhou X" first="Xianzhi" last="Zhou">Xianzhi Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Hao" sort="Wu, Hao" uniqKey="Wu H" first="Hao" last="Wu">Hao Wu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Beijing You'an Hospital, Capital Medical University, Beijing 100054, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing You'an Hospital, Capital Medical University, Beijing 100054</wicri:regionArea></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15964242</idno><idno type="pmc">7106242</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106242</idno><idno type="RBID">PMC:7106242</idno><idno type="doi">10.1016/j.clim.2005.04.015</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000E95</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E95</idno><idno type="wicri:Area/Pmc/Curation">000E95</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome</title><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yonggang" sort="Li, Yonggang" uniqKey="Li Y" first="Yonggang" last="Li">Yonggang Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Ming" sort="Shi, Ming" uniqKey="Shi M" first="Ming" last="Shi">Ming Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xianzhi" sort="Zhou, Xianzhi" uniqKey="Zhou X" first="Xianzhi" last="Zhou">Xianzhi Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Hao" sort="Wu, Hao" uniqKey="Wu H" first="Hao" last="Wu">Hao Wu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Beijing You'an Hospital, Capital Medical University, Beijing 100054, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing You'an Hospital, Capital Medical University, Beijing 100054</wicri:regionArea></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Immunology (Orlando, Fla.)</title><idno type="ISSN">1521-6616</idno><idno type="eISSN">1521-7035</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5–7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liang, W N" uniqKey="Liang W">W.N. Liang</name></author><author><name sortKey="Mi, J" uniqKey="Mi J">J. Mi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K S" uniqKey="Chan K">K.S. Chan</name></author><author><name sortKey="Hung, I F" uniqKey="Hung I">I.F. Hung</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Law, K I" uniqKey="Law K">K.I. Law</name></author><author><name sortKey="Tang, B S" uniqKey="Tang B">B.S. Tang</name></author><author><name sortKey="Hon, T Y" uniqKey="Hon T">T.Y. Hon</name></author><author><name sortKey="Chan, C S" uniqKey="Chan C">C.S. Chan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Ng, J S" uniqKey="Ng J">J.S. Ng</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="Ng, W L" uniqKey="Ng W">W.L. Ng</name></author><author><name sortKey="Lai, R W" uniqKey="Lai R">R.W. Lai</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, R S" uniqKey="Wong R">R.S. Wong</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A. Wu</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Lam, C W" uniqKey="Lam C">C.W. Lam</name></author><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Ng, M H" uniqKey="Ng M">M.H. Ng</name></author><author><name sortKey="Yu, L M" uniqKey="Yu L">L.M. Yu</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Tam, J S" uniqKey="Tam J">J.S. Tam</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, W" uniqKey="Cui W">W. Cui</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y. Fan</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Wang, J Y" uniqKey="Wang J">J.Y. Wang</name></author><author><name sortKey="Ni, A P" uniqKey="Ni A">A.P. Ni</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Carbone, F R" uniqKey="Carbone F">F.R. Carbone</name></author><author><name sortKey="Heath, W R" uniqKey="Heath W">W.R. Heath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y J" uniqKey="Liu Y">Y.J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerosa, F" uniqKey="Gerosa F">F. Gerosa</name></author><author><name sortKey="Baldani Guerra, B" uniqKey="Baldani Guerra B">B. Baldani-Guerra</name></author><author><name sortKey="Nisii, C" uniqKey="Nisii C">C. Nisii</name></author><author><name sortKey="Marchesini, V" uniqKey="Marchesini V">V. Marchesini</name></author><author><name sortKey="Carra, G" uniqKey="Carra G">G. Carra</name></author><author><name sortKey="Trinchieri, G" uniqKey="Trinchieri G">G. Trinchieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cella, M" uniqKey="Cella M">M. Cella</name></author><author><name sortKey="Facchetti, F" uniqKey="Facchetti F">F. Facchetti</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A. Lanzavecchia</name></author><author><name sortKey="Colonna, A" uniqKey="Colonna A">A. Colonna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y J" uniqKey="Liu Y">Y.J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langenkamp, A" uniqKey="Langenkamp A">A. Langenkamp</name></author><author><name sortKey="Messi, M" uniqKey="Messi M">M. Messi</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A. Lanzavecchia</name></author><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F. Sallusto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donaghy, H" uniqKey="Donaghy H">H. Donaghy</name></author><author><name sortKey="Gazzard, B" uniqKey="Gazzard B">B. Gazzard</name></author><author><name sortKey="Gotch, F" uniqKey="Gotch F">F. Gotch</name></author><author><name sortKey="Patterson, S" uniqKey="Patterson S">S. Patterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soumelis, V" uniqKey="Soumelis V">V. Soumelis</name></author><author><name sortKey="Scott, I" uniqKey="Scott I">I. Scott</name></author><author><name sortKey="Gheyas, E" uniqKey="Gheyas E">E. Gheyas</name></author><author><name sortKey="Bouhour, D" uniqKey="Bouhour D">D. Bouhour</name></author><author><name sortKey="Cozon, G" uniqKey="Cozon G">G. Cozon</name></author><author><name sortKey="Cotte, L" uniqKey="Cotte L">L. Cotte</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L. Huang</name></author><author><name sortKey="Levy, J A" uniqKey="Levy J">J.A. Levy</name></author><author><name sortKey="Liu, Y J" uniqKey="Liu Y">Y.J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anthony, D D" uniqKey="Anthony D">D.D. Anthony</name></author><author><name sortKey="Yonkers, N L" uniqKey="Yonkers N">N.L. Yonkers</name></author><author><name sortKey="Post, A B" uniqKey="Post A">A.B. Post</name></author><author><name sortKey="Asaad, R" uniqKey="Asaad R">R. Asaad</name></author><author><name sortKey="Heinzel, F P" uniqKey="Heinzel F">F.P. Heinzel</name></author><author><name sortKey="Lederman, M M" uniqKey="Lederman M">M.M. Lederman</name></author><author><name sortKey="Lehmann, P V" uniqKey="Lehmann P">P.V. Lehmann</name></author><author><name sortKey="Valdez, H" uniqKey="Valdez H">H. Valdez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beckebaum, S" uniqKey="Beckebaum S">S. Beckebaum</name></author><author><name sortKey="Cicinnati, V R" uniqKey="Cicinnati V">V.R. Cicinnati</name></author><author><name sortKey="Dworacki, G" uniqKey="Dworacki G">G. Dworacki</name></author><author><name sortKey="Muller Berghaus, J" uniqKey="Muller Berghaus J">J. Muller-Berghaus</name></author><author><name sortKey="Stolz, D" uniqKey="Stolz D">D. Stolz</name></author><author><name sortKey="Harnaha, J" uniqKey="Harnaha J">J. Harnaha</name></author><author><name sortKey="Whiteside, T L" uniqKey="Whiteside T">T.L. Whiteside</name></author><author><name sortKey="Thomson, A W" uniqKey="Thomson A">A.W. Thomson</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Fung, J J" uniqKey="Fung J">J.J. Fung</name></author><author><name sortKey="Bonham, C A" uniqKey="Bonham C">C.A. Bonham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duan, X Z" uniqKey="Duan X">X.Z. Duan</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Zhuang, H" uniqKey="Zhuang H">H. Zhuang</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name></author><author><name sortKey="Liu, J C" uniqKey="Liu J">J.C. Liu</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author><author><name sortKey="Chen, J M" uniqKey="Chen J">J.M. Chen</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Chu, F L" uniqKey="Chu F">F.L. Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Lee, K C" uniqKey="Lee K">K.C. Lee</name></author><author><name sortKey="Ng, W F" uniqKey="Ng W">W.F. Ng</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Leung, C Y" uniqKey="Leung C">C.Y. Leung</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Hui, P K" uniqKey="Hui P">P.K. Hui</name></author><author><name sortKey="Mak, K L" uniqKey="Mak K">K.L. Mak</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Yan, K W" uniqKey="Yan K">K.W. Yan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, N C" uniqKey="Tsang N">N.C. Tsang</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zou, Z" uniqKey="Zou Z">Z. Zou</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Xin, S" uniqKey="Xin S">S. Xin</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name></author><author><name sortKey="Mao, Y" uniqKey="Mao Y">Y. Mao</name></author><author><name sortKey="Hu, L" uniqKey="Hu L">L. Hu</name></author><author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name></author><author><name sortKey="Chang, B" uniqKey="Chang B">B. Chang</name></author><author><name sortKey="Chang, W" uniqKey="Chang W">W. Chang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X. Ma</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, J C" uniqKey="Ho J">J.C. Ho</name></author><author><name sortKey="Ooi, G C" uniqKey="Ooi G">G.C. Ooi</name></author><author><name sortKey="Mok, T Y" uniqKey="Mok T">T.Y. Mok</name></author><author><name sortKey="Chan, J W" uniqKey="Chan J">J.W. Chan</name></author><author><name sortKey="Hung, I" uniqKey="Hung I">I. Hung</name></author><author><name sortKey="Lam, B" uniqKey="Lam B">B. Lam</name></author><author><name sortKey="Wong, P C" uniqKey="Wong P">P.C. Wong</name></author><author><name sortKey="Li, P C" uniqKey="Li P">P.C. Li</name></author><author><name sortKey="Ho, P L" uniqKey="Ho P">P.L. Ho</name></author><author><name sortKey="Lam, W K" uniqKey="Lam W">W.K. Lam</name></author><author><name sortKey="Ng, C K" uniqKey="Ng C">C.K. Ng</name></author><author><name sortKey="Ip, M S" uniqKey="Ip M">M.S. Ip</name></author><author><name sortKey="Lai, K N" uniqKey="Lai K">K.N. Lai</name></author><author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M. Chan-Yeung</name></author><author><name sortKey="Tsang, K W" uniqKey="Tsang K">K.W. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Chu, F" uniqKey="Chu F">F. Chu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jego, G" uniqKey="Jego G">G. Jego</name></author><author><name sortKey="Palucka, A K" uniqKey="Palucka A">A.K. Palucka</name></author><author><name sortKey="Blanck, J P" uniqKey="Blanck J">J.P. Blanck</name></author><author><name sortKey="Chalouni, C" uniqKey="Chalouni C">C. Chalouni</name></author><author><name sortKey="Pascual, V" uniqKey="Pascual V">V. Pascual</name></author><author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J. Banchereau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Kang, W" uniqKey="Kang W">W. Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stohr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author><author><name sortKey="Chu, F L" uniqKey="Chu F">F.L. Chu</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author><author><name sortKey="Li, Y G" uniqKey="Li Y">Y.G. Li</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M. Shi</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H. Wu</name></author><author><name sortKey="Mounds, J M" uniqKey="Mounds J">J.M. Mounds</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shodell, M" uniqKey="Shodell M">M. Shodell</name></author><author><name sortKey="Siegal, F P" uniqKey="Siegal F">F.P. Siegal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shodell, M" uniqKey="Shodell M">M. Shodell</name></author><author><name sortKey="Shah, K" uniqKey="Shah K">K. Shah</name></author><author><name sortKey="Siegal, F P" uniqKey="Siegal F">F.P. Siegal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunetti, M" uniqKey="Brunetti M">M. Brunetti</name></author><author><name sortKey="Martelli, N" uniqKey="Martelli N">N. Martelli</name></author><author><name sortKey="Colasante, A" uniqKey="Colasante A">A. Colasante</name></author><author><name sortKey="Piantelli, M" uniqKey="Piantelli M">M. Piantelli</name></author><author><name sortKey="Musiani, P" uniqKey="Musiani P">P. Musiani</name></author><author><name sortKey="Aiello, F B" uniqKey="Aiello F">F.B. Aiello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, M" uniqKey="Yang M">M. Yang</name></author><author><name sortKey="Li, C K" uniqKey="Li C">C.K. Li</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Hon, K L" uniqKey="Hon K">K.L. Hon</name></author><author><name sortKey="Ng, M H" uniqKey="Ng M">M.H. Ng</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Fok, T F" uniqKey="Fok T">T.F. Fok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uehira, K" uniqKey="Uehira K">K. Uehira</name></author><author><name sortKey="Amakawa, R" uniqKey="Amakawa R">R. Amakawa</name></author><author><name sortKey="Ito, T" uniqKey="Ito T">T. Ito</name></author><author><name sortKey="Tajima, K" uniqKey="Tajima K">K. Tajima</name></author><author><name sortKey="Naitoh, S" uniqKey="Naitoh S">S. Naitoh</name></author><author><name sortKey="Ozaki, Y" uniqKey="Ozaki Y">Y. Ozaki</name></author><author><name sortKey="Shimizu, T" uniqKey="Shimizu T">T. Shimizu</name></author><author><name sortKey="Yamaguchi, K" uniqKey="Yamaguchi K">K. Yamaguchi</name></author><author><name sortKey="Uemura, Y" uniqKey="Uemura Y">Y. Uemura</name></author><author><name sortKey="Kitajima, H" uniqKey="Kitajima H">H. Kitajima</name></author><author><name sortKey="Yonezu, S" uniqKey="Yonezu S">S. Yonezu</name></author><author><name sortKey="Fukuhara, S" uniqKey="Fukuhara S">S. Fukuhara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moser, M" uniqKey="Moser M">M. Moser</name></author><author><name sortKey="De Smedt, T" uniqKey="De Smedt T">T. de Smedt</name></author><author><name sortKey="Sornasse, T" uniqKey="Sornasse T">T. Sornasse</name></author><author><name sortKey="Tielemans, F" uniqKey="Tielemans F">F. Tielemans</name></author><author><name sortKey="Chentoufi, A A" uniqKey="Chentoufi A">A.A. Chentoufi</name></author><author><name sortKey="Muraille, E" uniqKey="Muraille E">E. Muraille</name></author><author><name sortKey="Van Mechelen, M" uniqKey="Van Mechelen M">M. van Mechelen</name></author><author><name sortKey="Urbain, J" uniqKey="Urbain J">J. Urbain</name></author><author><name sortKey="Leo, O" uniqKey="Leo O">O. Leo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brokaw, J J" uniqKey="Brokaw J">J.J. Brokaw</name></author><author><name sortKey="White, G W" uniqKey="White G">G.W. White</name></author><author><name sortKey="Baluk, P" uniqKey="Baluk P">P. Baluk</name></author><author><name sortKey="Anderson, G P" uniqKey="Anderson G">G.P. Anderson</name></author><author><name sortKey="Umemoto, E Y" uniqKey="Umemoto E">E.Y. Umemoto</name></author><author><name sortKey="Mcdonald, D M" uniqKey="Mcdonald D">D.M. McDonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacedon, R" uniqKey="Sacedon R">R. Sacedon</name></author><author><name sortKey="Vicente, A" uniqKey="Vicente A">A. Vicente</name></author><author><name sortKey="Varas, A" uniqKey="Varas A">A. Varas</name></author><author><name sortKey="Jimenez, E" uniqKey="Jimenez E">E. Jimenez</name></author><author><name sortKey="Munoz, J J" uniqKey="Munoz J">J.J. Munoz</name></author><author><name sortKey="Zapata, A G" uniqKey="Zapata A">A.G. Zapata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piemonti, L" uniqKey="Piemonti L">L. Piemonti</name></author><author><name sortKey="Monti, P" uniqKey="Monti P">P. Monti</name></author><author><name sortKey="Allavena, P" uniqKey="Allavena P">P. Allavena</name></author><author><name sortKey="Sironi, M" uniqKey="Sironi M">M. Sironi</name></author><author><name sortKey="Soldini, L" uniqKey="Soldini L">L. Soldini</name></author><author><name sortKey="Leone, B E" uniqKey="Leone B">B.E. Leone</name></author><author><name sortKey="Socci, C" uniqKey="Socci C">C. Socci</name></author><author><name sortKey="Di Carlo, V" uniqKey="Di Carlo V">V. Di Carlo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisen Vandervelde, A L" uniqKey="Eisen Vandervelde A">A.L. Eisen-Vandervelde</name></author><author><name sortKey="Yao, Z Q" uniqKey="Yao Z">Z.Q. Yao</name></author><author><name sortKey="Hahn, Y S" uniqKey="Hahn Y">Y.S. Hahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Wo, J" uniqKey="Wo J">J. Wo</name></author><author><name sortKey="Shao, J" uniqKey="Shao J">J. Shao</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="Wu, N" uniqKey="Wu N">N. Wu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Yao, H" uniqKey="Yao H">H. Yao</name></author><author><name sortKey="Hu, M" uniqKey="Hu M">M. Hu</name></author><author><name sortKey="Dennin, R H" uniqKey="Dennin R">R.H. Dennin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Ganesh, L" uniqKey="Ganesh L">L. Ganesh</name></author><author><name sortKey="Leung, K" uniqKey="Leung K">K. Leung</name></author><author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name></author><author><name sortKey="Schwartz, O" uniqKey="Schwartz O">O. Schwartz</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N. Vasilieva</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name></author><author><name sortKey="Berne, M A" uniqKey="Berne M">M.A. Berne</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M. Somasundaran</name></author><author><name sortKey="Sullivan, J L" uniqKey="Sullivan J">J.L. Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K. Luzuriaga</name></author><author><name sortKey="Greenough, T C" uniqKey="Greenough T">T.C. Greenough</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="He, L" uniqKey="He L">L. He</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author><author><name sortKey="Che, X" uniqKey="Che X">X. Che</name></author><author><name sortKey="Hou, J" uniqKey="Hou J">J. Hou</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Qiu, L" uniqKey="Qiu L">L. Qiu</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J. Geng</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J. Cai</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Kang, W" uniqKey="Kang W">W. Kang</name></author><author><name sortKey="Weng, D" uniqKey="Weng D">D. Weng</name></author><author><name sortKey="Liang, P" uniqKey="Liang P">P. Liang</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, V S" uniqKey="Chan V">V.S. Chan</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="Chen, Y X" uniqKey="Chen Y">Y.X. Chen</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Khoo, U S" uniqKey="Khoo U">U.S. Khoo</name></author><author><name sortKey="Altmeyer, R" uniqKey="Altmeyer R">R. Altmeyer</name></author><author><name sortKey="Ding, Y Q" uniqKey="Ding Y">Y.Q. Ding</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author><author><name sortKey="Tam, P K" uniqKey="Tam P">P.K. Tam</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turville, S G" uniqKey="Turville S">S.G. Turville</name></author><author><name sortKey="Cameron, P U" uniqKey="Cameron P">P.U. Cameron</name></author><author><name sortKey="Handley, A" uniqKey="Handley A">A. Handley</name></author><author><name sortKey="Lin, G" uniqKey="Lin G">G. Lin</name></author><author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S. Pohlmann</name></author><author><name sortKey="Doms, R W" uniqKey="Doms R">R.W. Doms</name></author><author><name sortKey="Cunningham, A L" uniqKey="Cunningham A">A.L. Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, B M" uniqKey="Jones B">B.M. Jones</name></author><author><name sortKey="Ma, E S" uniqKey="Ma E">E.S. Ma</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Wong, P C" uniqKey="Wong P">P.C. Wong</name></author><author><name sortKey="Ho, J C" uniqKey="Ho J">J.C. Ho</name></author><author><name sortKey="Lam, B" uniqKey="Lam B">B. Lam</name></author><author><name sortKey="Lai, K N" uniqKey="Lai K">K.N. Lai</name></author><author><name sortKey="Tsang, K W" uniqKey="Tsang K">K.W. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Wang, F S" uniqKey="Wang F">F.S. Wang</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author><author><name sortKey="Chen, J M" uniqKey="Chen J">J.M. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berney, C" uniqKey="Berney C">C. Berney</name></author><author><name sortKey="Herren, S" uniqKey="Herren S">S. Herren</name></author><author><name sortKey="Power, C A" uniqKey="Power C">C.A. Power</name></author><author><name sortKey="Gordon, S" uniqKey="Gordon S">S. Gordon</name></author><author><name sortKey="Martinez Pomares, L" uniqKey="Martinez Pomares L">L. Martinez-Pomares</name></author><author><name sortKey="Kosco Vilbois, M H" uniqKey="Kosco Vilbois M">M.H. Kosco-Vilbois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Garcia, V C" uniqKey="De Garcia V">V.C. de Garcia</name></author><author><name sortKey="Gulbranson Judge, A" uniqKey="Gulbranson Judge A">A. Gulbranson-Judge</name></author><author><name sortKey="Khan, M" uniqKey="Khan M">M. Khan</name></author><author><name sortKey="O Leary, P" uniqKey="O Leary P">P. O'Leary</name></author><author><name sortKey="Cascalho, M" uniqKey="Cascalho M">M. Cascalho</name></author><author><name sortKey="Wabl, M" uniqKey="Wabl M">M. Wabl</name></author><author><name sortKey="Klaus, G G" uniqKey="Klaus G">G.G. Klaus</name></author><author><name sortKey="Owen, M J" uniqKey="Owen M">M.J. Owen</name></author><author><name sortKey="Maclennan, I C" uniqKey="Maclennan I">I.C. MacLennan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Immunol</journal-id><journal-title-group><journal-title>Clinical Immunology (Orlando, Fla.)</journal-title></journal-title-group><issn pub-type="ppub">1521-6616</issn><issn pub-type="epub">1521-7035</issn><publisher><publisher-name>Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15964242</article-id><article-id pub-id-type="pmc">7106242</article-id><article-id pub-id-type="publisher-id">S1521-6616(05)00151-8</article-id><article-id pub-id-type="doi">10.1016/j.clim.2005.04.015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Zheng</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Dongping</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yonggang</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Lei</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Ming</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Min</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Xianzhi</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Hao</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>George F.</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Fu-Sheng</given-names></name><email>fswang@public.bta.net.cn</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</aff><aff id="aff2"><label>b</label>Beijing You'an Hospital, Capital Medical University, Beijing 100054, China</aff><aff id="aff3"><label>c</label>Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Fax: +86 10 6383 1870. <email>fswang@public.bta.net.cn</email></corresp><fn id="fn1"><label>1</label><p>Ph.D. student of Beijing Institute of Radiation Medicine, Beijing 100850, China.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>16</day><month>6</month><year>2005</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>9</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>16</day><month>6</month><year>2005</year></pub-date><volume>116</volume><issue>3</issue><fpage>225</fpage><lpage>235</lpage><history><date date-type="received"><day>22</day><month>12</month><year>2004</year></date><date date-type="accepted"><day>17</day><month>4</month><year>2005</year></date></history><permissions><copyright-statement>Copyright © 2005 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5–7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.</p></abstract><kwd-group><title>Keywords</title><kwd>SARS</kwd><kwd>Myeloid dendritic cells</kwd><kwd>Plasmacytoid dendritic cells</kwd><kwd>Coronavirus</kwd><kwd>Steroid</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E95 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000E95 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:7106242
|texte= Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:15964242" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |