Adverse Effects of Ribavirin and Outcome in Severe Acute Respiratory Syndrome
Identifieur interne : 000E80 ( Pmc/Curation ); précédent : 000E79; suivant : 000E81Adverse Effects of Ribavirin and Outcome in Severe Acute Respiratory Syndrome
Auteurs : Hsueh-Erh Chiou [Taïwan] ; Ching-Lung Liu [Taïwan] ; Mary Jeanne Buttrey [Taïwan] ; Han-Pin Kuo [Taïwan] ; Hui-Wen Liu [Taïwan] ; Hsu-Tah Kuo [Taïwan] ; Yen-Ta Lu [Taïwan]Source :
- Chest [ 0012-3692 ] ; 2005.
Abstract
To assess the effect of ribavirin-induced anemia on the outcome of severe acute respiratory syndrome (SARS).
A retrospective observational study.
Two medical centers in Taiwan.
Forty-four patients with SARS who received ribavirin and 7 patients with SARS who did not receive ribavirin.
The mean peak C-reactive protein and lactate dehydrogenase levels were higher in SARS patients who were receiving ribavirin therapy than in SARS patients who were not receiving ribavirin therapy. The mortality was also higher, but the difference was not statistically significant. On multivariate analysis, hemoglobin level was an independent prognostic correlate of hypoxemia or mortality (odds ratio, 2.0; 95% confidence interval, 1.1 to 3.8; p = 0.03). The hemoglobin began decreasing in two thirds of SARS patients (32 of 44 patients; 73%) who were receiving ribavirin 3 days after therapy with the antiviral drug was started. Patients with a drop in hemoglobin level of > 2 g/dL had a significantly higher mortality rate than the other patients. Hypoxemia developed in one third of SARS patients (17 of 44 patients; 39%) who were receiving ribavirin, all of whom were anemic. Of the 17 hypoxemic patients, 11 (65%) had a drop in hemoglobin of > 2 g/dL, and 4 patients (24%) required a blood transfusion. The mean slope of the hemoglobin decrease was significantly steeper (p = 0.001) in hypoxemic patients with SARS who were receiving ribavirin than in the nonhypoxemic patients with SARS who were receiving ribavirin. Only one of seven SARS patients (14%) who was not receiving ribavirin became anemic, but this individual was not hypoxemic. Eventually, 5 of 17 hypoxemic and anemic SARS patients (29%) who were receiving ribavirin died. The combination of hypoxia with anemia was thus significantly associated with a higher mortality (p < 0.001).
Hypoxia combined with anemia increased the risk for death in SARS patients. Unless ribavirin can be shown to be effective against SARS-coronavirus, the risk of anemia posed by this drug argues against its use in SARS patients.
Url:
DOI: 10.1378/chest.128.1.263
PubMed: 16002945
PubMed Central: 7094379
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<author><name sortKey="Liu, Ching Lung" sort="Liu, Ching Lung" uniqKey="Liu C" first="Ching-Lung" last="Liu">Ching-Lung Liu</name>
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<author><name sortKey="Buttrey, Mary Jeanne" sort="Buttrey, Mary Jeanne" uniqKey="Buttrey M" first="Mary Jeanne" last="Buttrey">Mary Jeanne Buttrey</name>
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<author><name sortKey="Kuo, Han Pin" sort="Kuo, Han Pin" uniqKey="Kuo H" first="Han-Pin" last="Kuo">Han-Pin Kuo</name>
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<author><name sortKey="Lu, Yen Ta" sort="Lu, Yen Ta" uniqKey="Lu Y" first="Yen-Ta" last="Lu">Yen-Ta Lu</name>
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<series><title level="j">Chest</title>
<idno type="ISSN">0012-3692</idno>
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<imprint><date when="2005">2005</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Study objectives</title>
<p>To assess the effect of ribavirin-induced anemia on the outcome of severe acute respiratory syndrome (SARS).</p>
</sec>
<sec><title>Design</title>
<p>A retrospective observational study.</p>
</sec>
<sec><title>Setting</title>
<p>Two medical centers in Taiwan.</p>
</sec>
<sec><title>Patients</title>
<p>Forty-four patients with SARS who received ribavirin and 7 patients with SARS who did not receive ribavirin.</p>
</sec>
<sec><title>Measurements and results</title>
<p>The mean peak C-reactive protein and lactate dehydrogenase levels were higher in SARS patients who were receiving ribavirin therapy than in SARS patients who were not receiving ribavirin therapy. The mortality was also higher, but the difference was not statistically significant. On multivariate analysis, hemoglobin level was an independent prognostic correlate of hypoxemia or mortality (odds ratio, 2.0; 95% confidence interval, 1.1 to 3.8; p = 0.03). The hemoglobin began decreasing in two thirds of SARS patients (32 of 44 patients; 73%) who were receiving ribavirin 3 days after therapy with the antiviral drug was started. Patients with a drop in hemoglobin level of > 2 g/dL had a significantly higher mortality rate than the other patients. Hypoxemia developed in one third of SARS patients (17 of 44 patients; 39%) who were receiving ribavirin, all of whom were anemic. Of the 17 hypoxemic patients, 11 (65%) had a drop in hemoglobin of > 2 g/dL, and 4 patients (24%) required a blood transfusion. The mean slope of the hemoglobin decrease was significantly steeper (p = 0.001) in hypoxemic patients with SARS who were receiving ribavirin than in the nonhypoxemic patients with SARS who were receiving ribavirin. Only one of seven SARS patients (14%) who was not receiving ribavirin became anemic, but this individual was not hypoxemic. Eventually, 5 of 17 hypoxemic and anemic SARS patients (29%) who were receiving ribavirin died. The combination of hypoxia with anemia was thus significantly associated with a higher mortality (p < 0.001).</p>
</sec>
<sec><title>Conclusions</title>
<p>Hypoxia combined with anemia increased the risk for death in SARS patients. Unless ribavirin can be shown to be effective against SARS-coronavirus, the risk of anemia posed by this drug argues against its use in SARS patients.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Chest</journal-id>
<journal-id journal-id-type="iso-abbrev">Chest</journal-id>
<journal-title-group><journal-title>Chest</journal-title>
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<issn pub-type="ppub">0012-3692</issn>
<issn pub-type="epub">1931-3543</issn>
<publisher><publisher-name>The American College of Chest Physicians. Published by Elsevier Inc.</publisher-name>
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<article-meta><article-id pub-id-type="pmid">16002945</article-id>
<article-id pub-id-type="pmc">7094379</article-id>
<article-id pub-id-type="publisher-id">S0012-3692(15)37956-3</article-id>
<article-id pub-id-type="doi">10.1378/chest.128.1.263</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Adverse Effects of Ribavirin and Outcome in Severe Acute Respiratory Syndrome</article-title>
<subtitle>Experience in Two Medical Centers</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author" id="au10"><name><surname>Chiou</surname>
<given-names>Hsueh-Erh</given-names>
</name>
<degrees>MS</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au20"><name><surname>Liu</surname>
<given-names>Ching-Lung</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au30"><name><surname>Buttrey</surname>
<given-names>Mary Jeanne</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au40"><name><surname>Kuo</surname>
<given-names>Han-Pin</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au50"><name><surname>Liu</surname>
<given-names>Hui-Wen</given-names>
</name>
<degrees>MS</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au60"><name><surname>Kuo</surname>
<given-names>Hsu-Tah</given-names>
</name>
<degrees>MD, FCCP</degrees>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author" id="au70"><name><surname>Lu</surname>
<given-names>Yen-Ta</given-names>
</name>
<degrees>MD, PhD</degrees>
<email>ytlhl@ms2.mmh.org.tw</email>
<xref rid="aff4" ref-type="aff">d</xref>
<xref rid="cor1" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Pharmacy Department, Mackay Memorial Hospital, Taipei, Taiwan</aff>
<aff id="aff2"><label>b</label>
Division of Chest Medicine, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan</aff>
<aff id="aff3"><label>c</label>
Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan</aff>
<aff id="aff4"><label>d</label>
Department of Respiratory Care, Taipei Medical University, Taipei, Taiwan</aff>
<aff id="aff5"><label>e</label>
Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Linkou, Taiwan</aff>
<author-notes><corresp id="cor1"><label>*</label>
Correspondence to: Yen-Ta Lu, MD, PhD, Division of Chest Medicine, Department of Internal Medicine, Mackay Memorial Hospital, 92, Sec 2, Chung-Shan North Rd, Taipei, 10449, Taiwan <email>ytlhl@ms2.mmh.org.tw</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>24</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>7</month>
<year>2005</year>
</pub-date>
<pub-date pub-type="epub"><day>24</day>
<month>12</month>
<year>2015</year>
</pub-date>
<volume>128</volume>
<issue>1</issue>
<fpage>263</fpage>
<lpage>272</lpage>
<history><date date-type="received"><day>20</day>
<month>9</month>
<year>2004</year>
</date>
<date date-type="accepted"><day>20</day>
<month>12</month>
<year>2004</year>
</date>
</history>
<permissions><copyright-statement>© 2005 The American College of Chest Physicians</copyright-statement>
<copyright-year>2005</copyright-year>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ceab10"><sec><title>Study objectives</title>
<p>To assess the effect of ribavirin-induced anemia on the outcome of severe acute respiratory syndrome (SARS).</p>
</sec>
<sec><title>Design</title>
<p>A retrospective observational study.</p>
</sec>
<sec><title>Setting</title>
<p>Two medical centers in Taiwan.</p>
</sec>
<sec><title>Patients</title>
<p>Forty-four patients with SARS who received ribavirin and 7 patients with SARS who did not receive ribavirin.</p>
</sec>
<sec><title>Measurements and results</title>
<p>The mean peak C-reactive protein and lactate dehydrogenase levels were higher in SARS patients who were receiving ribavirin therapy than in SARS patients who were not receiving ribavirin therapy. The mortality was also higher, but the difference was not statistically significant. On multivariate analysis, hemoglobin level was an independent prognostic correlate of hypoxemia or mortality (odds ratio, 2.0; 95% confidence interval, 1.1 to 3.8; p = 0.03). The hemoglobin began decreasing in two thirds of SARS patients (32 of 44 patients; 73%) who were receiving ribavirin 3 days after therapy with the antiviral drug was started. Patients with a drop in hemoglobin level of > 2 g/dL had a significantly higher mortality rate than the other patients. Hypoxemia developed in one third of SARS patients (17 of 44 patients; 39%) who were receiving ribavirin, all of whom were anemic. Of the 17 hypoxemic patients, 11 (65%) had a drop in hemoglobin of > 2 g/dL, and 4 patients (24%) required a blood transfusion. The mean slope of the hemoglobin decrease was significantly steeper (p = 0.001) in hypoxemic patients with SARS who were receiving ribavirin than in the nonhypoxemic patients with SARS who were receiving ribavirin. Only one of seven SARS patients (14%) who was not receiving ribavirin became anemic, but this individual was not hypoxemic. Eventually, 5 of 17 hypoxemic and anemic SARS patients (29%) who were receiving ribavirin died. The combination of hypoxia with anemia was thus significantly associated with a higher mortality (p < 0.001).</p>
</sec>
<sec><title>Conclusions</title>
<p>Hypoxia combined with anemia increased the risk for death in SARS patients. Unless ribavirin can be shown to be effective against SARS-coronavirus, the risk of anemia posed by this drug argues against its use in SARS patients.</p>
</sec>
</abstract>
<kwd-group id="cekeyws10"><kwd>anemia</kwd>
<kwd>hypoxemia</kwd>
<kwd>ribavirin</kwd>
<kwd>severe acute respiratory syndrome</kwd>
</kwd-group>
<kwd-group id="cekeyws20"><title>Abbreviations</title>
<kwd>AE, adverse effect</kwd>
<kwd>CoV, coronavirus</kwd>
<kwd>FD, fever day</kwd>
<kwd>hospital C, Chang Gung Memorial Hospital</kwd>
<kwd>hospital M, Mackay Memorial Hospital</kwd>
<kwd>SARS, severe acute respiratory syndrome</kwd>
<kwd>S-R-H, severe acute respiratory syndrome-ribavirin-hypoxemic</kwd>
<kwd>S-R-NH, severe acute respiratory syndrome-ribavirin-nonhypoxemic</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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