Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia
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Auteurs : Ashok K. ShettySource :
- Aging and Disease [ 2152-5250 ] ; 2020.
Abstract
A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (
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DOI: 10.14336/AD.2020.0301
PubMed: 32257554
PubMed Central: 7069463
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia</title><author><name sortKey="Shetty, Ashok K" sort="Shetty, Ashok K" uniqKey="Shetty A" first="Ashok K" last="Shetty">Ashok K. Shetty</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32257554</idno><idno type="pmc">7069463</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069463</idno><idno type="RBID">PMC:7069463</idno><idno type="doi">10.14336/AD.2020.0301</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000A19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A19</idno><idno type="wicri:Area/Pmc/Curation">000A19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia</title><author><name sortKey="Shetty, Ashok K" sort="Shetty, Ashok K" uniqKey="Shetty A" first="Ashok K" last="Shetty">Ashok K. Shetty</name></author></analytic><series><title level="j">Aging and Disease</title><idno type="eISSN">2152-5250</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (<italic>Leng et al., Aging Dis, 11:216-228, 2020</italic>). This study demonstrated that intravenous infusion of MSCs is a safe and effective approach for treating patients with COVID-19 pneumonia, including elderly patients displaying severe pneumonia. COVID-19 is a severe acute respiratory illness caused by a new coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, treating COVID-19 patients, particularly those afflicted with severe pneumonia, is challenging as no specific drugs or vaccines against SARS-CoV-2 are available. Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. Additional studies in a larger cohort of patients are needed to validate this therapeutic intervention further, however.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Leng, Z" uniqKey="Leng Z">Z Leng</name></author><author><name sortKey="Zhu, R" uniqKey="Zhu R">R Zhu</name></author><author><name sortKey="Hou, W" uniqKey="Hou W">W Hou</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Han, Q" uniqKey="Han Q">Q Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Koopmans, M" uniqKey="Koopmans M">M Koopmans</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van 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sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Niu, P" uniqKey="Niu P">P Niu</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name></author><author><name sortKey="Yang, X L" uniqKey="Yang X">X-L Yang</name></author><author><name sortKey="Wang, X G" uniqKey="Wang X">X-G Wang</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, M" uniqKey="Hoffmann M">M Hoffmann</name></author><author><name sortKey="Kleine Weber, H" uniqKey="Kleine Weber 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uniqKey="Larson B">BL Larson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shetty, Ak" uniqKey="Shetty A">AK Shetty</name></author><author><name sortKey="Upadhya, R" uniqKey="Upadhya R">R Upadhya</name></author><author><name sortKey="Madhu, Ln" uniqKey="Madhu L">LN Madhu</name></author><author><name sortKey="Kodali, M" uniqKey="Kodali M">M Kodali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shetty, Ak" uniqKey="Shetty A">AK Shetty</name></author><author><name sortKey="Kodali, M" uniqKey="Kodali M">M Kodali</name></author><author><name sortKey="Upadhya, R" uniqKey="Upadhya R">R Upadhya</name></author><author><name sortKey="Madhu, Ln" uniqKey="Madhu L">LN Madhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, R" uniqKey="Thomas R">R Thomas</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Su, Dm" uniqKey="Su D">DM Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Sj" uniqKey="Oh S">SJ Oh</name></author><author><name sortKey="Lee, Jk" uniqKey="Lee J">JK Lee</name></author><author><name sortKey="Shin, Os" uniqKey="Shin O">OS Shin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Aging Dis</journal-id><journal-id journal-id-type="iso-abbrev">Aging Dis</journal-id><journal-title-group><journal-title>Aging and Disease</journal-title></journal-title-group><issn pub-type="epub">2152-5250</issn><publisher><publisher-name>JKL International LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32257554</article-id><article-id pub-id-type="pmc">7069463</article-id><article-id pub-id-type="publisher-id">ad-11-2-462</article-id><article-id pub-id-type="doi">10.14336/AD.2020.0301</article-id><article-categories><subj-group subj-group-type="heading"><subject>Editorial</subject></subj-group></article-categories><title-group><article-title>Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shetty</surname><given-names>Ashok K</given-names></name><xref ref-type="corresp" rid="cor1-ad-11-2-462"><sup>*</sup></xref></contrib><aff id="aff16-ad-11-2-462"><addr-line>Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University College of Medicine, College Station, Texas, USA</addr-line></aff></contrib-group><author-notes><corresp id="cor1-ad-11-2-462"><label>*</label>Correspondence should be addressed to: Dr. Ashok K. Shetty, Institute for Regenerative Medicine, Texas A&M Health Science Center, College of Medicine, College Station, TX 77843, USA. E-mail: <email>akskrs@tamu.edu</email></corresp></author-notes><pub-date pub-type="collection"><month>4</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>9</day><month>3</month><year>2020</year></pub-date><volume>11</volume><issue>2</issue><fpage>462</fpage><lpage>464</lpage><history><date date-type="received"><day>1</day><month>3</month><year>2020</year></date><date date-type="rev-request"><day>1</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>1</day><month>3</month><year>2020</year></date></history><permissions><copyright-statement>Copyright: © 2020 Shetty et al.</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.</license-p></license></permissions><abstract><p>A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (<italic>Leng et al., Aging Dis, 11:216-228, 2020</italic>). This study demonstrated that intravenous infusion of MSCs is a safe and effective approach for treating patients with COVID-19 pneumonia, including elderly patients displaying severe pneumonia. COVID-19 is a severe acute respiratory illness caused by a new coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, treating COVID-19 patients, particularly those afflicted with severe pneumonia, is challenging as no specific drugs or vaccines against SARS-CoV-2 are available. Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. Additional studies in a larger cohort of patients are needed to validate this therapeutic intervention further, however.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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