Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)
Identifieur interne : 000927 ( Pmc/Curation ); précédent : 000926; suivant : 000928Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)
Auteurs : Leatrice N. Vogel [États-Unis] ; Anjeanette Roberts [États-Unis] ; Christopher D. Paddock [États-Unis] ; Gillian L. Genrich [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Sagar U. Kapadia [États-Unis] ; John K. Rose [États-Unis] ; Sherif R. Zaki [États-Unis] ; Kanta Subbarao [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2006.
Abstract
The causative agent of Severe Acute Respiratory Syndrome (SARS) was identified as a coronavirus (CoV) following the outbreak of 2002–2003. There are currently no licensed vaccines or treatments for SARS-CoV infections. Potential prevention and control strategies that show promise in vitro must be evaluated in animal models. The aged BALB/c mouse model for SARS supports a high level of viral replication in association with clinical illness and disease that mimics SARS in the elderly. We tested two preventive strategies, vaccination and passive transfer of serum antibody, to determine the extent of protection achieved against SARS-CoV challenge in this model. These approaches were able to achieve or induce antibody titers sufficient to reduce viral load, protect from weight loss and reduce or eliminate histopathologic changes in the lungs of aged mice. This study validates the utility of the aged BALB/c mouse model for evaluation of the efficacy of vaccines and immunoprophylaxis.
Url:
DOI: 10.1016/j.vaccine.2006.11.055
PubMed: 17227689
PubMed Central: 1847333
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Vogel</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</wicri:regionArea></affiliation></author><author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</wicri:regionArea></affiliation></author><author><name sortKey="Paddock, Christopher D" sort="Paddock, Christopher D" uniqKey="Paddock C" first="Christopher D." last="Paddock">Christopher D. Paddock</name><affiliation wicri:level="1"><nlm:aff id="aff2">Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea></affiliation></author><author><name sortKey="Genrich, Gillian L" sort="Genrich, Gillian L" uniqKey="Genrich G" first="Gillian L." last="Genrich">Gillian L. Genrich</name><affiliation wicri:level="1"><nlm:aff id="aff2">Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. 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Rose</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Yale University School of Medicine, New Haven, CT 06510</wicri:regionArea></affiliation></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name><affiliation wicri:level="1"><nlm:aff id="aff2">Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</wicri:regionArea></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The causative agent of Severe Acute Respiratory Syndrome (SARS) was identified as a coronavirus (CoV) following the outbreak of 2002–2003. There are currently no licensed vaccines or treatments for SARS-CoV infections. Potential prevention and control strategies that show promise in vitro must be evaluated in animal models. The aged BALB/c mouse model for SARS supports a high level of viral replication in association with clinical illness and disease that mimics SARS in the elderly. We tested two preventive strategies, vaccination and passive transfer of serum antibody, to determine the extent of protection achieved against SARS-CoV challenge in this model. These approaches were able to achieve or induce antibody titers sufficient to reduce viral load, protect from weight loss and reduce or eliminate histopathologic changes in the lungs of aged mice. This study validates the utility of the aged BALB/c mouse model for evaluation of the efficacy of vaccines and immunoprophylaxis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccine</journal-id><journal-id journal-id-type="iso-abbrev">Vaccine</journal-id><journal-title-group><journal-title>Vaccine</journal-title></journal-title-group><issn pub-type="ppub">0264-410X</issn><issn pub-type="epub">1873-2518</issn><publisher><publisher-name>Elsevier Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17227689</article-id><article-id pub-id-type="pmc">1847333</article-id><article-id pub-id-type="publisher-id">S0264-410X(06)01251-5</article-id><article-id pub-id-type="doi">10.1016/j.vaccine.2006.11.055</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Leatrice N.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Roberts</surname><given-names>Anjeanette</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Paddock</surname><given-names>Christopher D.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Genrich</surname><given-names>Gillian L.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Lamirande</surname><given-names>Elaine W.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Kapadia</surname><given-names>Sagar U.</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Rose</surname><given-names>John K.</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Zaki</surname><given-names>Sherif R.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><email>Ksubbarao@niaid.nih.gov</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, United States</aff><aff id="aff2"><label>b</label>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States</aff><aff id="aff3"><label>c</label>Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author at: Laboratory of Infectious Diseases, NIAID, Bldg. 50, Room 6132, 50 South Drive, MSC 8007, Bethesda, MD 20892, United States. Tel.: +1 301 451 3839; fax: +1 301 496 8312. <email>Ksubbarao@niaid.nih.gov</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>11</day><month>12</month><year>2006</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>8</day><month>3</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>11</day><month>12</month><year>2006</year></pub-date><volume>25</volume><issue>12</issue><fpage>2173</fpage><lpage>2179</lpage><history><date date-type="received"><day>8</day><month>9</month><year>2006</year></date><date date-type="rev-recd"><day>13</day><month>11</month><year>2006</year></date><date date-type="accepted"><day>21</day><month>11</month><year>2006</year></date></history><permissions><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>The causative agent of Severe Acute Respiratory Syndrome (SARS) was identified as a coronavirus (CoV) following the outbreak of 2002–2003. There are currently no licensed vaccines or treatments for SARS-CoV infections. Potential prevention and control strategies that show promise in vitro must be evaluated in animal models. The aged BALB/c mouse model for SARS supports a high level of viral replication in association with clinical illness and disease that mimics SARS in the elderly. We tested two preventive strategies, vaccination and passive transfer of serum antibody, to determine the extent of protection achieved against SARS-CoV challenge in this model. These approaches were able to achieve or induce antibody titers sufficient to reduce viral load, protect from weight loss and reduce or eliminate histopathologic changes in the lungs of aged mice. This study validates the utility of the aged BALB/c mouse model for evaluation of the efficacy of vaccines and immunoprophylaxis.</p></abstract><kwd-group><title>Keywords</title><kwd>SARS-CoV</kwd><kwd>Aged mouse model</kwd><kwd>Prophylaxis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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