Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome
Identifieur interne : 000898 ( Pmc/Curation ); précédent : 000897; suivant : 000899Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome
Auteurs : Wei Liu ; Arnaud Fontanet ; Pan-He Zhang ; Lin Zhan ; Zhong-Tao Xin ; Laurence Baril ; Fang Tang ; Hui Lv ; Wu-Chun CaoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Abstract
In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16
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DOI: 10.1086/500469
PubMed: 16479513
PubMed Central: 7109932
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome</title><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name></author><author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name></author><author><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name></author><author><name sortKey="Zhan, Lin" sort="Zhan, Lin" uniqKey="Zhan L" first="Lin" last="Zhan">Lin Zhan</name></author><author><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name></author><author><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name></author><author><name sortKey="Lv, Hui" sort="Lv, Hui" uniqKey="Lv H" first="Hui" last="Lv">Hui Lv</name></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16479513</idno><idno type="pmc">7109932</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109932</idno><idno type="RBID">PMC:7109932</idno><idno type="doi">10.1086/500469</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000898</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000898</idno><idno type="wicri:Area/Pmc/Curation">000898</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000898</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome</title><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name></author><author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name></author><author><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name></author><author><name sortKey="Zhan, Lin" sort="Zhan, Lin" uniqKey="Zhan L" first="Lin" last="Zhan">Lin Zhan</name></author><author><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name></author><author><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name></author><author><name sortKey="Lv, Hui" sort="Lv, Hui" uniqKey="Lv H" first="Hui" last="Lv">Hui Lv</name></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Song, Hd" uniqKey="Song H">HD Song</name></author><author><name sortKey="Tu, Cc" uniqKey="Tu C">CC Tu</name></author><author><name sortKey="Zhang, Gw" uniqKey="Zhang G">GW Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nie, Y" uniqKey="Nie Y">Y Nie</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcintosh, K" uniqKey="Mcintosh K">K McIntosh</name></author><author><name sortKey="Chao, Rk" uniqKey="Chao R">RK Chao</name></author><author><name sortKey="Krause, He" uniqKey="Krause H">HE Krause</name></author><author><name sortKey="Wasil, R" uniqKey="Wasil R">R Wasil</name></author><author><name sortKey="Mocega, He" uniqKey="Mocega H">HE Mocega</name></author><author><name sortKey="Mufson, Ma" uniqKey="Mufson M">MA Mufson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Callow, Ka" uniqKey="Callow K">KA Callow</name></author><author><name sortKey="Parry, Hf" uniqKey="Parry H">HF Parry</name></author><author><name sortKey="Sergeant, M" uniqKey="Sergeant M">M Sergeant</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Tang, F" uniqKey="Tang F">F Tang</name></author><author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name></author><author><name sortKey="Qiu, M" uniqKey="Qiu M">M Qiu</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burton, Dr" uniqKey="Burton D">DR Burton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Infectious Diseases Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16479513</article-id><article-id pub-id-type="pmc">7109932</article-id><article-id pub-id-type="doi">10.1086/500469</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Liu</surname><given-names>Wei</given-names></name><pmc-comment>caowc@nic.bmi.ac.cn </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Fontanet</surname><given-names>Arnaud</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Pan-He</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhan</surname><given-names>Lin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Xin</surname><given-names>Zhong-Tao</given-names></name></contrib><contrib contrib-type="author"><name><surname>Baril</surname><given-names>Laurence</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Fang</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lv</surname><given-names>Hui</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cao</surname><given-names>Wu-Chun</given-names></name></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</institution></aff><aff id="aff3"><label>3</label><institution>Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France</institution></aff><aff id="aff2"><label>2</label><institution>Department of Biochemistry, Beijing Institute of Basic Medical Sciences, Beijing, People’s Republic of China;</institution></aff><author-notes><corresp id="cor1">Reprints or correspondence: Dr. Wu-Chun Cao, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, 20 Dong-Da St., Fengtai District, Beijing 100071, P.R. China (<email>caowc@nic.bmi.ac.cn</email>)</corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>3</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>3</month><year>2006</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>193</volume><issue>6</issue><fpage>792</fpage><lpage>795</lpage><history><date date-type="received"><day>4</day><month>7</month><year>2005</year></date><date date-type="accepted"><day>15</day><month>9</month><year>2005</year></date></history><permissions><copyright-statement>© 2006 by the Infectious Diseases Society of America</copyright-statement><copyright-year>2006</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="193-6-792.pdf"></self-uri><abstract><title>Abstract</title><p>In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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