The spike protein of SARS-CoV — a target for vaccine and therapeutic development
Identifieur interne : 000566 ( Pmc/Curation ); précédent : 000565; suivant : 000567The spike protein of SARS-CoV — a target for vaccine and therapeutic development
Auteurs : Lanying Du [États-Unis] ; Yuxian He [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Shuwen Liu [République populaire de Chine] ; Bo-Jian Zheng [République populaire de Chine] ; Shibo Jiang [États-Unis]Source :
- Nature Reviews. Microbiology [ 1740-1526 ] ; 2009.
Abstract
This Review provides an overview on the spike (S) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) as a target for the development of vaccines and therapeutics for the prevention and treatment of SARS. SARS is a newly emerging infectious disease, caused by SARS-CoV, a novel coronavirus that caused a global outbreak of SARS. SARS-CoV S protein mediates binding of the virus with its receptor angiotensin-converting enzyme 2 and promotes the fusion between the viral and host cell membranes and virus entry into the host cell. SARS-CoV S protein induces humoral and cellular immune responses against SARS-CoV. SARS S protein is the target of new SARS vaccines. These vaccines are based on SARS-CoV full-length S protein and its receptor-binding domain, including DNA-, viral vector- and subunit-based vaccines Peptides, antibodies, organic compounds and short interfering RNAs are additional anti-SARS-CoV therapeutics that target the S protein. The work on SARS-CoV S protein-based vaccines and drugs will be useful as a model for the development of prophylactic strategies and therapies against other viruses with class I fusion proteins that can cause emerging infectious diseases.
Url:
DOI: 10.1038/nrmicro2090
PubMed: 19198616
PubMed Central: 2750777
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000566
Links to Exploration step
PMC:2750777Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The spike protein of SARS-CoV — a target for vaccine and therapeutic development</title><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author><author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="1"><nlm:aff id="Aff2">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution>School of Pharmaceutical Sciences, Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Microbiology,</institution><institution>University of Hong Kong, Pokfulam,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19198616</idno><idno type="pmc">2750777</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750777</idno><idno type="RBID">PMC:2750777</idno><idno type="doi">10.1038/nrmicro2090</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000566</idno><idno type="wicri:Area/Pmc/Curation">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000566</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The spike protein of SARS-CoV — a target for vaccine and therapeutic development</title><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author><author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="1"><nlm:aff id="Aff2">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution>School of Pharmaceutical Sciences, Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Microbiology,</institution><institution>University of Hong Kong, Pokfulam,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</nlm:aff><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><wicri:regionArea>310 East 67th Street, New York</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Reviews. Microbiology</title><idno type="ISSN">1740-1526</idno><idno type="eISSN">1740-1534</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p id="Par7"><list list-type="bullet"><list-item><p id="Par8">This Review provides an overview on the spike (S) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) as a target for the development of vaccines and therapeutics for the prevention and treatment of SARS.</p></list-item><list-item><p id="Par9">SARS is a newly emerging infectious disease, caused by SARS-CoV, a novel coronavirus that caused a global outbreak of SARS.</p></list-item><list-item><p id="Par10">SARS-CoV S protein mediates binding of the virus with its receptor angiotensin-converting enzyme 2 and promotes the fusion between the viral and host cell membranes and virus entry into the host cell.</p></list-item><list-item><p id="Par11">SARS-CoV S protein induces humoral and cellular immune responses against SARS-CoV.</p></list-item><list-item><p id="Par12">SARS S protein is the target of new SARS vaccines. These vaccines are based on SARS-CoV full-length S protein and its receptor-binding domain, including DNA-, viral vector- and subunit-based vaccines</p></list-item><list-item><p id="Par13">Peptides, antibodies, organic compounds and short interfering RNAs are additional anti-SARS-CoV therapeutics that target the S protein.</p></list-item><list-item><p id="Par14">The work on SARS-CoV S protein-based vaccines and drugs will be useful as a model for the development of prophylactic strategies and therapies against other viruses with class I fusion proteins that can cause emerging infectious diseases.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleck, F" uniqKey="Fleck F">F Fleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, G" uniqKey="Liang G">G Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Wn" uniqKey="Liang W">WN Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Normile, D" uniqKey="Normile D">D Normile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orellana, C" uniqKey="Orellana C">C Orellana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, Hy" uniqKey="Mo H">HY Mo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, X" uniqKey="Zhong X">X Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, T" uniqKey="Li T">T Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See, Rh" uniqKey="See R">RH See</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutta, Nk" uniqKey="Dutta N">NK Dutta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhi, Y" uniqKey="Zhi Y">Y Zhi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, Uj" uniqKey="Buchholz U">UJ Buchholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakhartchouk, An" uniqKey="Zakhartchouk A">AN Zakhartchouk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Cy" uniqKey="Zhang C">CY Zhang</name></author><author><name sortKey="Wei, Jf" uniqKey="Wei J">JF Wei</name></author><author><name sortKey="He, Sh" uniqKey="He S">SH He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weissenhorn, W" uniqKey="Weissenhorn W">W Weissenhorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sainz, B" uniqKey="Sainz B">B Sainz</name></author><author><name sortKey="Rausch, Jm" uniqKey="Rausch J">JM Rausch</name></author><author><name sortKey="Gallaher, Wr" uniqKey="Gallaher W">WR Gallaher</name></author><author><name sortKey="Garry, Rf" uniqKey="Garry R">RF Garry</name></author><author><name sortKey="Wimley, Wc" uniqKey="Wimley W">WC Wimley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Bartelink, W" uniqKey="Bartelink W">W Bartelink</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, L" uniqKey="Lai L">L Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name></author><author><name sortKey="Chakraborti, S" uniqKey="Chakraborti S">S Chakraborti</name></author><author><name sortKey="Dimitrov, As" uniqKey="Dimitrov A">AS Dimitrov</name></author><author><name sortKey="Gramatikoff, K" uniqKey="Gramatikoff K">K Gramatikoff</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babcock, Gj" uniqKey="Babcock G">GJ Babcock</name></author><author><name sortKey="Esshaki, Dj" uniqKey="Esshaki D">DJ Esshaki</name></author><author><name sortKey="Thomas, Wd" uniqKey="Thomas W">WD Thomas</name></author><author><name sortKey="Ambrosino, Dm" uniqKey="Ambrosino D">DM Ambrosino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qu, Xx" uniqKey="Qu X">XX Qu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Jh" uniqKey="Kuhn J">JH Kuhn</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zheng, N" uniqKey="Zheng N">N Zheng</name></author><author><name sortKey="Hao, P" uniqKey="Hao P">P Hao</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeffers, Sa" uniqKey="Jeffers S">SA Jeffers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Dp" uniqKey="Han D">DP Han</name></author><author><name sortKey="Lohani, M" uniqKey="Lohani M">M Lohani</name></author><author><name sortKey="Cho, Mw" uniqKey="Cho M">MW Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tripet, B" uniqKey="Tripet B">B Tripet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, T" uniqKey="Zhou T">T Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keng, Ct" uniqKey="Keng C">CT Keng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A Bukreyev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisht, H" uniqKey="Bisht H">H Bisht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kam, Yw" uniqKey="Kam Y">YW Kam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Heck, S" uniqKey="Heck S">S Heck</name></author><author><name sortKey="Lustigman, S" uniqKey="Lustigman S">S Lustigman</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Czub, M" uniqKey="Czub M">M Czub</name></author><author><name sortKey="Weingartl, H" uniqKey="Weingartl H">H Weingartl</name></author><author><name sortKey="Czub, S" uniqKey="Czub S">S Czub</name></author><author><name sortKey="He, R" uniqKey="He R">R He</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weingartl, H" uniqKey="Weingartl H">H Weingartl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonavia, A" uniqKey="Bonavia A">A Bonavia</name></author><author><name sortKey="Zelus, Bd" uniqKey="Zelus B">BD Zelus</name></author><author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Yamada, Yk" uniqKey="Yamada Y">YK Yamada</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P Siddiqui</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, C" uniqKey="Qin C">C Qin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogel, Ln" uniqKey="Vogel L">LN Vogel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Dp" uniqKey="Han D">DP Han</name></author><author><name sortKey="Penn Nicholson, A" uniqKey="Penn Nicholson A">A Penn-Nicholson</name></author><author><name sortKey="Cho, Mw" uniqKey="Cho M">MW Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Lin, K" uniqKey="Lin K">K Lin</name></author><author><name sortKey="Strick, N" uniqKey="Strick N">N Strick</name></author><author><name sortKey="Neurath, Ar" uniqKey="Neurath A">AR Neurath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wild, Ct" uniqKey="Wild C">CT Wild</name></author><author><name sortKey="Shugars, Dc" uniqKey="Shugars D">DC Shugars</name></author><author><name sortKey="Greenwell, Tk" uniqKey="Greenwell T">TK Greenwell</name></author><author><name sortKey="Mcdanal, Cb" uniqKey="Mcdanal C">CB Mcdanal</name></author><author><name sortKey="Matthews, Tj" uniqKey="Matthews T">TJ Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Dc" uniqKey="Chan D">DC Chan</name></author><author><name sortKey="Kim, Ps" uniqKey="Kim P">PS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, K" uniqKey="Yuan K">K Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcroy, Wc" uniqKey="Mcroy W">WC Mcroy</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P Siddiqui</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Sc" uniqKey="Lai S">SC Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welt, S" uniqKey="Welt S">S Welt</name></author><author><name sortKey="Ritter, G" uniqKey="Ritter G">G Ritter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nie, Y" uniqKey="Nie Y">Y Nie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coughlin, M" uniqKey="Coughlin M">M Coughlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Brink, En" uniqKey="Van Den Brink E">EN Van Den Brink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ic" uniqKey="Huang I">IC Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ic" uniqKey="Huang I">IC Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simmons, G" uniqKey="Simmons G">G Simmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simmons, G" uniqKey="Simmons G">G Simmons</name></author><author><name sortKey="Rennekamp, Aj" uniqKey="Rennekamp A">AJ Rennekamp</name></author><author><name sortKey="Bates, P" uniqKey="Bates P">P Bates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadler, K" uniqKey="Stadler K">K Stadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, L" uniqKey="Yi L">L Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, Ry" uniqKey="Kao R">RY Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, T" uniqKey="Li T">T Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitlin, L" uniqKey="Gitlin L">L Gitlin</name></author><author><name sortKey="Karelsky, S" uniqKey="Karelsky S">S Karelsky</name></author><author><name sortKey="Andino, R" uniqKey="Andino R">R Andino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Cj" uniqKey="Wu C">CJ Wu</name></author><author><name sortKey="Huang, Hw" uniqKey="Huang H">HW Huang</name></author><author><name sortKey="Liu, Cy" uniqKey="Liu C">CY Liu</name></author><author><name sortKey="Hong, Cf" uniqKey="Hong C">CF Hong</name></author><author><name sortKey="Chan, Yl" uniqKey="Chan Y">YL Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akerstrom, S" uniqKey="Akerstrom S">S Akerstrom</name></author><author><name sortKey="Mirazimi, A" uniqKey="Mirazimi A">A Mirazimi</name></author><author><name sortKey="Tan, Yj" uniqKey="Tan Y">YJ Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Ml" uniqKey="He M">ML He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, Zl" uniqKey="Qin Z">ZL Qin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Bj" uniqKey="Li B">BJ Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simmons, G" uniqKey="Simmons G">G Simmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Ujike, M" uniqKey="Ujike M">M Ujike</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S Morikawa</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M Tashiro</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qinfen, Z" uniqKey="Qinfen Z">Z Qinfen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name></author><author><name sortKey="Mcnutt, Ma" uniqKey="Mcnutt M">MA Mcnutt</name></author><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M Heise</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stertz, S" uniqKey="Stertz S">S Stertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakansson Mcreynolds, S" uniqKey="Hakansson Mcreynolds S">S Hakansson-Mcreynolds</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Rong, L" uniqKey="Rong L">L Rong</name></author><author><name sortKey="Caffrey, M" uniqKey="Caffrey M">M Caffrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, P" uniqKey="Zhao P">P Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Dr" uniqKey="Taylor D">DR Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kliger, Y" uniqKey="Kliger Y">Y Kliger</name></author><author><name sortKey="Levanon, Ey" uniqKey="Levanon E">EY Levanon</name></author><author><name sortKey="Gerber, D" uniqKey="Gerber D">D Gerber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Xd" uniqKey="Wu X">XD Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ujike, M" uniqKey="Ujike M">M Ujike</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitsuki, Yy" uniqKey="Mitsuki Y">YY Mitsuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ter Meulen, J" uniqKey="Ter Meulen J">J Ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Rev Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Microbiol</journal-id><journal-title-group><journal-title>Nature Reviews. Microbiology</journal-title></journal-title-group><issn pub-type="ppub">1740-1526</issn><issn pub-type="epub">1740-1534</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19198616</article-id><article-id pub-id-type="pmc">2750777</article-id><article-id pub-id-type="publisher-id">BFnrmicro2090</article-id><article-id pub-id-type="doi">10.1038/nrmicro2090</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The spike protein of SARS-CoV — a target for vaccine and therapeutic development</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Du</surname><given-names>Lanying</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><bio><p id="Par1">Lanying Du received her PhD from the University of Hong Kong and is now a research fellow at the Viral Immunology Laboratory, the Lindsley F. Kimball Research Institute of New York Blood Center, USA. Her research interests focus on studies of the structure and function of the severe acute respiratory syndrome-coronavirus (SARS-CoV) spike protein and the development of spike protein-based SARS vaccines.</p></bio></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Yuxian</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><bio><p id="Par2">Yuxian He is an assistant member at the Viral Immunology Laboratory, the Lindsley F. Kimball Research Institute of New York Blood Center, USA, where he has made dedicated efforts to develop vaccines and therapeutics against emerging infectious viruses, including HIV, severe acute respiratory syndrome-coronavirus (SARS-CoV) and highly pathogenic influenza virus H5N1.</p></bio></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Yusen</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><bio><p id="Par3">Yusen Zhou is Professor and Director of the Department of Pathogen Molecular Biology at the Beijing Institute of Microbiology and Epidemiology, China, where he has focused on studies of viral immunology and pathogenesis of hepatitis and emerging infectious diseases, including severe acute respiratory syndrome (SARS), H5N1 avian influenza and haemorrhagic fever with renal syndrome.</p></bio></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Shuwen</given-names></name><xref ref-type="aff" rid="Aff3">3</xref><bio><p id="Par4">Shuwen Liu is Professor and Executive Director of the Antiviral Research Center, School of Pharmaceutical Sciences of the Southern Medical University, Guangzhou, China, where he has worked on the development of antiviral therapeutics against HIV, severe acute respiratory syndrome-coronavirus (SARS-CoV), influenza virus, hepatitis B virus and hepatitis C virus.</p></bio></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Bo-Jian</given-names></name><xref ref-type="aff" rid="Aff4">4</xref><bio><p id="Par5">Bo-Jian Zheng is Professor and Director of the Vaccine Laboratory, Department of Microbiology, the University of Hong Kong, where he has worked on the epidemiology, immunology and anti-viral therapy of viral emerging infectious diseases, with a focus on severe acute respiratory syndrome (SARS) and H5N1 avian influenza.</p></bio></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jiang</surname><given-names>Shibo</given-names></name><address><email>sjiang@nybloodcenter.org</email></address><xref ref-type="aff" rid="Aff1">1</xref><bio><p id="Par6">Shibo Jiang is Head of the Viral Immunology Laboratory at the Lindsley F. Kimball Research Institute of the New York Blood Center, USA, where he has focused on the development of envelope glycoprotein-based therapeutics and vaccines against HIV and severe acute respiratory syndrome-coronavirus (SARS-CoV). He was the first to discover the highly potent anti-HIV peptide derived from the HIV-1 glycoprotein 41 HR2 region, and later licensed the patent to Trimeris Pharmaceuticals, who then developed the peptidic anti-HIV drug enfuvirtide, the first HIV fusion inhibitor approved by the US Food and Drug Administration. This discovery opened a new avenue to the development of viral fusion inhibitors against viruses with class I fusion proteins.</p></bio></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.250415.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0442 2075</institution-id><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution></institution-wrap>310 East 67th Street, New York, 10065 New York USA</aff><aff id="Aff2"><label>2</label>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071 China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution>School of Pharmaceutical Sciences, Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Microbiology,</institution><institution>University of Hong Kong, Pokfulam,</institution></institution-wrap>Hong Kong SAR, China</aff></contrib-group><pub-date pub-type="epub"><day>9</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="ppub"><year>2009</year></pub-date><volume>7</volume><issue>3</issue><fpage>226</fpage><lpage>236</lpage><permissions><copyright-statement>© Nature Publishing Group 2009</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1" abstract-type="KeyPoints"><title>Key Points</title><p id="Par7"><list list-type="bullet"><list-item><p id="Par8">This Review provides an overview on the spike (S) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) as a target for the development of vaccines and therapeutics for the prevention and treatment of SARS.</p></list-item><list-item><p id="Par9">SARS is a newly emerging infectious disease, caused by SARS-CoV, a novel coronavirus that caused a global outbreak of SARS.</p></list-item><list-item><p id="Par10">SARS-CoV S protein mediates binding of the virus with its receptor angiotensin-converting enzyme 2 and promotes the fusion between the viral and host cell membranes and virus entry into the host cell.</p></list-item><list-item><p id="Par11">SARS-CoV S protein induces humoral and cellular immune responses against SARS-CoV.</p></list-item><list-item><p id="Par12">SARS S protein is the target of new SARS vaccines. These vaccines are based on SARS-CoV full-length S protein and its receptor-binding domain, including DNA-, viral vector- and subunit-based vaccines</p></list-item><list-item><p id="Par13">Peptides, antibodies, organic compounds and short interfering RNAs are additional anti-SARS-CoV therapeutics that target the S protein.</p></list-item><list-item><p id="Par14">The work on SARS-CoV S protein-based vaccines and drugs will be useful as a model for the development of prophylactic strategies and therapies against other viruses with class I fusion proteins that can cause emerging infectious diseases.</p></list-item></list></p></abstract><abstract id="Abs2" abstract-type="web-summary"><p id="Par15">The outbreaks of severe acute respiratory syndrome (SARS) between 2002 and 2004 killed hundreds of people. Vaccines against the SARS coronavirus (SARS-CoV) could protect the population during future outbreaks. In this Review, Shibo Jiang and colleagues describe such vaccines, as well as other therapeutics, based on the SARS-CoV spike protein.</p></abstract><abstract id="Abs3"><p id="Par16">Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Nature Limited 2009</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000566 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000566 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:2750777
|texte= The spike protein of SARS-CoV — a target for vaccine and therapeutic development
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:19198616" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |