Identification of a new human coronavirus
Identifieur interne : 000443 ( Pmc/Curation ); précédent : 000442; suivant : 000444Identification of a new human coronavirus
Auteurs : Lia Van Der Hoek [Pays-Bas] ; Krzysztof Pyrc [Pays-Bas] ; Maarten F. Jebbink [Pays-Bas] ; Wilma Vermeulen-Oost ; Ron J M. Berkhout ; Katja C. Wolthers [Pays-Bas] ; Pauline M E. Wertheim-Van Dillen [Pays-Bas] ; Jos Kaandorp ; Joke Spaargaren ; Ben Berkhout [Pays-Bas]Source :
- Nature Medicine [ 1078-8956 ] ; 2004.
Abstract
Three human coronaviruses are known to exist: human coronavirus 229E (HCoV-229E), HCoV-OC43 and severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). Here we report the identification of a fourth human coronavirus, HCoV-NL63, using a new method of virus discovery. The virus was isolated from a 7-month-old child suffering from bronchiolitis and conjunctivitis. The complete genome sequence indicates that this virus is not a recombinant, but rather a new group 1 coronavirus. The
The online version of this article (doi:10.1038/nm1024) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm1024
PubMed: 15034574
PubMed Central: 7095789
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Wilma Vermeulen-Oost<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.416050.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 0369 6840</institution-id><institution>Pediatric Department,</institution><institution>Slotervaart Hospital, Louwesweg 6,</institution></institution-wrap>Amsterdam, 1066 EC The Netherlands</nlm:aff><wicri:noCountry code="subfield">1066 EC The Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a new human coronavirus</title><author><name sortKey="Van Der Hoek, Lia" sort="Van Der Hoek, Lia" uniqKey="Van Der Hoek L" first="Lia" last="Van Der Hoek">Lia Van Der Hoek</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Jebbink, Maarten F" sort="Jebbink, Maarten F" uniqKey="Jebbink M" first="Maarten F" last="Jebbink">Maarten F. Jebbink</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Vermeulen Oost, Wilma" sort="Vermeulen Oost, Wilma" uniqKey="Vermeulen Oost W" first="Wilma" last="Vermeulen-Oost">Wilma Vermeulen-Oost</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berkhout, Ron J M" sort="Berkhout, Ron J M" uniqKey="Berkhout R" first="Ron J M" last="Berkhout">Ron J M. Berkhout</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Wolthers, Katja C" sort="Wolthers, Katja C" uniqKey="Wolthers K" first="Katja C" last="Wolthers">Katja C. Wolthers</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wertheim Van Dillen, Pauline M E" sort="Wertheim Van Dillen, Pauline M E" uniqKey="Wertheim Van Dillen P" first="Pauline M E" last="Wertheim-Van Dillen">Pauline M E. Wertheim-Van Dillen</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Department of Medical Microbiology/Clinical Virology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaandorp, Jos" sort="Kaandorp, Jos" uniqKey="Kaandorp J" first="Jos" last="Kaandorp">Jos Kaandorp</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.416050.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 0369 6840</institution-id><institution>Pediatric Department,</institution><institution>Slotervaart Hospital, Louwesweg 6,</institution></institution-wrap>Amsterdam, 1066 EC The Netherlands</nlm:aff><wicri:noCountry code="subfield">1066 EC The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Spaargaren, Joke" sort="Spaargaren, Joke" uniqKey="Spaargaren J" first="Joke" last="Spaargaren">Joke Spaargaren</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berkhout, Ben" sort="Berkhout, Ben" uniqKey="Berkhout B" first="Ben" last="Berkhout">Ben Berkhout</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15034574</idno><idno type="pmc">7095789</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095789</idno><idno type="RBID">PMC:7095789</idno><idno type="doi">10.1038/nm1024</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000443</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000443</idno><idno type="wicri:Area/Pmc/Curation">000443</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000443</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of a new human coronavirus</title><author><name sortKey="Van Der Hoek, Lia" sort="Van Der Hoek, Lia" uniqKey="Van Der Hoek L" first="Lia" last="Van Der Hoek">Lia Van Der Hoek</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Jebbink, Maarten F" sort="Jebbink, Maarten F" uniqKey="Jebbink M" first="Maarten F" last="Jebbink">Maarten F. Jebbink</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Vermeulen Oost, Wilma" sort="Vermeulen Oost, Wilma" uniqKey="Vermeulen Oost W" first="Wilma" last="Vermeulen-Oost">Wilma Vermeulen-Oost</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berkhout, Ron J M" sort="Berkhout, Ron J M" uniqKey="Berkhout R" first="Ron J M" last="Berkhout">Ron J M. Berkhout</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Wolthers, Katja C" sort="Wolthers, Katja C" uniqKey="Wolthers K" first="Katja C" last="Wolthers">Katja C. Wolthers</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wertheim Van Dillen, Pauline M E" sort="Wertheim Van Dillen, Pauline M E" uniqKey="Wertheim Van Dillen P" first="Pauline M E" last="Wertheim-Van Dillen">Pauline M E. Wertheim-Van Dillen</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Department of Medical Microbiology/Clinical Virology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaandorp, Jos" sort="Kaandorp, Jos" uniqKey="Kaandorp J" first="Jos" last="Kaandorp">Jos Kaandorp</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.416050.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 0369 6840</institution-id><institution>Pediatric Department,</institution><institution>Slotervaart Hospital, Louwesweg 6,</institution></institution-wrap>Amsterdam, 1066 EC The Netherlands</nlm:aff><wicri:noCountry code="subfield">1066 EC The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Spaargaren, Joke" sort="Spaargaren, Joke" uniqKey="Spaargaren J" first="Joke" last="Spaargaren">Joke Spaargaren</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</nlm:aff><wicri:noCountry code="subfield">1018 WT The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berkhout, Ben" sort="Berkhout, Ben" uniqKey="Berkhout B" first="Ben" last="Berkhout">Ben Berkhout</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</nlm:aff><orgName type="university">Université d'Amsterdam</orgName><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName></affiliation></author></analytic><series><title level="j">Nature Medicine</title><idno type="ISSN">1078-8956</idno><idno type="eISSN">1546-170X</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Three human coronaviruses are known to exist: human coronavirus 229E (HCoV-229E), HCoV-OC43 and severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). Here we report the identification of a fourth human coronavirus, HCoV-NL63, using a new method of virus discovery. The virus was isolated from a 7-month-old child suffering from bronchiolitis and conjunctivitis. The complete genome sequence indicates that this virus is not a recombinant, but rather a new group 1 coronavirus. The <italic>in vitro</italic> host cell range of HCoV-NL63 is notable because it replicates on tertiary monkey kidney cells and the monkey kidney LLC-MK2 cell line. The viral genome contains distinctive features, including a unique N-terminal fragment within the spike protein. Screening of clinical specimens from individuals suffering from respiratory illness identified seven additional HCoV-NL63-infected individuals, indicating that the virus was widely spread within the human population.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nm1024) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author><author><name sortKey="Hinton, Dr" uniqKey="Hinton D">DR Hinton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jubelt, B" uniqKey="Jubelt B">B Jubelt</name></author><author><name sortKey="Berger, Jr" uniqKey="Berger J">JR Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shingadia, D" uniqKey="Shingadia D">D Shingadia</name></author><author><name sortKey="Bose, A" uniqKey="Bose A">A Bose</name></author><author><name sortKey="Booy, R" uniqKey="Booy R">R Booy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bachem, Cw" uniqKey="Bachem C">CW Bachem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Lai, Mmc" uniqKey="Lai M">MMC Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guy, Js" uniqKey="Guy J">JS Guy</name></author><author><name sortKey="Breslin, Jj" uniqKey="Breslin J">JJ Breslin</name></author><author><name sortKey="Breuhaus, B" uniqKey="Breuhaus B">B Breuhaus</name></author><author><name sortKey="Vivrette, S" uniqKey="Vivrette S">S Vivrette</name></author><author><name sortKey="Smith, Lg" uniqKey="Smith L">LG Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyrrell, Daj" uniqKey="Tyrrell D">DAJ Tyrrell</name></author><author><name sortKey="Bynoe, Ml" uniqKey="Bynoe M">ML Bynoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamre, D" uniqKey="Hamre D">D Hamre</name></author><author><name sortKey="Procknow, Jj" uniqKey="Procknow J">JJ Procknow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almeida, Jd" uniqKey="Almeida J">JD Almeida</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Herold, J" uniqKey="Herold J">J Herold</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B Schelle</name></author><author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcintosh, K" uniqKey="Mcintosh K">K McIntosh</name></author><author><name sortKey="Dees, Jh" uniqKey="Dees J">JH Dees</name></author><author><name sortKey="Becker, Wb" uniqKey="Becker W">WB Becker</name></author><author><name sortKey="Kapikian, Az" uniqKey="Kapikian A">AZ Kapikian</name></author><author><name sortKey="Chanock, Rm" uniqKey="Chanock R">RM Chanock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hendley, Jo" uniqKey="Hendley J">JO Hendley</name></author><author><name sortKey="Fishburne, Hb" uniqKey="Fishburne H">HB Fishburne</name></author><author><name sortKey="Gwaltney, Jm" uniqKey="Gwaltney J">JM Gwaltney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mounir, S" uniqKey="Mounir S">S Mounir</name></author><author><name sortKey="Labonte, P" uniqKey="Labonte P">P Labonte</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kunkel, F" uniqKey="Kunkel F">F Kunkel</name></author><author><name sortKey="Herrler, G" uniqKey="Herrler G">G Herrler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradburne, Af" uniqKey="Bradburne A">AF Bradburne</name></author><author><name sortKey="Bynoe, Ml" uniqKey="Bynoe M">ML Bynoe</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Mm" uniqKey="Lai M">MM Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, Be" uniqKey="Martina B">BE Martina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamparian, Vv" uniqKey="Hamparian V">VV Hamparian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Ll" uniqKey="Chen L">LL Chen</name></author><author><name sortKey="Ou, Hy" uniqKey="Ou H">HY Ou</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Zhang, Ct" uniqKey="Zhang C">CT Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawicki, Sg" uniqKey="Sawicki S">SG Sawicki</name></author><author><name sortKey="Sawicki, Dl" uniqKey="Sawicki D">DL Sawicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Marle, G" uniqKey="Van Marle G">G van Marle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lole, Ks" uniqKey="Lole K">KS Lole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mounir, S" uniqKey="Mounir S">S Mounir</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, M" uniqKey="Duarte M">M Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godet, M" uniqKey="Godet M">M Godet</name></author><author><name sortKey="Grosclaude, J" uniqKey="Grosclaude J">J Grosclaude</name></author><author><name sortKey="Delmas, B" uniqKey="Delmas B">B Delmas</name></author><author><name sortKey="Laude, H" uniqKey="Laude H">H Laude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krempl, C" uniqKey="Krempl C">C Krempl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonavia, A" uniqKey="Bonavia A">A Bonavia</name></author><author><name sortKey="Zelus, Bd" uniqKey="Zelus B">BD Zelus</name></author><author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaughn, Em" uniqKey="Vaughn E">EM Vaughn</name></author><author><name sortKey="Halbur, Pg" uniqKey="Halbur P">PG Halbur</name></author><author><name sortKey="Paul, Ps" uniqKey="Paul P">PS Paul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcintosh, K" uniqKey="Mcintosh K">K McIntosh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pene, F" uniqKey="Pene F">F Pene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myint, S" uniqKey="Myint S">S Myint</name></author><author><name sortKey="Johnston, S" uniqKey="Johnston S">S Johnston</name></author><author><name sortKey="Sanderson, G" uniqKey="Sanderson G">G Sanderson</name></author><author><name sortKey="Simpson, H" uniqKey="Simpson H">H Simpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephensen, Cb" uniqKey="Stephensen C">CB Stephensen</name></author><author><name sortKey="Casebolt, Db" uniqKey="Casebolt D">DB Casebolt</name></author><author><name sortKey="Gangopadhyay, Nn" uniqKey="Gangopadhyay N">NN Gangopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boom, R" uniqKey="Boom R">R Boom</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Med</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Med</journal-id><journal-title-group><journal-title>Nature Medicine</journal-title></journal-title-group><issn pub-type="ppub">1078-8956</issn><issn pub-type="epub">1546-170X</issn><publisher><publisher-name>Nature Publishing Group US</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15034574</article-id><article-id pub-id-type="pmc">7095789</article-id><article-id pub-id-type="publisher-id">BFnm1024</article-id><article-id pub-id-type="doi">10.1038/nm1024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Identification of a new human coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>van der Hoek</surname><given-names>Lia</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pyrc</surname><given-names>Krzysztof</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jebbink</surname><given-names>Maarten F</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vermeulen-Oost</surname><given-names>Wilma</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Berkhout</surname><given-names>Ron J M</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wolthers</surname><given-names>Katja C</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wertheim-van Dillen</surname><given-names>Pauline M E</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kaandorp</surname><given-names>Jos</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Spaargaren</surname><given-names>Joke</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Berkhout</surname><given-names>Ben</given-names></name><address><email>b.berkhout@amc.uva.nl</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label>Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.416278.e</institution-id><institution>Public Health Laboratory, Municipal Health Service, Nieuwe Achtergracht 100,</institution></institution-wrap>Amsterdam, 1018 WT The Netherlands</aff><aff id="Aff3"><label>3</label>Department of Medical Microbiology/Clinical Virology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ The Netherlands</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.416050.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 0369 6840</institution-id><institution>Pediatric Department,</institution><institution>Slotervaart Hospital, Louwesweg 6,</institution></institution-wrap>Amsterdam, 1066 EC The Netherlands</aff></contrib-group><pub-date pub-type="epub"><day>21</day><month>3</month><year>2004</year></pub-date><pub-date pub-type="ppub"><year>2004</year></pub-date><volume>10</volume><issue>4</issue><fpage>368</fpage><lpage>373</lpage><history><date date-type="received"><day>10</day><month>12</month><year>2003</year></date><date date-type="accepted"><day>8</day><month>3</month><year>2004</year></date></history><permissions><copyright-statement>© Nature Publishing Group 2004</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Three human coronaviruses are known to exist: human coronavirus 229E (HCoV-229E), HCoV-OC43 and severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). Here we report the identification of a fourth human coronavirus, HCoV-NL63, using a new method of virus discovery. The virus was isolated from a 7-month-old child suffering from bronchiolitis and conjunctivitis. The complete genome sequence indicates that this virus is not a recombinant, but rather a new group 1 coronavirus. The <italic>in vitro</italic> host cell range of HCoV-NL63 is notable because it replicates on tertiary monkey kidney cells and the monkey kidney LLC-MK2 cell line. The viral genome contains distinctive features, including a unique N-terminal fragment within the spike protein. Screening of clinical specimens from individuals suffering from respiratory illness identified seven additional HCoV-NL63-infected individuals, indicating that the virus was widely spread within the human population.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nm1024) contains supplementary material, which is available to authorized users.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s), under exclusive licence to Springer Nature America, Inc. 2004</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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