Pathogen Detection in the Genomic Era
Identifieur interne : 000074 ( Pmc/Curation ); précédent : 000073; suivant : 000075Pathogen Detection in the Genomic Era
Auteurs : Elizabeth M. Marlowe ; Donna M. WolkSource :
- Advanced Techniques in Diagnostic Microbiology ; 2006.
Abstract
In the 21st century, one of the greatest challenges to public health and clinical microbiologists is the rapid detection and identification of emerging and reemerging pathogens. Complex factors such as genetic variation in the host and pathogen, environmental changes, population pressures, and global travel can all influence the emergence of infectious diseases. The SARS epidemic of 2003 highlighted the potential of an emerging pathogen to spread globally in a very short time frame (Peruski and Peruski, 2003). The diagnostics of such infectious diseases has been greatly affected in the past 20 years. No longer is cultivation and microscopy the only means of detecting infectious agents. With the introduction of molecular diagnostics, the ability to detect minute amounts of microbial nucleic acids in clinical specimens has revolutionized clinical microbiology. In particular, the utility of PCR allows the detection and quantitation of specific agents in a matter of hours. PCR sequencing of specific segments of nucleic acid allows for the determination of specific drug resistance that now aids in guiding viral therapies.
Url:
DOI: 10.1007/0-387-32892-0_28
PubMed: NONE
PubMed Central: 7120690
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathogen Detection in the Genomic Era</title><author><name sortKey="Marlowe, Elizabeth M" sort="Marlowe, Elizabeth M" uniqKey="Marlowe E" first="Elizabeth M." last="Marlowe">Elizabeth M. Marlowe</name></author><author><name sortKey="Wolk, Donna M" sort="Wolk, Donna M" uniqKey="Wolk D" first="Donna M." last="Wolk">Donna M. Wolk</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7120690</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120690</idno><idno type="RBID">PMC:7120690</idno><idno type="doi">10.1007/0-387-32892-0_28</idno><idno type="pmid">NONE</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000074</idno><idno type="wicri:Area/Pmc/Curation">000074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000074</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pathogen Detection in the Genomic Era</title><author><name sortKey="Marlowe, Elizabeth M" sort="Marlowe, Elizabeth M" uniqKey="Marlowe E" first="Elizabeth M." last="Marlowe">Elizabeth M. Marlowe</name></author><author><name sortKey="Wolk, Donna M" sort="Wolk, Donna M" uniqKey="Wolk D" first="Donna M." last="Wolk">Donna M. Wolk</name></author></analytic><series><title level="j">Advanced Techniques in Diagnostic Microbiology</title><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the 21st century, one of the greatest challenges to public health and clinical microbiologists is the rapid detection and identification of emerging and reemerging pathogens. Complex factors such as genetic variation in the host and pathogen, environmental changes, population pressures, and global travel can all influence the emergence of infectious diseases. The SARS epidemic of 2003 highlighted the potential of an emerging pathogen to spread globally in a very short time frame (Peruski and Peruski, 2003). The diagnostics of such infectious diseases has been greatly affected in the past 20 years. No longer is cultivation and microscopy the only means of detecting infectious agents. With the introduction of molecular diagnostics, the ability to detect minute amounts of microbial nucleic acids in clinical specimens has revolutionized clinical microbiology. In particular, the utility of PCR allows the detection and quantitation of specific agents in a matter of hours. PCR sequencing of specific segments of nucleic acid allows for the determination of specific drug resistance that now aids in guiding viral therapies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aarestrup, F M" uniqKey="Aarestrup F">F. M. Aarestrup</name></author><author><name sortKey="Ahrens, P" uniqKey="Ahrens P">P. Ahrens</name></author><author><name sortKey="Madsen, M" uniqKey="Madsen M">M. 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<front><journal-meta><journal-id journal-id-type="publisher-id">978-0-387-32892-8</journal-id><journal-id journal-id-type="doi">10.1007/0-387-32892-0</journal-id><journal-id journal-id-type="nlm-ta">Advanced Techniques in Diagnostic Microbiology</journal-id><journal-title-group><journal-title>Advanced Techniques in Diagnostic Microbiology</journal-title></journal-title-group><isbn publication-format="print">978-0-387-29741-5</isbn><isbn publication-format="electronic">978-0-387-32892-8</isbn></journal-meta><article-meta><article-id pub-id-type="pmc">7120690</article-id><article-id pub-id-type="publisher-id">28</article-id><article-id pub-id-type="doi">10.1007/0-387-32892-0_28</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pathogen Detection in the Genomic Era</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marlowe</surname><given-names>Elizabeth M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wolk</surname><given-names>Donna M.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><year>2006</year></pub-date><fpage>505</fpage><lpage>523</lpage><permissions><copyright-statement>© Springer 2006</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>In the 21st century, one of the greatest challenges to public health and clinical microbiologists is the rapid detection and identification of emerging and reemerging pathogens. Complex factors such as genetic variation in the host and pathogen, environmental changes, population pressures, and global travel can all influence the emergence of infectious diseases. The SARS epidemic of 2003 highlighted the potential of an emerging pathogen to spread globally in a very short time frame (Peruski and Peruski, 2003). The diagnostics of such infectious diseases has been greatly affected in the past 20 years. No longer is cultivation and microscopy the only means of detecting infectious agents. With the introduction of molecular diagnostics, the ability to detect minute amounts of microbial nucleic acids in clinical specimens has revolutionized clinical microbiology. In particular, the utility of PCR allows the detection and quantitation of specific agents in a matter of hours. PCR sequencing of specific segments of nucleic acid allows for the determination of specific drug resistance that now aids in guiding viral therapies.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>West Nile Virus</kwd><kwd>Clinical Microbiology</kwd><kwd>Nucleic Acid Extraction</kwd><kwd>Pathogen Detection</kwd><kwd>Molecular Microbiology</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer 2006</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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