Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
Identifieur interne : 000046 ( Pmc/Curation ); précédent : 000045; suivant : 000047Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
Auteurs : Haibo Zhang [République populaire de Chine, Canada] ; Josef M. Penninger [Autriche] ; Yimin Li [République populaire de Chine] ; Nanshan Zhong [République populaire de Chine] ; Arthur S. Slutsky [Canada, République populaire de Chine]Source :
- Intensive Care Medicine [ 0342-4642 ] ; 2020.
Url:
DOI: 10.1007/s00134-020-05985-9
PubMed: 32125455
PubMed Central: 7079879
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Haibo Zhang<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415502.7</institution-id><institution>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute,</institution><institution>St. Michaels Hospital,</institution></institution-wrap>209 Victoria Street, Room 608, Toronto, ON M5B 1T8 Canada</nlm:aff><wicri:noCountry code="subfield">ON M5B 1T8 Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.470124.4</institution-id><institution>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health,</institution><institution>The First Affiliated Hospital of Guangzhou Medical University,</institution></institution-wrap>Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution>Interdepartmental Division of Critical Care Medicine; Departments of Anesthesia and Physiology,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.17091.3e</institution-id><institution-id institution-id-type="ISNI">0000 0001 2288 9830</institution-id><institution>Department of Medical Genetics, Life Science Institute,</institution><institution>University of British Columbia,</institution></institution-wrap>Vancouver, BC Canada</nlm:aff><wicri:noCountry code="subfield">BC Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.4299.6</institution-id><institution-id institution-id-type="ISNI">0000 0001 2169 3852</institution-id><institution>IMBA, Institute of Molecular Biotechnology,</institution><institution>Austrian Academy of Sciences,</institution></institution-wrap>Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Vienna</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415502.7</institution-id><institution>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute,</institution><institution>St. Michaels Hospital,</institution></institution-wrap>209 Victoria Street, Room 608, Toronto, ON M5B 1T8 Canada</nlm:aff><wicri:noCountry code="subfield">ON M5B 1T8 Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution>Interdepartmental Division of Critical Care Medicine,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.470124.4</institution-id><institution>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health,</institution><institution>The First Affiliated Hospital of Guangzhou Medical University,</institution></institution-wrap>Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation>Le document en format XML
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Intensive Care Med</journal-id><journal-id journal-id-type="iso-abbrev">Intensive Care Med</journal-id><journal-title-group><journal-title>Intensive Care Medicine</journal-title></journal-title-group><issn pub-type="ppub">0342-4642</issn><issn pub-type="epub">1432-1238</issn><publisher><publisher-name>Springer Berlin Heidelberg</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32125455</article-id><article-id pub-id-type="pmc">7079879</article-id><article-id pub-id-type="publisher-id">5985</article-id><article-id pub-id-type="doi">10.1007/s00134-020-05985-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Understanding the Disease</subject></subj-group></article-categories><title-group><article-title>Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1714-3038</contrib-id><name><surname>Zhang</surname><given-names>Haibo</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Penninger</surname><given-names>Josef M.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yimin</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Nanshan</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Slutsky</surname><given-names>Arthur S.</given-names></name><address><email>arthur.slutsky@unityhealth.to</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.415502.7</institution-id><institution>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute,</institution><institution>St. Michaels Hospital,</institution></institution-wrap>209 Victoria Street, Room 608, Toronto, ON M5B 1T8 Canada</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution>Interdepartmental Division of Critical Care Medicine,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, Canada</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.470124.4</institution-id><institution>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health,</institution><institution>The First Affiliated Hospital of Guangzhou Medical University,</institution></institution-wrap>Guangzhou, China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.17091.3e</institution-id><institution-id institution-id-type="ISNI">0000 0001 2288 9830</institution-id><institution>Department of Medical Genetics, Life Science Institute,</institution><institution>University of British Columbia,</institution></institution-wrap>Vancouver, BC Canada</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.4299.6</institution-id><institution-id institution-id-type="ISNI">0000 0001 2169 3852</institution-id><institution>IMBA, Institute of Molecular Biotechnology,</institution><institution>Austrian Academy of Sciences,</institution></institution-wrap>Vienna, Austria</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution>Interdepartmental Division of Critical Care Medicine; Departments of Anesthesia and Physiology,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, Canada</aff></contrib-group><pub-date pub-type="epub"><day>3</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>3</month><year>2020</year></pub-date><fpage>1</fpage><lpage>5</lpage><history><date date-type="received"><day>17</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000028</institution-id><institution>Institute of Circulatory and Respiratory Health</institution></institution-wrap></funding-source><award-id>FDN143285</award-id></award-group></funding-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/100000001</institution-id><institution>"Natural Science Foundation of China"</institution></institution-wrap></funding-source><award-id>81270125</award-id><award-id>81490530</award-id><award-id>2018GZR0201002</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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