Current concepts in SARS treatment
Identifieur interne : 001832 ( Pmc/Corpus ); précédent : 001831; suivant : 001833Current concepts in SARS treatment
Auteurs : Takeshi Fujii ; Aikichi IwamotoSource :
- Journal of Infection and Chemotherapy [ 1341-321X ] ; 2004.
Abstract
The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. Other agents, including the HIV protease inhibitor glycyrrhizin and convalescent plasma, remain to be evaluated.
Url:
DOI: 10.1007/s10156-003-0296-9
PubMed: 14991510
PubMed Central: 7088022
Links to Exploration step
PMC:7088022Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current concepts in SARS treatment</title><author><name sortKey="Fujii, Takeshi" sort="Fujii, Takeshi" uniqKey="Fujii T" first="Takeshi" last="Fujii">Takeshi Fujii</name></author><author><name sortKey="Iwamoto, Aikichi" sort="Iwamoto, Aikichi" uniqKey="Iwamoto A" first="Aikichi" last="Iwamoto">Aikichi Iwamoto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">14991510</idno><idno type="pmc">7088022</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088022</idno><idno type="RBID">PMC:7088022</idno><idno type="doi">10.1007/s10156-003-0296-9</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">001832</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001832</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current concepts in SARS treatment</title><author><name sortKey="Fujii, Takeshi" sort="Fujii, Takeshi" uniqKey="Fujii T" first="Takeshi" last="Fujii">Takeshi Fujii</name></author><author><name sortKey="Iwamoto, Aikichi" sort="Iwamoto, Aikichi" uniqKey="Iwamoto A" first="Aikichi" last="Iwamoto">Aikichi Iwamoto</name></author></analytic><series><title level="j">Journal of Infection and Chemotherapy</title><idno type="ISSN">1341-321X</idno><idno type="eISSN">1437-7780</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Chemother</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Chemother</journal-id><journal-title-group><journal-title>Journal of Infection and Chemotherapy</journal-title></journal-title-group><issn pub-type="ppub">1341-321X</issn><issn pub-type="epub">1437-7780</issn><publisher><publisher-name>Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">14991510</article-id><article-id pub-id-type="pmc">7088022</article-id><article-id pub-id-type="publisher-id">S1341-321X(04)71089-2</article-id><article-id pub-id-type="doi">10.1007/s10156-003-0296-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Current concepts in SARS treatment</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Fujii</surname><given-names>Takeshi</given-names></name><email>tmks@ims.u-tokyo.ac.jp</email><xref rid="cor1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Iwamoto</surname><given-names>Aikichi</given-names></name></contrib></contrib-group><aff id="aff0005">Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.</aff><contrib-group><contrib contrib-type="author" id="aut0010"><name><surname>Nakamura</surname><given-names>Tetsuya</given-names></name></contrib><contrib contrib-type="author" id="aut1015"><name><surname>Iwamoto</surname><given-names>Aikichi</given-names></name></contrib></contrib-group><aff id="aff0010">Department of Infectious Diseases and Applied Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan</aff><author-notes><corresp id="cor1"><label>*</label>Tel. +81-3-5449-5338; Fax +81-3-5449-5427 <email>tmks@ims.u-tokyo.ac.jp</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>18</day><month>3</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><year>2004</year></pub-date><pub-date pub-type="epub"><day>18</day><month>3</month><year>2014</year></pub-date><volume>10</volume><issue>1</issue><fpage>1</fpage><lpage>7</lpage><history><date date-type="received"><day>16</day><month>12</month><year>2003</year></date></history><permissions><copyright-statement>Copyright © 2004 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2004</copyright-year><copyright-holder>Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0005"><p>The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. 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