SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics
Identifieur interne : 001826 ( Pmc/Corpus ); précédent : 001825; suivant : 001827SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics
Auteurs : Qing Cao ; Yi-Ching Chen ; Chyi-Liang Chen ; Cheng-Hsun ChiuSource :
- Journal of the Formosan Medical Association [ 0929-6646 ] ; 2020.
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DOI: 10.1016/j.jfma.2020.02.009
PubMed: 32139299
PubMed Central: 7126646
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics</title><author><name sortKey="Cao, Qing" sort="Cao, Qing" uniqKey="Cao Q" first="Qing" last="Cao">Qing Cao</name><affiliation><nlm:aff id="aff1">Department of Infectious Diseases, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yi Ching" sort="Chen, Yi Ching" uniqKey="Chen Y" first="Yi-Ching" last="Chen">Yi-Ching Chen</name><affiliation><nlm:aff id="aff2">Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Chyi Liang" sort="Chen, Chyi Liang" uniqKey="Chen C" first="Chyi-Liang" last="Chen">Chyi-Liang Chen</name><affiliation><nlm:aff id="aff3">Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chiu, Cheng Hsun" sort="Chiu, Cheng Hsun" uniqKey="Chiu C" first="Cheng-Hsun" last="Chiu">Cheng-Hsun Chiu</name><affiliation><nlm:aff id="aff2">Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32139299</idno><idno type="pmc">7126646</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126646</idno><idno type="RBID">PMC:7126646</idno><idno type="doi">10.1016/j.jfma.2020.02.009</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001826</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001826</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics</title><author><name sortKey="Cao, Qing" sort="Cao, Qing" uniqKey="Cao Q" first="Qing" last="Cao">Qing Cao</name><affiliation><nlm:aff id="aff1">Department of Infectious Diseases, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yi Ching" sort="Chen, Yi Ching" uniqKey="Chen Y" first="Yi-Ching" last="Chen">Yi-Ching Chen</name><affiliation><nlm:aff id="aff2">Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Chyi Liang" sort="Chen, Chyi Liang" uniqKey="Chen C" first="Chyi-Liang" last="Chen">Chyi-Liang Chen</name><affiliation><nlm:aff id="aff3">Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chiu, Cheng Hsun" sort="Chiu, Cheng Hsun" uniqKey="Chiu C" first="Cheng-Hsun" last="Chiu">Cheng-Hsun Chiu</name><affiliation><nlm:aff id="aff2">Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the Formosan Medical Association</title><idno type="ISSN">0929-6646</idno><idno type="eISSN">0929-6646</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Health Commission Of Hubei Province Wuhan Hubei" uniqKey="Health Commission Of Hubei Province Wuhan Hubei">Health Commission of Hubei Province, Wuhan, Hubei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, J T F" uniqKey="Lau J">J.T.F. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Formos Med Assoc</journal-id><journal-id journal-id-type="iso-abbrev">J. Formos. Med. Assoc</journal-id><journal-title-group><journal-title>Journal of the Formosan Medical Association</journal-title></journal-title-group><issn pub-type="ppub">0929-6646</issn><issn pub-type="epub">0929-6646</issn><publisher><publisher-name>Formosan Medical Association. Published by Elsevier Taiwan LLC.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32139299</article-id><article-id pub-id-type="pmc">7126646</article-id><article-id pub-id-type="publisher-id">S0929-6646(20)30067-X</article-id><article-id pub-id-type="doi">10.1016/j.jfma.2020.02.009</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Cao</surname><given-names>Qing</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Chen</surname><given-names>Yi-Ching</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Chen</surname><given-names>Chyi-Liang</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Chiu</surname><given-names>Cheng-Hsun</given-names></name><email>chchiu@adm.cgmh.org.tw</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Infectious Diseases, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China</aff><aff id="aff2"><label>b</label>Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</aff><aff id="aff3"><label>c</label>Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, No. 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. <email>chchiu@adm.cgmh.org.tw</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>2</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>2</day><month>3</month><year>2020</year></pub-date><volume>119</volume><issue>3</issue><fpage>670</fpage><lpage>673</lpage><history><date date-type="received"><day>25</day><month>2</month><year>2020</year></date><date date-type="rev-recd"><day>26</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>26</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Formosan Medical Association. Published by Elsevier Taiwan LLC.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="p0010">The emergence and spread of a novel coronavirus (SARS-CoV-2) from Wuhan, China, have become a Public Health Emergency of International Concern, designated by World Health Organization. As of February 26, 2020, the National Health Commission of the People's Republic of China has received a total of 77,663 confirmed cases from across China.<xref rid="bib1" ref-type="bibr"><sup>1</sup></xref> As of February 26, 126 confirmed cases were reported from Hong Kong (HK), Macao, and Taiwan, and 1804 from 37 countries worldwide.<xref rid="bib1" ref-type="bibr"><sup>1</sup></xref> During the previous outbreaks of Severe Acute Respiratory Syndrome (SARS) in HK and Middle East Respiratory Syndrome (MERS) in South Korean, very few pediatric patients were reported, respectively.<xref rid="bib2" ref-type="bibr"><sup>2</sup></xref><sup>,</sup><xref rid="bib3" ref-type="bibr"><sup>3</sup></xref> Despite a high mortality rate of SARS and MERS in the adults, there were no fatalities in the pediatric patients.<xref rid="bib2" ref-type="bibr"><sup>2</sup></xref><sup>,</sup><xref rid="bib3" ref-type="bibr"><sup>3</sup></xref> Children appeared to have a milder form of the disease caused by the coronaviruses, including SARS-CoV-2.<xref rid="bib2" ref-type="bibr"><sup>2</sup></xref><sup>,</sup><xref rid="bib3" ref-type="bibr"><sup>3</sup></xref></p><p id="p0015">The first confirmed pediatric case of SARS-CoV-2 infection was reported in Shenzhen on January 20.<xref rid="bib4" ref-type="bibr"><sup>4</sup></xref> As of February 10, a total of 398 confirmed pediatric cases and 10,924 adult cases were reported nationwide, excluding the Hubei province (<xref rid="fig1" ref-type="fig">Fig. 1</xref>A). The data from Hubei province was incomplete because children were rarely screened for SARS-CoV-2 initially. However, a recent study that analyzed 44,672 laboratory-confirmed cases from across China as of February 11, 2020, only 416 (0.9%) were less than 10 years of age and 549 (1.2%) between 10 and 20 years of age.<xref rid="bib5" ref-type="bibr"><sup>5</sup></xref> In this outbreak, with the increase in the number of adult contacts who turned out to be the infected, the number of pediatric infections also increased concomitantly. With more diagnostic detection done, the proportion of mild infections mainly in children and young adults became higher.<xref rid="bib5" ref-type="bibr"><sup>5</sup></xref> The formation of the so-called “second-generation” infections in a short period of time indicates that the virus is highly contagious.<fig id="fig1"><label>Figure. 1</label><caption><p>Accumulated and daily new case numbers of laboratory-confirmed COVID-19 in children in China and the transmission dynamics. <bold>(A)</bold> Accumulated and daily new case numbers in China outside Hubei province between January 20 and February 10, 2020. Upper panel shows total case number of adults; lower panel the case number of children. <bold>(B)</bold> Transmission dynamics of SARS-CoV-2 infection in children. During the emerging stage of the COVID-19, the infection starts from person-to-person transmission in the community, almost exclusively in adults. The virus further spreads to the family to cause intrafamilial transmission, especially to the elderly and children, who are vulnerable to the infection. Perinatal infection can occur if the baby is born to a pregnant woman with confirmed infection via vaginal delivery. If the disease further extends without being contained, the outbreak may go into the explosion stage, when the school transmission mixed with a wider community spread can occur. The children at that stage can become a main spreader of the virus. The red lines indicate the transmission route with confirmed evidence in the SARS-CoV-2 outbreak in China, and the red dotted lines indicate the transmission route that may happen if the outbreak becomes more extensive afterwards.</p></caption><alt-text id="alttext0010">Fig. 1</alt-text><graphic xlink:href="gr1_lrg"></graphic></fig></p><p id="p0020">Humans can be infected readily by respiratory droplets containing the virus. Natural infections are therefore assumed to occur through respiratory route. Coronavirus can also be transmitted by contact with contaminated objects, such as toys and doorknobs. A previous SARS outbreak occurred at a housing complex in HK where more than 300 residents were infected, suggesting airborne or aerosol transmission can sometimes occur.<xref rid="bib6" ref-type="bibr"><sup>6</sup></xref> As shown in <xref rid="fig1" ref-type="fig">Fig. 1</xref>B, during the emerging stage of the SARS-CoV-2 outbreak, the infection was disseminated by person-to-person transmission in the community almost exclusively among adults. After the stage, likely after mid-January, 2020, the virus further spread to the family via infected adults to cause intrafamilial transmission, especially transmission to the elderly and children, who are vulnerable to the infection. The first pediatric case was identified at that time in a familial cluster.<xref rid="bib4" ref-type="bibr"><sup>4</sup></xref> With the progression of the outbreak, the first infant case was reported from Xiaogan, Hubei province.<xref rid="bib7" ref-type="bibr"><sup>7</sup></xref> This is a 3-month-old female infant who had fever for one day. She was admitted on January 26, 2020 with the following blood testing results: white blood cell (WBC) count 9680/mm<sup>3</sup> (neutrophil 45% and lymphocyte 44%). Throat swab test for influenza was negative. Chest radiograph taken on admission and CT 3 days later showed only mildly increased infiltrates at bilateral lung. Before she was admitted, her parents were symptomless. Her father started to have fever and fatigue on February 2, 8 days after she was admitted. A chest CT showed a ground glass opacity at lingulate lobe of left lung, and his throat swab was also positive for SARS-CoV-2. The infant's mother had no fever, cough or diarrhea, but the mother's throat swab testing showed positive for the virus on two consecutive days, February 3 and 4. The infant was tested positive by throat swab on January 27 (day 2), January 30 (day 5), and negative on February 3 (day 9), 5 (day 11), and 9 (day 15). The infant's urine, stool and sputum were tested negative; however, on February 9, a test on stool was positive. After appropriate supportive treatment, she was discharged uneventfully on February 10, 2020. This report showed an infant who was diagnosed to have the infection prior to the onset of the illness in her parents. A recent study on 9 hospitalized infants also found families of these infants had at least 1 infected family member, with the infant's infection occurring after the family member's infection.<xref rid="bib8" ref-type="bibr"><sup>8</sup></xref> The infant case report by Zhang et al. therefore raised a question if the infant showed a shorter period of incubation than adults or her parents actually acquire the infection from the baby. Nevertheless, all these children belonged to familial cluster circles, so aggregative onset is an important feature in pediatric cases, and this is also a strong indicator that the virus is highly contagious.</p><p id="p0025">The first pediatric case outside Hubei province was reported from Shanghai, China.<xref rid="bib9" ref-type="bibr"><sup>9</sup></xref> This is a 7-year-old boy who complained fever for 1 day. The boy with his father returned from Wuhan on January 11. His father also had fever since January 14. The father was admitted to a hospital because of fever and progressive cough, and soon was diagnosed as coronavirus disease 2019 (COVID-19) on January 19. Blood test showed WBC 16,000/mm<sup>3</sup> (neutrophil 70% and lymphocytes 23%) and normal platelet and hemoglobulin. Nasal and throat swabs taken on January 19 were positive for SARS-CoV-2. Follow-up testing for SARS-CoV-2 on January 24 (day 5) and January 28 (day 9) were still positive but turned negative on January 31 (day 12) and February 1 (day 13). He recovered gradually after supportive treatment. The child's mother, who did not go to Wuhan but came to hospital to take of him was tested positive for SARS-CoV-2 by nasal and throat swabs. The mother remained symptomless throughout his admission. The case reported by Cai et al. probably was the first evidence indicating children as a source of adult infection.<xref rid="bib9" ref-type="bibr"><sup>9</sup></xref></p><p id="p0030">Perinatal infection can occur if the baby is born to a pregnant woman with confirmed infection (<xref rid="fig1" ref-type="fig">Fig. 1</xref>B). A recent study by Chen et al. reported the clinical characteristics of nine livebirths born to nine pregnant women with laboratory-confirmed COVID-19 via cesarean section; all nine neonates were later confirmed negative for the infection.<xref rid="bib10" ref-type="bibr"><sup>10</sup></xref> We assume that neonates born to infected mothers via vaginal delivery could still be at risk for the infection due to close baby-mother contact during the delivery. The retrospective case report by Chen et al., however, still suggests that there is no evidence of intrauterine infection.<xref rid="bib10" ref-type="bibr"><sup>10</sup></xref> As of February 20, 2020, there were 3 neonatal cases in China.<xref rid="bib1" ref-type="bibr"><sup>1</sup></xref> The first case was a 17-day-old male newborn, who contracted the infection via contact with his parents, who have had fever and cough for 3 days.<xref rid="bib11" ref-type="bibr"><sup>11</sup></xref> The baby, also from Wuhan, was found to have runny nose and vomiting for one week before he was brought to the hospital. He was then tested positive for SARS-CoV-2 by a throat swab test. The initial WBC count was 7660/mm<sup>3</sup> (neutrophil 15% and lymphocyte 73%). Chest CT showed mildly increased bilateral linear opacities. The patient was given supportive treatment and recovered gradually. Another 30-h-old neonate, born to an infected mother, initially presented with respiratory distress without fever, and later was confirmed positive for SARS-CoV-2, according to a news report by China News Service.</p><p id="p0035">If the disease went further extension without being efficiently contained, the outbreak might go into an explosion stage, when the school transmission mixed with a wider community spread could occur (<xref rid="fig1" ref-type="fig">Fig. 1</xref>B). Children at that stage can further become the main spreader of SARS-CoV-2 because their infection is usually mild. At this stage, temporary school closure may be necessary to contain the spread of the infection. The situation is similar to what we have seen in influenza outbreak, where school children are the driver for the dissemination of influenza virus either in the household or in the community. In <xref rid="fig1" ref-type="fig">Fig. 1</xref>A, 398 pediatric cases outside the Hubei province have been identified before February 10, 2020, indicating that the epidemic in China has spread widely in many regions in addition to the Hubei province and reached the explosion stage. The positive correlation of the accumulated cases from adult and pediatric populations strongly supports the transmission dynamics of pediatric patients we described (<xref rid="fig1" ref-type="fig">Fig. 1</xref>B).</p><p id="p0040">Infected children may be asymptomatic or have fever, dry cough and fatigue; some patients experience gastrointestinal symptoms, including abdominal discomfort, nausea, vomiting, abdominal pain and diarrhea.<xref rid="bib7" ref-type="bibr">7</xref>, <xref rid="bib8" ref-type="bibr">8</xref>, <xref rid="bib9" ref-type="bibr">9</xref>, <xref rid="bib10" ref-type="bibr">10</xref>, <xref rid="bib11" ref-type="bibr">11</xref> Most infected children have mild clinical manifestations and usually have a good prognosis. Usually they recover within 1–2 weeks after the onset of the disease.<xref rid="bib7" ref-type="bibr">7</xref>, <xref rid="bib8" ref-type="bibr">8</xref>, <xref rid="bib9" ref-type="bibr">9</xref>, <xref rid="bib10" ref-type="bibr">10</xref>, <xref rid="bib11" ref-type="bibr">11</xref> Having said that, we noticed that there were 2 severe pediatric cases in Wuhan. A 1-year-old infant with severe COVID-19 was reported by Chen et al. in Wuhan Children's Hospital.<xref rid="bib12" ref-type="bibr"><sup>12</sup></xref> The child presented with fever and respiratory distress for 1 day and vomiting and diarrhea for 6 days.<xref rid="bib12" ref-type="bibr"><sup>12</sup></xref> Chest radiography and CT showed pneumonia, and he was admitted to intensive care unit and intubated immediately. After the treatment, including assisted ventilation and continuous venovenous hemofiltration, he recovered gradually. So far, there has been no mortality among the children with COVID-19 in China.</p><p id="p0045">Adults with COVID-19 usually showed a significant or progressive decrease in the absolute number of peripheral blood lymphocytes at the early stage of the disease. T lymphocyte subsets showed a decrease in both CD4<sup>+</sup> and CD8<sup>+</sup> T cell subsets, and neutrophil-to-lymphocyte ratio is an early and reliable indicator for the development of severe COVID-19, suggesting that SARS-CoV-2 can consume lymphocytes, which may also be an important reason for the virus to proliferate and spread in the early stage of the disease.<xref rid="bib13" ref-type="bibr"><sup>13</sup></xref> Severe cases in adults usually progress 7–10 days after the onset of disease, likely due to rapid virus replication, inflammatory cell infiltration, and an increased proinflammatory cytokine and chemokine response, leading to acute respiratory distress syndrome (ARDS), a fatal acute lung injury.<xref rid="bib13" ref-type="bibr"><sup>13</sup></xref> In children, however, white blood cell count and absolute lymphocyte count were mostly normal, and no lymphocyte depletion occurred, suggesting less immune dysfunction after the SARS-CoV-2 infection.<xref rid="bib7" ref-type="bibr">7</xref>, <xref rid="bib8" ref-type="bibr">8</xref>, <xref rid="bib9" ref-type="bibr">9</xref>, <xref rid="bib10" ref-type="bibr">10</xref>, <xref rid="bib11" ref-type="bibr">11</xref> On the other hand, the mild disease in children may be related to trained immunity. Trained immunity, as a new immune model, refers to the use of certain vaccines such as Bacille Calmette-Guérin (BCG) to train innate immunity to generate immune memory.<xref rid="bib14" ref-type="bibr"><sup>14</sup></xref> BCG has been proved to provide nonspecific protection of mice against influenza virus infection probably by the induction of trained immunity.<xref rid="bib14" ref-type="bibr"><sup>14</sup></xref> Most, if not all, of the infants received regular immunizations, including BCG, in China and other Asian countries, and it is well known that influenza can cause more ARDS in the adults, yet very less in children.</p><p id="p0050">In conclusion, understanding the role of pediatric population in the transmission dynamics of the outbreak is important, as children may become a significant spreader at the explosion stage of the outbreak. 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