Geographical structure of bat SARS-related coronaviruses
Identifieur interne : 001787 ( Pmc/Corpus ); précédent : 001786; suivant : 001788Geographical structure of bat SARS-related coronaviruses
Auteurs : Ping Yu ; Ben Hu ; Zheng-Li Shi ; Jie CuiSource :
- Infection, Genetics and Evolution [ 1567-1348 ] ; 2019.
Abstract
Bats are the natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the outbreak of human SARS in 2002–2003. We introduce the genetic diversity of SARS-related coronaviruses (SARSr-CoVs) discovered in bats and provide insights on the bat origin of human SARS. We also analyze the viral geographical structure that may improve our understanding of the evolution of bat SARSr-CoVs.
Url:
DOI: 10.1016/j.meegid.2019.02.001
PubMed: 30735813
PubMed Central: 7106260
Links to Exploration step
PMC:7106260Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Geographical structure of bat SARS-related coronaviruses</title><author><name sortKey="Yu, Ping" sort="Yu, Ping" uniqKey="Yu P" first="Ping" last="Yu">Ping Yu</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation><affiliation><nlm:aff id="af0010">University of Chinese Academy of Sciences, Beijing 100049, China</nlm:aff></affiliation></author><author><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author><author><name sortKey="Cui, Jie" sort="Cui, Jie" uniqKey="Cui J" first="Jie" last="Cui">Jie Cui</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30735813</idno><idno type="pmc">7106260</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106260</idno><idno type="RBID">PMC:7106260</idno><idno type="doi">10.1016/j.meegid.2019.02.001</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">001787</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001787</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Geographical structure of bat SARS-related coronaviruses</title><author><name sortKey="Yu, Ping" sort="Yu, Ping" uniqKey="Yu P" first="Ping" last="Yu">Ping Yu</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation><affiliation><nlm:aff id="af0010">University of Chinese Academy of Sciences, Beijing 100049, China</nlm:aff></affiliation></author><author><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author><author><name sortKey="Cui, Jie" sort="Cui, Jie" uniqKey="Cui J" first="Jie" last="Cui">Jie Cui</name><affiliation><nlm:aff id="af0005">CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff></affiliation></author></analytic><series><title level="j">Infection, Genetics and Evolution</title><idno type="ISSN">1567-1348</idno><idno type="eISSN">1567-7257</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bats are the natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the outbreak of human SARS in 2002–2003. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Genet Evol</journal-id><journal-id journal-id-type="iso-abbrev">Infect. Genet. Evol</journal-id><journal-title-group><journal-title>Infection, Genetics and Evolution</journal-title></journal-title-group><issn pub-type="ppub">1567-1348</issn><issn pub-type="epub">1567-7257</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30735813</article-id><article-id pub-id-type="pmc">7106260</article-id><article-id pub-id-type="publisher-id">S1567-1348(18)30902-X</article-id><article-id pub-id-type="doi">10.1016/j.meegid.2019.02.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Geographical structure of bat SARS-related coronaviruses</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Yu</surname><given-names>Ping</given-names></name><xref rid="af0005" ref-type="aff">a</xref><xref rid="af0010" ref-type="aff">b</xref><xref rid="fn0005" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0010"><name><surname>Hu</surname><given-names>Ben</given-names></name><xref rid="af0005" ref-type="aff">a</xref><xref rid="fn0005" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0015"><name><surname>Shi</surname><given-names>Zheng-Li</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0020"><name><surname>Cui</surname><given-names>Jie</given-names></name><email>jiecui@wh.iov.cn</email><xref rid="af0005" ref-type="aff">a</xref><xref rid="cr0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af0005"><label>a</label>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</aff><aff id="af0010"><label>b</label>University of Chinese Academy of Sciences, Beijing 100049, China</aff><author-notes><corresp id="cr0005"><label>⁎</label>Corresponding author. <email>jiecui@wh.iov.cn</email></corresp><fn id="fn0005"><label>1</label><p id="np0005">Contributed equally.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>6</day><month>2</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>6</day><month>2</month><year>2019</year></pub-date><volume>69</volume><fpage>224</fpage><lpage>229</lpage><history><date date-type="received"><day>18</day><month>11</month><year>2018</year></date><date date-type="rev-recd"><day>2</day><month>2</month><year>2019</year></date><date date-type="accepted"><day>3</day><month>2</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0005"><p>Bats are the natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the outbreak of human SARS in 2002–2003. We introduce the genetic diversity of SARS-related coronaviruses (SARSr-CoVs) discovered in bats and provide insights on the bat origin of human SARS. We also analyze the viral geographical structure that may improve our understanding of the evolution of bat SARSr-CoVs.</p></abstract><abstract abstract-type="author-highlights" id="ab0010"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="li0005"><label>•</label><p id="p0005">Genetic diverse SARS-related coronaviruses (SARSr-CoVs) have been discovered in bats in different provinces in China.</p></list-item><list-item id="li0010"><label>•</label><p id="p0010">The lack of a species-specific host restriction and the existence of host shift in bat SARSr-CoVs</p></list-item><list-item id="li0015"><label>•</label><p id="p0015">Bat SARSr-CoVs have a geographical structure in terms of their evolution and transmission.</p></list-item><list-item id="li0020"><label>•</label><p id="p0020">Ancestor of human SARS-CoVs likely originated from Yunnan province, China.</p></list-item></list></p></abstract><kwd-group id="ks0005"><title>Keywords</title><kwd>Bats</kwd><kwd>SARS</kwd><kwd>Geographical structure</kwd><kwd>Phylogeny</kwd><kwd>Host switch</kwd></kwd-group></article-meta></front><body><sec id="s0005"><label>1</label><title>Introduction</title><p id="p0025">Coronaviruses (CoVs) are enveloped positive-sense, single-stranded RNA viruses belonging to the subfamily <italic>Coronavirinae</italic>, family <italic>Coronaviridae</italic>, in the order <italic>Nidovirales</italic>, which are further divided into four genera, <italic>Alpha</italic>-, <italic>Beta</italic>-, <italic>Gamma</italic>- and <italic>Deltacoronavirus</italic> (<xref rid="bb0050" ref-type="bibr">de Groot et al., 2011</xref>; <xref rid="bb0165" ref-type="bibr">Payne, 2017</xref>). CoVs are the pathogenic agents for both avian and mammals, and have a worldwide distribution, usually causing respiratory diseases when infecting humans. In 2002–2003, a novel coronavirus termed Severe Acute Respiratory Syndrome (SARS) coronavirus caused >8000 cases of infection with a mortality of approximately 10%, drawing the attention for CoVs of zoonotic origin (<xref rid="bb0115" ref-type="bibr">Ksiazek et al., 2003</xref>; <xref rid="bb0170" ref-type="bibr">Peiris et al., 2004</xref>). Subsequently, more CoVs were identified from humans and different animals, containing human coronavirus NL63 (HCoV-NL63), HCoV-HKU1, Middle East respiratory syndrome coronavirus (MERS-CoV), swine acute diarrhoea syndrome coronavirus (SADS-CoV), bat-CoV HKU4, bat-CoV HKU5, white-eye coronavirus HKU16 (WECoV HKU16), sparrow coronavirus HKU17 (SpCoV HKU17), magpie robin coronavirus (MRCoV HKU18) and so on (<xref rid="bb0185" ref-type="bibr">Raj et al., 2014</xref>; <xref rid="bb0220" ref-type="bibr">Su et al., 2016</xref>; <xref rid="bb0255" ref-type="bibr">Woo et al., 2012</xref>; <xref rid="bb0245" ref-type="bibr">Woo et al., 2007</xref>; <xref rid="bb0295" ref-type="bibr">Zhou et al., 2018</xref>), indicating that CoVs have greater diversity and host range than estimated and remain a potential risk for the public health. Frequent contacts with humans and animals carrying coronaviruses provide a greater chance to facilitate cross-species viral transmission and emerge new viral variants.</p><sec id="s0010"><label>1.1</label><title>The emergence and tracing the animal origin of SARS</title><p id="p0030">In late 2002, SARS first emerged in Guangdong Province in southern China, and rapidly spread to other provinces and other countries, resulting in a global pandemic of severe respiratory diseases (<xref rid="bb0290" ref-type="bibr">Zhong et al., 2003</xref>). Initial investigations and researches indicated that marketplace masked palm civets (<italic>Paguma larvata</italic>) were likely to be the animal origin for SARS coronavirus (SARS-CoV) (<xref rid="bb0080" ref-type="bibr">Guan et al., 2003</xref>; <xref rid="bb0110" ref-type="bibr">Kan et al., 2005</xref>; <xref rid="bb0210" ref-type="bibr">Song et al., 2005</xref>), but no SARS-CoV was detected in farmed or wild-caught civets in the subsequent epidemiological studies, revealing that civets probably served only as intermediate hosts for SARS-CoV transmission (<xref rid="bb0030" ref-type="bibr">Chan and Chan, 2013</xref>; <xref rid="bb0205" ref-type="bibr">Shi and Hu, 2008</xref>; <xref rid="bb0225" ref-type="bibr">Tu et al., 2004</xref>).</p></sec><sec id="s0015"><label>1.2</label><title>Discovery of bat SARS-related coronaviruses (SARSr-CoVs)</title><p id="p0035">In 2005, the discovery of novel CoVs related to human SARS-CoVs in Chinese horseshoe bats (genus <italic>Rhinolophus</italic>), named SARS-related coronaviruses (SARSr-CoVs), provided new clue that bats may be the natural host for SARS-CoV (<xref rid="bb0120" ref-type="bibr">Lau et al., 2005</xref>; <xref rid="bb0140" ref-type="bibr">Li et al., 2005</xref>). Since then, genetically diverse SARSr-CoVs have been discovered in Asia, Europe, and Africa, including China, South Korea, Thailand, Bulgaria, Slovenia, Italy, Luxembourg, Nigeria, and Kenya (<xref rid="bb0015" ref-type="bibr">Balboni et al., 2012b</xref>; <xref rid="bb0060" ref-type="bibr">Drexler et al., 2010</xref>; <xref rid="bb0090" ref-type="bibr">He et al., 2014</xref>; <xref rid="bb0125" ref-type="bibr">Lau et al., 2010</xref>; <xref rid="bb0120" ref-type="bibr">Lau et al., 2005</xref>; <xref rid="bb0140" ref-type="bibr">Li et al., 2005</xref>; <xref rid="bb0160" ref-type="bibr">Pauly et al., 2017</xref>; <xref rid="bb0190" ref-type="bibr">Ren et al., 2006</xref>; <xref rid="bb0195" ref-type="bibr">Rihtaric et al., 2010</xref>; <xref rid="bb0270" ref-type="bibr">Yang et al., 2013</xref>; <xref rid="bb0280" ref-type="bibr">Yuan et al., 2010</xref>). Importantly, it was reported that some bat SARSr-CoVs were able to use angiotensin converting enzyme II (ACE2) from humans, civets and Chinese horseshoe bats as a receptor for cell entry (<xref rid="bb0070" ref-type="bibr">Ge et al., 2013</xref>), further supporting human SARS-CoV originated from Chinese horseshoe bats and suggesting that these SARSr-CoVs had the ability to infect humans immediately without other intermediate hosts. Furthermore, serological evidence by ELISA of infection of bat SARSr-CoVs in human who live close to the bat cave in Yunnan, China, where diverse SARSr-CoVs were detected in bats, suggested the potential spillover of SARSr-CoVs from bats to humans (<xref rid="bb0240" ref-type="bibr">Wang et al., 2018</xref>).</p></sec><sec id="s0020"><label>1.3</label><title>Genetic diversity of SARSr-CoVs</title><p id="p0040">SARS-CoV and SARSr-CoVs belong to lineage B of genus <italic>Betacoronavirus</italic> in the family <italic>Coronaviridae</italic> and share the same genomic organization with other coronaviruses, including genes coding for 16 nonstructural proteins (nsp, in ORF1ab domain), the structural proteins like spike protein (S), envelope (E), membrane (M), nucleocapsid (N) and other several genes (<xref rid="bb0175" ref-type="bibr">Perlman and Netland, 2009</xref>; <xref rid="bb0250" ref-type="bibr">Woo et al., 2009</xref>). The major distinction between SARS-CoV and SARSr-CoV genomes lies in the non-structural protein 3 (nsp3), ORF3, S and ORF8, among which S gene and ORF8 are the most variable (<xref rid="bb0205" ref-type="bibr">Shi and Hu, 2008</xref>; <xref rid="bb0260" ref-type="bibr">Wu et al., 2016</xref>). The S gene coding for spike protein can be further divided into two subunits S1 and S2, responsible for receptor binding and cellular membrane fusion, respectively (<xref rid="bb0025" ref-type="bibr">Belouzard et al., 2009</xref>). The S1 subunit is composed of the N-terminal domain (NTD) and the receptor-binding domain (RBD), the latter of which is critical for host-receptor binding and plays an important role on determining host range (<xref rid="bb0020" ref-type="bibr">Becker et al., 2008</xref>; <xref rid="bb0055" ref-type="bibr">de Haan et al., 2006</xref>; <xref rid="bb0135" ref-type="bibr">Li, 2013</xref>; <xref rid="bb0200" ref-type="bibr">Schickli et al., 2004</xref>; <xref rid="bb0230" ref-type="bibr">Tusell et al., 2007</xref>). Compared with human/civet SARS-CoV, most known SARSr-CoVs had two deletions in the RBD domain such as Rp3 (DQ071615), while a Bulgarian strain BM48–31 (GU190215) from <italic>Rhinolophus blasii</italic> had only one deletion in that region (<xref rid="bb0060" ref-type="bibr">Drexler et al., 2010</xref>; <xref rid="bb0090" ref-type="bibr">He et al., 2014</xref>). Several strains like WIV1 (KF367457) had same sequences length with SARS-CoV in the RBD regions, which were authenticated to be able to use human ACE2 as a cellular entry receptor (<xref rid="bb0070" ref-type="bibr">Ge et al., 2013</xref>; <xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>; <xref rid="bb0275" ref-type="bibr">Yang et al., 2015</xref>). However, these SARSr-CoVs without any deletions have so far been merely discovered in Yunnan, indicating that the origin of the S genes of the immediate ancestors of SARS-CoV had been restricted in Yunnan. The ORF8 was highly variable during the course of the SARS epidemic in China (<xref rid="bb0035" ref-type="bibr">CSME, 2004</xref>). Most bat SARSr-CoVs (except the strain HKU3–8, Rs4084 and African and European bat SARSr-CoVs) and the early human SARS-CoV contain a single ORF8 (<xref rid="bb0010" ref-type="bibr">Balboni et al., 2012a</xref>). The HKU3–8 (GQ153543) has a 26 nt deletion in the ORF8 gene which subdivides its ORF8 into ORF8a, b, c. The ORF8 of Rs4084 is split into 8a and 8b due to a 5 nt deletion in its ORF8, similar to the ORF8a/8b of the middle/late human SARS-CoVs with a 29-nt deletion in the ORF8. In the European strain BM48–31, the ORF8 was entirely absent (<xref rid="bb0060" ref-type="bibr">Drexler et al., 2010</xref>; <xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>; <xref rid="bb0125" ref-type="bibr">Lau et al., 2010</xref>). Moreover, compared with other bat SARSr-CoVs, some viruses such as WIV1 and WIV16 had an additional ORF (named ORFx) in their gene organization, involved in modulation of the host immune response (<xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>; <xref rid="bb0275" ref-type="bibr">Yang et al., 2015</xref>; <xref rid="bb0285" ref-type="bibr">Zeng et al., 2016</xref>).</p></sec></sec><sec id="s0025"><label>2</label><title>Geographical restriction of SARSr-CoVs</title><sec id="s0030"><label>2.1</label><title>The phylogeny of SARS-CoV and SARSr-CoVs</title><p id="p0045">SARSr-CoVs have been detected in bats from a wide range of provinces in China, including Guangdong, Guangxi, Guizhou, Hebei, Henan, Hong Kong, Hubei, Jilin, Shaanxi, Shanxi, Taiwan and Zhejiang (<xref rid="t0005" ref-type="table">Table 1</xref>). Except several from <italic>Hipposideridae</italic>, these viruses were mainly detected in bats from the family <italic>Rhinolophidae</italic>, indicating that they are likely to be natural hosts for SARSr-CoVs.<table-wrap position="float" id="t0005"><label>Table 1</label><caption><p>Host information and distribution of SARSr-CoVs available in GenBank.</p></caption><alt-text id="al0015">Table 1</alt-text><table frame="hsides" rules="groups"><thead><tr><th>Provinces</th><th>Bat species</th></tr></thead><tbody><tr><td>Guangdong</td><td><italic>Rhinolophus sinicus</italic></td></tr><tr><td>Guangxi</td><td><italic>Rhinolophus pearsonii</italic>, <italic>Rhinolophus sinicus</italic></td></tr><tr><td>Guizhou</td><td><italic>Rhinolophus rex</italic>, <italic>Rhinolophus sinicus</italic></td></tr><tr><td>Hebei</td><td><italic>Rhinolophus ferrumequinum</italic></td></tr><tr><td>Henan</td><td><italic>Rhinolophus ferrumequinum</italic></td></tr><tr><td>Hong Kong</td><td><italic>Rhinolophus sinicus</italic></td></tr><tr><td>Hubei</td><td><italic>Rhinolophus ferrumequinum</italic>, <italic>Rhinolophus macrotis</italic>, <italic>Rhinolophus sinicus</italic></td></tr><tr><td>Jilin</td><td><italic>Rhinolophus ferrumequinum</italic></td></tr><tr><td>Shaanxi</td><td><italic>Rhinolophus pusillus</italic></td></tr><tr><td>Shanxi</td><td><italic>Rhinolophus ferrumequinum</italic></td></tr><tr><td>Taiwan</td><td><italic>Rhinolophus monoceros</italic></td></tr><tr><td>Yunnan</td><td><italic>Aselliscus stoliczkanus</italic>, <italic>Rhinolophus affinis</italic>, <italic>Rhinolophus ferrumequinum, Rhinolophus sinicus</italic></td></tr><tr><td>Zhejiang</td><td><italic>Rhinolophus monoceros</italic>, <italic>Rhinolophus pearsonii</italic>, <italic>Rhinolophus sinicus</italic>, <italic>Rhinolophus thomasi</italic></td></tr></tbody></table></table-wrap></p><p id="p0050">We collected the full-length RNA-dependent RNA polymerase (RdRp) sequences of previously reported SARSr-CoVs and SARS-CoVs retrieved from GenBank (Table S1). We used the Xia' test, Phi test/RDP and likelihood mapping analysis to check the Saturation Index, recombination and phylogenetic signal of our data, respectively before performing the phylogenetic reconstruction (<xref rid="bb0105" ref-type="bibr">Huson and Bryant, 2006</xref>; <xref rid="bb0150" ref-type="bibr">Martin et al., 2015</xref>; <xref rid="bb0215" ref-type="bibr">Strimmer and von Haeseler, 1997</xref>; <xref rid="bb0265" ref-type="bibr">Xia, 2013</xref>). Subsequently, we constructed a phylogenetic tree using these nucleotide sequences of full-length RdRp gene with the maximum likelihood (ML) method under the GTR + I + Γ model of nucleotide substitution as implemented in PhyML (version 3.1) (<xref rid="bb0085" ref-type="bibr">Guindon et al., 2010</xref>). Optimal model of nucleotide substitution were determined using Akaike Information Criterion (AIC) available in jModelTest (version 2.1.10) (<xref rid="bb0045" ref-type="bibr">Darriba et al., 2012</xref>). Three main lineages were found from that phylogenetic tree when HKU4–1 (EF065505) was set as a outgroup (<xref rid="f0005" ref-type="fig">Fig. 1</xref>A). The lineage 1, composed of bat SARSr-CoVs from the southwestern provinces including Yunnan, Guizhou and Guangxi with human/civet SARS-CoV. The viruses from other southern regions containing Guangdong, Hong Kong, Hubei and Zhejiang made up the second lineage (lineage 2). The third lineage (lineage 3) consisted of the strains from the central and northern areas such as Hubei, Henan, Shanxi, Shaanxi, Hebei and Jilin. Although SARS first emerged in Guangdong province, the lineage 1 SARSr-CoVs from southwestern China were closer to human SARS-CoV than other provinces in China including Guangdong, indicating Guangdong is unlikely to be the geographical origin of SARS-CoV and the direct progenitor of human SARS-CoV may have originated from lineage 1 (<xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>). Additionally, the SARSr-CoVs from adjacent provinces grouped together (<xref rid="f0005" ref-type="fig">Fig. 1</xref>B), revealing that similar viruses have circulated in the neighboring provinces. In addition, it is also suggested that the bat hosts of SARSr-CoVs from southern China were more diversified than those from other locations.<fig id="f0005"><label>Fig. 1</label><caption><p>Phylogenetic analysis of SARS-CoVs and bat SARSr-CoVs. (A) The phylogenetic tree was constructed using the complete RdRp coding sequences and viewed in iTOL (<ext-link ext-link-type="uri" xlink:href="http://itol.embl.de/" id="ir0005">http://itol.embl.de/</ext-link>). All strains here were named using abbreviations of virus ID and sampling provinces. The strain HKU4-1 (NC_009019) was used as a outgroup of that tree. The taxa for lineage 1, lineage 2 and lineage 3 are highlighted in light red, light green and light blue, respectively. The lineage 1, lineage 2 and lineage 3 are displayed with colored pentagrams. The taxa for the only European strain European BM48–31 (GU190215) is displayed by light purple. The branch of SARS-CoV is marked in red. These strains from Zhejiang were collapsed into a triangle named ZJ-SL/Zhejiang. The viruses from Hong Kong also were collapsed into a triangle named HKU3/Hong Kong. The numbers adjacent to the node represents the bootstrap value of 1000 replicates and only bootstrap values ≥70% are shown. (B) The geographical distribution of bat SARSr-CoVs and their hosts from the lineage 1, lineage 2 and lineage 3 in the A diagram. The South Korea and Chinese provinces from the three lineages are marked in the map using the corresponding colored pentagrams. The bat hosts are also mapped to the corresponding regions in the map. Location abbreviations are as follows: YN, Yunnan; GZ, Guizhou; GX, Guangxi; GD, Guangdong; HK, Hong Kong; SAX, Shaanxi; HuB, Hubei; SX, Shanxi; HeN, Henan; HeB, Hebei; ZJ, Zhejiang; JL, Jilin; SK, South Korea. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)</p></caption><alt-text id="al0005">Fig. 1</alt-text><graphic xlink:href="gr1_lrg"></graphic></fig></p></sec><sec id="s0035"><label>2.2</label><title>Relationships between bat coronaviruses and their hosts</title><p id="p0055">Coronaviruses are single-stranded RNA viruses easy to mutate, which increases the diversity of the species and give them the ability to rapidly adapt to new hosts (<xref rid="bb0145" ref-type="bibr">Longdon et al., 2014</xref>). Nevertheless, the evolution and development of CoVs were not only the consequence of the coronavirus phylogeny and biology, but also the results of the interaction between CoVs and their hosts (<xref rid="bb0040" ref-type="bibr">Cui et al., 2007</xref>; <xref rid="bb0075" ref-type="bibr">Graham and Baric, 2010</xref>; <xref rid="bb0145" ref-type="bibr">Longdon et al., 2014</xref>; <xref rid="bb0155" ref-type="bibr">Parrish et al., 2008</xref>). Bats are the only mammals naturally capable of true and sustained flight. The bat tagging exercise had shown that the longest distance of the migration of the Chinese horseshoe bats is 17 km and other <italic>Rhinolophus</italic> species may migrate up to 30 km for hibernation (<xref rid="bb0125" ref-type="bibr">Lau et al., 2010</xref>). Such migration distance would help the transmission of SARSr-CoVs carried by bats within a certain geographical range. In order to identify the relationships between bat CoVs and their hosts, a tanglegram was made connecting the RdRp phylogeny of the SARSr-CoVs and the cytochrome <italic>b</italic> (CytB) phylogeny of their hosts (<xref rid="f0010" ref-type="fig">Fig. 2</xref>; Table S2). Different bat species in the same location like Yunnan, Guizhou and Zhejiang harbor closely related SARSr-CoVs, suggesting the lack of a strict host restriction and the existence of host shift in bat SARSr-CoVs (<xref rid="bb0040" ref-type="bibr">Cui et al., 2007</xref>). In addition, host shift mostly happened in different species under the same genus <italic>Rhinolophus</italic>, indicating that genetic distance between hosts as a key factor determines both the host shifts and cross-species transmission. Besides, though from same bat species, the SARSr-CoVs from adjacent provinces clustered, further supporting that the evolution of SARSr-CoVs were restricted by geography rather than by bat species.<fig id="f0010"><label>Fig. 2</label><caption><p>Phylogenetic relationships between human/civet SARS-CoVs, bat SARSr-CoVs and their hosts. The left tree was inferred based on the nucleotide of the complete RdRp sequences of human/civet SARS-CoVs and bat SARSr-CoVs. The right tree was constructed using the nucleotide of the CytB sequences of hosts. The branch of SARS-CoV from the left tree is marked in red. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)</p></caption><alt-text id="al0010">Fig. 2</alt-text><graphic xlink:href="gr2_lrg"></graphic></fig></p></sec><sec id="s0040"><label>2.3</label><title>Recombinant origin of SARS-CoV from bat SARSr-CoVs</title><p id="p0060">Recombination plays a significant role in the evolution of virus, which may create emerging virus, expand their host range (<xref rid="bb0075" ref-type="bibr">Graham and Baric, 2010</xref>; <xref rid="bb0235" ref-type="bibr">Vennema et al., 1998</xref>). Recombination events have been discovered in SARS-CoV and bat SARSr-CoVs (<xref rid="bb0075" ref-type="bibr">Graham and Baric, 2010</xref>; <xref rid="bb0095" ref-type="bibr">Hon et al., 2008</xref>). The two major recombination hotspots between bat SARSr-CoVs and SARS-CoV are S gene and ORF8, which probably contributes to the variability of the two genes (<xref rid="bb0095" ref-type="bibr">Hon et al., 2008</xref>; <xref rid="bb0130" ref-type="bibr">Lau et al., 2015</xref>; <xref rid="bb0260" ref-type="bibr">Wu et al., 2016</xref>). All the genomic constituents of SARS-CoV including the hypervariable regions S and ORF8 were discovered from different bat SARSr-CoVs in the same cave in Yunnan, with evidence of recombination events detected between these bat SARSr-CoVs (<xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>), suggesting that human SARS-CoV may originate from the recombinant of bat SARSr-CoVs in this region. The SARSr-CoVs without any deletion at the RBD domain were only identified in Yunnan, so the S genes of human SARS-CoVs were from the recombination of these viruses in Yunnan. As recombination occurs frequently among bat SARSr-CoVs, further genomic characterization of bat SARS-CoVs in a broader range of host species and geographical origin needs to be done to understand the role of recombination plays in the evolution of SARSr-CoVs.</p></sec></sec><sec id="s0045"><label>3</label><title>Conclusions</title><p id="p0065">As bats have been identified to be the natural reservoirs of various emerging viruses, the concept of zoonotic origin of important viral pathogens becomes widely accepted (<xref rid="bb0155" ref-type="bibr">Parrish et al., 2008</xref>).Deciphering the evolution of a viral pathogen is vital for us to understand the context of its emergence. Although SARS were controlled and vanished in 2004, those recently identified SARSr-CoVs which are able to use human ACE2 receptor have posed a potential risk of future emergence (<xref rid="bb0070" ref-type="bibr">Ge et al., 2013</xref>; <xref rid="bb0075" ref-type="bibr">Graham and Baric, 2010</xref>; <xref rid="bb0155" ref-type="bibr">Parrish et al., 2008</xref>). In particular, the serological evidence of bat SARSr-CoV infected in human was discovered in Yunnan, suggesting these viruses may have spilled over to human from bats directly or via other intermediate hosts in Yunnan.</p><p id="p0070">Up to present, bat SARSr-CoVs have been discovered in Asia, Europe and Africa (<xref rid="bb0015" ref-type="bibr">Balboni et al., 2012b</xref>; <xref rid="bb0060" ref-type="bibr">Drexler et al., 2010</xref>; <xref rid="bb0090" ref-type="bibr">He et al., 2014</xref>; <xref rid="bb0125" ref-type="bibr">Lau et al., 2010</xref>, <xref rid="bb0120" ref-type="bibr">2005</xref>; <xref rid="bb0140" ref-type="bibr">Li et al., 2005</xref>; <xref rid="bb0190" ref-type="bibr">Ren et al., 2006</xref>; <xref rid="bb0195" ref-type="bibr">Rihtaric et al., 2010</xref>; <xref rid="bb0270" ref-type="bibr">Yang et al., 2013</xref>; <xref rid="bb0280" ref-type="bibr">Yuan et al., 2010</xref>). However, for most of these strains from countries other than China, only partial RdRp fragment were obtained and full-length genome sequences have been determined for only few of them, thus the available genetic information is insufficient to explore the evolution and spread of these SARSr-CoVs. Phylogeny using these short sequences of currently known SARSr-CoVs indicated that the bat SARSr-CoVs from China are closer to human SARS-CoV than those from other countries (<xref rid="bb0005" ref-type="bibr">Ar Gouilh et al., 2018</xref>; <xref rid="bb0060" ref-type="bibr">Drexler et al., 2010</xref>; <xref rid="bb0180" ref-type="bibr">Quan et al., 2010</xref>; <xref rid="bb0195" ref-type="bibr">Rihtaric et al., 2010</xref>), suggesting that human SARS-CoV may have originated from China.</p><p id="p0075">Our analysis revealed that the human SARS-CoV may have originated from south China including Yunnan, Guangxi and Guizhou, and similar viruses likely circulated in these provinces for an extended time period before eventually emerging in humans. In addition, SARSr-CoVs clustered according to their geographical location of sampling, indicating that geographical range overlap between hosts is likely to play an important role in shaping the evolution of these viruses (<xref rid="bb0065" ref-type="bibr">Faria et al., 2013</xref>). Co-phylogeny analysis indicated the lack of a host restriction and the existence of frequent host shift in bat SARSr-CoVs, mainly occurred in horseshoe bats (genus <italic>Rhinolophus</italic>), which may be due to that close relatives of the hosts offer a similar environment for the virus to adapt (<xref rid="bb0145" ref-type="bibr">Longdon et al., 2014</xref>). However, space presents a greater barrier to virus diversification than host species for the evolution of bat SARSr-CoVs. Most importantly, cross-species transmission and frequent recombination of SARSr-CoVs within horseshoe bat populations in Yunnan could eventually lead to the generation of human SARS-CoV (<xref rid="bb0075" ref-type="bibr">Graham and Baric, 2010</xref>; <xref rid="bb0095" ref-type="bibr">Hon et al., 2008</xref>; <xref rid="bb0100" ref-type="bibr">Hu et al., 2017</xref>). Although <italic>Rhinolophus</italic> species may migrate up to 30 km (<xref rid="bb0125" ref-type="bibr">Lau et al., 2010</xref>), it is very unlikely for them to migrate a long distance such as from Yunnan to Guangdong.</p><p id="p0080">There are still some gaps needed to be filled in the origin of human SARS-CoV. Given that human SARS-CoV originated from bats in southwestern China including Yunnan, Guangxi and Guizhou, their transmission and migration to Guangdong where human SARS first appeared are unclear and needed to be clarified in the future. Although the serological evidence of bat SARSr-CoV infection was discovered in human living in proximity to the cave where diverse SARSr-CoVs are circulating (<xref rid="bb0240" ref-type="bibr">Wang et al., 2018</xref>), it is unable to judge that the SARSr-CoVs infecting those human populations are from bats or other animals inhabiting with bats. 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person-group-type="author"><name><surname>Zhou</surname><given-names>P.</given-names></name><name><surname>Fan</surname><given-names>H.</given-names></name><name><surname>Lan</surname><given-names>T.</given-names></name><name><surname>Yang</surname><given-names>X.-L.</given-names></name><name><surname>Shi</surname><given-names>W.-F.</given-names></name><name><surname>Zhang</surname><given-names>W.</given-names></name><name><surname>Zhu</surname><given-names>Y.</given-names></name><name><surname>Zhang</surname><given-names>Y.-W.</given-names></name><name><surname>Xie</surname><given-names>Q.-M.</given-names></name><name><surname>Mani</surname><given-names>S.</given-names></name><name><surname>Zheng</surname><given-names>X.-S.</given-names></name><name><surname>Li</surname><given-names>B.</given-names></name><name><surname>Li</surname><given-names>J.-M.</given-names></name><name><surname>Guo</surname><given-names>H.</given-names></name><name><surname>Pei</surname><given-names>G.-Q.</given-names></name><name><surname>An</surname><given-names>X.-P.</given-names></name><name><surname>Chen</surname><given-names>J.-W.</given-names></name><name><surname>Zhou</surname><given-names>L.</given-names></name><name><surname>Mai</surname><given-names>K.-J.</given-names></name><name><surname>Wu</surname><given-names>Z.-X.</given-names></name><name><surname>Li</surname><given-names>D.</given-names></name><name><surname>Anderson</surname><given-names>D.E.</given-names></name><name><surname>Zhang</surname><given-names>L.-B.</given-names></name><name><surname>Li</surname><given-names>S.-Y.</given-names></name><name><surname>Mi</surname><given-names>Z.-Q.</given-names></name><name><surname>He</surname><given-names>T.-T.</given-names></name><name><surname>Cong</surname><given-names>F.</given-names></name><name><surname>Guo</surname><given-names>P.-J.</given-names></name><name><surname>Huang</surname><given-names>R.</given-names></name><name><surname>Luo</surname><given-names>Y.</given-names></name><name><surname>Liu</surname><given-names>X.-L.</given-names></name><name><surname>Chen</surname><given-names>J.</given-names></name><name><surname>Huang</surname><given-names>Y.</given-names></name><name><surname>Sun</surname><given-names>Q.</given-names></name><name><surname>Zhang</surname><given-names>X.-L.-L.</given-names></name><name><surname>Wang</surname><given-names>Y.-Y.</given-names></name><name><surname>Xing</surname><given-names>S.-Z.</given-names></name><name><surname>Chen</surname><given-names>Y.-S.</given-names></name><name><surname>Sun</surname><given-names>Y.</given-names></name><name><surname>Li</surname><given-names>J.</given-names></name><name><surname>Daszak</surname><given-names>P.</given-names></name><name><surname>Wang</surname><given-names>L.-F.</given-names></name><name><surname>Shi</surname><given-names>Z.-L.</given-names></name><name><surname>Tong</surname><given-names>Y.-G.</given-names></name><name><surname>Ma</surname><given-names>J.-Y.</given-names></name></person-group><article-title>Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin</article-title><source>Nature</source><volume>556</volume><year>2018</year><fpage>255</fpage><lpage>258</lpage><pub-id pub-id-type="pmid">29618817</pub-id></element-citation></ref></ref-list><sec id="s0050" sec-type="supplementary-material"><label>Appendix A</label><title>Supplementary data</title><p id="p0090"><supplementary-material content-type="local-data" id="ec0005"><caption><p>Supplementary material</p></caption><media xlink:href="mmc1.docx"><alt-text>Image 1</alt-text></media></supplementary-material></p></sec><ack id="ac0005"><title>Acknowledgement</title><p>This work was funded by CAS Pioneer Hundred Talents Program to JC, and WIV <funding-source id="gts0005">“One-Three-Five” Strategic Program</funding-source> (WIV-135-TP1) to JC and ZLS.</p></ack><fn-group><fn id="s0055" fn-type="supplementary-material"><label>Appendix A</label><p id="p0095">Supplementary data to this article can be found online at <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.meegid.2019.02.001" id="ir0010">https://doi.org/10.1016/j.meegid.2019.02.001</ext-link>.</p></fn></fn-group></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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