Role of interferons in the treatment of severe acute respiratory syndrome
Identifieur interne : 001767 ( Pmc/Corpus ); précédent : 001766; suivant : 001768Role of interferons in the treatment of severe acute respiratory syndrome
Auteurs : Jindrich Cinatl Jr ; Martin Michaelis ; Martin Scholz ; Hans Wilhelm DoerrSource :
- Expert Opinion on Biological Therapy [ 1471-2598 ] ; 2005.
Abstract
Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SCV). The disease appeared in the Guandong province of southern China in 2002. The epidemic affected > 8422 patients and caused 908 deaths in 29 countries on 5 continents. Several treatment modalities were tried with limited success to treat SARS and a variety of experimental drugs are under development. Type I interferons (IFNs-α/β) were suggested as potential candidates to treat SARS. Several animal and human coronaviruses, including SCV, were shown to be sensitive to IFNs both in vitro and in vivo. A pilot clinical report showed effectiveness of IFN-α for the treatment of SARS patients. This review summarises antiviral activities of IFNs with special regard to SARS, and reviews the published clinical and experimental data describing the use of IFNs for SARS.
Url:
DOI: 10.1517/14712598.4.6.827
PubMed: 15174965
PubMed Central: 7103669
Links to Exploration step
PMC:7103669Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of interferons in the treatment of severe acute respiratory syndrome</title><author><name sortKey="Cinatl Jr, Jindrich" sort="Cinatl Jr, Jindrich" uniqKey="Cinatl Jr J" first="Jindrich" last="Cinatl Jr">Jindrich Cinatl Jr</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Scholz, Martin" sort="Scholz, Martin" uniqKey="Scholz M" first="Martin" last="Scholz">Martin Scholz</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15174965</idno><idno type="pmc">7103669</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103669</idno><idno type="RBID">PMC:7103669</idno><idno type="doi">10.1517/14712598.4.6.827</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001767</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001767</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of interferons in the treatment of severe acute respiratory syndrome</title><author><name sortKey="Cinatl Jr, Jindrich" sort="Cinatl Jr, Jindrich" uniqKey="Cinatl Jr J" first="Jindrich" last="Cinatl Jr">Jindrich Cinatl Jr</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Scholz, Martin" sort="Scholz, Martin" uniqKey="Scholz M" first="Martin" last="Scholz">Martin Scholz</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation><nlm:aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</nlm:aff></affiliation></author></analytic><series><title level="j">Expert Opinion on Biological Therapy</title><idno type="ISSN">1471-2598</idno><idno type="eISSN">1744-7682</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SCV). The disease appeared in the Guandong province of southern China in 2002. The epidemic affected > 8422 patients and caused 908 deaths in 29 countries on 5 continents. Several treatment modalities were tried with limited success to treat SARS and a variety of experimental drugs are under development. Type I interferons (IFNs-α/β) were suggested as potential candidates to treat SARS. Several animal and human coronaviruses, including SCV, were shown to be sensitive to IFNs both in vitro and in vivo. A pilot clinical report showed effectiveness of IFN-α for the treatment of SARS patients. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Opin Biol Ther</journal-id><journal-id journal-id-type="iso-abbrev">Expert Opin Biol Ther</journal-id><journal-id journal-id-type="publisher-id">IEBT</journal-id><journal-id journal-id-type="publisher-id">iebt20</journal-id><journal-title-group><journal-title>Expert Opinion on Biological Therapy</journal-title></journal-title-group><issn pub-type="ppub">1471-2598</issn><issn pub-type="epub">1744-7682</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15174965</article-id><article-id pub-id-type="pmc">7103669</article-id><article-id pub-id-type="publisher-id">11195749</article-id><article-id pub-id-type="doi">10.1517/14712598.4.6.827</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Role of interferons in the treatment of severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cinatl Jr</surname><given-names>Jindrich</given-names></name><xref ref-type="aff" rid="AFF0001"></xref></contrib><contrib contrib-type="author"><name><surname>Michaelis</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="AFF0001"></xref></contrib><contrib contrib-type="author"><name><surname>Scholz</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="AFF0001"></xref></contrib><contrib contrib-type="author"><name><surname>Doerr</surname><given-names>Hans Wilhelm</given-names></name><xref ref-type="aff" rid="AFF0001"></xref></contrib><aff id="AFF0001">Klinikum der Johann Wolfgang Goethe-Universitat, Institut fur Medizinische Virologie, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Cinatl@em.uni-frankfurt.de</aff></contrib-group><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>23</day><month>2</month><year>2005</year></pub-date><volume>4</volume><issue>6</issue><fpage seq="7">827</fpage><lpage>836</lpage><permissions><copyright-statement>2004 ¦ Ashley Publications Ltd ISSN 1471-2598</copyright-statement><copyright-year>2004</copyright-year><copyright-holder>Ashley Publications Ltd ISSN 1471-2598</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IEBT_4_11195749.pdf"></self-uri><abstract><p>Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SCV). The disease appeared in the Guandong province of southern China in 2002. The epidemic affected > 8422 patients and caused 908 deaths in 29 countries on 5 continents. Several treatment modalities were tried with limited success to treat SARS and a variety of experimental drugs are under development. Type I interferons (IFNs-α/β) were suggested as potential candidates to treat SARS. Several animal and human coronaviruses, including SCV, were shown to be sensitive to IFNs both in vitro and in vivo. A pilot clinical report showed effectiveness of IFN-α for the treatment of SARS patients. 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