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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study</title>
<author><name sortKey="Shi, Heshui" sort="Shi, Heshui" uniqKey="Shi H" first="Heshui" last="Shi">Heshui Shi</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Han, Xiaoyu" sort="Han, Xiaoyu" uniqKey="Han X" first="Xiaoyu" last="Han">Xiaoyu Han</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jiang, Nanchuan" sort="Jiang, Nanchuan" uniqKey="Jiang N" first="Nanchuan" last="Jiang">Nanchuan Jiang</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cao, Yukun" sort="Cao, Yukun" uniqKey="Cao Y" first="Yukun" last="Cao">Yukun Cao</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alwalid, Osamah" sort="Alwalid, Osamah" uniqKey="Alwalid O" first="Osamah" last="Alwalid">Osamah Alwalid</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gu, Jin" sort="Gu, Jin" uniqKey="Gu J" first="Jin" last="Gu">Jin Gu</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fan, Yanqing" sort="Fan, Yanqing" uniqKey="Fan Y" first="Yanqing" last="Fan">Yanqing Fan</name>
<affiliation><nlm:aff id="aff3">Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Chuansheng" sort="Zheng, Chuansheng" uniqKey="Zheng C" first="Chuansheng" last="Zheng">Chuansheng Zheng</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32105637</idno>
<idno type="pmc">7159053</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159053</idno>
<idno type="RBID">PMC:7159053</idno>
<idno type="doi">10.1016/S1473-3099(20)30086-4</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">001240</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001240</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study</title>
<author><name sortKey="Shi, Heshui" sort="Shi, Heshui" uniqKey="Shi H" first="Heshui" last="Shi">Heshui Shi</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Han, Xiaoyu" sort="Han, Xiaoyu" uniqKey="Han X" first="Xiaoyu" last="Han">Xiaoyu Han</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jiang, Nanchuan" sort="Jiang, Nanchuan" uniqKey="Jiang N" first="Nanchuan" last="Jiang">Nanchuan Jiang</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cao, Yukun" sort="Cao, Yukun" uniqKey="Cao Y" first="Yukun" last="Cao">Yukun Cao</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alwalid, Osamah" sort="Alwalid, Osamah" uniqKey="Alwalid O" first="Osamah" last="Alwalid">Osamah Alwalid</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gu, Jin" sort="Gu, Jin" uniqKey="Gu J" first="Jin" last="Gu">Jin Gu</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fan, Yanqing" sort="Fan, Yanqing" uniqKey="Fan Y" first="Yanqing" last="Fan">Yanqing Fan</name>
<affiliation><nlm:aff id="aff3">Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Chuansheng" sort="Zheng, Chuansheng" uniqKey="Zheng C" first="Chuansheng" last="Zheng">Chuansheng Zheng</name>
<affiliation><nlm:aff id="aff1">Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Infectious Diseases</title>
<idno type="ISSN">1473-3099</idno>
<idno type="eISSN">1474-4457</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuhan, China. We aimed to describe the CT findings across different timepoints throughout the disease course.</p>
</sec>
<sec><title>Methods</title>
<p>Patients with COVID-19 pneumonia (confirmed by next-generation sequencing or RT-PCR) who were admitted to one of two hospitals in Wuhan and who underwent serial chest CT scans were retrospectively enrolled. Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done ≤1 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). Imaging features and their distribution were analysed and compared across the four groups.</p>
</sec>
<sec><title>Findings</title>
<p>81 patients admitted to hospital between Dec 20, 2019, and Jan 23, 2020, were retrospectively enrolled. The cohort included 42 (52%) men and 39 (48%) women, and the mean age was 49·5 years (SD 11·0). The mean number of involved lung segments was 10·5 (SD 6·4) overall, 2·8 (3·3) in group 1, 11·1 (5·4) in group 2, 13·0 (5·7) in group 3, and 12·1 (5·9) in group 4. The predominant pattern of abnormality observed was bilateral (64 [79%] patients), peripheral (44 [54%]), ill-defined (66 [81%]), and ground-glass opacification (53 [65%]), mainly involving the right lower lobes (225 [27%] of 849 affected segments). In group 1 (n=15), the predominant pattern was unilateral (nine [60%]) and multifocal (eight [53%]) ground-glass opacities (14 [93%]). Lesions quickly evolved to bilateral (19 [90%]), diffuse (11 [52%]) ground-glass opacity predominance (17 [81%]) in group 2 (n=21). Thereafter, the prevalence of ground-glass opacities continued to decrease (17 [57%] of 30 patients in group 3, and five [33%] of 15 in group 4), and consolidation and mixed patterns became more frequent (12 [40%] in group 3, eight [53%] in group 4).</p>
</sec>
<sec><title>Interpretation</title>
<p>COVID-19 pneumonia manifests with chest CT imaging abnormalities, even in asymptomatic patients, with rapid evolution from focal unilateral to diffuse bilateral ground-glass opacities that progressed to or co-existed with consolidations within 1–3 weeks. Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia.</p>
</sec>
<sec><title>Funding</title>
<p>None.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Chen, P" uniqKey="Chen P">P Chen</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
</author>
<author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Na, Z" uniqKey="Na Z">Z Na</name>
</author>
<author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name>
</author>
<author><name sortKey="Wen, W" uniqKey="Wen W">W Wen</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Tsang, Kw" uniqKey="Tsang K">KW Tsang</name>
</author>
<author><name sortKey="Ho, Pl" uniqKey="Ho P">PL Ho</name>
</author>
<author><name sortKey="Ooi, Gc" uniqKey="Ooi G">GC Ooi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Al Tawfq, Ja" uniqKey="Al Tawfq J">JA Al-Tawfq</name>
</author>
<author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Richman, Dd" uniqKey="Richman D">DD Richman</name>
</author>
<author><name sortKey="Whitley, Rj" uniqKey="Whitley R">RJ Whitley</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name>
</author>
<author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name>
</author>
<author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name>
</author>
<author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
<author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Nl" uniqKey="Muller N">NL Müller</name>
</author>
<author><name sortKey="Ooi, Gc" uniqKey="Ooi G">GC Ooi</name>
</author>
<author><name sortKey="Khong, Pl" uniqKey="Khong P">PL Khong</name>
</author>
<author><name sortKey="Nicolaou, S" uniqKey="Nicolaou S">S Nicolaou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Kt" uniqKey="Wong K">KT Wong</name>
</author>
<author><name sortKey="Antonio, Ge" uniqKey="Antonio G">GE Antonio</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name>
</author>
<author><name sortKey="Liang, C" uniqKey="Liang C">C Liang</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name>
</author>
<author><name sortKey="He, H" uniqKey="He H">H He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Das, Km" uniqKey="Das K">KM Das</name>
</author>
<author><name sortKey="Lee, Ey" uniqKey="Lee E">EY Lee</name>
</author>
<author><name sortKey="Enani, Ma" uniqKey="Enani M">MA Enani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ajlan, Am" uniqKey="Ajlan A">AM Ajlan</name>
</author>
<author><name sortKey="Ahyad, Ra" uniqKey="Ahyad R">RA Ahyad</name>
</author>
<author><name sortKey="Jamjoom, Lg" uniqKey="Jamjoom L">LG Jamjoom</name>
</author>
<author><name sortKey="Alharthy, A" uniqKey="Alharthy A">A Alharthy</name>
</author>
<author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Das, Km" uniqKey="Das K">KM Das</name>
</author>
<author><name sortKey="Lee, Ey" uniqKey="Lee E">EY Lee</name>
</author>
<author><name sortKey="Al Jawder, Se" uniqKey="Al Jawder S">SE Al Jawder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qureshi, Nr" uniqKey="Qureshi N">NR Qureshi</name>
</author>
<author><name sortKey="Hien, Tt" uniqKey="Hien T">TT Hien</name>
</author>
<author><name sortKey="Farrar, J" uniqKey="Farrar J">J Farrar</name>
</author>
<author><name sortKey="Gleeson, Fv" uniqKey="Gleeson F">FV Gleeson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ujita, M" uniqKey="Ujita M">M Ujita</name>
</author>
<author><name sortKey="Renzoni, Ea" uniqKey="Renzoni E">EA Renzoni</name>
</author>
<author><name sortKey="Veeraraghavan, S" uniqKey="Veeraraghavan S">S Veeraraghavan</name>
</author>
<author><name sortKey="Wells, Au" uniqKey="Wells A">AU Wells</name>
</author>
<author><name sortKey="Hansell, Dm" uniqKey="Hansell D">DM Hansell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Travis, Wd" uniqKey="Travis W">WD Travis</name>
</author>
<author><name sortKey="Costabel, U" uniqKey="Costabel U">U Costabel</name>
</author>
<author><name sortKey="Hansell, Dm" uniqKey="Hansell D">DM Hansell</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Lancet Infect Dis</journal-id>
<journal-title-group><journal-title>The Lancet. Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">1473-3099</issn>
<issn pub-type="epub">1474-4457</issn>
<publisher><publisher-name>Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32105637</article-id>
<article-id pub-id-type="pmc">7159053</article-id>
<article-id pub-id-type="publisher-id">S1473-3099(20)30086-4</article-id>
<article-id pub-id-type="doi">10.1016/S1473-3099(20)30086-4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au10"><name><surname>Shi</surname>
<given-names>Heshui</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au20"><name><surname>Han</surname>
<given-names>Xiaoyu</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au30"><name><surname>Jiang</surname>
<given-names>Nanchuan</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au40"><name><surname>Cao</surname>
<given-names>Yukun</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au50"><name><surname>Alwalid</surname>
<given-names>Osamah</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au60"><name><surname>Gu</surname>
<given-names>Jin</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au70"><name><surname>Fan</surname>
<given-names>Yanqing</given-names>
</name>
<degrees>MD</degrees>
<email>1024932023@qq.com</email>
<xref rid="aff3" ref-type="aff">c</xref>
<xref rid="fn2" ref-type="fn">†</xref>
<xref rid="cor1" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author" id="au80"><name><surname>Zheng</surname>
<given-names>Chuansheng</given-names>
</name>
<degrees>Prof</degrees>
<degrees>MD</degrees>
<email>hqzcsxh@sina.com</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="fn2" ref-type="fn">†</xref>
<xref rid="cor2" ref-type="corresp">**</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</aff>
<aff id="aff2"><label>b</label>
Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China</aff>
<aff id="aff3"><label>c</label>
Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei, China</aff>
<author-notes><corresp id="cor1"><label>*</label>
Correspondence to: Dr Yanqing Fan, Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei 430022, China <email>1024932023@qq.com</email>
</corresp>
<corresp id="cor2"><label>**</label>
Prof Chuansheng Zheng, Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China <email>hqzcsxh@sina.com</email>
</corresp>
<fn id="fn1"><label>*</label>
<p id="cenpara20">Contributed equally</p>
</fn>
<fn id="fn2"><label>†</label>
<p id="cenpara30">Contributed equally</p>
</fn>
</author-notes>
<pub-date pub-type="pmc-release"><day>24</day>
<month>2</month>
<year>2020</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>24</day>
<month>2</month>
<year>2020</year>
</pub-date>
<permissions><copyright-statement>© 2020 Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>Elsevier Ltd</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<related-article related-article-type="article-reference" id="d32e551" ext-link-type="doi" xlink:href="10.1016/S1473-3099(20)30134-1"></related-article>
<abstract id="ceab10"><title>Summary</title>
<sec><title>Background</title>
<p>A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuhan, China. We aimed to describe the CT findings across different timepoints throughout the disease course.</p>
</sec>
<sec><title>Methods</title>
<p>Patients with COVID-19 pneumonia (confirmed by next-generation sequencing or RT-PCR) who were admitted to one of two hospitals in Wuhan and who underwent serial chest CT scans were retrospectively enrolled. Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done ≤1 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). Imaging features and their distribution were analysed and compared across the four groups.</p>
</sec>
<sec><title>Findings</title>
<p>81 patients admitted to hospital between Dec 20, 2019, and Jan 23, 2020, were retrospectively enrolled. The cohort included 42 (52%) men and 39 (48%) women, and the mean age was 49·5 years (SD 11·0). The mean number of involved lung segments was 10·5 (SD 6·4) overall, 2·8 (3·3) in group 1, 11·1 (5·4) in group 2, 13·0 (5·7) in group 3, and 12·1 (5·9) in group 4. The predominant pattern of abnormality observed was bilateral (64 [79%] patients), peripheral (44 [54%]), ill-defined (66 [81%]), and ground-glass opacification (53 [65%]), mainly involving the right lower lobes (225 [27%] of 849 affected segments). In group 1 (n=15), the predominant pattern was unilateral (nine [60%]) and multifocal (eight [53%]) ground-glass opacities (14 [93%]). Lesions quickly evolved to bilateral (19 [90%]), diffuse (11 [52%]) ground-glass opacity predominance (17 [81%]) in group 2 (n=21). Thereafter, the prevalence of ground-glass opacities continued to decrease (17 [57%] of 30 patients in group 3, and five [33%] of 15 in group 4), and consolidation and mixed patterns became more frequent (12 [40%] in group 3, eight [53%] in group 4).</p>
</sec>
<sec><title>Interpretation</title>
<p>COVID-19 pneumonia manifests with chest CT imaging abnormalities, even in asymptomatic patients, with rapid evolution from focal unilateral to diffuse bilateral ground-glass opacities that progressed to or co-existed with consolidations within 1–3 weeks. Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia.</p>
</sec>
<sec><title>Funding</title>
<p>None.</p>
</sec>
</abstract>
</article-meta>
</front>
<body><sec id="cesec10"><title>Introduction</title>
<p id="para10">Beginning in December, 2019, a cluster of cases of pneumonia with unknown cause was reported in Wuhan, in the Hubei province of China.<xref rid="bib1" ref-type="bibr"><sup>1</sup>
</xref>
On Jan 7, 2020, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously known as 2019-nCoV), was identified as the causative organism by Chinese facilities via deep sequencing analysis of patients' respiratory tract samples.<xref rid="bib2" ref-type="bibr">2</xref>
, <xref rid="bib3" ref-type="bibr">3</xref>
SARS-CoV-2 has been shown to infect human respiratory epithelial cells through an interaction between the viral S protein and the angiotensin-converting enzyme 2 receptor on human cells; thus, SARS-CoV-2 possesses a strong capability to infect humans.<xref rid="bib3" ref-type="bibr"><sup>3</sup>
</xref>
</p>
<p id="para20">Most of the initial cases of coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, were epidemiologically linked to exposure to Wuhan's Huanan seafood market, where wild animals are traded.<xref rid="bib4" ref-type="bibr">4</xref>
, <xref rid="bib5" ref-type="bibr">5</xref>
Although the market has been closed since Jan 1, 2020, as part of efforts to contain the outbreak, patients without exposure to the market but with a history of travel to Wuhan or close physical contact with a patient confirmed to have COVID-19, including health-care workers, have also been identified, suggesting strong human-to-human transmission. The number of cases has been increasing rapidly: by Feb 15, 2020, more than 60 000 cases of COVID-19 pneumonia had been reported in China and in other countries worldwide (including Thailand, Japan, South Korea, and the USA),<xref rid="bib6" ref-type="bibr">6</xref>
, <xref rid="bib7" ref-type="bibr">7</xref>
, <xref rid="bib8" ref-type="bibr">8</xref>
, <xref rid="bib9" ref-type="bibr">9</xref>
and 1524 patients had died, equivalent to a mortality rate of around 2%.</p>
<p id="para30">The clinical features of the initial 41 patients confirmed to be infected with SARS-CoV-2 included lower respiratory tract illness with fever, dry cough, and dyspnoea,<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
a manifestation similar to those of two other diseases caused by coronaviruses, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS).<xref rid="bib10" ref-type="bibr">10</xref>
, <xref rid="bib11" ref-type="bibr">11</xref>
However, the radiological changes in the lungs of people with COVID-19 pneumonia have not been fully characterised. CT is important in the diagnosis and treatment of lung diseases. In our experience, the imaging features of COVID-19 pneumonia are diverse, ranging from normal appearance to diffuse changes in the lungs. In addition, different radiological patterns are observed at different times throughout the disease course. Because the time between onset of symptoms and the development of acute respiratory distress syndrome (ARDS) was as short as 9 days among the initial patients with COVID-19 pneumonia,<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
early recognition of the disease is essential for the management of these patients.</p>
<p id="para40"><boxed-text id="cetextbox10"><caption><title>Research in context</title>
</caption>
<p id="para50"><bold>Evidence before this study</bold>
</p>
<p id="para60">Before this study, we searched PubMed, Medline, and Google Scholar on Jan, 24, 2020, for articles describing the radiological features of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously known as 2019 novel coronavirus [2019-nCoV]), using the search terms “novel coronavirus” or “2019-nCoV” and “radiology “or “imaging” or “CT”, with no time restrictions. We also searched CNKI and Wanfang Data using the same terms in Chinese, with no time restrictions. We found only previously published research discussing the radiological characteristics of severe acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus, and preliminary studies on the evolution of SARS-CoV-2 in Wuhan. We found no published work about the radiological characteristics of patients with pneumonia caused by SARS-CoV-2 infection.</p>
<p id="para70"><bold>Added value of this study</bold>
</p>
<p id="para80">We analysed chest CT images from 81 patients confirmed to have COVID-19 pneumonia caused by SARS-CoV-2 infection, and described the imaging findings across different follow-up periods of the disease, including subclinical and clinical stages up to 3 weeks after symptom onset. This study is, to the best of our knowledge, the largest case series to date on the CT findings of COVID-19 pneumonia worldwide, and provides detailed information on the radiological, clinical, and laboratory features of these patients. Our findings provide insight in the evolution of the disease and its corresponding imaging changes, and suggest potential associations between imaging findings and patient outcomes, which requires further study.</p>
<p id="para90"><bold>Implications of all the available evidence</bold>
</p>
<p id="para100">SARS-CoV-2 has substantial capacity to infect humans, and is capable of human-to-human transmission. Infection can lead to severe respiratory symptoms, including acute respiratory distress syndrome, and the mortality rate is around 2%. Combining imaging assessments with clinical and laboratory findings could help to identify SARS-CoV-2 infections early.</p>
</boxed-text>
</p>
<p id="para110">We aimed to analyse the evolution of chest CT imaging features in patients with COVID-19 pneumonia, and to compare the imaging findings across the disease course, to facilitate early diagnosis of this newly emerging, life-threatening infection.</p>
</sec>
<sec id="cesec20"><title>Methods</title>
<sec id="cesec30"><title>Study design and participants</title>
<p id="para120">This was a retrospective study done at two centres in Wuhan. Patients with confirmed COVID-19 pneumonia who were admitted to Wuhan Jinyintan hospital or Union Hospital of Tongji Medical College, and who underwent serial chest CT scans, were retrospectively enrolled.</p>
<p id="para130">In the patients who presented to Wuhan Jinyintan Hospital, SARS-CoV-2 infection was confirmed by next-generation sequencing or real-time RT-PCR, in according with a previously published protocol.<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
The following primers and probe targeted to the envelope gene of SARS-CoV-2 were used: forward primer 5ʹ-TCAGAATGCCAATCTCCCCAAC-3ʹ; reverse primer 5ʹ-AAAGGTCCACCCGATACATTGA-3ʹ; probe 5ʹCY5-CTAGTTACACTAGCCATCCTTACTGC-3ʹBHQ1.</p>
<p id="para140">The diagnosis of the cases from Union Hospital was initially based on the criteria published by WHO on Jan 12, 2020,<xref rid="bib12" ref-type="bibr"><sup>12</sup>
</xref>
and all cases were later confirmed by real-time RT-PCR analysis of throat swab specimens, using the same protocol as above when PCR kits were available.</p>
<p id="para150">Based on the time interval between onset of symptoms and the CT scan, we designated four groups of patients in our study: group 1 (subclinical cases, in which CT scans were done before onset of symptoms); group 2 (CT scans done ≤1 week after symptom onset); group 3 (CT scans done >1 to 2 weeks after symptom onset); and group 4 (CT scans done >2 weeks to 3 weeks after symptom onset). Three readers (XH, NJ, and YF) recorded the clinical characteristics, laboratory findings, and comorbidities of the patients at the time of imaging.</p>
<p id="para160">This study was approved by the institutional review boards of the relevant centres. The requirement for informed patient consent was waived by the ethics committee for this retrospective study.</p>
</sec>
<sec id="cesec40"><title>CT image acquisition</title>
<p id="para170">All CT scans were obtained with patients in the supine position, using one of the following scanners: SOMATOM Perspective, SOMATOM Spirit, or SOMATOM Definition AS+ (Siemens Healthineers, Forchheim, Germany). Scans were done from the level of the upper thoracic inlet to the inferior level of the costophrenic angle, and the following parameters were used: detector collimation widths 64 × 0·6 mm, 128 × 0·6 mm, 64 × 0·6 mm, and 64 × 0·6 mm; and tube voltage 120 kV. The tube current was regulated by an automatic exposure control system (CARE Dose 4D; Siemens Healthineers). Images were reconstructed with a slice thickness of 1·5 mm or 1 mm and an interval of 1·5 mm or 1 mm, respectively. The reconstructed images were transmitted to the workstation and picture archiving and communication systems (PACS) for multiplanar reconstruction post-processing.</p>
</sec>
<sec id="cesec50"><title>Image interpretation</title>
<p id="para180">Images from cases seen at Union Hospital were analysed by two radiologists (HS [a senior thoracic radiologist with 30 years' experience] and XH [a radiology resident with 4 years' experience in interpreting chest CT images]). Images from cases seen at Wuhan Jinyintan Hospital were interpreted by two radiologists experienced in thoracic radiology (YF [12 years' experience] and NJ [10 years' experience]). All Digital Imaging and Communications in Medicine (DICOM) images from the CT studies were analysed without access to clinical or laboratory findings. The evaluators independently and freely assessed the CT features using both axial CT images and multiplanar reconstruction images. After separate evaluations, any disagreements were resolved by discussion and consensus. CT imaging features recorded from our cohort are summarised in the <xref rid="sec1" ref-type="sec">appendix 2 (p 4)</xref>
.</p>
</sec>
<sec id="cesec60"><title>Follow-up chest CT</title>
<p id="para190">Follow-up chest CT scans were reviewed by two radiologists (HS and YF). The images were assessed and the evolution of lesions rated as either no significant change, resolution, or progression, compared with the previous chest CT from the same patient (<xref rid="sec1" ref-type="sec">appendix 2 p 4</xref>
). Decisions were reached by consensus.</p>
</sec>
<sec id="cesec70"><title>Statistical analysis</title>
<p id="para200">Analyses were done with SAS software version 9.4. Distribution normality was assessed using the Kolmogorov-Smirnov test. Normally distributed data were presented as mean (SD), non-normally distributed data as median (IQR), and categorical variables as frequency (%). CIs of proportions were calculated using the Clopper-Pearson method. Differences between groups were analysed by Fisher's exact test (for categorical data) or one-way ANOVA (for continuous data).</p>
</sec>
<sec id="cesec80"><title>Role of the funding source</title>
<p id="para210">There was no funding source for this study.</p>
</sec>
</sec>
<sec id="cesec90"><title>Results</title>
<p id="para220">81 patients who were admitted to Wuhan Jinyintan hospital (n=49) or Union Hospital of Tongji Medical College (n=32) between Dec 20, 2019, and Jan 23, 2020, and who had confirmed COVID-19 pneumonia were retrospectively enrolled in our study. Epidemiologically, there were four main clusters of patients: 31 (38%) patients had direct exposure to Huanan seafood market, 15 (19%) were health-care workers who had close contact with patients at the hospital who had confirmed COVID-19 pneumonia, seven (9%) were familial clusters, and the remaining 28 (35%) did not have any obvious history of exposure. Patients were assigned to groups on the basis of time between symptom onset and first CT scan: 15 (19%) patients (including health-care workers who had had close contact with patients with confirmed COVID-19 pneumonia) were assigned to group 1, 21 (26%) to group 2, 30 (37%) to group 3, and 15 (19%) to group 4.</p>
<p id="para230">The clinical characteristics and laboratory results of patients by group are summarised in the <xref rid="tbl1" ref-type="table">table</xref>
(see <xref rid="sec1" ref-type="sec">appendix 2 [pp 1–3]</xref>
for additional data). In the full cohort, the mean age was 49·5 years (SD 11; range 25–81), and there was no gender difference (42 [52%] men and 39 [48%] women). No significant differences in age (p=0·2778) or sex distribution (p=0·0871) between groups were identified. The most common symptoms at onset were fever (59 [73%] patients) and dry cough (48 [59%]). Other non-specific symptoms included dizziness (two [2%] patients), diarrhoea (three [4%]), vomiting (four [5%]), headache (five [6%]), and generalised weakness (seven [9%]). Among groups 2–4 (symptomatic patients), no significant differences in clinical parameters were found. Patients in group 1 had significantly lower mean concentrations of C-reactive protein (6·9 mg/L, p=0·0051) and aspartate aminotransferase (30·2 U/L, p=0·0026) than patients in the other three groups. Other laboratory findings did not significantly differ among groups, and the prevalence of underlying diseases was similar in all groups.<table-wrap position="float" id="tbl1"><label>Table</label>
<caption><p>Clinical characteristics and laboratory findings of patients with COVID-19 pneumonia</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th></th>
<th></th>
<th align="left"><bold>All patients (n=81)</bold>
</th>
<th align="left"><bold>Group 1 (n=15)</bold>
</th>
<th align="left"><bold>Group 2 (n=21)</bold>
</th>
<th align="left"><bold>Group 3 (n=30)</bold>
</th>
<th align="left"><bold>Group 4 (n=15)</bold>
</th>
<th align="left"><bold>p value</bold>
<xref rid="tbl1fn1" ref-type="table-fn">*</xref>
</th>
</tr>
</thead>
<tbody><tr><td colspan="8" align="left"><bold>Characteristics</bold>
</td>
</tr>
<tr><td colspan="2" align="left">Age, years</td>
<td align="left">49·5 (11·0)</td>
<td align="left">44·9 (9·0)</td>
<td align="left">48·8 (13·0)</td>
<td align="left">52·3 (13·0)</td>
<td align="left">49·5 (11·0)</td>
<td align="left">0·2778</td>
</tr>
<tr><td></td>
<td align="left">>50</td>
<td align="left">40 (49%)</td>
<td align="left">4 (27%)</td>
<td align="left">10 (48%)</td>
<td align="left">19 (63%)</td>
<td align="left">7 (47%)</td>
<td align="left">0·1444</td>
</tr>
<tr><td></td>
<td align="left">≤50</td>
<td align="left">41 (51%)</td>
<td align="left">11 (73%)</td>
<td align="left">11 (52%)</td>
<td align="left">11 (37%)</td>
<td align="left">8 (53%)</td>
<td align="left"><italic>..</italic>
</td>
</tr>
<tr><td colspan="2" align="left">Sex</td>
<td align="left">..</td>
<td align="left">..</td>
<td align="left">..</td>
<td align="left">..</td>
<td align="left">..</td>
<td align="left">0·0871</td>
</tr>
<tr><td></td>
<td align="left">Male</td>
<td align="left">42 (52%)</td>
<td align="left">4 (27%)</td>
<td align="left">11 (52%)</td>
<td align="left">20 (67%)</td>
<td align="left">7 (47%)</td>
<td align="left">..</td>
</tr>
<tr><td></td>
<td align="left">Female</td>
<td align="left">39 (48%)</td>
<td align="left">11 (73%)</td>
<td align="left">10 (48%)</td>
<td align="left">10 (33%)</td>
<td align="left">8 (53%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">History of exposure to Huanan market</td>
<td align="left">31 (38%)</td>
<td align="left">0</td>
<td align="left">8 (38%)</td>
<td align="left">14 (47%)</td>
<td align="left">9 (60%)</td>
<td align="left">0·0013</td>
</tr>
<tr><td colspan="8" align="left"><bold>Symptoms</bold>
</td>
</tr>
<tr><td colspan="2" align="left">Fever</td>
<td align="left">59 (73%)</td>
<td align="left">0</td>
<td align="left">18 (86%)</td>
<td align="left">27 (90%)</td>
<td align="left">14 (93%)</td>
<td align="left"><0·0001</td>
</tr>
<tr><td colspan="2" align="left">Maximum temperature, °C</td>
<td align="left">..</td>
<td align="left">36·6 (0·1)</td>
<td align="left">38·1 (0·8)</td>
<td align="left">38·2 (0·8)</td>
<td align="left">38·5 (0·7)</td>
<td align="left"><0·0001</td>
</tr>
<tr><td></td>
<td align="left">≤37·3</td>
<td align="left">24 (30%)</td>
<td align="left">15 (100%)</td>
<td align="left">3 (14%)</td>
<td align="left">5 (17%)</td>
<td align="left">1 (7%)</td>
<td align="left"><0·0001</td>
</tr>
<tr><td></td>
<td align="left">37·3–38</td>
<td align="left">20 (25%)</td>
<td align="left">0</td>
<td align="left">9 (43%)</td>
<td align="left">8 (27%)</td>
<td align="left">3 (20%)</td>
<td align="left">..</td>
</tr>
<tr><td></td>
<td align="left">38–39</td>
<td align="left">23 (28%)</td>
<td align="left">0</td>
<td align="left">7 (33%)</td>
<td align="left">11 (37%)</td>
<td align="left">5 (33%)</td>
<td align="left">..</td>
</tr>
<tr><td></td>
<td align="left">>39</td>
<td align="left">14 (17%)</td>
<td align="left">0</td>
<td align="left">2 (10%)</td>
<td align="left">6 (20%)</td>
<td align="left">6 (40%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">Dyspnoea</td>
<td align="left">34 (42%)</td>
<td align="left">0</td>
<td align="left">9 (43%)</td>
<td align="left">13 (43%)</td>
<td align="left">12 (80%)</td>
<td align="left"><0·0001</td>
</tr>
<tr><td colspan="2" align="left">Chest tightness</td>
<td align="left">18 (22%)</td>
<td align="left">0</td>
<td align="left">5 (24%)</td>
<td align="left">7 (23%)</td>
<td align="left">6 (40%)</td>
<td align="left">0·0467</td>
</tr>
<tr><td colspan="2" align="left">Cough</td>
<td align="left">48 (59%)</td>
<td align="left">0</td>
<td align="left">15 (71%)</td>
<td align="left">21 (70%)</td>
<td align="left">12 (80%)</td>
<td align="left"><0·0001</td>
</tr>
<tr><td colspan="2" align="left">Sputum</td>
<td align="left">15 (19%)</td>
<td align="left">0</td>
<td align="left">3 (14%)</td>
<td align="left">6 (20%)</td>
<td align="left">6 (40%)</td>
<td align="left">0·0385</td>
</tr>
<tr><td colspan="2" align="left">Rhinorrhea</td>
<td align="left">21 (26%)</td>
<td align="left">0</td>
<td align="left">5 (24%)</td>
<td align="left">10 (33%)</td>
<td align="left">6 (40%)</td>
<td align="left">0·0279</td>
</tr>
<tr><td colspan="2" align="left">Anorexia</td>
<td align="left">1 (1%)</td>
<td align="left">0</td>
<td align="left">1 (5%)</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">0·6296</td>
</tr>
<tr><td colspan="2" align="left">Weakness</td>
<td align="left">7 (9%)</td>
<td align="left">0</td>
<td align="left">1 (5%)</td>
<td align="left">4 (13%)</td>
<td align="left">2 (13%)</td>
<td align="left">0·4065</td>
</tr>
<tr><td colspan="2" align="left">Vomiting</td>
<td align="left">4 (5%)</td>
<td align="left">0</td>
<td align="left">2 (10%)</td>
<td align="left">2 (7%)</td>
<td align="left">0</td>
<td align="left">0·5777</td>
</tr>
<tr><td colspan="2" align="left">Headache</td>
<td align="left">5 (6%)</td>
<td align="left">0</td>
<td align="left">2 (10%)</td>
<td align="left">2 (7%)</td>
<td align="left">1 (7%)</td>
<td align="left">0·8645</td>
</tr>
<tr><td colspan="2" align="left">Dizziness</td>
<td align="left">2 (2%)</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">1 (3%)</td>
<td align="left">1 (7%)</td>
<td align="left">0·8056</td>
</tr>
<tr><td colspan="2" align="left">Diarrhoea</td>
<td align="left">3 (4%)</td>
<td align="left">0</td>
<td align="left">1 (5%)</td>
<td align="left">1 (3%)</td>
<td align="left">1 (7%)</td>
<td align="left">1·0000</td>
</tr>
<tr><td colspan="8" align="left"><bold>Laboratory results</bold>
</td>
</tr>
<tr><td colspan="2" align="left">Leukocyte count, × 10<sup>9</sup>
/L</td>
<td align="left">8·1 (3·4)</td>
<td align="left">8·0 (2·5)</td>
<td align="left">7·8 (3·6)</td>
<td align="left">8·4 (3·5)</td>
<td align="left">8·2 (4·2)</td>
<td align="left">0·9337</td>
</tr>
<tr><td></td>
<td align="left"><10</td>
<td align="left">55 (68%)</td>
<td align="left">12 (80%)</td>
<td align="left">14 (67%)</td>
<td align="left">19 (63%)</td>
<td align="left">10 (67%)</td>
<td align="left">0·7647</td>
</tr>
<tr><td></td>
<td align="left">≥10</td>
<td align="left">26 (32%)</td>
<td align="left">3 (20%)</td>
<td align="left">7 (33%)</td>
<td align="left">11 (37%)</td>
<td align="left">5 (33%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">Lymphocyte count, × 10<sup>9</sup>
/L</td>
<td align="left">1·1 (0·3)</td>
<td align="left">1·1 (0·3)</td>
<td align="left">1·0 (0·3)</td>
<td align="left">1·1 (0·3)</td>
<td align="left">1·1 (0·3)</td>
<td align="left">0·8557</td>
</tr>
<tr><td></td>
<td align="left"><1·0</td>
<td align="left">27 (33%)</td>
<td align="left">3 (20%)</td>
<td align="left">9 (43%)</td>
<td align="left">11 (37%)</td>
<td align="left">4 (27%)</td>
<td align="left">0·4941</td>
</tr>
<tr><td></td>
<td align="left">≥1·0</td>
<td align="left">54 (67%)</td>
<td align="left">12 (80%)</td>
<td align="left">12 (57%)</td>
<td align="left">19 (63%)</td>
<td align="left">11 (73%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">Platelet count, × 10<sup>9</sup>
/L</td>
<td align="left">212·2 (99·7)</td>
<td align="left">202·9 (67·4)</td>
<td align="left">213·5 (100·8)</td>
<td align="left">206·8 (96·1)</td>
<td align="left">230·5 (134·8)</td>
<td align="left">0·8723</td>
</tr>
<tr><td></td>
<td align="left"><100</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">..</td>
</tr>
<tr><td></td>
<td align="left">≥100</td>
<td align="left">81 (100%)</td>
<td align="left">15 (100%)</td>
<td align="left">21 (100%)</td>
<td align="left">30 (100%)</td>
<td align="left">15 (100%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">Haemoglobin, ng/mL</td>
<td align="left">123·9 (12·0)</td>
<td align="left">125·1 (13·5)</td>
<td align="left">126·7 (13·4)</td>
<td align="left">119·6 (12·8)</td>
<td align="left">124·8 (9·1)</td>
<td align="left">0·6494</td>
</tr>
<tr><td colspan="2" align="left">C-reactive protein, mg/L</td>
<td align="left">47·6 (41·8)</td>
<td align="left">6·9 (5·4)</td>
<td align="left">61·4 (39·6)</td>
<td align="left">71·3 (39·8)</td>
<td align="left">49·8 (42·4)</td>
<td align="left">0·0051</td>
</tr>
<tr><td colspan="2" align="left">Serum amyloid A protein, mg/L</td>
<td align="left">213·5 (177·8)</td>
<td align="left">143·3 (108·4)</td>
<td align="left">257·6 (264·2)</td>
<td align="left">216·6 (66·7)</td>
<td align="left">NA</td>
<td align="left">0·3300</td>
</tr>
<tr><td colspan="2" align="left">Alanine aminotransferase, U/L</td>
<td align="left">46·2 (29·5)</td>
<td align="left">30·8 (8·9)</td>
<td align="left">50·6 (24·8)</td>
<td align="left">48·7 (33·1)</td>
<td align="left">50·6 (37·7)</td>
<td align="left">0·1629</td>
</tr>
<tr><td colspan="2" align="left">Aspartate aminotransferase, U/L</td>
<td align="left">40·8 (17·9)</td>
<td align="left">30·2 (8·7)</td>
<td align="left">47·7 (20·8)</td>
<td align="left">42·7 (18·0)</td>
<td align="left">37·8 (16·4)</td>
<td align="left">0·0026</td>
</tr>
<tr><td></td>
<td align="left">≤40</td>
<td align="left">38 (47%)</td>
<td align="left">11 (73%)</td>
<td align="left">8 (38%)</td>
<td align="left">12 (40%)</td>
<td align="left">7 (47%)</td>
<td align="left">0·1586</td>
</tr>
<tr><td></td>
<td align="left">>40</td>
<td align="left">43 (53%)</td>
<td align="left">4 (27%)</td>
<td align="left">13 (62%)</td>
<td align="left">18 (60%)</td>
<td align="left">8 (53%)</td>
<td align="left">..</td>
</tr>
<tr><td colspan="2" align="left">Total bilirubin, μmol/L</td>
<td align="left">11·9 (3·6)</td>
<td align="left">9·2 (0·6)</td>
<td align="left">14·1 (4·3)</td>
<td align="left">11·9 (3·9)</td>
<td align="left">NA</td>
<td align="left">0·4526</td>
</tr>
<tr><td colspan="2" align="left">Albumin, g/L</td>
<td align="left">32·9 (8·1)</td>
<td align="left">NA</td>
<td align="left">34·0 (9·3)</td>
<td align="left">30·1 (2·8)</td>
<td align="left">NA</td>
<td align="left">0·5666</td>
</tr>
<tr><td colspan="2" align="left">Glucose, mmol/L</td>
<td align="left">6·4 (2·1)</td>
<td align="left">6·4 (5·0)</td>
<td align="left">5·2 (1·9)</td>
<td align="left">6·8 (1·6)</td>
<td align="left">NA</td>
<td align="left">0·8713</td>
</tr>
<tr><td colspan="2" align="left">Creatinine, μmol/L</td>
<td align="left">75·4 (29·8)</td>
<td align="left">63·7 (16·5)</td>
<td align="left">68·0 (15·4)</td>
<td align="left">115·4 (46·2)</td>
<td align="left">58·4 (1·3)</td>
<td align="left">0·1803</td>
</tr>
<tr><td colspan="2" align="left">Prothrombin time, s</td>
<td align="left">10·7 (0·9)</td>
<td align="left">10·6 (0·9)</td>
<td align="left">10·5 (0·4)</td>
<td align="left">10·7 (1·0)</td>
<td align="left">10·9 (1·6)</td>
<td align="left">0·9022</td>
</tr>
<tr><td colspan="2" align="left">Activated partial thromboplastin time, s</td>
<td align="left">32·1 (7·6)</td>
<td align="left">26·9 (3·9)</td>
<td align="left">34·3 (6·7)</td>
<td align="left">34·5 (13·1)</td>
<td align="left">29·2 (2·4)</td>
<td align="left">0·4814</td>
</tr>
<tr><td colspan="2" align="left">Thrombin time, s</td>
<td align="left">28·9 (8·4)</td>
<td align="left">21·8 (5·4)</td>
<td align="left">32·3 (8·2)</td>
<td align="left">24·9 (7·6)</td>
<td align="left">32·3 (7·9)</td>
<td align="left">0·3169</td>
</tr>
<tr><td colspan="2" align="left">Fibrinogen, g/L</td>
<td align="left">1·5 (2·3)</td>
<td align="left">0·7 (0·3)</td>
<td align="left">1·92 (3·5)</td>
<td align="left">2·3 (3·0)</td>
<td align="left">0·3 (0·1)</td>
<td align="left">0·7960</td>
</tr>
<tr><td colspan="2" align="left">D-dimers, mg/L</td>
<td align="left">6·5 (0·8)</td>
<td align="left">6·5 (0·3)</td>
<td align="left">6·9 (1·1)</td>
<td align="left">5·8 (0·2)</td>
<td align="left">NA</td>
<td align="left">0·4940</td>
</tr>
<tr><td colspan="8" align="left"><bold>Comorbidities</bold>
</td>
</tr>
<tr><td colspan="2" align="left">Any</td>
<td align="left">21 (26%)</td>
<td align="left">4 (27%)</td>
<td align="left">5 (24%)</td>
<td align="left">9 (30%)</td>
<td align="left">3 (20%)</td>
<td align="left">0·9397</td>
</tr>
<tr><td colspan="2" align="left">Chronic pulmonary disease</td>
<td align="left">9 (11%)</td>
<td align="left">1 (7%)</td>
<td align="left">3 (14%)</td>
<td align="left">3 (10%)</td>
<td align="left">2 (13%)</td>
<td align="left">0·8945</td>
</tr>
<tr><td colspan="2" align="left">Diabetes</td>
<td align="left">10 (12%)</td>
<td align="left">3 (20%)</td>
<td align="left">2 (10%)</td>
<td align="left">3 (10%)</td>
<td align="left">2 (13%)</td>
<td align="left">0·8005</td>
</tr>
<tr><td colspan="2" align="left">Hypertension</td>
<td align="left">12 (15%)</td>
<td align="left">2 (13%)</td>
<td align="left">1 (5%)</td>
<td align="left">7 (23%)</td>
<td align="left">2 (13%)</td>
<td align="left">0·3571</td>
</tr>
<tr><td colspan="2" align="left">Chronic renal failure</td>
<td align="left">3 (4%)</td>
<td align="left">0</td>
<td align="left">0</td>
<td align="left">3 (10%)</td>
<td align="left">0</td>
<td align="left">0·3101</td>
</tr>
<tr><td colspan="2" align="left">Cardiovascular disease</td>
<td align="left">8 (10%)</td>
<td align="left">3 (20%)</td>
<td align="left">1 (5%)</td>
<td align="left">3 (10%)</td>
<td align="left">1 (7%)</td>
<td align="left">0·5494</td>
</tr>
<tr><td colspan="2" align="left">Cerebrovascular disease</td>
<td align="left">6 (7%)</td>
<td align="left">1 (7%)</td>
<td align="left">1 (5%)</td>
<td align="left">3 (10%)</td>
<td align="left">1 (7%)</td>
<td align="left">0·9367</td>
</tr>
<tr><td colspan="2" align="left">Malignancy</td>
<td align="left">4 (5%)</td>
<td align="left">1 (7%)</td>
<td align="left">1 (5%)</td>
<td align="left">2 (7%)</td>
<td align="left">0</td>
<td align="left">0·9148</td>
</tr>
<tr><td colspan="2" align="left">Hepatitis or liver cirrhosis</td>
<td align="left">7 (9%)</td>
<td align="left">0</td>
<td align="left">2 (10%)</td>
<td align="left">3 (10%)</td>
<td align="left">2 (13%)</td>
<td align="left">0·6812</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Data are mean (SD) or n (%). NA=not available.</p>
</fn>
</table-wrap-foot>
<table-wrap-foot><fn id="tbl1fn1"><label>*</label>
<p id="cenpara10">Difference among groups 1–4.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p id="para240">All patients had abnormal CT imaging features (<xref rid="sec1" ref-type="sec">appendix 2 pp 5–6</xref>
). Although all lung segments can be involved, there was a slight predilection for the right lower lobe (225 (27%) of 849 affected segments among all patients). The mean number of segments involved among all groups was 10·5 (SD 6·4; range 1–18; <xref rid="sec1" ref-type="sec">appendix 2 pp 7–8</xref>
), with significantly more segments involved in groups 2–4 (symptomatic patients) than group 1 (asymptomatic patients; p<0·0001). Group 3 had the highest mean number of involved segments (13·0 [5·7]; <xref rid="fig1" ref-type="fig">figure 1</xref>
).<fig id="fig1"><label>Figure 1</label>
<caption><p>Number of involved lung segments at various timepoints from symptom onset</p>
<p>Bars show the mean number of involved lung segments on CT scans from patients in group 1 (scan before symptom onset; n=15), group 2 (scan ≤1 week after symptom onset; n=21), group 3 (scan >1 week to 2 weeks after symptom onset; n=30), and group 4 (scan >2 weeks to 3 weeks after symptom onset; n=15).</p>
</caption>
<graphic xlink:href="gr1_lrg"></graphic>
</fig>
</p>
<p id="para250">64 [79%] patients had bilateral lung involvement, 44 [54%] showed peripheral distribution, and 36 [44%] showed diffuse distribution of CT abnormalities (<xref rid="fig2" ref-type="fig">figure 2</xref>
). The most common patterns seen on chest CT were ground-glass opacity (53 [65%] patients; <xref rid="fig2" ref-type="fig">figure 2A</xref>
), in addition to ill-defined margins (66 [81%]), smooth or irregular interlobular septal thickening (28 [35%] patients; <xref rid="fig2" ref-type="fig">figure 2A</xref>
), air bronchogram (38 [47%]; <xref rid="fig2" ref-type="fig">figure 2A, D</xref>
), crazy-paving pattern (eight [10%]; <xref rid="fig2" ref-type="fig">figure 2B</xref>
), and thickening of the adjacent pleura (26 [32%]). Less common CT findings were nodules (five [6%] patients), cystic changes (eight [10%]; <xref rid="fig2" ref-type="fig">figure 2C</xref>
), bronchiolectasis (nine [11%]), pleural effusion (four [5%]; <xref rid="fig2" ref-type="fig">figure 2D</xref>
), and lymphadenopathy (five [6%]). Tree-in-bud signs, masses, cavitation, and calcifications were not observed in our case series.<fig id="fig2"><label>Figure 2</label>
<caption><p>Transverse thin-section CT scans in patients with COVID-19 pneumonia</p>
<p>(A) 56-year-old man, day 3 after symptom onset: focal ground-glass opacity associated with smooth interlobular and intralobular septal thickening in the right lower lobes. (B) 74-year-old woman, day 10 after symptom onset: bilateral, peripheral ground-glass opacity associated with smooth interlobular and intralobular septal thickening (crazy-paving pattern). (C) 61-year-old woman, day 20 after symptom onset: bilateral and peripheral predominant consolidation pattern with a round cystic change internally (arrow). (D) 63-year-old woman, day 17 after symptom onset: bilateral, peripheral mixed pattern associated with air bronchograms in both lower and upper lobes, with a small amount of pleural effusion (arrows).</p>
</caption>
<graphic xlink:href="gr2_lrg"></graphic>
</fig>
</p>
<p id="para260">The typical pattern of CT imaging features from preclinical patients (group 1) comprised unilateral (nine [60%] patients), multifocal (eight [53%]), and ground-glass opacification (14 [93%]). Interlobular septal thickening, thickening of the adjacent pleura, nodules, round cystic changes, bronchiolectasis, pleural effusion, and lymphadenopathy were rarely observed in this group. In group 2 (first week after symptom onset), lesions quickly evolved to become bilateral (19 [90%] patients) and diffuse (11 [52%]), but remained predominantly of ground-glass opacity appearance (17 [81%]). Pleural effusion (one [5%]) and lymphadenopathy (three [14%]) were detected at this stage. In group 3 (second week after symptom onset), as the disease progressed, the ground-glass opacity pattern was still the predominant CT finding (17 [57%]); however, consolidation patterns (nine [30%]) were also noted. In group 4 (third week after symptom onset), ground-glass opacities (five [33%]) and reticular patterns (five [33%]) were the predominant imaging pattern (<xref rid="fig3" ref-type="fig">figure 3</xref>
). Bronchiolectasis (two [13%]), thickening of the adjacent pleura (seven [47%]), pleural effusions (two [13%]), and lymphadenopathy (two [13%]) could also be seen at this stage (<xref rid="sec1" ref-type="sec">appendix 2 pp 5–6</xref>
).<fig id="fig3"><label>Figure 3</label>
<caption><p>Distribution of various patterns of lung changes on CT scans at various timepoints from symptom onset</p>
<p>Stacked bars show the proportion of patients in whom the predominant CT pattern was ground-glass opacity, reticular, mixed, or consolidation. Patients were grouped by time from symptom onset: group 1 (scan before symptom onset; n=15), group 2 (scan ≤1 week after symptom onset; n=21), group 3 (scan >1 week to 2 weeks after symptom onset; n=30), and group 4 (scan >2 weeks to 3 weeks after symptom onset; n=15).</p>
</caption>
<graphic xlink:href="gr3_lrg"></graphic>
</fig>
</p>
<p id="para270">By Feb 8, 2020, 62 (77%) patients had been discharged, with a mean interval between symptom onset and discharge of 23·2 days (SD 6; range 12–41). 16 (20%) patients were still in hospital, and three (4%) patients had died (on days 12, 14, and 30, after hospital admission due to ARDS). Patient 1, who died on day 12 after admission, was a 60-year-old man with chronic pulmonary disease (tuberculosis). The CT scan obtained from this patient on day 8 after symptom onset showed extensive ground-glass opacities in both lungs, giving a white lung appearance (<xref rid="fig4" ref-type="fig">figure 4</xref>
). The second patient who died (patient 2) was 73-year-old man who had had type 2 diabetes for several years, and showed progressive radiographic deterioration on CT scans taken on days 3, 7, and 11 after symptom onset. Patient 3, who died on day 30 after admission, was a 77-year-old man with hypertension, cardiovascular disease, and cerebrovascular disease. A CT scan showed mild pneumonia on day 5 after symptom onset in this patient (<xref rid="fig5" ref-type="fig">figure 5A</xref>
), and two follow-up CT scans 10 days and 15 days later revealed rapid progression of the lung lesions with bilateral pleural effusions (<xref rid="fig5" ref-type="fig">figure 5B, C</xref>
).<fig id="fig4"><label>Figure 4</label>
<caption><p>Transverse CT scans from a 60-year-old man (day 8 after symptom onset)</p>
<p>Selected images from CT scans at different levels. Extensive ground-glass opacities can be seen in both lungs, involving almost the entire lower lobes, and most of the upper lobes and right middle lobe, giving a white lung appearance, with air bronchograms. The patient died 4 days after this scan.</p>
</caption>
<graphic xlink:href="gr4_lrg"></graphic>
</fig>
<fig id="fig5"><label>Figure 5</label>
<caption><p>Transverse thin-section serial CT scans from a 77-year-old man</p>
<p>(A) Day 5 after symptom onset: patchy ground-glass opacities affecting the bilateral, subpleural lung parenchyma. (B) Day 15: subpleural crescent-shaped ground-glass opacities in both lungs, as well as posterior reticular opacities and subpleural crescent-shaped consolidations. (C) Day 20: expansion of bilateral pulmonary lesions, with enlargement and denser pulmonary consolidations and bilateral pleural effusions (arrows). The patient died 10 days after the final scan.</p>
</caption>
<graphic xlink:href="gr5_lrg"></graphic>
</fig>
</p>
<p id="para280">Follow-up CT images were obtained from 57 (70%) patients (36 from Wuhan Jinyintan hospital, and 21 from Union Hospital). 23 of these patients had two CT scans, 19 had three scans, and 15 had four scans available. Four patterns of evolution throughout the series of CT scans were observed among these 57 patients: initial progression to peak level, followed by radiographic improvement (type 1), seen in 26 (46%) patients (<xref rid="fig6" ref-type="fig">figure 6</xref>
), of whom 24 (92%) patients were discharged from hospital (median stay 25 days [IQR 20–27]); radiographic deterioration (type 2), seen in 18 (32%) patients (<xref rid="fig5" ref-type="fig">figure 5</xref>
), of whom two (11%) died (patients 2 and 3); radiographic improvement (type 3), seen in eight (14%) patients, of whom five (63%) were discharged from hospital (median stay 19 days [IQR 11–25]); and unchanged radiographic appearance (type 4), seen in five (9%) patients, all of whom were still in hospital at the cutoff date (Feb 8).<fig id="fig6"><label>Figure 6</label>
<caption><p>Transverse thin-section serial CT scans from a 42-year-old woman</p>
<p>(A) Day 3 after symptom onset: multifocal consolidations affecting the bilateral, subpleural lung parenchyma. (B) Day 7: the lesions had increased in extent and the density became heterogeneous, with internal bronchovascular bundle thickening. (C) Day 11: previous opacifications being dissipated into ground-glass opacities and irregular linear opacities. (D) Day 18: further resolution of the lesions. The patient was discharged from hospital 2 days after the final scan.</p>
</caption>
<graphic xlink:href="gr6_lrg"></graphic>
</fig>
</p>
</sec>
<sec id="cesec100"><title>Discussion</title>
<p id="para290">The Coronaviridae family of viruses includes six previously known human-infecting coronaviruses, which are enveloped, non-segmented, positive-sense RNA viruses that are broadly distributed in humans and other mammals.<xref rid="bib13" ref-type="bibr"><sup>13</sup>
</xref>
Although four of these coronaviruses cause only mild respiratory symptoms similar to the common cold, epidemics caused by two betacoronaviruses, SARS-CoV in 2002<xref rid="bib14" ref-type="bibr">14</xref>
, <xref rid="bib15" ref-type="bibr">15</xref>
and MERS-CoV in 2012, involved more than 8000 patients and 1000 patients, respectively,<xref rid="bib16" ref-type="bibr">16</xref>
, <xref rid="bib17" ref-type="bibr">17</xref>
with high mortality rates (10% for SARS-CoV and 37% for MERS-CoV). The novel coronavirus SARS-CoV-2 is the seventh member of the Coronaviridae family known to infect humans. The mortality rate of COVID-19 so far is lower than that of SARS or MERS coronavirus diseases; however, SARS-CoV-2 is highly infectious and could be a significant health threat.</p>
<p id="para300">In our study, the predisposing conditions for COVID-19 pneumonia tended to be old age and medical comorbidities (such as chronic pulmonary disease, diabetes, and other chronic diseases), similar to previous viral infections such as influenza H7N9.<xref rid="bib18" ref-type="bibr">18</xref>
, <xref rid="bib19" ref-type="bibr">19</xref>
There was no obvious predilection for males or females in our cohort. However, another study reported that 30 (73%) of 41 infected patients were men.<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
This discrepancy might be due to the differences in demographic features and small cohorts. By Feb 8, 2020, three patients in our study had died, representing a mortality rate of around 4%. All deaths occurred in men older than 60 years who had underlying diseases, consistent with previous reports.<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
Thus, old age, male sex, and presence of comorbidities might be risk factors for poor prognosis.</p>
<p id="para310">Fever, cough, and dyspnoea were the most common symptoms in patients with COVID-19 pneumonia, consistent with the manifestation of lower respiratory tract infections. By contrast, upper respiratory tract symptoms were less common in these patients, indicating that the cells targeted by the virus might be located in the lower airway.<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
Other non-specific symptoms included dizziness, diarrhoea, vomiting, headache, and generalised weakness, which occurred in around 2–9% of patients. Notably, 15 cases of asymptomatic infection were discovered on the basis of abnormal lung findings on CT scans, suggesting that chest CT scans or serum antibody tests should be done in asymptomatic high-risk individuals with a history of exposure to patients with COVID-19 pneumonia to facilitate early identification of the disease.</p>
<p id="para320">In our cohort, leukocytosis was detected in 26 (32%) patients and lymphocytosis in 54 (67%) patients. Concentrations of C-reactive protein and serum amyloid A protein were elevated in most patients, as observed in previous betacoronavirus infections.<xref rid="bib10" ref-type="bibr">10</xref>
, <xref rid="bib11" ref-type="bibr">11</xref>
, <xref rid="bib20" ref-type="bibr">20</xref>
In the subgroup of asymptomatic patients (group 1), concentrations of C-reactive protein (6·9 mg/L) and aspartate aminotransferase (30·2 U/L) were lower than those in symptomatic patients.</p>
<p id="para330">The mean number of involved lung segments in our cohort was 10·5, with the right lower lobes most commonly affected. This finding is similar to those of a previous radiological study of patients with H7N9 influenza infection.<xref rid="bib21" ref-type="bibr"><sup>21</sup>
</xref>
This finding might be due to the anatomical structure of the trachea and bronchi: as the right bronchus is short and straight, the causative virus might tend to favour this location.</p>
<p id="para340">The extent of disease on CT scans showed a marked increase from the subclinical period through the first and second weeks after symptom onset, then decreased gradually in the third week. A previous study showed that the median time from onset of symptoms to mechanical ventilation was 10·5 days (IQR 7·0–14·0) and to intensive care unit admission was 10·5 days (8·0–17·0).<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
Thus, our findings indicate that the radiological evolution of COVID-19 pneumonia is consistent with the clinical course of the disease.</p>
<p id="para350">Most patients in our cohort showed bilateral lung involvement, with lesions mainly located peripherally and subpleurally with diffuse distribution. The predominant pattern was ground-glass opacity, with ill-defined margins, air bronchograms, smooth or irregular interlobular or septal thickening, and thickening of the adjacent pleura. These imaging characteristics are non-specific and bear some resemblance to those of SARS-CoV<xref rid="bib22" ref-type="bibr">22</xref>
, <xref rid="bib23" ref-type="bibr">23</xref>
, <xref rid="bib24" ref-type="bibr">24</xref>
and MERS-CoV infections.<xref rid="bib25" ref-type="bibr">25</xref>
, <xref rid="bib26" ref-type="bibr">26</xref>
However, unlike SARS-CoV infections, some patients in our study presented with pleural effusion, lymphadenopathy, and round cystic changes on CT. Previous studies showed that the presence of pleural effusion in patients infected with MERS-CoV or avian influenza H5N1 was a poor prognostic indicator.<xref rid="bib25" ref-type="bibr">25</xref>
, <xref rid="bib27" ref-type="bibr">27</xref>
, <xref rid="bib28" ref-type="bibr">28</xref>
Similarly, in one patient who died in our study (patient 3), a follow-up CT scans showed that he had developed bilateral pleural effusion. On the other hand, lymphadenopathy has also been seen in cases of H5N1 infection,<xref rid="bib28" ref-type="bibr"><sup>28</sup>
</xref>
which can present as a rapidly progressive pneumonia that results in ARDS. Round cystic changes on CT might be associated with the process of resorption of consolidation; which might be explained by the infection causing damage to the alveolar walls and leading to pneumatoceles. Other findings included intralobular or interlobular septal thickening, and a crazy-paving pattern. However, none of the CT features of COVID-19 seem to be specific or diagnostic, and COVID-19 pneumonia shares CT features with other non-infectious conditions that present as subpleural air-space disease. For example, patients with bronchiolitis obliterans with organising pneumonia<xref rid="bib29" ref-type="bibr">29</xref>
, <xref rid="bib30" ref-type="bibr">30</xref>
often show nodules (32%),<xref rid="bib29" ref-type="bibr"><sup>29</sup>
</xref>
lymphadenopathy (13%),<xref rid="bib30" ref-type="bibr"><sup>30</sup>
</xref>
and pleural effusion (20%).<xref rid="bib30" ref-type="bibr"><sup>30</sup>
</xref>
These findings were present, albeit with lower frequency, among our patients with COVID-19 pneumonia (nodules 6%, lymphadenopathy 13%, pleural effusion 5%). However, tree-in-bud signs, masses, cavitations, and calcifications, often suggestive of bacterial or chronic infections, were absent in our study.</p>
<p id="para360">The typical pattern of CT images in subclinical patients (group 1) was unilateral, multifocal, predominantly ground-glass opacities. In the first week after symptom onset (group 2), lesions quickly evolved to bilateral, diffuse disease, with a relative decrease in the frequency of ground-glass opacities and a transition to consolidation and mixed-pattern development. Pleural effusion and lymphadenopathy were also detected in group 2. Subsequently, ground-glass opacities continued to decrease in frequency throughout the second week after symptom onset (group 3), while consolidation became the second most common pattern. A reticular pattern associated with bronchiolectasis and irregular interlobular or septal thickening were also noted to increase progressively from the second week. These findings indicated the appearance of interstitial changes, suggesting the development of fibrosis. However, since the natural history of COVID-19 pneumonia is yet to be fully explored, it is too early to label these lung changes as irreversible fibrosis. As the disease progressed in the third week after symptom onset, consolidation and mixed patterns became more common, while ground-glass opacities decreased further. Bronchiolectasis, thickening of the adjacent pleura, and pleural effusion mainly appeared at this stage.</p>
<p id="para370">Serial CT imaging of patients could help to continuously monitor disease changes. Follow-up CT showed progression or improvement of lung lesions during treatment, sensitively reflecting therapeutic effects, and these changes might be related to outcomes in such patients. The most common pattern of evolution throughout series of CT scans in this study was initial progression to a peak level, followed by radiographic improvement (type 1), and most of these patients were subsequently discharged. In addition, most patients who showed a pattern of radiographic improvement across several scans (type 3) were discharged from hospital. Thus, a type 1 or type 3 disease course might be associated with favourable outcomes. On the other hand, progressive radiographic deterioration despite medical treatment seems to be associated with poor prognosis, with two deaths in our study occurring among the 18 patients with the type 2 pattern.</p>
<p id="para380">Our study had several limitations. First, at the time of data collection, nucleic acid testing for the diagnosis of SARS-CoV-2 infection had not yet been introduced at Union Hospital, and 33 patients were therefore diagnosed clinically on the basis of WHO criteria.<xref rid="bib12" ref-type="bibr"><sup>12</sup>
</xref>
However, all these cases were confirmed by nucleic acid testing when kits became available later. Second, we compared imaging patterns between four groups of different time intervals from the onset of symptoms, which does not account for potential individual variations. Third, because of the short time for case collection, follow-up CT scans were available for only 57 patients, around 40% of whom had only two CT scans. Although we have outlined the main patterns of evolution seen on CT imaging in patients with COVID-19 pneumonia, long-term radiological follow-up is needed to confirm our findings. Finally, as lung biopsy specimens were not available in this study, the relationship between radiological and histopathological findings remains to be investigated. Therefore, other potential causes of ground-glass opacity, such as pulmonary oedema and haemorrhage, cannot be estimated.</p>
<p id="para390">In conclusion, COVID-19 pneumonia tends to manifest on lung CT scans as bilateral, subpleural, ground-glass opacities with air bronchograms, ill-defined margins, and a slight predominance in the right lower lobe. Abnormal lung CT findings can be present even in asymptomatic patients, and lesions can rapidly evolve into a diffuse ground-glass opacity predominance or consolidation pattern within 1–3 weeks after onset of symptoms, peaking at around 2 weeks after onset. Old age, male sex, underlying comorbidities and progressive radiographic deterioration on follow-up CT might be risk factors for poor prognosis in patients with COVID-19 pneumonia.</p>
</sec>
</body>
<back><ref-list id="bibl10"><title>References</title>
<ref id="bib1"><label>1</label>
<element-citation publication-type="other" id="sbref10"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Novel coronavirus—China</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/" id="interrefs10">https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/</ext-link>
<year>Jan 12, 2020</year>
</element-citation>
</ref>
<ref id="bib2"><label>2</label>
<element-citation publication-type="other" id="sbref20"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Coronavirus disease (COVID-19) outbreak</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/emergencies/diseases/novel-coronavirus-2019" id="interrefs20">https://www.who.int/emergencies/diseases/novel-coronavirus-2019</ext-link>
<year>2020</year>
</element-citation>
</ref>
<ref id="bib3"><label>3</label>
<element-citation publication-type="journal" id="sbref30"><person-group person-group-type="author"><name><surname>Xu</surname>
<given-names>X</given-names>
</name>
<name><surname>Chen</surname>
<given-names>P</given-names>
</name>
<name><surname>Wang</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission</article-title>
<source>Sci China Life Sci</source>
<year>2020</year>
<comment>published online Jan 21.</comment>
<pub-id pub-id-type="doi">10.1007/s11427-020-1637-5</pub-id>
</element-citation>
</ref>
<ref id="bib4"><label>4</label>
<element-citation publication-type="journal" id="sbref40"><person-group person-group-type="author"><name><surname>Tan</surname>
<given-names>W</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>X</given-names>
</name>
<name><surname>Ma</surname>
<given-names>X</given-names>
</name>
</person-group>
<article-title>Notes from the field: a novel coronavirus genome identified in a cluster of pneumonia cases—Wuhan, China 2019–2020</article-title>
<source>China CDC Weekly</source>
<volume>2</volume>
<year>2020</year>
<fpage>61</fpage>
<lpage>62</lpage>
</element-citation>
</ref>
<ref id="bib5"><label>5</label>
<element-citation publication-type="journal" id="sbref50"><person-group person-group-type="author"><name><surname>Na</surname>
<given-names>Z</given-names>
</name>
<name><surname>Ding</surname>
<given-names>Z</given-names>
</name>
<name><surname>Wen</surname>
<given-names>W</given-names>
</name>
</person-group>
<article-title>Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China</article-title>
<source>Lancet</source>
<volume>395</volume>
<year>2020</year>
<fpage>497</fpage>
<lpage>605</lpage>
<pub-id pub-id-type="pmid">31986264</pub-id>
</element-citation>
</ref>
<ref id="bib6"><label>6</label>
<element-citation publication-type="other" id="sbref60"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Novel coronavirus—Thailand (ex-China)</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en/" id="interrefs40">https://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en/</ext-link>
<year>Jan 14, 2020</year>
</element-citation>
</ref>
<ref id="bib7"><label>7</label>
<element-citation publication-type="other" id="sbref70"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Novel coronavirus—Japan (ex-China)</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/" id="interrefs50">https://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/</ext-link>
<year>Jan 17, 2020</year>
</element-citation>
</ref>
<ref id="bib8"><label>8</label>
<element-citation publication-type="other" id="sbref80"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Novel coronavirus—Republic of Korea (ex-China)</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en/" id="interrefs60">https://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en/</ext-link>
<year>Jan 21, 2020</year>
</element-citation>
</ref>
<ref id="bib9"><label>9</label>
<element-citation publication-type="other" id="sbref90"><person-group person-group-type="author"><collab>US Centers for Disease Control and Prevention</collab>
</person-group>
<article-title>First travel-related case of 2019 novel coronavirus detected in United States</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html" id="interrefs70">https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html</ext-link>
<year>Jan 21, 2020</year>
</element-citation>
</ref>
<ref id="bib10"><label>10</label>
<element-citation publication-type="journal" id="sbref100"><person-group person-group-type="author"><name><surname>Tsang</surname>
<given-names>KW</given-names>
</name>
<name><surname>Ho</surname>
<given-names>PL</given-names>
</name>
<name><surname>Ooi</surname>
<given-names>GC</given-names>
</name>
</person-group>
<article-title>A cluster of cases of severe acute respiratory syndrome in Hong Kong</article-title>
<source>N Engl J Med</source>
<volume>348</volume>
<year>2003</year>
<fpage>1977</fpage>
<lpage>1985</lpage>
<pub-id pub-id-type="pmid">12671062</pub-id>
</element-citation>
</ref>
<ref id="bib11"><label>11</label>
<element-citation publication-type="journal" id="sbref110"><person-group person-group-type="author"><name><surname>Assiri</surname>
<given-names>A</given-names>
</name>
<name><surname>Al-Tawfq</surname>
<given-names>JA</given-names>
</name>
<name><surname>Al-Rabeeah</surname>
<given-names>AA</given-names>
</name>
</person-group>
<article-title>Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study</article-title>
<source>Lancet Infect Dis</source>
<volume>13</volume>
<year>2013</year>
<fpage>752</fpage>
<lpage>761</lpage>
<pub-id pub-id-type="pmid">23891402</pub-id>
</element-citation>
</ref>
<ref id="bib12"><label>12</label>
<element-citation publication-type="other" id="sbref120"><person-group person-group-type="author"><collab>WHO</collab>
</person-group>
<article-title>Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance</article-title>
<ext-link ext-link-type="uri" xlink:href="https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf" id="interrefs80">https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf</ext-link>
<year>Jan 28, 2020</year>
</element-citation>
</ref>
<ref id="bib13"><label>13</label>
<element-citation publication-type="book" id="sbref130"><person-group person-group-type="editor"><name><surname>Richman</surname>
<given-names>DD</given-names>
</name>
<name><surname>Whitley</surname>
<given-names>RJ</given-names>
</name>
<name><surname>Hayden</surname>
<given-names>FG</given-names>
</name>
</person-group>
<source>Clinical virology</source>
<edition>4th edn.</edition>
<year>2016</year>
<publisher-name>ASM Press</publisher-name>
<publisher-loc>Washington</publisher-loc>
</element-citation>
</ref>
<ref id="bib14"><label>14</label>
<element-citation publication-type="journal" id="sbref140"><person-group person-group-type="author"><name><surname>Ksiazek</surname>
<given-names>TG</given-names>
</name>
<name><surname>Erdman</surname>
<given-names>D</given-names>
</name>
<name><surname>Goldsmith</surname>
<given-names>CS</given-names>
</name>
</person-group>
<article-title>A novel coronavirus associated with severe acute respiratory syndrome</article-title>
<source>N Engl J Med</source>
<volume>348</volume>
<year>2003</year>
<fpage>1953</fpage>
<lpage>1966</lpage>
<pub-id pub-id-type="pmid">12690092</pub-id>
</element-citation>
</ref>
<ref id="bib15"><label>15</label>
<element-citation publication-type="journal" id="sbref150"><person-group person-group-type="author"><name><surname>Kuiken</surname>
<given-names>T</given-names>
</name>
<name><surname>Fouchier</surname>
<given-names>RAM</given-names>
</name>
<name><surname>Schutten</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome</article-title>
<source>Lancet</source>
<volume>362</volume>
<year>2003</year>
<fpage>263</fpage>
<lpage>270</lpage>
<pub-id pub-id-type="pmid">12892955</pub-id>
</element-citation>
</ref>
<ref id="bib16"><label>16</label>
<element-citation publication-type="journal" id="sbref160"><person-group person-group-type="author"><name><surname>de Groot</surname>
<given-names>RJ</given-names>
</name>
<name><surname>Baker</surname>
<given-names>SC</given-names>
</name>
<name><surname>Baric</surname>
<given-names>RS</given-names>
</name>
</person-group>
<article-title>Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group</article-title>
<source>J Virol</source>
<volume>87</volume>
<year>2013</year>
<fpage>7790</fpage>
<lpage>7792</lpage>
<pub-id pub-id-type="pmid">23678167</pub-id>
</element-citation>
</ref>
<ref id="bib17"><label>17</label>
<element-citation publication-type="journal" id="sbref170"><person-group person-group-type="author"><name><surname>Zaki</surname>
<given-names>AM</given-names>
</name>
<name><surname>van Boheemen</surname>
<given-names>S</given-names>
</name>
<name><surname>Bestebroer</surname>
<given-names>TM</given-names>
</name>
<name><surname>Osterhaus</surname>
<given-names>AD</given-names>
</name>
<name><surname>Fouchier</surname>
<given-names>RA</given-names>
</name>
</person-group>
<article-title>Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia</article-title>
<source>N Engl J Med</source>
<volume>367</volume>
<year>2012</year>
<fpage>1814</fpage>
<lpage>1820</lpage>
<pub-id pub-id-type="pmid">23075143</pub-id>
</element-citation>
</ref>
<ref id="bib18"><label>18</label>
<element-citation publication-type="journal" id="sbref180"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>S</given-names>
</name>
<name><surname>Sun</surname>
<given-names>J</given-names>
</name>
<name><surname>Cai</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province, China</article-title>
<source>J Infect</source>
<volume>67</volume>
<year>2013</year>
<fpage>595</fpage>
<lpage>605</lpage>
<pub-id pub-id-type="pmid">23958687</pub-id>
</element-citation>
</ref>
<ref id="bib19"><label>19</label>
<element-citation publication-type="journal" id="sbref190"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>X</given-names>
</name>
<name><surname>Yang</surname>
<given-names>Z</given-names>
</name>
<name><surname>Lu</surname>
<given-names>Y</given-names>
</name>
<name><surname>Xu</surname>
<given-names>Q</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Q</given-names>
</name>
<name><surname>Chen</surname>
<given-names>L</given-names>
</name>
</person-group>
<article-title>Clinical features and factors associated with outcomes of patients infected with a novel influenza A (H7N9) virus: a preliminary study</article-title>
<source>PLoS One</source>
<volume>8</volume>
<year>2013</year>
<object-id pub-id-type="publisher-id">e73362</object-id>
</element-citation>
</ref>
<ref id="bib20"><label>20</label>
<element-citation publication-type="journal" id="sbref200"><person-group person-group-type="author"><name><surname>Lee</surname>
<given-names>N</given-names>
</name>
<name><surname>Hui</surname>
<given-names>D</given-names>
</name>
<name><surname>Wu</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>A major outbreak of severe acute respiratory syndrome in Hong Kong</article-title>
<source>N Engl J Med</source>
<volume>348</volume>
<year>2003</year>
<fpage>1986</fpage>
<lpage>1994</lpage>
<pub-id pub-id-type="pmid">12682352</pub-id>
</element-citation>
</ref>
<ref id="bib21"><label>21</label>
<element-citation publication-type="journal" id="sbref210"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>Q</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Z</given-names>
</name>
<name><surname>Shi</surname>
<given-names>Y</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>Y</given-names>
</name>
</person-group>
<article-title>Emerging H7N9 influenza A (novel reassortant avian-origin) pneumonia: radiologic findings</article-title>
<source>Radiology</source>
<volume>268</volume>
<year>2013</year>
<fpage>882</fpage>
<lpage>889</lpage>
<pub-id pub-id-type="pmid">23821754</pub-id>
</element-citation>
</ref>
<ref id="bib22"><label>22</label>
<element-citation publication-type="journal" id="sbref220"><person-group person-group-type="author"><name><surname>Müller</surname>
<given-names>NL</given-names>
</name>
<name><surname>Ooi</surname>
<given-names>GC</given-names>
</name>
<name><surname>Khong</surname>
<given-names>PL</given-names>
</name>
<name><surname>Nicolaou</surname>
<given-names>S</given-names>
</name>
</person-group>
<article-title>Severe acute respiratory syndrome: radiographic and CT findings</article-title>
<source>AJR Am J Roentgenol</source>
<volume>181</volume>
<year>2003</year>
<fpage>3</fpage>
<lpage>8</lpage>
<pub-id pub-id-type="pmid">12818821</pub-id>
</element-citation>
</ref>
<ref id="bib23"><label>23</label>
<element-citation publication-type="journal" id="sbref230"><person-group person-group-type="author"><name><surname>Wong</surname>
<given-names>KT</given-names>
</name>
<name><surname>Antonio</surname>
<given-names>GE</given-names>
</name>
<name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
</person-group>
<article-title>Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease</article-title>
<source>Radiology</source>
<volume>228</volume>
<year>2003</year>
<fpage>395</fpage>
<lpage>400</lpage>
<pub-id pub-id-type="pmid">12738877</pub-id>
</element-citation>
</ref>
<ref id="bib24"><label>24</label>
<element-citation publication-type="journal" id="sbref240"><person-group person-group-type="author"><name><surname>Zhao</surname>
<given-names>Z</given-names>
</name>
<name><surname>Liang</surname>
<given-names>C</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>J</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>R</given-names>
</name>
<name><surname>He</surname>
<given-names>H</given-names>
</name>
</person-group>
<article-title>Clinical and imaging findings in patients with severe acute respiratory syndrome</article-title>
<source>Chin Med J (Engl)</source>
<volume>116</volume>
<year>2003</year>
<fpage>1104</fpage>
<lpage>1105</lpage>
<pub-id pub-id-type="pmid">12890393</pub-id>
</element-citation>
</ref>
<ref id="bib25"><label>25</label>
<element-citation publication-type="journal" id="sbref250"><person-group person-group-type="author"><name><surname>Das</surname>
<given-names>KM</given-names>
</name>
<name><surname>Lee</surname>
<given-names>EY</given-names>
</name>
<name><surname>Enani</surname>
<given-names>MA</given-names>
</name>
</person-group>
<article-title>CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus</article-title>
<source>AJR Am J Roentgenol</source>
<volume>204</volume>
<year>2015</year>
<fpage>736</fpage>
<lpage>742</lpage>
<pub-id pub-id-type="pmid">25615627</pub-id>
</element-citation>
</ref>
<ref id="bib26"><label>26</label>
<element-citation publication-type="journal" id="sbref260"><person-group person-group-type="author"><name><surname>Ajlan</surname>
<given-names>AM</given-names>
</name>
<name><surname>Ahyad</surname>
<given-names>RA</given-names>
</name>
<name><surname>Jamjoom</surname>
<given-names>LG</given-names>
</name>
<name><surname>Alharthy</surname>
<given-names>A</given-names>
</name>
<name><surname>Madani</surname>
<given-names>TA</given-names>
</name>
</person-group>
<article-title>Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings</article-title>
<source>AJR Am J Roentgenol</source>
<volume>203</volume>
<year>2014</year>
<fpage>782</fpage>
<lpage>787</lpage>
<pub-id pub-id-type="pmid">24918624</pub-id>
</element-citation>
</ref>
<ref id="bib27"><label>27</label>
<element-citation publication-type="journal" id="sbref270"><person-group person-group-type="author"><name><surname>Das</surname>
<given-names>KM</given-names>
</name>
<name><surname>Lee</surname>
<given-names>EY</given-names>
</name>
<name><surname>Al Jawder</surname>
<given-names>SE</given-names>
</name>
</person-group>
<article-title>Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients</article-title>
<source>AJR Am J Roentgenol</source>
<volume>205</volume>
<year>2015</year>
<fpage>W267</fpage>
<lpage>W274</lpage>
<pub-id pub-id-type="pmid">26102309</pub-id>
</element-citation>
</ref>
<ref id="bib28"><label>28</label>
<element-citation publication-type="journal" id="sbref280"><person-group person-group-type="author"><name><surname>Qureshi</surname>
<given-names>NR</given-names>
</name>
<name><surname>Hien</surname>
<given-names>TT</given-names>
</name>
<name><surname>Farrar</surname>
<given-names>J</given-names>
</name>
<name><surname>Gleeson</surname>
<given-names>FV</given-names>
</name>
</person-group>
<article-title>The radiologic manifestations of H5N1 avian influenza</article-title>
<source>J Thorac Imaging</source>
<volume>21</volume>
<year>2006</year>
<fpage>259</fpage>
<lpage>264</lpage>
<pub-id pub-id-type="pmid">17110849</pub-id>
</element-citation>
</ref>
<ref id="bib29"><label>29</label>
<element-citation publication-type="journal" id="sbref290"><person-group person-group-type="author"><name><surname>Ujita</surname>
<given-names>M</given-names>
</name>
<name><surname>Renzoni</surname>
<given-names>EA</given-names>
</name>
<name><surname>Veeraraghavan</surname>
<given-names>S</given-names>
</name>
<name><surname>Wells</surname>
<given-names>AU</given-names>
</name>
<name><surname>Hansell</surname>
<given-names>DM</given-names>
</name>
</person-group>
<article-title>Organizing pneumonia: perilobular pattern at thin-section CT</article-title>
<source>Radiology</source>
<volume>232</volume>
<year>2004</year>
<fpage>757</fpage>
<lpage>761</lpage>
<pub-id pub-id-type="pmid">15229349</pub-id>
</element-citation>
</ref>
<ref id="bib30"><label>30</label>
<element-citation publication-type="journal" id="sbref300"><person-group person-group-type="author"><name><surname>Travis</surname>
<given-names>WD</given-names>
</name>
<name><surname>Costabel</surname>
<given-names>U</given-names>
</name>
<name><surname>Hansell</surname>
<given-names>DM</given-names>
</name>
</person-group>
<article-title>An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias</article-title>
<source>Am J Respir Crit Care Med</source>
<volume>188</volume>
<year>2013</year>
<fpage>733</fpage>
<lpage>748</lpage>
<pub-id pub-id-type="pmid">24032382</pub-id>
</element-citation>
</ref>
</ref-list>
<sec id="sec1" sec-type="supplementary-material"><title>Supplementary Materials</title>
<p id="para460"><supplementary-material content-type="local-data" id="ecomp10"><caption><title>Chinese translation of the abstract</title>
</caption>
<media xlink:href="mmc1.pdf"></media>
</supplementary-material>
</p>
<p id="para470"><supplementary-material content-type="local-data" id="ecomp20"><caption><title>Supplementary appendix 2</title>
</caption>
<media xlink:href="mmc2.pdf"></media>
</supplementary-material>
</p>
</sec>
<ack id="ceack10"><sec><title>Acknowledgments</title>
<p>We thank all our colleagues who helped us during the current study. We greatly appreciate the kind assistance of Xiaoming Yang (Radiology, University of Washington, Seattle, WA, USA) and Hanping Wu (Radiology, University of Michigan, Ann Arbor, MI, USA) in editing and revising the manuscript, as well as Hongwei Jiang (Epidemiology & Biostatistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) for his assistance in statistical analysis. We are also grateful to the many front-line medical staff for their dedication in the face of this outbreak, despite the potential threat to their own lives and the lives of their families.</p>
</sec>
</ack>
<ack><title>Contributors</title>
<p>HS, YF, and CZ conceived and designed the study. XH and NJ contributed to the literature search. XH, NJ, JG, YF, and CZ contributed to data collection. HS, XH, and YC contributed to data analysis. YC and OA contributed to data interpretation. HS, XH, NJ and YF contributed to the figures. HS, XH, NJ, and OA contributed to writing of the report.</p>
</ack>
<ack><title>Declaration of interests</title>
<p>We declare no competing interests.</p>
</ack>
</back>
</pmc>
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