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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus</title><author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M" last="Patrick">David M. Patrick</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M" last="Skowronski">Danuta M. Skowronski</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Guasparini, Roland" sort="Guasparini, Roland" uniqKey="Guasparini R" first="Roland" last="Guasparini">Roland Guasparini</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Krajden, Mel" sort="Krajden, Mel" uniqKey="Krajden M" first="Mel" last="Krajden">Mel Krajden</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Mcgeer, Patrick" sort="Mcgeer, Patrick" uniqKey="Mcgeer P" first="Patrick" last="Mcgeer">Patrick Mcgeer</name><affiliation><nlm:aff id="aff4">Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver</nlm:aff></affiliation></author><author><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Gustafson, Larry" sort="Gustafson, Larry" uniqKey="Gustafson L" first="Larry" last="Gustafson">Larry Gustafson</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Dubord, Janet" sort="Dubord, Janet" uniqKey="Dubord J" first="Janet" last="Dubord">Janet Dubord</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Macdonald, Diane" sort="Macdonald, Diane" uniqKey="Macdonald D" first="Diane" last="Macdonald">Diane Macdonald</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="David, Samara T" sort="David, Samara T" uniqKey="David S" first="Samara T" last="David">Samara T. David</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Srour, Leila F" sort="Srour, Leila F" uniqKey="Srour L" first="Leila F" last="Srour">Leila F. Srour</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Parker, Robert" sort="Parker, Robert" uniqKey="Parker R" first="Robert" last="Parker">Robert Parker</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Isaac Renton, Judith" sort="Isaac Renton, Judith" uniqKey="Isaac Renton J" first="Judith" last="Isaac-Renton">Judith Isaac-Renton</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Loewen, Nadine" sort="Loewen, Nadine" uniqKey="Loewen N" first="Nadine" last="Loewen">Nadine Loewen</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Mcnabb, Gail" sort="Mcnabb, Gail" uniqKey="Mcnabb G" first="Gail" last="Mcnabb">Gail Mcnabb</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Mcnabb, Alan" sort="Mcnabb, Alan" uniqKey="Mcnabb A" first="Alan" last="Mcnabb">Alan Mcnabb</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Goh, Swee Han" sort="Goh, Swee Han" uniqKey="Goh S" first="Swee-Han" last="Goh">Swee-Han Goh</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Henwick, Scott" sort="Henwick, Scott" uniqKey="Henwick S" first="Scott" last="Henwick">Scott Henwick</name><affiliation><nlm:aff id="aff5">Surrey Memorial Hospital, Surrey</nlm:aff></affiliation></author><author><name sortKey="Astell, Caroline" sort="Astell, Caroline" uniqKey="Astell C" first="Caroline" last="Astell">Caroline Astell</name><affiliation><nlm:aff id="aff6">British Columbia Cancer Agency’s Genome Sciences Centre, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Guo, Jian Ping" sort="Guo, Jian Ping" uniqKey="Guo J" first="Jian Ping" last="Guo">Jian Ping Guo</name><affiliation><nlm:aff id="aff4">Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver</nlm:aff></affiliation></author><author><name sortKey="Drebot, Michael" sort="Drebot, Michael" uniqKey="Drebot M" first="Michael" last="Drebot">Michael Drebot</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Tellier, Raymond" sort="Tellier, Raymond" uniqKey="Tellier R" first="Raymond" last="Tellier">Raymond Tellier</name><affiliation><nlm:aff id="aff7">Hospital for Sick Children, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Plummer, Francis" sort="Plummer, Francis" uniqKey="Plummer F" first="Francis" last="Plummer">Francis Plummer</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C" last="Brunham">Robert C. Brunham</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18382647</idno><idno type="pmc">2095096</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095096</idno><idno type="RBID">PMC:2095096</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000C46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus</title><author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M" last="Patrick">David M. Patrick</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M" last="Skowronski">Danuta M. Skowronski</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Guasparini, Roland" sort="Guasparini, Roland" uniqKey="Guasparini R" first="Roland" last="Guasparini">Roland Guasparini</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Krajden, Mel" sort="Krajden, Mel" uniqKey="Krajden M" first="Mel" last="Krajden">Mel Krajden</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Mcgeer, Patrick" sort="Mcgeer, Patrick" uniqKey="Mcgeer P" first="Patrick" last="Mcgeer">Patrick Mcgeer</name><affiliation><nlm:aff id="aff4">Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver</nlm:aff></affiliation></author><author><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Gustafson, Larry" sort="Gustafson, Larry" uniqKey="Gustafson L" first="Larry" last="Gustafson">Larry Gustafson</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Dubord, Janet" sort="Dubord, Janet" uniqKey="Dubord J" first="Janet" last="Dubord">Janet Dubord</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Macdonald, Diane" sort="Macdonald, Diane" uniqKey="Macdonald D" first="Diane" last="Macdonald">Diane Macdonald</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="David, Samara T" sort="David, Samara T" uniqKey="David S" first="Samara T" last="David">Samara T. David</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Srour, Leila F" sort="Srour, Leila F" uniqKey="Srour L" first="Leila F" last="Srour">Leila F. Srour</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Parker, Robert" sort="Parker, Robert" uniqKey="Parker R" first="Robert" last="Parker">Robert Parker</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Isaac Renton, Judith" sort="Isaac Renton, Judith" uniqKey="Isaac Renton J" first="Judith" last="Isaac-Renton">Judith Isaac-Renton</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Loewen, Nadine" sort="Loewen, Nadine" uniqKey="Loewen N" first="Nadine" last="Loewen">Nadine Loewen</name><affiliation><nlm:aff id="aff2">Fraser Health Authority, Vancouver, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Mcnabb, Gail" sort="Mcnabb, Gail" uniqKey="Mcnabb G" first="Gail" last="Mcnabb">Gail Mcnabb</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Mcnabb, Alan" sort="Mcnabb, Alan" uniqKey="Mcnabb A" first="Alan" last="Mcnabb">Alan Mcnabb</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Goh, Swee Han" sort="Goh, Swee Han" uniqKey="Goh S" first="Swee-Han" last="Goh">Swee-Han Goh</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author><author><name sortKey="Henwick, Scott" sort="Henwick, Scott" uniqKey="Henwick S" first="Scott" last="Henwick">Scott Henwick</name><affiliation><nlm:aff id="aff5">Surrey Memorial Hospital, Surrey</nlm:aff></affiliation></author><author><name sortKey="Astell, Caroline" sort="Astell, Caroline" uniqKey="Astell C" first="Caroline" last="Astell">Caroline Astell</name><affiliation><nlm:aff id="aff6">British Columbia Cancer Agency’s Genome Sciences Centre, British Columbia</nlm:aff></affiliation></author><author><name sortKey="Guo, Jian Ping" sort="Guo, Jian Ping" uniqKey="Guo J" first="Jian Ping" last="Guo">Jian Ping Guo</name><affiliation><nlm:aff id="aff4">Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver</nlm:aff></affiliation></author><author><name sortKey="Drebot, Michael" sort="Drebot, Michael" uniqKey="Drebot M" first="Michael" last="Drebot">Michael Drebot</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Tellier, Raymond" sort="Tellier, Raymond" uniqKey="Tellier R" first="Raymond" last="Tellier">Raymond Tellier</name><affiliation><nlm:aff id="aff7">Hospital for Sick Children, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Plummer, Francis" sort="Plummer, Francis" uniqKey="Plummer F" first="Francis" last="Plummer">Francis Plummer</name><affiliation><nlm:aff id="aff3">Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</nlm:aff></affiliation></author><author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C" last="Brunham">Robert C. Brunham</name><affiliation><nlm:aff id="aff1">University of British Columbia Centre for Disease Control</nlm:aff></affiliation></author></analytic><series><title level="j">The Canadian Journal of Infectious Diseases & Medical Microbiology</title><idno type="ISSN">1712-9532</idno><idno type="eISSN">1918-1493</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In summer 2003, a respiratory outbreak was investigated in British Columbia, during which nucleic acid tests and serology unexpectedly indicated reactivity for severe acute respiratory syndrome coronavirus (SARS-CoV).</p></sec><sec><title>Methods</title><p>Cases at a care facility were epidemiologically characterized and sequentially investigated for conventional agents of respiratory infection, SARS-CoV and other human CoVs. Serological cross-reactivity between SARS-CoV and human CoV-OC43 (HCoV-OC43) was investigated by peptide spot assay.</p></sec><sec><title>Results</title><p>Ninety-five of 142 residents (67%) and 53 of 160 staff members (33%) experienced symptoms of respiratory infection. Symptomatic residents experienced cough (66%), fever (21%) and pneumonia (12%). Eight residents died, six with pneumonia. No staff members developed pneumonia. Findings on reverse transcriptase-polymerase chain reaction assays for SARS-CoV at a national reference laboratory were suspected to represent false positives, but this was confounded by concurrent identification of antibody to N protein on serology. Subsequent testing by reverse transcriptase-polymerase chain reaction confirmed HCoV-OC43 infection. Convalescent serology ruled out SARS. Notably, sera demonstrated cross-reactivity against nucleocapsid peptide sequences common to HCoV-OC43 and SARS-CoV.</p></sec><sec><title>Conclusions</title><p>These findings underscore the virulence of human CoV-OC43 in elderly populations and confirm that cross-reactivity to antibody against nucleocapsid proteins from these viruses must be considered when interpreting serological tests for SARS-CoV.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can J Infect Dis Med Microbiol</journal-id><journal-id journal-id-type="publisher-id">PGI</journal-id><journal-title-group><journal-title>The Canadian Journal of Infectious Diseases & Medical Microbiology</journal-title></journal-title-group><issn pub-type="ppub">1712-9532</issn><issn pub-type="epub">1918-1493</issn><publisher><publisher-name>Pulsus Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18382647</article-id><article-id pub-id-type="pmc">2095096</article-id><article-id pub-id-type="other">JIDMM.v17.i6.pg330</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Patrick</surname><given-names>David M</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Petric</surname><given-names>Martin</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Skowronski</surname><given-names>Danuta M</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guasparini</surname><given-names>Roland</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Booth</surname><given-names>Timothy F</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Krajden</surname><given-names>Mel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>McGeer</surname><given-names>Patrick</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bastien</surname><given-names>Nathalie</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gustafson</surname><given-names>Larry</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dubord</surname><given-names>Janet</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>MacDonald</surname><given-names>Diane</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>David</surname><given-names>Samara T</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Srour</surname><given-names>Leila F</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Parker</surname><given-names>Robert</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Andonov</surname><given-names>Anton</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Isaac-Renton</surname><given-names>Judith</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Loewen</surname><given-names>Nadine</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>McNabb</surname><given-names>Gail</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>McNabb</surname><given-names>Alan</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Goh</surname><given-names>Swee-Han</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Henwick</surname><given-names>Scott</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Astell</surname><given-names>Caroline</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Jian Ping</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Drebot</surname><given-names>Michael</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tellier</surname><given-names>Raymond</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Plummer</surname><given-names>Francis</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Brunham</surname><given-names>Robert C</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>University of British Columbia Centre for Disease Control</aff><aff id="aff2"><label>2</label>Fraser Health Authority, Vancouver, British Columbia</aff><aff id="aff3"><label>3</label>Public Health Agency of Canada, Winnipeg, Manitoba and Ottawa, Ontario</aff><aff id="aff4"><label>4</label>Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver</aff><aff id="aff5"><label>5</label>Surrey Memorial Hospital, Surrey</aff><aff id="aff6"><label>6</label>British Columbia Cancer Agency’s Genome Sciences Centre, British Columbia</aff><aff id="aff7"><label>7</label>Hospital for Sick Children, Toronto, Ontario</aff><author-notes><corresp id="cor1">Correspondence and reprints: Dr David M Patrick, University of British Columbia Centre for Disease Control, 655 West 12th Avenue, 2nd Floor, Vancouver, British Columbia V5Z 4R4. Telephone 604-660-3199, fax 604-660-0197, e-mail <email>david.patrick@bccdc.ca</email></corresp></author-notes><pub-date pub-type="ppub"><season>Nov-Dec</season><year>2006</year></pub-date><volume>17</volume><issue>6</issue><fpage>330</fpage><lpage>336</lpage><history><date date-type="received"><day>4</day><month>8</month><year>2006</year></date><date date-type="accepted"><day>22</day><month>9</month><year>2006</year></date></history><permissions><copyright-statement>© 2006, Pulsus Group Inc. All rights reserved</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract><sec><title>Background</title><p>In summer 2003, a respiratory outbreak was investigated in British Columbia, during which nucleic acid tests and serology unexpectedly indicated reactivity for severe acute respiratory syndrome coronavirus (SARS-CoV).</p></sec><sec><title>Methods</title><p>Cases at a care facility were epidemiologically characterized and sequentially investigated for conventional agents of respiratory infection, SARS-CoV and other human CoVs. Serological cross-reactivity between SARS-CoV and human CoV-OC43 (HCoV-OC43) was investigated by peptide spot assay.</p></sec><sec><title>Results</title><p>Ninety-five of 142 residents (67%) and 53 of 160 staff members (33%) experienced symptoms of respiratory infection. Symptomatic residents experienced cough (66%), fever (21%) and pneumonia (12%). Eight residents died, six with pneumonia. No staff members developed pneumonia. Findings on reverse transcriptase-polymerase chain reaction assays for SARS-CoV at a national reference laboratory were suspected to represent false positives, but this was confounded by concurrent identification of antibody to N protein on serology. Subsequent testing by reverse transcriptase-polymerase chain reaction confirmed HCoV-OC43 infection. Convalescent serology ruled out SARS. Notably, sera demonstrated cross-reactivity against nucleocapsid peptide sequences common to HCoV-OC43 and SARS-CoV.</p></sec><sec><title>Conclusions</title><p>These findings underscore the virulence of human CoV-OC43 in elderly populations and confirm that cross-reactivity to antibody against nucleocapsid proteins from these viruses must be considered when interpreting serological tests for SARS-CoV.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>Coronavirus</kwd><kwd>Human coronavirus OC43</kwd><kwd>Outbreak</kwd><kwd>Respiratory infection</kwd><kwd>SARS-CoV</kwd><kwd>SARS coronavirus</kwd><kwd>Severe acute respiratory syndrome</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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| This area was generated with Dilib version V0.6.33. |  |