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A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China

Identifieur interne : 000C37 ( Pmc/Corpus ); précédent : 000C36; suivant : 000C38

A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China

Auteurs : Yu Shi ; Xiangshi Wang ; Gongbao Liu ; Qirong Zhu ; Jianshe Wang ; Hui Yu ; Chuanqing Wang ; Libo Wang ; Mingzhi Zhang ; Lingen Zhang ; Guoping Lu ; Zhujin Lu ; Jian Yu ; Zhongwei Qiao ; Ying Gu ; Guomei Shen ; Hong Xu ; Mei Zeng ; Xiaowen Zhai ; Guoying Huang

Source :

RBID : PMC:7154461

Abstract

Background

A recent cluster of pneumonia cases in China was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the screening and diagnosis of corona virus disease 2019 (COVID-19) in our hospital.

Methods

Developed a procedure for the identification of children cases with COVID-19 in outpatient and emergency department of our hospital, then we observed how this process works.

Results

(I) There were 56 cases considered suspected cases, and 10 cases were confirmed as COVID-19. (II) Of the 10 confirmed COVID-19 cases admitted in our hospital, 5 were males and 5 were females, aged from 7 months to 11 years, the average age is 6.0±4.2 years, 6 cases were mild pneumonia, the others were upper respiratory tract infection. (III) We followed up 68 patients in isolation at home until symptoms disappeared. Non were missed in the patient’s first visit. The sensitivity of this method is 100% and the specificity is 71.3%.

Conclusions

Our screening process works well, and it is also necessary to establish a screening network in the hospital.


Url:
DOI: 10.21037/atm.2020.03.22
PubMed: NONE
PubMed Central: 7154461

Links to Exploration step

PMC:7154461

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<name sortKey="Zhu, Qirong" sort="Zhu, Qirong" uniqKey="Zhu Q" first="Qirong" last="Zhu">Qirong Zhu</name>
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<name sortKey="Wang, Libo" sort="Wang, Libo" uniqKey="Wang L" first="Libo" last="Wang">Libo Wang</name>
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<nlm:aff id="aff4">Department of Respiration, National Children’s Medical Center,
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<name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name>
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<name sortKey="Zhang, Lingen" sort="Zhang, Lingen" uniqKey="Zhang L" first="Lingen" last="Zhang">Lingen Zhang</name>
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<addr-line>Shanghai 201102</addr-line>
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<name sortKey="Lu, Guoping" sort="Lu, Guoping" uniqKey="Lu G" first="Guoping" last="Lu">Guoping Lu</name>
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<name sortKey="Qiao, Zhongwei" sort="Qiao, Zhongwei" uniqKey="Qiao Z" first="Zhongwei" last="Qiao">Zhongwei Qiao</name>
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<nlm:aff id="aff7">Department of Medical Image, National Children’s Medical Center,
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<country>China</country>
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<country>China</country>
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<addr-line>Shanghai 201102</addr-line>
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<addr-line>Shanghai 201102</addr-line>
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<country>China</country>
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<nlm:aff id="aff13">Heart Center, National Children’s Medical Center,
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<name sortKey="Shi, Yu" sort="Shi, Yu" uniqKey="Shi Y" first="Yu" last="Shi">Yu Shi</name>
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<name sortKey="Wang, Chuanqing" sort="Wang, Chuanqing" uniqKey="Wang C" first="Chuanqing" last="Wang">Chuanqing Wang</name>
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<nlm:aff id="aff3">Department of Hospital Infection Control, National Children’s Medical Center,
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<addr-line>Shanghai 201102</addr-line>
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<country>China</country>
</nlm:aff>
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<name sortKey="Wang, Libo" sort="Wang, Libo" uniqKey="Wang L" first="Libo" last="Wang">Libo Wang</name>
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<nlm:aff id="aff4">Department of Respiration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
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<name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name>
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<nlm:aff id="aff4">Department of Respiration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
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<author>
<name sortKey="Zhang, Lingen" sort="Zhang, Lingen" uniqKey="Zhang L" first="Lingen" last="Zhang">Lingen Zhang</name>
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<nlm:aff id="aff5">Department of Critical Care Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lu, Guoping" sort="Lu, Guoping" uniqKey="Lu G" first="Guoping" last="Lu">Guoping Lu</name>
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<nlm:aff id="aff5">Department of Critical Care Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
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<country>China</country>
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</affiliation>
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<author>
<name sortKey="Lu, Zhujin" sort="Lu, Zhujin" uniqKey="Lu Z" first="Zhujin" last="Lu">Zhujin Lu</name>
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<nlm:aff id="aff5">Department of Critical Care Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<affiliation>
<nlm:aff id="aff6">Department of Traditional Chinese Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Qiao, Zhongwei" sort="Qiao, Zhongwei" uniqKey="Qiao Z" first="Zhongwei" last="Qiao">Zhongwei Qiao</name>
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<nlm:aff id="aff7">Department of Medical Image, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
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<country>China</country>
</nlm:aff>
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<author>
<name sortKey="Gu, Ying" sort="Gu, Ying" uniqKey="Gu Y" first="Ying" last="Gu">Ying Gu</name>
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<nlm:aff id="aff8">Department of Nursing, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shen, Guomei" sort="Shen, Guomei" uniqKey="Shen G" first="Guomei" last="Shen">Guomei Shen</name>
<affiliation>
<nlm:aff id="aff9">Outpatient and Emergency Management Office, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
<affiliation>
<nlm:aff id="aff10">Department of Nephrology/Rheumatology, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff11">Hospital Administration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zeng, Mei" sort="Zeng, Mei" uniqKey="Zeng M" first="Mei" last="Zeng">Mei Zeng</name>
<affiliation>
<nlm:aff id="aff2">Department of Infectious Disease, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhai, Xiaowen" sort="Zhai, Xiaowen" uniqKey="Zhai X" first="Xiaowen" last="Zhai">Xiaowen Zhai</name>
<affiliation>
<nlm:aff id="aff11">Hospital Administration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff12">Department of Hematology/Oncology, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Huang, Guoying" sort="Huang, Guoying" uniqKey="Huang G" first="Guoying" last="Huang">Guoying Huang</name>
<affiliation>
<nlm:aff id="aff11">Hospital Administration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff13">Heart Center, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Annals of Translational Medicine</title>
<idno type="ISSN">2305-5839</idno>
<idno type="eISSN">2305-5847</idno>
<imprint>
<date when="2020">2020</date>
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<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>A recent cluster of pneumonia cases in China was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the screening and diagnosis of corona virus disease 2019 (COVID-19) in our hospital.</p>
</sec>
<sec>
<title>Methods</title>
<p>Developed a procedure for the identification of children cases with COVID-19 in outpatient and emergency department of our hospital, then we observed how this process works.</p>
</sec>
<sec>
<title>Results</title>
<p>(I) There were 56 cases considered suspected cases, and 10 cases were confirmed as COVID-19. (II) Of the 10 confirmed COVID-19 cases admitted in our hospital, 5 were males and 5 were females, aged from 7 months to 11 years, the average age is 6.0±4.2 years, 6 cases were mild pneumonia, the others were upper respiratory tract infection. (III) We followed up 68 patients in isolation at home until symptoms disappeared. Non were missed in the patient’s first visit. The sensitivity of this method is 100% and the specificity is 71.3%.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Our screening process works well, and it is also necessary to establish a screening network in the hospital.</p>
</sec>
</div>
</front>
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<issn pub-type="ppub">2305-5839</issn>
<issn pub-type="epub">2305-5847</issn>
<publisher>
<publisher-name>AME Publishing Company</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmc">7154461</article-id>
<article-id pub-id-type="publisher-id">atm-08-05-241</article-id>
<article-id pub-id-type="doi">10.21037/atm.2020.03.22</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Shi</surname>
<given-names>Yu</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="afn2">
<sup>#</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Xiangshi</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="afn2">
<sup>#</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Gongbao</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="afn2">
<sup>#</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhu</surname>
<given-names>Qirong</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Jianshe</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Hui</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Chuanqing</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Libo</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang</surname>
<given-names>Mingzhi</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang</surname>
<given-names>Lingen</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lu</surname>
<given-names>Guoping</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lu</surname>
<given-names>Zhujin</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Jian</given-names>
</name>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Qiao</surname>
<given-names>Zhongwei</given-names>
</name>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gu</surname>
<given-names>Ying</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shen</surname>
<given-names>Guomei</given-names>
</name>
<xref ref-type="aff" rid="aff9">
<sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Xu</surname>
<given-names>Hong</given-names>
</name>
<xref ref-type="aff" rid="aff10">
<sup>10</sup>
</xref>
<xref ref-type="aff" rid="aff11">
<sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Zeng</surname>
<given-names>Mei</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Zhai</surname>
<given-names>Xiaowen</given-names>
</name>
<xref ref-type="aff" rid="aff11">
<sup>11</sup>
</xref>
<xref ref-type="aff" rid="aff12">
<sup>12</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Huang</surname>
<given-names>Guoying</given-names>
</name>
<xref ref-type="aff" rid="aff11">
<sup>11</sup>
</xref>
<xref ref-type="aff" rid="aff13">
<sup>13</sup>
</xref>
</contrib>
<aff id="aff1">
<label>1</label>
Division of Medical Administration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff2">
<label>2</label>
Department of Infectious Disease, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff3">
<label>3</label>
Department of Hospital Infection Control, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff4">
<label>4</label>
Department of Respiration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff5">
<label>5</label>
Department of Critical Care Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff6">
<label>6</label>
Department of Traditional Chinese Medicine, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff7">
<label>7</label>
Department of Medical Image, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff8">
<label>8</label>
Department of Nursing, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff9">
<label>9</label>
Outpatient and Emergency Management Office, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff10">
<label>10</label>
Department of Nephrology/Rheumatology, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff11">
<label>11</label>
Hospital Administration, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff12">
<label>12</label>
Department of Hematology/Oncology, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
<aff id="aff13">
<label>13</label>
Heart Center, National Children’s Medical Center,
<institution>Children’s Hospital of Fudan University</institution>
,
<addr-line>Shanghai 201102</addr-line>
,
<country>China</country>
</aff>
</contrib-group>
<author-notes>
<fn id="afn1">
<p>
<italic>Contributions:</italic>
(I) Conception and design: Y Shi, X Wang, G Liu, M Zeng, X Zhai, G Huang; (II) Administrative support: M Zeng, X Zhai, G Huang; (III) Provision of study materials or patients: X Wang, M Zeng; (IV) Collection and assembly of data: Y Shi, G Liu; (V) Data analysis and interpretation: Y Shi, G Liu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.</p>
</fn>
<fn id="afn2" fn-type="equal">
<label>#</label>
<p>These authors contributed equally to this work.</p>
</fn>
<corresp id="cor1">
<italic>Correspondence to:</italic>
Mei Zeng. Department of Infectious Disease, Children’s Hospital of Fudan University, Shanghai 201102, China. Email:
<email xlink:href="zengmeigao@aliyun.com">zengmeigao@aliyun.com</email>
; Xiaowen Zhai. Department of Hematology/Oncology, Children’s Hospital of Fudan University, Shanghai 201102, China. Email:
<email xlink:href="zhaixiaowendy@163.com">zhaixiaowendy@163.com</email>
; Guoying Huang. Heart Center, Children’s Hospital of Fudan University, Shanghai 201102, China. Email:
<email xlink:href="gyhuang@shmu.edu.cn">gyhuang@shmu.edu.cn</email>
.</corresp>
<fn fn-type="COI-statement">
<p>
<italic>Conflicts of Interest:</italic>
The authors have no conflicts of interest to declare.</p>
</fn>
</author-notes>
<pub-date pub-type="epub-ppub">
<month>3</month>
<year>2020</year>
</pub-date>
<pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub">
<month>3</month>
<year>2020</year>
</pub-date>
<volume>8</volume>
<issue>5</issue>
<elocation-id>241</elocation-id>
<history>
<date date-type="received">
<day>19</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="accepted">
<day>10</day>
<month>3</month>
<year>2020</year>
</date>
</history>
<permissions>
<copyright-statement>2020 Annals of Translational Medicine. All rights reserved.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>Annals of Translational Medicine.</copyright-holder>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>A recent cluster of pneumonia cases in China was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the screening and diagnosis of corona virus disease 2019 (COVID-19) in our hospital.</p>
</sec>
<sec>
<title>Methods</title>
<p>Developed a procedure for the identification of children cases with COVID-19 in outpatient and emergency department of our hospital, then we observed how this process works.</p>
</sec>
<sec>
<title>Results</title>
<p>(I) There were 56 cases considered suspected cases, and 10 cases were confirmed as COVID-19. (II) Of the 10 confirmed COVID-19 cases admitted in our hospital, 5 were males and 5 were females, aged from 7 months to 11 years, the average age is 6.0±4.2 years, 6 cases were mild pneumonia, the others were upper respiratory tract infection. (III) We followed up 68 patients in isolation at home until symptoms disappeared. Non were missed in the patient’s first visit. The sensitivity of this method is 100% and the specificity is 71.3%.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Our screening process works well, and it is also necessary to establish a screening network in the hospital.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="author">
<title>Keywords: </title>
<kwd>Corona virus disease 2019 (COVID-19)</kwd>
<kwd>severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)</kwd>
<kwd>child</kwd>
<kwd>diagnosis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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