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Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria

Identifieur interne : 000C19 ( Pmc/Corpus ); précédent : 000C18; suivant : 000C20

Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria

Auteurs : George Chlipala ; Shunyan Mo ; Esperanza J. Carcache De Blanco ; Aiko Ito ; Stanley Bazarek ; Jimmy Orjala

Source :

RBID : PMC:3061310

Abstract

A culture collection of cyanobacteria has been established at the University of Illinois at Chicago. This collection includes marine, terrestrial, and freshwater strains and contains representatives of the five orders of cyanobacteria: Chroococcales, Pleurocapsales, Oscillatoriales, Nostocales, and Stigonematales. In this study, extracts from a subset of 61 strains, 16 marine and 45 freshwater/terrestrial, were evaluated against three current protease targets, i.e. 20S proteasome and two SARS viral proteases, two important bacterial targets, i.e. Mycobacterium tuberculosis and Bacillus anthracis, and in the Artemia salina toxicity assay. In total, extracts of 12 strains possessed significant levels of activity in one or more targets. The overwhelming majority of active extracts (11 of 12) were from either freshwater or terrestrial forms of cyanobacteria, with the greater part of these (9 of 12) being heterocyst-forming strains. These results further support the use of cultured cyanobacteria as a source of biologically active natural products.


Url:
DOI: 10.1080/13880200802415483
PubMed: 21430788
PubMed Central: 3061310

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PMC:3061310

Le document en format XML

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<name sortKey="Carcache De Blanco, Esperanza J" sort="Carcache De Blanco, Esperanza J" uniqKey="Carcache De Blanco E" first="Esperanza J." last="Carcache De Blanco">Esperanza J. Carcache De Blanco</name>
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<name sortKey="Bazarek, Stanley" sort="Bazarek, Stanley" uniqKey="Bazarek S" first="Stanley" last="Bazarek">Stanley Bazarek</name>
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<p id="P1">A culture collection of cyanobacteria has been established at the University of Illinois at Chicago. This collection includes marine, terrestrial, and freshwater strains and contains representatives of the five orders of cyanobacteria: Chroococcales, Pleurocapsales, Oscillatoriales, Nostocales, and Stigonematales. In this study, extracts from a subset of 61 strains, 16 marine and 45 freshwater/terrestrial, were evaluated against three current protease targets, i.e. 20S proteasome and two SARS viral proteases, two important bacterial targets, i.e.
<italic>Mycobacterium tuberculosis</italic>
and
<italic>Bacillus anthracis</italic>
, and in the
<italic>Artemia salina</italic>
toxicity assay. In total, extracts of 12 strains possessed significant levels of activity in one or more targets. The overwhelming majority of active extracts (11 of 12) were from either freshwater or terrestrial forms of cyanobacteria, with the greater part of these (9 of 12) being heterocyst-forming strains. These results further support the use of cultured cyanobacteria as a source of biologically active natural products.</p>
</div>
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<journal-id journal-id-type="pubmed-jr-id">36064</journal-id>
<journal-id journal-id-type="nlm-ta">Pharm Biol</journal-id>
<journal-title>Pharmaceutical biology</journal-title>
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<issn pub-type="epub">1744-5116</issn>
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<article-id pub-id-type="manuscript">NIHMS248025</article-id>
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<article-title>Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria</article-title>
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<name>
<surname>Chlipala</surname>
<given-names>George</given-names>
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<aff id="A1">
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Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois</aff>
<aff id="A2">
<label>2</label>
Division of Medicinal Chemistry, Ohio State University, Columbus, Ohio, USA</aff>
<author-notes>
<corresp id="cor1">
<italic>Address for Correspondence</italic>
: Jimmy Orjala, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood St., Chicago, IL 60612-7231, Tel.: 312-996-5583; Fax: 312-996-7107;
<email>orjala@uic.edu</email>
</corresp>
<fn id="FN1" fn-type="conflict">
<p id="P43">
<bold>
<italic>Declaration of interest:</italic>
</bold>
</p>
<p id="P44">The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>2</day>
<month>11</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<month>1</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>21</day>
<month>3</month>
<year>2011</year>
</pub-date>
<volume>47</volume>
<issue>1</issue>
<fpage>53</fpage>
<lpage>60</lpage>
<permissions>
<copyright-statement>© 2009 Informa UK Ltd</copyright-statement>
<copyright-year>2009</copyright-year>
</permissions>
<abstract>
<p id="P1">A culture collection of cyanobacteria has been established at the University of Illinois at Chicago. This collection includes marine, terrestrial, and freshwater strains and contains representatives of the five orders of cyanobacteria: Chroococcales, Pleurocapsales, Oscillatoriales, Nostocales, and Stigonematales. In this study, extracts from a subset of 61 strains, 16 marine and 45 freshwater/terrestrial, were evaluated against three current protease targets, i.e. 20S proteasome and two SARS viral proteases, two important bacterial targets, i.e.
<italic>Mycobacterium tuberculosis</italic>
and
<italic>Bacillus anthracis</italic>
, and in the
<italic>Artemia salina</italic>
toxicity assay. In total, extracts of 12 strains possessed significant levels of activity in one or more targets. The overwhelming majority of active extracts (11 of 12) were from either freshwater or terrestrial forms of cyanobacteria, with the greater part of these (9 of 12) being heterocyst-forming strains. These results further support the use of cultured cyanobacteria as a source of biologically active natural products.</p>
</abstract>
<kwd-group>
<kwd>Anthrax</kwd>
<kwd>antimicrobial</kwd>
<kwd>brine shrimp</kwd>
<kwd>cyanobacteria</kwd>
<kwd>protease inhibition</kwd>
<kwd>proteasome</kwd>
<kwd>SARS</kwd>
<kwd>tuberculosis</kwd>
</kwd-group>
<contract-num rid="GM1">R01 GM075856-01 ||GM</contract-num>
<contract-sponsor id="GM1">National Institute of General Medical Sciences : NIGMS</contract-sponsor>
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