Is systems biology the key to preventing the next pandemic?
Identifieur interne : 000C13 ( Pmc/Corpus ); précédent : 000C12; suivant : 000C14Is systems biology the key to preventing the next pandemic?
Auteurs : Jennifer R. Tisoncik ; Sarah E. Belisle ; Deborah L. Diamond ; Marcus J. Korth ; Michael G. KatzeSource :
- Future virology [ 1746-0794 ] ; 2009.
Abstract
Sporadic outbreaks of epizootics including SARS coronavirus and H5N1 avian influenza remind us of the potential for communicable diseases to quickly spread into worldwide epidemics. To confront emerging viral threats, nations have implemented strategies to prepare for pandemics and to control virus spread. Despite improved surveillance and quarantine measures, we find ourselves in the midst of a H1N1 influenza pandemic. Effective therapeutics and vaccines are essential to protect against current and future pandemics. The best route to effective therapeutics and vaccines is through a detailed and global view of virus–host interactions that can be achieved using a systems biology approach. Here, we provide our perspective on the role of systems biology in deepening our understanding of virus–host interactions and in improving drug and vaccine development. We offer examples from influenza virus research, as well as from research on other pandemics of our time – HIV/AIDS and HCV – to demonstrate that systems biology offers one possible key to stopping the cycle of viral pandemics.
Url:
DOI: 10.2217/fvl.09.53
PubMed: 20352075
PubMed Central: 2843927
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101278124</journal-id><journal-id journal-id-type="pubmed-jr-id">34879</journal-id><journal-id journal-id-type="nlm-ta">Future Virol</journal-id><journal-title>Future virology</journal-title><issn pub-type="ppub">1746-0794</issn><issn pub-type="epub">1746-0808</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20352075</article-id><article-id pub-id-type="pmc">2843927</article-id><article-id pub-id-type="doi">10.2217/fvl.09.53</article-id><article-id pub-id-type="manuscript">NIHMS171802</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Is systems biology the key to preventing the next pandemic?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tisoncik</surname><given-names>Jennifer R</given-names></name><aff id="A1">University of Washington, Department of Microbiology, Seattle, WA 98195-8070, USA, Tel.: +1 206 732 6120, Fax: +1 206 732 6056</aff><email>tisoncik@u.washington.edu</email></contrib><contrib contrib-type="author"><name><surname>Belisle</surname><given-names>Sarah E</given-names></name><aff id="A2">University of Washington, Department of Microbiology, Seattle, WA 98195-8070, USA, Tel.: +1 206 732 6119, Fax: +1 206 732 6056</aff><email>sbelisle@u.washington.edu</email></contrib><contrib contrib-type="author"><name><surname>Diamond</surname><given-names>Deborah L</given-names></name><aff id="A3">University of Washington, Department of Microbiology, Seattle, WA 98195-8070, USA, Tel.: +1 206 732 6047, Fax: +1 206 732 6056</aff><email>ddiamond@u.washington.edu</email></contrib><contrib contrib-type="author"><name><surname>Korth</surname><given-names>Marcus J</given-names></name><aff id="A4">University of Washington, Department of Microbiology, Seattle, WA 98195-8070, USA, Tel.: +1 206 732 6154, Fax: +1 206 732 6154</aff><email>korth@u.washington.edu</email></contrib><contrib contrib-type="author"><name><surname>Katze</surname><given-names>Michael G</given-names></name><xref rid="FN1" ref-type="author-notes">†</xref><aff id="A5">University of Washington, Department of Microbiology and Washington National Primate Research Center, Box 358070, Seattle, WA 98195-8070, USA, Tel.: +1 206 732 6135, Fax: +1 206 732 6056</aff><email>honey@u.washingon.edu</email></contrib></contrib-group><author-notes><corresp id="FN1"><label>†</label>Author for correspondence: University of Washington, Department of Microbiology and Washington National Primate Research Center, Box 358070, Seattle, WA 98195-98070, USA ▪ Tel.: +1 206 732 6135 ▪ Fax: +1 206 732 6056 ▪ <email>honey@u.washingon.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>9</month><year>2010</year></pub-date><volume>4</volume><issue>6</issue><fpage>553</fpage><lpage>561</lpage><abstract><p id="P1">Sporadic outbreaks of epizootics including SARS coronavirus and H5N1 avian influenza remind us of the potential for communicable diseases to quickly spread into worldwide epidemics. To confront emerging viral threats, nations have implemented strategies to prepare for pandemics and to control virus spread. Despite improved surveillance and quarantine measures, we find ourselves in the midst of a H1N1 influenza pandemic. Effective therapeutics and vaccines are essential to protect against current and future pandemics. The best route to effective therapeutics and vaccines is through a detailed and global view of virus–host interactions that can be achieved using a systems biology approach. Here, we provide our perspective on the role of systems biology in deepening our understanding of virus–host interactions and in improving drug and vaccine development. We offer examples from influenza virus research, as well as from research on other pandemics of our time – HIV/AIDS and HCV – to demonstrate that systems biology offers one possible key to stopping the cycle of viral pandemics.</p></abstract><kwd-group><kwd>antiviral therapeutics</kwd><kwd>genomics</kwd><kwd>metabolomics</kwd><kwd>next-generation sequencing</kwd><kwd>proteomics</kwd><kwd>systems biology</kwd><kwd>vaccines</kwd><kwd>viral pandemics</kwd></kwd-group><contract-num rid="RR1">R24 RR016354-07
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