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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unraveling the complexities of the interferon response during SARS-CoV infection</title><author><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name></author><author><name sortKey="Baas, Tracey" sort="Baas, Tracey" uniqKey="Baas T" first="Tracey" last="Baas">Tracey Baas</name></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name></author><author><name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19885368</idno><idno type="pmc">2680287</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680287</idno><idno type="RBID">PMC:2680287</idno><idno type="doi">10.2217/17460794.4.1.71</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000C12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unraveling the complexities of the interferon response during SARS-CoV infection</title><author><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name></author><author><name sortKey="Baas, Tracey" sort="Baas, Tracey" uniqKey="Baas T" first="Tracey" last="Baas">Tracey Baas</name></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name></author><author><name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></analytic><series><title level="j">Future virology</title><idno type="ISSN">1746-0794</idno><idno type="eISSN">1746-0808</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection <italic>in vitro</italic>. Given the pivotal role of interferons during viral infections, (differential) induction of interferons may affect the outcome of the infection. Therefore, the functional implication of interferon production during SARS-CoV infection remains to be re-investigated.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101278124</journal-id><journal-id journal-id-type="pubmed-jr-id">34879</journal-id><journal-id journal-id-type="nlm-ta">Future Virol</journal-id><journal-title>Future virology</journal-title><issn pub-type="ppub">1746-0794</issn><issn pub-type="epub">1746-0808</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19885368</article-id><article-id pub-id-type="pmc">2680287</article-id><article-id pub-id-type="manuscript">NIHMS88172</article-id><article-id pub-id-type="doi">10.2217/17460794.4.1.71</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Unraveling the complexities of the interferon response during SARS-CoV infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>de Lang</surname><given-names>Anna</given-names></name><aff id="A1">Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Baas</surname><given-names>Tracey</given-names></name><aff id="A2">Department of Microbiology, School of Medicine, University of Washington, Seattle, WA, USA</aff></contrib><contrib contrib-type="author"><name><surname>Smits</surname><given-names>Saskia L</given-names></name><aff id="A3">Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Katze</surname><given-names>Michael G</given-names></name><aff id="A4">Department of Microbiology, School of Medicine, University of Washington, Seattle, WA, USA</aff></contrib><contrib contrib-type="author"><name><surname>Osterhaus</surname><given-names>Albert DME</given-names></name><aff id="A5">Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Haagmans</surname><given-names>Bart L</given-names></name><xref ref-type="corresp" rid="cor1">†</xref><aff id="A6">Department of Virology, Erasmus MC, PO box 2040, 3000 CA Rotterdam, The Netherlands, Tel.: +31 107 044 004;, Fax: +31 107 044 760;<email>b.haagmans@erasmusmc.nl</email></aff></contrib></contrib-group><author-notes><corresp id="cor1"><label>†</label>Author for correspondence: Department of Virology, Erasmus MC, PO box 2040, 3000 CA Rotterdam,, The Netherlands, Tel.: +31 107 044 004, Fax: +31 107 044 760, <email>b.haagmans@erasmusmc.nl</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>1</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>1</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2009</year></pub-date><volume>4</volume><issue>1</issue><fpage>71</fpage><lpage>78</lpage><permissions><copyright-statement>© 2009 Future Medicine</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><p id="P1">Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection <italic>in vitro</italic>. Given the pivotal role of interferons during viral infections, (differential) induction of interferons may affect the outcome of the infection. Therefore, the functional implication of interferon production during SARS-CoV infection remains to be re-investigated.</p></abstract><kwd-group><kwd>innate immunity</kwd><kwd>interferon</kwd><kwd>plasmacytoid dendritic cell</kwd><kwd>SARS coronavirus</kwd></kwd-group><contract-num rid="HL1">R01 HL080621-01A1
||HL</contract-num><contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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