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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Secondary Household Transmission of SARS, Singapore</title><author><name sortKey="Goh, Denise Li Meng" sort="Goh, Denise Li Meng" uniqKey="Goh D" first="Denise Li-Meng" last="Goh">Denise Li-Meng Goh</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lee, Bee Wah" sort="Lee, Bee Wah" uniqKey="Lee B" first="Bee Wah" last="Lee">Bee Wah Lee</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Heng, Bee Hoon" sort="Heng, Bee Hoon" uniqKey="Heng B" first="Bee Hoon" last="Heng">Bee Hoon Heng</name><affiliation><nlm:aff id="aff2">National Healthcare Group, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chen, Mark" sort="Chen, Mark" uniqKey="Chen M" first="Mark" last="Chen">Mark Chen</name><affiliation><nlm:aff id="aff3">Tan Tock Seng Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ma, Stefan" sort="Ma, Stefan" uniqKey="Ma S" first="Stefan" last="Ma">Stefan Ma</name><affiliation><nlm:aff id="aff4">Ministry of Health, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tan, Chorh Chuan" sort="Tan, Chorh Chuan" uniqKey="Tan C" first="Chorh Chuan" last="Tan">Chorh Chuan Tan</name><affiliation><nlm:aff id="aff4">Ministry of Health, Singapore</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15030688</idno><idno type="pmc">3322927</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322927</idno><idno type="RBID">PMC:3322927</idno><idno type="doi">10.3201/eid1002.030676</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000848</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Secondary Household Transmission of SARS, Singapore</title><author><name sortKey="Goh, Denise Li Meng" sort="Goh, Denise Li Meng" uniqKey="Goh D" first="Denise Li-Meng" last="Goh">Denise Li-Meng Goh</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lee, Bee Wah" sort="Lee, Bee Wah" uniqKey="Lee B" first="Bee Wah" last="Lee">Bee Wah Lee</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="aff1">National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Heng, Bee Hoon" sort="Heng, Bee Hoon" uniqKey="Heng B" first="Bee Hoon" last="Heng">Bee Hoon Heng</name><affiliation><nlm:aff id="aff2">National Healthcare Group, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chen, Mark" sort="Chen, Mark" uniqKey="Chen M" first="Mark" last="Chen">Mark Chen</name><affiliation><nlm:aff id="aff3">Tan Tock Seng Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ma, Stefan" sort="Ma, Stefan" uniqKey="Ma S" first="Stefan" last="Ma">Stefan Ma</name><affiliation><nlm:aff id="aff4">Ministry of Health, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tan, Chorh Chuan" sort="Tan, Chorh Chuan" uniqKey="Tan C" first="Chorh Chuan" last="Tan">Chorh Chuan Tan</name><affiliation><nlm:aff id="aff4">Ministry of Health, Singapore</nlm:aff></affiliation></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Secondary household transmission of severe acute respiratory syndrome (SARS) was studied in 114 households involving 417 contacts. The attack rate was low (6.2%). Occupation of the index case was the factor that most influenced household transmission (adjusted hazard ratio for healthcare workers 0.157; 95% confidence interval 0.042 to 0.588).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15030688</article-id><article-id pub-id-type="pmc">3322927</article-id><article-id pub-id-type="publisher-id">03-0676</article-id><article-id pub-id-type="doi">10.3201/eid1002.030676</article-id><article-categories><subj-group subj-group-type="heading"><subject>Dispatch</subject></subj-group></article-categories><title-group><article-title>Secondary Household Transmission of SARS, Singapore</article-title><alt-title alt-title-type="running-head">Disease Transmission</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Goh</surname><given-names>Denise Li-Meng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Bee Wah</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chia</surname><given-names>Kee Seng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Heng</surname><given-names>Bee Hoon</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Chorh Chuan</given-names></name><xref ref-type="aff" rid="aff4">§</xref></contrib><aff id="aff1"><label>*</label>National University of Singapore, Singapore</aff><aff id="aff2"><label>†</label>National Healthcare Group, Singapore</aff><aff id="aff3"><label>‡</label>Tan Tock Seng Hospital, Singapore</aff><aff id="aff4"><label>§</label>Ministry of Health, Singapore</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Denise Li-Meng Goh, Dept of Paediatrics, National University of Singapore, 5 Lower Kent Ridge Road, S 119074, Singapore; fax:(65)-6779-7486; email: <email xlink:href="paegohlm@nus.edu.sg">paegohlm@nus.edu.sg</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2004</year></pub-date><volume>10</volume><issue>2</issue><fpage>232</fpage><lpage>234</lpage><abstract><p>Secondary household transmission of severe acute respiratory syndrome (SARS) was studied in 114 households involving 417 contacts. The attack rate was low (6.2%). Occupation of the index case was the factor that most influenced household transmission (adjusted hazard ratio for healthcare workers 0.157; 95% confidence interval 0.042 to 0.588).</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>severe acute respiratory syndrome</kwd><kwd>coronavirus</kwd><kwd>secondary</kwd><kwd>household</kwd><kwd>transmission</kwd><kwd>attack rate</kwd></kwd-group></article-meta></front><body><p>Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the SARS-associated coronavirus (SARS-CoV) (<xref ref-type="bibr" rid="R1"><italic>1</italic></xref>). Attack rates are >50% in hospitals (<xref ref-type="bibr" rid="R2"><italic>2</italic></xref>). A similar trend was seen in Singapore, with SARS spreading to five hospitals and two Specialty Centres within 8 weeks (<xref ref-type="bibr" rid="R3"><italic>3</italic></xref>). This rapid rate of transmission caused a national health alert and resulted in large amounts of manpower and resources being deployed.</p><p>On the other hand, transmission within the household was less efficient. We, therefore, examined the attack rate and the factors influencing secondary transmission of SARS in Singapore households. Data on probable SARS cases were collected by Singapore’s Ministry of Health Epidemiology Unit, Singapore. The case definition of probable SARS was in accordance with the World Health Organization (WHO) (<xref ref-type="bibr" rid="R4"><italic>4</italic></xref>).</p><p>Probable SARS cases that were also a household index were identified by using the definition that follow. A household was defined as a residential place with a unique address. A household index was a person with probable SARS and the first person to introduce SARS into the household. A household contact was defined as a person living in the same household as the household index.</p><p>Demographic and clinical data were collected. For the household index, the following information was collected: age, sex, if the household index was a healthcare worker (defined as a person who works in a healthcare setting), number of days spent at home after onset of symptoms, and number of contacts in household. For household contacts, the following information was collected: age, sex, if the contact was a healthcare worker, and if the contact was a family member. The week of the SARS outbreak in Singapore was also evaluated to see if there was a time trend in the risk for transmission.</p><p>All household contacts were followed prospectively for (<xref ref-type="bibr" rid="R1"><italic>1</italic></xref>) clinical symptoms until 20 days after the last contact with the household index, and (<xref ref-type="bibr" rid="R2"><italic>2</italic></xref>) evidence of positive PCR (polymerase chain reaction) or serologic test for SARS-CoV (according to criteria set by WHO). Secondary household transmission was said to have occurred if the household contact fulfilled the case definition of probable SARS (<xref ref-type="bibr" rid="R4"><italic>4</italic></xref>).</p><p>Households were excluded if the household index lived alone, the household index did not spend time at home after onset of symptoms, if the period of household exposure to the index was not clearly defined (e.g., not isolated promptly upon hospital admission), or more than one index lived in the household (shown through contact tracing or onset <2 days after SARS developed in the first person in the household).</p><p>Statistical tests (Mann-Whitney, chi-square and Fisher exact test) were used to test for associations when appropriate. The Cox Regression model was used to evaluate the influence of demographic and clinical factors on secondary household transmission. All analyses were performed with SPSS version 11.5.</p><p>There were 205 probable SARS cases in Singapore during the period between February 24 and April 29, 2003. These 205 probable SARS cases resided in 163 households. A total of 114 households fulfilled the inclusion and exclusion criteria. Forty-nine households were excluded (12 because the index lived alone, 20 because the household index did not spend time at home after onset of symptoms, 10 because the period of household exposure to the index was not clearly defined, 7 because more than one index patient was in that household). Seventy-two of the 114 household indexes (63.2%) were healthcare workers. Ten were doctors, 37 were nurses, 4 were nursing students, and 21 were paramedical staff.</p><p>From these 114 households, 417 household contacts were identified and followed prospectively. Secondary transmission occurred in only 14 households (12.3%), giving rise to 26 household cases of probable SARS. Household transmissions occurred within 2–11 days (mean 5.3 ± 2.6 days) after the onset of symptoms in the index cases. Symptoms developed in eight contacts (30%) while on home quarantine orders. The remaining 18 were not given home quarantine orders because they were either already in hospital with SARS or were not identified by contact tracing. The mean length of stay at home after onset of symptoms was not statistically different between the home-quarantined group and the group not quarantined at home (p = 0.09).</p><p>The secondary household attack rate was thus low (6.2% [95% confidence interval 3.9% to 8.6%]) and concurs with that reported by Beijing, China (<xref ref-type="bibr" rid="R5"><italic>5</italic></xref>). In that study, the attack rate was 4.6% in persons who had contact with a probable SARS case-patient during the symptomatic period and lived in the same residence (which included some persons who visited or cared for a SARS patient). These findings are in contrast to the high attack rate seen in the healthcare setting (<xref ref-type="bibr" rid="R6"><italic>6</italic></xref>). One possible explanation for this difference is the phase of the illness. SARS case-patients in the household tend to be in the early phase of illness whereas SARS case-patients in the healthcare settings tend to be in the later phase. In addition, coexisting conditions and invasive procedures done within the hospital setting may also influence risk of transmitting disease (<xref ref-type="bibr" rid="R7"><italic>7</italic></xref>).</p><p>The low rate of household transmission suggests that the magnitude of a household outbreak would be less than a hospital-based one, which could help allay public fear and panic, a societal concern evident in the recent outbreak (<xref ref-type="bibr" rid="R2"><italic>2</italic></xref>,<xref ref-type="bibr" rid="R7"><italic>7</italic></xref>). This knowledge will also enable public health officers to develop a more sensitive and responsive surveillance system. As the expected attack rate is known, healthcare professionals can be prepared early if the observed attack rate in the households is higher than predicted, allowing rational rather than empirical implementation of public health measures and justify rapid and aggressive investigative and containment measures needed to prevent a large outbreak. These considerations are particularly important for countries with limited healthcare and fiscal resources. In Singapore, we learned the usefulness of educating persons on the need and means of doing daily temperature monitoring, to have a centralized temperature recording database for hospital staff and patients so that a cluster of fevers could be spotted early, to evaluate symptomatic hospital staff in designated hospital clinics, and to trace contacts by using many resources including the police and army. The authorities in Hong Kong did not have the benefit of this information as little was known then about SARS. Perhaps in the future, such knowledge will help prevent another situation similar to that seen in Amoy Gardens, Hong Kong Special Administrative Region (<xref ref-type="bibr" rid="R8"><italic>8</italic></xref>).</p><p>Factors influencing household transmission were also studied in the Singapore cohort. Univariate analysis (<xref ref-type="table" rid="T1">Table 1</xref>) showed that household index cases were less likely to transmit SARS to their household contacts if they were younger or were healthcare workers. Contacts were more likely to develop SARS if they were not healthcare workers or family members. The Cox regression model (<xref ref-type="fig" rid="F1">Figure</xref> and <xref ref-type="table" rid="T2">Table 2</xref>) verified two of these four factors, index occupation and age.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><title>Characteristics of household contacts and index cases<sup>a</sup></title></caption><table frame="hsides" rules="groups"><col width="112" span="1"></col><col width="99" span="1"></col><col width="153" span="1"></col><col width="72" span="1"></col><thead><tr><th valign="bottom" align="left" scope="col" rowspan="1" colspan="1">Risk Factor</th><th valign="bottom" align="left" scope="col" rowspan="1" colspan="1">Household contacts with SARS
(n = 26)
(mean <underline>+</underline> 1 SD)</th><th valign="bottom" align="left" scope="col" rowspan="1" colspan="1">Household contacts without SARS
(n = 391) (mean <underline>+</underline> 1 SD)</th><th valign="bottom" align="left" scope="col" rowspan="1" colspan="1">p value</th></tr></thead><tbody><tr><td valign="bottom" align="left" scope="col" rowspan="1" colspan="1">Household contact<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Age (y)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">35.3 ± 19.8<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">30.3 ± 17.4<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.17<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Sex (female)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">14 (53.8%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">225 (57.5%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.71<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Healthcare worker<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1 (3.8%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">84 (21.5%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.04<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Family member<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">24 (92.3%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">269 (68.8%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.01<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="col" rowspan="1" colspan="1">Index case<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Age (y)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">53.5 ± 16.2<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">35.4 ± 13.6<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><0.001<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Sex (female)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">20 (76.9%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">290 (74.2%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.76<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Healthcare worker<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">4 (15.4%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">273 (69.8%)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><0.001<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">Days index spent at home after onset of symptoms<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">5.3 ± 2.5<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">4.8 ± 2.5<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.43<hr></hr></td></tr><tr><td valign="bottom" align="left" scope="row" rowspan="1" colspan="1">No. of persons in household</td><td valign="bottom" align="left" rowspan="1" colspan="1">5.0 ± 3.0</td><td valign="bottom" align="left" rowspan="1" colspan="1">4.8 ± 2.4</td><td valign="bottom" align="left" rowspan="1" colspan="1">0.79</td></tr></tbody></table><table-wrap-foot><p><sup>a</sup>Using Univariate analysis, SARS, severe acute respiratory syndrome.</p></table-wrap-foot></table-wrap><fig id="F1" fig-type="figure" position="float"><label>Figure</label><caption><p>Survival analysis for secondary household transmission (Cox regression model). Household contacts were more likely to get SARS if the index was older or a nonhealthcare worker. Hazard ratios of risk factors analyzed are tabulated in <xref ref-type="table" rid="T2">Table 2</xref>. The -2log likelihood for this analysis was 253.77. HH, household; HCW, healthcare worker; NHCW, nonhealthcare worker.</p></caption><graphic xlink:href="03-0676-F"></graphic></fig><table-wrap id="T2" position="float"><label>Table 2</label><caption><title>Hazard ratios of risk factors analyzed<sup>a</sup></title></caption><table frame="hsides" rules="groups"><col width="254" span="1"></col><col width="105" span="1"></col><col width="45" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Independent risk factor</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Hazard ratio (95% CI)</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">p value</th></tr></thead><tbody><tr><td valign="top" align="left" scope="col" rowspan="1" colspan="1">Household contact<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Age (yrs)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.013 (0.992 to 1.034)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.222<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Sex (female)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.232 (0.542 to 2.796)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.619<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Healthcare worker<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.692 (0.137 to 20.926)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.682<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Family member<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.936 (0.372 to 10.076)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.432<hr></hr></td></tr><tr><td valign="top" align="left" scope="col" rowspan="1" colspan="1">Household index<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Age (y)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.055 (1.015 to 1.097)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.007<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Sex (female)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.274 (0.451 to 3.595)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.648<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Healthcare worker<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.157 (0.042 to 0.588)<hr></hr></td><td valign="middle" align="left" rowspan="1" colspan="1">0.006<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Days index spent at home after onset of symptoms<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.942 (0.794 to 1.117)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.493<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">No. of persons in household<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">1.060 (0.899 to 1.249)<hr></hr></td><td valign="bottom" align="left" rowspan="1" colspan="1">0.490<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Week of outbreak</td><td valign="bottom" align="left" rowspan="1" colspan="1">1.019 (0.733 to 1.417)</td><td valign="bottom" align="left" rowspan="1" colspan="1">0.911</td></tr></tbody></table><table-wrap-foot><p><sup>a</sup> Using Cox Regression Model; CI, confidence interval.</p></table-wrap-foot></table-wrap><p>The most consistent and important factor influencing household transmission was whether or not the index case was a healthcare worker (adjusted hazard ratio 0.157; 95% CI 0.042 to 0.588). This was independent of length of exposure or demographics. The reason for this finding was not evident from the data available. A difference in social behavior between healthcare worker and nonhealthcare worker is a possible explanation for this disparity in risks of household transmission. For example, healthcare workers may be more acutely aware of the risk of acquiring and transmitting SARS and may alter hygiene practices at home. In addition, better health and disease prevention knowledge may influence the efficacy of such practices. Qualitative differences in social behavior between healthcare worker and nonhealthcare worker should be investigated, as this knowledge may be useful in containing future SARS outbreaks.</p><p>The risk for household transmission was also lower if the index case was younger. This finding may correlate with milder disease seen in younger persons and lower infectivity. The week of the outbreak did not significantly influence the model, indicating the lack of a time trend in household transmission.</p><p>In conclusion, this study is the first to characterize secondary household transmission of SARS. We have shown that the attack rate is low and the most significant factor influencing household transmission was the occupation of the index case. The results of this study challenge some of the current concepts about SARS. Given that the study numbers are not large, a multicenter analysis of the past SARS cases would be helpful in verifying these findings.</p></body><back><fn-group><fn fn-type="citation"><p><italic>Suggested citation for this article:</italic> Goh DL-M, Lee BW, Chia KS, Heng BH, Chen M, Ma S, et al. Secondary household transmission of SARS, Singapore. Emerg Infect Dis [serial online] 2004 Feb [<italic>date cited</italic>]. Available from: URL: <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/ncidod/EID/vol10no2/03-0676.htm">http://www.cdc.gov/ncidod/EID/vol10no2/03-0676.htm</ext-link></p></fn></fn-group><ack><title>Acknowledgments</title><p>We thank the clinical and healthcare workers in Singapore, in particular the Tan Tock Seng Hospital, for their dedication and professionalism in the fight against SARS.</p></ack><bio><p>Dr. Denise Goh is a pediatrician and geneticist at the National University of Singapore and the National University Hospital, Singapore. Her interests are in childhood diseases.</p></bio><ref-list><title>References</title><ref id="R1"><label>1. </label><mixed-citation publication-type="journal"><string-name><surname>Ksiazek</surname><given-names>TG</given-names></string-name>, <string-name><surname>Erdman</surname><given-names>D</given-names></string-name>, <string-name><surname>Goldsmith</surname><given-names>CS</given-names></string-name>, <string-name><surname>Zaki</surname><given-names>SR</given-names></string-name>, <string-name><surname>Peret</surname><given-names>T</given-names></string-name>, <string-name><surname>Emery</surname><given-names>S</given-names></string-name>, <etal></etal><article-title>A novel coronavirus associated with severe acute respiratory syndrome.</article-title><source>N Engl J Med</source>. <year>2003</year>;<volume>348</volume>:<fpage>1953</fpage><pub-id pub-id-type="doi">10.1056/NEJMoa030781</pub-id><pub-id pub-id-type="pmid">12690092</pub-id></mixed-citation></ref><ref id="R2"><label>2. </label><mixed-citation publication-type="journal"><collab>World Health Organization</collab><article-title>Outbreak news—severe acute respiratory syndrome (SARS).</article-title><source>Wkly Epidemiol Rec</source>. <year>2003</year>;<volume>78</volume>:<fpage>81</fpage><pub-id pub-id-type="pmid">12701272</pub-id></mixed-citation></ref><ref id="R3"><label>3. </label><mixed-citation publication-type="journal"><string-name><surname>Hsu</surname><given-names>L-Y</given-names></string-name>, <string-name><surname>Lee</surname><given-names>C-C</given-names></string-name>, <string-name><surname>Green</surname><given-names>JA</given-names></string-name>, <string-name><surname>Ang</surname><given-names>B</given-names></string-name>, <string-name><surname>Paton</surname><given-names>NI</given-names></string-name>, <string-name><surname>Lee</surname><given-names>L</given-names></string-name>, <etal></etal><article-title>Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts.</article-title><source>Emerg Infect Dis</source>. <year>2003</year>;<volume>9</volume>:<fpage>713</fpage>–<lpage>7</lpage><pub-id pub-id-type="pmid">12781012</pub-id></mixed-citation></ref><ref id="R4"><label>4. </label><mixed-citation publication-type="journal"><string-name><surname>Lingappa</surname><given-names>JR</given-names></string-name>, <string-name><surname>McDonald</surname><given-names>C</given-names></string-name>, <string-name><surname>Parashar</surname><given-names>U</given-names></string-name>, <string-name><surname>Simone</surname><given-names>P</given-names></string-name>, <string-name><surname>Anderson</surname><given-names>L</given-names></string-name><article-title>SARS emergence from uncertainty.</article-title><source>Emerg Infect Dis</source>. <year>2004</year>;<volume>▪▪▪</volume>:<fpage>10</fpage></mixed-citation></ref><ref id="R5"><label>5. </label><mixed-citation publication-type="journal"><article-title>Efficiency of quarantine during an epidemic of severe acute respiratory syndrome—Beijing, China, 2003.</article-title><source>MMWR Morb Mortal Wkly Rep</source>. <year>2003</year>;<volume>52</volume>:<fpage>1037</fpage><pub-id pub-id-type="pmid">14586295</pub-id></mixed-citation></ref><ref id="R6"><label>6. </label><mixed-citation publication-type="journal"><collab>World Health Organization</collab><article-title>Outbreak news—severe acute respiratory syndrome (SARS).</article-title><source>Wkly Epidemiol Rec</source>. <year>2003</year>;<volume>78</volume>:<fpage>81</fpage><pub-id pub-id-type="pmid">12701272</pub-id></mixed-citation></ref><ref id="R7"><label>7. </label><mixed-citation publication-type="journal"><string-name><surname>Lee</surname><given-names>N</given-names></string-name>, <string-name><surname>Hui</surname><given-names>D</given-names></string-name>, <string-name><surname>Wu</surname><given-names>A</given-names></string-name>, <string-name><surname>Chan</surname><given-names>P</given-names></string-name>, <string-name><surname>Cameron</surname><given-names>P</given-names></string-name>, <string-name><surname>Joynt</surname><given-names>GM</given-names></string-name>, <etal></etal><article-title>A major outbreak of severe acute respiratory syndrome in Hong Kong.</article-title><source>N Engl J Med</source>. <year>2003</year>;<volume>348</volume>:<fpage>1986</fpage><pub-id pub-id-type="doi">10.1056/NEJMoa030685</pub-id><pub-id pub-id-type="pmid">12682352</pub-id></mixed-citation></ref><ref id="R8"><label>8. </label><mixed-citation publication-type="book"><collab>H.K.S.A.R.C. Department of Health</collab> Outbreak of Severe Acute Respiratory Syndrome (SARS) at Amoy Gardens, Kowloon Bay, Hong Kong. Main Findings of the Investigation; <year>2003</year></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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