Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study
Identifieur interne : 000843 ( Pmc/Corpus ); précédent : 000842; suivant : 000844Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study
Auteurs : Dominic T. S. Lee ; Y. K. Wing ; Henry C. M. Leung ; Joseph J. Y. Sung ; Y. K. Ng ; G. C. Yiu ; Ronald Y. L. Chen ; Helen F. K. ChiuSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2004.
Abstract
We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the acute phase of their illness. We reviewed all SARS-related psychiatric consultations in Hong Kong and investigated the risk factors for psychosis among patients with SARS in a matched case-control study. Patients with SARS-related psychosis received higher total doses of steroids and had higher rates of family history of psychiatric illness. The findings of the present study suggest that steroid toxicity, personal vulnerability, and, probably, psychosocial stressors jointly contributed to the development of psychosis in patients with SARS.
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DOI: 10.1086/424016
PubMed: 15486852
PubMed Central: 7107870
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study</title><author><name sortKey="Lee, Dominic T S" sort="Lee, Dominic T S" uniqKey="Lee D" first="Dominic T. S." last="Lee">Dominic T. S. Lee</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Social Medicine, Harvard Medical School</institution>,<addr-line>Boston, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wing, Y K" sort="Wing, Y K" uniqKey="Wing Y" first="Y. K." last="Wing">Y. K. Wing</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leung, Henry C M" sort="Leung, Henry C M" uniqKey="Leung H" first="Henry C. M." last="Leung">Henry C. M. Leung</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation><nlm:aff id="aff2"><institution>Department of Medicine and Therapeutics, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ng, Y K" sort="Ng, Y K" uniqKey="Ng Y" first="Y. K." last="Ng">Y. K. Ng</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yiu, G C" sort="Yiu, G C" uniqKey="Yiu G" first="G. C." last="Yiu">G. C. Yiu</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ronald Y L" sort="Chen, Ronald Y L" uniqKey="Chen R" first="Ronald Y. L." last="Chen">Ronald Y. L. Chen</name><affiliation><nlm:aff id="aff3"><institution>Department of Psychiatry, Hong Kong University</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chiu, Helen F K" sort="Chiu, Helen F K" uniqKey="Chiu H" first="Helen F. K." last="Chiu">Helen F. K. Chiu</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15486852</idno><idno type="pmc">7107870</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107870</idno><idno type="RBID">PMC:7107870</idno><idno type="doi">10.1086/424016</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000843</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000843</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study</title><author><name sortKey="Lee, Dominic T S" sort="Lee, Dominic T S" uniqKey="Lee D" first="Dominic T. S." last="Lee">Dominic T. S. Lee</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Social Medicine, Harvard Medical School</institution>,<addr-line>Boston, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wing, Y K" sort="Wing, Y K" uniqKey="Wing Y" first="Y. K." last="Wing">Y. K. Wing</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leung, Henry C M" sort="Leung, Henry C M" uniqKey="Leung H" first="Henry C. M." last="Leung">Henry C. M. Leung</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation><nlm:aff id="aff2"><institution>Department of Medicine and Therapeutics, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ng, Y K" sort="Ng, Y K" uniqKey="Ng Y" first="Y. K." last="Ng">Y. K. Ng</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yiu, G C" sort="Yiu, G C" uniqKey="Yiu G" first="G. C." last="Yiu">G. C. Yiu</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ronald Y L" sort="Chen, Ronald Y L" uniqKey="Chen R" first="Ronald Y. L." last="Chen">Ronald Y. L. Chen</name><affiliation><nlm:aff id="aff3"><institution>Department of Psychiatry, Hong Kong University</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chiu, Helen F K" sort="Chiu, Helen F K" uniqKey="Chiu H" first="Helen F. K." last="Chiu">Helen F. K. Chiu</name><affiliation><nlm:aff id="aff1"><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the acute phase of their illness. We reviewed all SARS-related psychiatric consultations in Hong Kong and investigated the risk factors for psychosis among patients with SARS in a matched case-control study. Patients with SARS-related psychosis received higher total doses of steroids and had higher rates of family history of psychiatric illness. The findings of the present study suggest that steroid toxicity, personal vulnerability, and, probably, psychosocial stressors jointly contributed to the development of psychosis in patients with SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cheng, Cc" uniqKey="Cheng C">CC Cheng</name></author><author><name sortKey="Hung, Fn" uniqKey="Hung F">FN Hung</name></author><author><name sortKey="Tang, Sf" uniqKey="Tang S">SF Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naber, D" uniqKey="Naber D">D Naber</name></author><author><name sortKey="Sand, P" uniqKey="Sand P">P Sand</name></author><author><name sortKey="Heigl, B" uniqKey="Heigl B">B Heigl</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Kk" uniqKey="Lau K">KK Lau</name></author><author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Lau, St" uniqKey="Lau S">ST Lau</name></author><author><name sortKey="Sheng, B" uniqKey="Sheng B">B Sheng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="First, Mb" uniqKey="First M">MB First</name></author><author><name sortKey="Spitzer, Rl" uniqKey="Spitzer R">RL Spitzer</name></author><author><name sortKey="Gibbon, M" uniqKey="Gibbon M">M Gibbon</name></author><author><name sortKey="Williams, Jb" uniqKey="Williams J">JB Williams</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>The University of Chicago Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15486852</article-id><article-id pub-id-type="pmc">7107870</article-id><article-id pub-id-type="doi">10.1086/424016</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Reports</subject></subj-group></article-categories><title-group><article-title>Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Dominic T. S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="corresp" rid="cor1"></xref><pmc-comment>tak_lee@hms.harvard.edu </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Wing</surname><given-names>Y. K.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Leung</surname><given-names>Henry C. M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sung</surname><given-names>Joseph J. Y.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Y. K.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yiu</surname><given-names>G. C.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ronald Y. L.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Helen F. K.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Department of Psychiatry, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></aff><aff id="aff2"><label>2</label><institution>Department of Medicine and Therapeutics, The Chinese University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line></aff><aff id="aff3"><label>3</label><institution>Department of Psychiatry, Hong Kong University</institution>,<addr-line>Hong Kong</addr-line></aff><aff id="aff4"><label>4</label><institution>Department of Social Medicine, Harvard Medical School</institution>,<addr-line>Boston, Massachusetts</addr-line></aff><author-notes><corresp id="cor1">Reprints or correspondence: Dr. Dominic T. S. Lee, c/o G/F Multi-Center, Taipo Hospital, NT, Hong Kong (<email>tak_lee@hms.harvard.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>10</month><year>2004</year></pub-date><pub-date pub-type="epub" iso-8601-date="2004-10-15"><day>15</day><month>10</month><year>2004</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>10</month><year>2004</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>39</volume><issue>8</issue><fpage>1247</fpage><lpage>1249</lpage><history><date date-type="received"><day>9</day><month>3</month><year>2004</year></date><date date-type="accepted"><day>20</day><month>5</month><year>2004</year></date></history><permissions><copyright-statement>© 2004 by the Infectious Diseases Society of America</copyright-statement><copyright-year>2004</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="39-8-1247.pdf"></self-uri><abstract><title>Abstract</title><p>We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the acute phase of their illness. We reviewed all SARS-related psychiatric consultations in Hong Kong and investigated the risk factors for psychosis among patients with SARS in a matched case-control study. Patients with SARS-related psychosis received higher total doses of steroids and had higher rates of family history of psychiatric illness. The findings of the present study suggest that steroid toxicity, personal vulnerability, and, probably, psychosocial stressors jointly contributed to the development of psychosis in patients with SARS.</p></abstract></article-meta></front><body><p>In February 2003, an outbreak of atypical pneumonia occurred in southern China. The infection, subsequently named “severe acute respiratory syndrome” (SARS), was spread by travelers to many parts of the world [<xref rid="ref1" ref-type="bibr">1</xref>]. The outbreak was so rampant that the World Health Organization issued warnings about international travel. In Hong Kong, within the short span of 6 months, >3000 people were infected with SARS, and, of them, >300 died.</p><p>During the SARS outbreak, we observed that a small number of patients with SARS developed acute psychotic disorders while they were receiving inpatient treatment. Psychosis among patients with SARS posed great challenges and threats to the clinical team. The psychotic symptoms—such as elation, irritable mood, persecutory delusions, agitation, and hyperactivity—rendered affected patients uncooperative with the clinical management and with the infection-control measures. When the psychosis was severe and the patient displayed disruptive behavior that posed harm to himself or others, physical restraint and sedation were necessary. However, even when wearing protective apparel, the clinical team faced a substantial risk of contracting SARS during the course of action.</p><p>Many patients with SARS were given high doses of steroids—as much as 160 mg of methylprednisolone per day—to control virus-induced autoimmune lung damage. Because previous research has shown that patients who receive high doses of steroids can develop manic symptoms or manic syndrome [<xref rid="ref2" ref-type="bibr">2</xref>, <xref rid="ref3" ref-type="bibr">3</xref>], it has been theorized that SARS-related psychosis was caused by steroid treatment. However, other etiologies should also be considered. SARS-associated coronavirus, the pathogen involved in SARS, has been detected in CSF samples obtained from patients with SARS [<xref rid="ref4" ref-type="bibr">4</xref>]. In addition, patients with SARS are subject to many physical and psychological stresses. Hypoxia, concomitant sepsis, sleep deprivation, social isolation (as a result of being quarantined), fear of death, and concurrent SARS infections within the family are all profound stressors that can precipitate psychosis. Last, the fact that only a small number of these highly stressed patients with SARS developed acute psychosis suggests that personal vulnerability may be relevant.</p><p><bold><italic>Patients and methods.</italic></bold> We studied the etiology of SARS-related psychosis retrospectively, using a case-control design. A total of 15 case patients with SARS-related psychosis and 30 nonpsychotic control subjects were compared.</p><p>All liaison psychiatrists in Hong Kong reviewed their SARS-related consultations that had occurred from 13 March through 31 May 2003. All patients who had received a recent diagnosis of a psychotic disorder after the onset of SARS were identified. Psychotic disorders were defined according to <italic>Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)</italic> criteria for diagnoses of Brief Psychotic Disorder, Delusional Disorder, Psychotic Disorder Due to a General Medical Condition, Manic Episode, Major Depressive Episode with Psychotic Features, Schizoaffective Disorder, Schizophrenia, Schizophreniform Disorder, Shared Psychotic Disorder, Substance-Induced Psychotic Disorder, and Psychotic Disorder Not Otherwise Specified.</p><p>For control comparison, we identified 30 age- and sex-matched patients with SARS who had no psychotic symptoms (twice the number of patients who had SARS-related psychosis), using the hospital's registry of patients with SARS. Two control subjects were matched, by age (±2 years) and sex, with each psychotic case patient. All control subjects had been assessed by a research psychiatrist (Y.K.W.), who used the Structured Clinical Interview for <italic>DSM-IV</italic> (SCID) to confirm the absence of psychotic symptoms [<xref rid="ref5" ref-type="bibr">5</xref>]. The SCID comprises an hour-long, semistructured clinical interview that addresses every symptom domain, ensuring accurate and reliable psychiatric diagnosis [<xref rid="ref5" ref-type="bibr">5</xref>].</p><p>The medical records of the case patients and control subjects were reviewed for information on sociodemographics, past medical history, and SARS development and treatment history. The ascertainment of risk factors was uniform between case patients and control subjects. We hypothesized that personal and family histories of psychiatric illness, intensive care unit admission, receipt of steroid treatment, steroid dosage, and SARS infection among family members would increase the risk of psychosis among patients with SARS.</p><p>Case patients and control subjects were compared using the χ<sup>2</sup> test or Fisher's exact test, for categorical variables, and the Mann-Whitney <italic>U</italic> test, for continuous variables. ORs with 95% CIs were calculated.</p><p><bold><italic>Results.</italic></bold> A total of 15 patients with psychotic disorders were identified among the 1744 patients with SARS who were identified during the study period, yielding an incidence rate of 0.9% (<xref ref-type="fig" rid="tab1">table 1</xref>). The clinical diagnoses made by the liaison psychiatrists were as follows: Steroid-Induced Manic Episode (<italic>n</italic> = 10), Steroid-Induced Psychotic Disorder (<italic>n</italic> = 3), Major Depressive Episode with Psychotic Features (<italic>n</italic> = 1), and Psychotic Disorder Not Otherwise Specified (<italic>n</italic> = 1). For 3 case patients (20%), the diagnosis of psychosis was determined only during the second assessment; the diagnosis of Adjustment Disorder was determined earlier during the study. All psychotic episodes met the <italic>DSM-IV</italic> criteria for “caseness,” and all case patients were receiving treatment for SARS when the psychotic episode began. None of the case patients or control subjects had a history of psychotic disorders.</p><fig id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Characteristics assessed as potential risk factors for psychosis among patients with SARS.</p></caption><graphic xlink:href="39-8-1247-tbl001"></graphic></fig><p>Family history of psychiatric illness was significantly more common among patients with SARS-related psychosis than among control subjects (33% vs. 0%; <italic>P</italic> = .002; <xref ref-type="fig" rid="tab1">table 1</xref>). Among the patients with SARS-related psychosis, there was also a higher rate of family members contracting SARS, but the trend was marginally insignificant (40% vs. 13%; OR, 4.3; 95% CI, 0.99–18.9; <italic>P</italic> = .06). We found that personal history of psychiatric illness and intensive care unit admission were not associated with psychosis among patients with SARS (<xref ref-type="fig" rid="tab1">table 1</xref>).</p><p>All case patients and control subjects had received steroid treatment for SARS. The patients with SARS-related psychosis received significantly higher cumulative doses of steroids during their inpatient hospital stays than did the control subjects (median dose of hydrocortisone equivalent, 10,975 mg vs. 6780 mg; <italic>P</italic> = .017). The mean daily steroid dose for the cohort of patients with SARS-related psychosis was also higher than that for the control subjects, but the trend was not statistically significant (568 mg vs. 482 mg of hydrocortisone equivalent per day; <italic>P</italic> = .142; <xref ref-type="fig" rid="tab1">table 1</xref>). Multivariate analysis was attempted, but no explanatory variable could be consistently identified in the logistic regression modeling.</p><p><bold><italic>Discussion.</italic></bold> All except 2 of the case patients with SARS-related psychosis were given a diagnosis of Steroid-Induced Mania Episode or Psychotic Disorder. These diagnoses were based on the clinical observation of the length of the interval between the introduction of steroid treatment and the onset of the manic or psychotic symptoms. Besides, the disturbance could not have been better attributed to a non—substance-induced psychotic disorder. That most of the case patients were manic at presentation also supported the relevance of receipt of steroids in the etiology [<xref rid="ref2" ref-type="bibr">2</xref>, <xref rid="ref3" ref-type="bibr">3</xref>]. Analysis of steroid dosage also suggested that the patients with SARS-related psychosis had received higher cumulative doses of steroids during their inpatient hospital stays.</p><p>However, data from the present study argued against simple, direct steroid toxicity as the etiology of psychosis among patients with SARS. An unusually high rate of family history of psychiatric illness was observed in the cohort of patients with SARS-related psychosis, which suggested that personal vulnerability is also relevant in determining which patients with SARS would experience a psychotic episode. The study also showed that psychosocial stressors, such as concurrent SARS infection in another family member, may also be relevant, but a study with a larger sample is needed to confirm this observed trend.</p><p>We would like to point out that acute psychosis is not the only form of mental illness that has been observed among patients with SARS. Another study from Hong Kong had reported that ∼40% of 148 patients with SARS had a been given a diagnosis of 1 or more <italic>DSM-IV</italic>-defined disorders during the acute and/or convalescent phases of their illness (Y.K.W., H.C.M.L., and I. Kam, unpublished data). The study also showed that ∼11% of patients with SARS who were treated with steroids displayed some manic symptoms during the acute phase of the illness.</p><p>The present study had several limitations that warrant Discussion. First, because of the small sample size and the methodological limitations, the study findings—both positive and negative ones—should be interpreted with caution. Second, we were not able to ascertain the nature of psychiatric illnesses within the patients' families, because the details were not always recorded in the case notes. Also, that none of the control subjects had a family history of psychiatric illness could well be a chance finding. Third, the patients with SARS-related psychosis were evaluated by clinical assessment rather than by a standardized research interview, such as the SCID. Last, the retrospective nature of this study is a key limitation. However, amidst the confusion, shock, panic, and fear associated with the SARS outbreak, it was difficult to design and launch a prospective study quickly enough to match the rapid course of the epidemic. Hence, we have had to resort to a retrospective study design, which limits our examination to variables that had been regularly recorded in the case notes.</p><p>A prospective study with detailed recording of the phenomenology of the outbreak would allow a researcher to ascertain whether the psychotic episodes observed had clinical features that distinguished them from the typical steroid-induced psychoses seen in other contexts. Likewise, routine MRI examination of each psychotic case patient would allow for the evaluation of direct CNS involvement of the SARS virus. Future studies should preferably employ 1 or 2 psychiatrists to collect clinical data in a systematic manner.</p><p>Although the rate of psychotic complications in the SARS population does not appear to be high, it is important to warn clinicians about the possibility of psychosis among patients during the management of this highly contagious disease. Before additional data are available, we believe that it would be advisable to routinely ascertain the family histories of psychiatric illness and, probably, the well-being of other family members during the clinical assessment of patients with SARS. This is especially important if high-dose or intravenously administered steroids are to be prescribed.</p></body><back><ack><title>Acknowledgments</title><p>We thank the other members of the Hong Kong SARS Psychosis Study: I. Kam, D. Nguyen, W. N. Tang, W. H. Leung, M. Tay, and V. Wong. 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