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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pulmonary Function in Survivors of Severe Acute Respiratory Syndrome (SARS)</title><author><name sortKey="Chan, Veronica L" sort="Chan, Veronica L" uniqKey="Chan V" first="Veronica L." last="Chan">Veronica L. Chan</name></author><author><name sortKey="Lam, Judy Y" sort="Lam, Judy Y" uniqKey="Lam J" first="Judy Y." last="Lam">Judy Y. Lam</name></author><author><name sortKey="Leung, Wah Shing" sort="Leung, Wah Shing" uniqKey="Leung W" first="Wah-Shing" last="Leung">Wah-Shing Leung</name></author><author><name sortKey="Lin, Alsa W" sort="Lin, Alsa W" uniqKey="Lin A" first="Alsa W." last="Lin">Alsa W. Lin</name></author><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130204</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130204</idno><idno type="RBID">PMC:7130204</idno><idno type="doi">10.1016/S0012-3692(16)46837-6</idno><idno type="pmid">NONE</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000772</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000772</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pulmonary Function in Survivors of Severe Acute Respiratory Syndrome (SARS)</title><author><name sortKey="Chan, Veronica L" sort="Chan, Veronica L" uniqKey="Chan V" first="Veronica L." last="Chan">Veronica L. Chan</name></author><author><name sortKey="Lam, Judy Y" sort="Lam, Judy Y" uniqKey="Lam J" first="Judy Y." last="Lam">Judy Y. Lam</name></author><author><name sortKey="Leung, Wah Shing" sort="Leung, Wah Shing" uniqKey="Leung W" first="Wah-Shing" last="Leung">Wah-Shing Leung</name></author><author><name sortKey="Lin, Alsa W" sort="Lin, Alsa W" uniqKey="Lin A" first="Alsa W." last="Lin">Alsa W. Lin</name></author><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name></author></analytic><series><title level="j">Chest</title><idno type="ISSN">0012-3692</idno><idno type="eISSN">1931-3543</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chest</journal-id><journal-id journal-id-type="iso-abbrev">Chest</journal-id><journal-title-group><journal-title>Chest</journal-title></journal-title-group><issn pub-type="ppub">0012-3692</issn><issn pub-type="epub">1931-3543</issn><publisher><publisher-name>The American College of Chest Physicians. Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130204</article-id><article-id pub-id-type="publisher-id">S0012-3692(16)46837-6</article-id><article-id pub-id-type="doi">10.1016/S0012-3692(16)46837-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pulmonary Function in Survivors of Severe Acute Respiratory Syndrome (SARS)</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Chan</surname><given-names>Veronica L.</given-names></name><degrees>MBChB*</degrees></contrib><contrib contrib-type="author" id="au20"><name><surname>Lam</surname><given-names>Judy Y.</given-names></name><degrees>MBBS</degrees></contrib><contrib contrib-type="author" id="au30"><name><surname>Leung</surname><given-names>Wah-Shing</given-names></name><degrees>MBChB</degrees></contrib><contrib contrib-type="author" id="au40"><name><surname>Lin</surname><given-names>Alsa W.</given-names></name><degrees>RN</degrees></contrib><contrib contrib-type="author" id="au50"><name><surname>Chu</surname><given-names>Chung-Ming</given-names></name><degrees>FCCP</degrees></contrib></contrib-group><aff id="aff1">United Christian Hospital, Kowloon, Hong Kong PRC</aff><pub-date pub-type="pmc-release"><day>29</day><month>3</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2004</year></pub-date><pub-date pub-type="epub"><day>29</day><month>3</month><year>2016</year></pub-date><volume>126</volume><issue>4</issue><fpage>858S</fpage><lpage>858S</lpage><permissions><copyright-statement>© 2004 The American College of Chest Physicians</copyright-statement><copyright-year>2004</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><sec id="cesec10"><title>Abstract</title><p id="para10"><bold>PURPOSE:</bold> Severe acute respiratory syndrome (SARS) is a newly recognized viral pneumonia caused by a novel coronavirus (SARS-CoV). It can cause diffuse alveolar damage and respiratory failure in the acute stage. It is unknown whether there is permanent impairment of pulmonary function. We aim to study whether SARS survivors have any persistent pulmonary function impairment.</p><p id="para20"><bold>METHODS:</bold> This is a prospective study of the pulmonary functions in SARS survivors. Pulmonary function tests including spirometry, diffusion capacity for carbon monoxide (DLCO) and static lung volumes were performed at 6 and 9 months after discharge for SARS. Impaired pulmonary function was defined by FVC < 80% predicted, FEV1 < 80% predicted, FEV1/FVC < 70% or DLCO < 70% predicted.</p><p id="para30"><bold>RESULTS:</bold> Sixty-three patients (22 male, 41 female, mean age 39.0 ± 11.9 years) who survived SARS during the epidemic in March 2003 were studied. At 6 months after discharge, 19 (30.2%) had impaired pulmonary function as defined above: 14 patients (22.2%) had mild impairment, 4 patients (6.4%) had moderate impairment and 1 patient (1.6%) had severe impairment. By 9 months, there were significant improvement in FVC (p=0.002), FEV1 (p=0.009) and DLCO (p<0.001); most patients (95.2%) had no respiratory impairment. Only 3 patients (4.7%) had mild impairment, and none had more severe impairment.</p><p id="para40"><bold>CONCLUSION:</bold> A significant proportion of SARS survivors had impaired pulmonary functions 6 months after discharge. However, most of them showed further improvement in follow up. No patient had moderate or severe respiratory impairment at 9 months after SARS.</p><p id="para50"><bold>CLINICAL IMPLICATIONS:</bold> Regular follow up of lung function is important in SARS survivors. Information from this study is important for the disability assessment in health care workers who contracted SARS at work.</p><p id="para60"><bold>DISCLOSURE:</bold> V.L. Chan, None.</p><p id="para70">Wednesday, October 27, 2004</p><p id="para80">12:30 PM- 2:00 PM</p></sec></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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