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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sputum cytology of patients with severe acute respiratory syndrome (SARS)</title><author><name sortKey="Tse, G M K" sort="Tse, G M K" uniqKey="Tse G" first="G M K" last="Tse">G M K. Tse</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Hui, P K" sort="Hui, P K" uniqKey="Hui P" first="P-K" last="Hui">P-K Hui</name><affiliation><nlm:aff id="aff2">Department of Pathology, Kwong Wah Hospital, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ma, T K F" sort="Ma, T K F" uniqKey="Ma T" first="T K F" last="Ma">T K F. Ma</name><affiliation><nlm:aff id="aff3">Department of Pathology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lo, A W I" sort="Lo, A W I" uniqKey="Lo A" first="A W I" last="Lo">A W I. Lo</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="To, K F" sort="To, K F" uniqKey="To K" first="K-F" last="To">K-F To</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chan, W Y" sort="Chan, W Y" uniqKey="Chan W" first="W Y" last="Chan">W Y Chan</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chow, L T C" sort="Chow, L T C" uniqKey="Chow L" first="L T C" last="Chow">L T C. Chow</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ng, H K" sort="Ng, H K" uniqKey="Ng H" first="H-K" last="Ng">H-K Ng</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">14990595</idno><idno type="pmc">1770235</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770235</idno><idno type="RBID">PMC:1770235</idno><idno type="doi">10.1136/jcp.2003.012948</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000658</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000658</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sputum cytology of patients with severe acute respiratory syndrome (SARS)</title><author><name sortKey="Tse, G M K" sort="Tse, G M K" uniqKey="Tse G" first="G M K" last="Tse">G M K. Tse</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Hui, P K" sort="Hui, P K" uniqKey="Hui P" first="P-K" last="Hui">P-K Hui</name><affiliation><nlm:aff id="aff2">Department of Pathology, Kwong Wah Hospital, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ma, T K F" sort="Ma, T K F" uniqKey="Ma T" first="T K F" last="Ma">T K F. Ma</name><affiliation><nlm:aff id="aff3">Department of Pathology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lo, A W I" sort="Lo, A W I" uniqKey="Lo A" first="A W I" last="Lo">A W I. Lo</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="To, K F" sort="To, K F" uniqKey="To K" first="K-F" last="To">K-F To</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chan, W Y" sort="Chan, W Y" uniqKey="Chan W" first="W Y" last="Chan">W Y Chan</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chow, L T C" sort="Chow, L T C" uniqKey="Chow L" first="L T C" last="Chow">L T C. Chow</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ng, H K" sort="Ng, H K" uniqKey="Ng H" first="H-K" last="Ng">H-K Ng</name><affiliation><nlm:aff id="aff1">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Pathology</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Severe acute respiratory syndrome (SARS) is a newly described form of atypical pneumonia linked to a novel coronavirus.</p><p><bold>Aims:</bold> To review the sputum cytology of 15 patients who fulfilled the World Health Organisation clinical criteria for SARS in an attempt to evaluate whether early diagnosis is feasible with routine sputum examination.</p><p><bold>Methods:</bold> All sputum samples from patients with SARS from the four major hospitals in Hong Kong were reviewed; abnormalities were sought in the cellular component, including abnormal numbers and morphology of the component cells compared with those from age matched controls taken over the same period one year ago.</p><p><bold>Results:</bold> Fifteen sputum samples from patients were compared with 25 control samples. In the patients with SARS, loose aggregates of macrophages were seen more frequently in the sputum. These macrophages frequently showed morphological changes, such as cytoplasmic foaminess, vacuole formation, and nuclear changes (including multinucleation and a ground glass appearance) when compared with the control samples.</p><p><bold>Conclusions:</bold> The cytological features of SARS are non-specific, but the observation of any of the described features should prompt further investigations, especially in patients with suspicious clinical features.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Pathol</journal-id><journal-id journal-id-type="publisher-id">jclinpath</journal-id><journal-title>Journal of Clinical Pathology</journal-title><issn pub-type="ppub">0021-9746</issn><issn pub-type="epub">1472-4146</issn><publisher><publisher-name>Copyright 2004 Journal of Clinical Pathology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">14990595</article-id><article-id pub-id-type="pmc">1770235</article-id><article-id pub-id-type="publisher-id">0570256</article-id><article-id pub-id-type="doi">10.1136/jcp.2003.012948</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Sputum cytology of patients with severe acute respiratory syndrome (SARS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tse</surname><given-names>G M K</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hui</surname><given-names>P-K</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>T K F</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lo</surname><given-names>A W I</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>To</surname><given-names>K-F</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>W Y</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chow</surname><given-names>L T C</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>H-K</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong</aff><aff id="aff2"><label>2</label>Department of Pathology, Kwong Wah Hospital, Hong Kong</aff><aff id="aff3"><label>3</label>Department of Pathology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong</aff><author-notes><fn><p>Correspondence to:
Dr G M K Tse
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Ngan Shing Street, NT, Hong Kong; <email>garytse@cuhk.edu.hk</email></p></fn></author-notes><pub-date pub-type="ppub"><month>3</month><year>2004</year></pub-date><volume>57</volume><issue>3</issue><fpage>256</fpage><lpage>259</lpage><history><date date-type="accepted"><day>7</day><month>9</month><year>2003</year></date></history><copyright-statement>Copyright © Copyright 2004 Journal of Clinical Pathology</copyright-statement><copyright-year>2004</copyright-year><abstract><p><bold>Background:</bold> Severe acute respiratory syndrome (SARS) is a newly described form of atypical pneumonia linked to a novel coronavirus.</p><p><bold>Aims:</bold> To review the sputum cytology of 15 patients who fulfilled the World Health Organisation clinical criteria for SARS in an attempt to evaluate whether early diagnosis is feasible with routine sputum examination.</p><p><bold>Methods:</bold> All sputum samples from patients with SARS from the four major hospitals in Hong Kong were reviewed; abnormalities were sought in the cellular component, including abnormal numbers and morphology of the component cells compared with those from age matched controls taken over the same period one year ago.</p><p><bold>Results:</bold> Fifteen sputum samples from patients were compared with 25 control samples. In the patients with SARS, loose aggregates of macrophages were seen more frequently in the sputum. These macrophages frequently showed morphological changes, such as cytoplasmic foaminess, vacuole formation, and nuclear changes (including multinucleation and a ground glass appearance) when compared with the control samples.</p><p><bold>Conclusions:</bold> The cytological features of SARS are non-specific, but the observation of any of the described features should prompt further investigations, especially in patients with suspicious clinical features.</p></abstract><kwd-group><kwd>severe acute respiratory syndrome</kwd><kwd>coronavirus</kwd><kwd>sputum</kwd><kwd>cytology</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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