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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging Respiratory Viruses: Challenges and Vaccine Strategies</title><author><name sortKey="Gillim Ross, Laura" sort="Gillim Ross, Laura" uniqKey="Gillim Ross L" first="Laura" last="Gillim-Ross">Laura Gillim-Ross</name><affiliation><nlm:aff id="aff0">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="aff0">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17041137</idno><idno type="pmc">1592697</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592697</idno><idno type="RBID">PMC:1592697</idno><idno type="doi">10.1128/CMR.00005-06</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000631</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emerging Respiratory Viruses: Challenges and Vaccine Strategies</title><author><name sortKey="Gillim Ross, Laura" sort="Gillim Ross, Laura" uniqKey="Gillim Ross L" first="Laura" last="Gillim-Ross">Laura Gillim-Ross</name><affiliation><nlm:aff id="aff0">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="aff0">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Microbiology Reviews</title><idno type="ISSN">0893-8512</idno><idno type="eISSN">1098-6618</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this review we describe the different approaches currently being evaluated in the development of vaccines against SARS-associated coronavirus and avian influenza viruses and also highlight the many obstacles encountered in the development of these vaccines. Lessons learned from current vaccine studies, coupled with our increasing knowledge of the host and viral factors involved in viral pathogenesis, will help to increase the speed with which efficacious vaccines targeting newly emerging viral pathogens can be developed.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Microbiol Rev</journal-id><journal-id journal-id-type="publisher-id">cmr</journal-id><journal-title>Clinical Microbiology Reviews</journal-title><issn pub-type="ppub">0893-8512</issn><issn pub-type="epub">1098-6618</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17041137</article-id><article-id pub-id-type="pmc">1592697</article-id><article-id pub-id-type="publisher-id">0005-06</article-id><article-id pub-id-type="doi">10.1128/CMR.00005-06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Emerging Respiratory Viruses: Challenges and Vaccine Strategies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gillim-Ross</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><xref ref-type="aff" rid="aff0"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff0">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: 50 South Drive, MSC 8007, Bethesda, MD 20892. Phone: (301) 451-3839. Fax: (301) 496-8312. E-mail: <email>ksubbarao@niaid.nih.gov</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2006</year></pub-date><volume>19</volume><issue>4</issue><fpage>614</fpage><lpage>636</lpage><copyright-year>2006</copyright-year><self-uri xlink:title="pdf" xlink:href="zcm00406000614.pdf"></self-uri><abstract><p>The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this review we describe the different approaches currently being evaluated in the development of vaccines against SARS-associated coronavirus and avian influenza viruses and also highlight the many obstacles encountered in the development of these vaccines. Lessons learned from current vaccine studies, coupled with our increasing knowledge of the host and viral factors involved in viral pathogenesis, will help to increase the speed with which efficacious vaccines targeting newly emerging viral pathogens can be developed.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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