Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">On the Role of Asymptomatic Infection in Transmission Dynamics of Infectious Diseases</title><author><name sortKey="Hsu, Sze Bi" sort="Hsu, Sze Bi" uniqKey="Hsu S" first="Sze-Bi" last="Hsu">Sze-Bi Hsu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38348.34</institution-id><institution-id institution-id-type="ISNI">0000000405320580</institution-id><institution>Department of Mathematics,</institution><institution>National Tsing-Hua University,</institution></institution-wrap>Hsinchu, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Ying Hen" sort="Hsieh, Ying Hen" uniqKey="Hsieh Y" first="Ying-Hen" last="Hsieh">Ying-Hen Hsieh</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.254145.3</institution-id><institution-id institution-id-type="ISNI">0000000100836092</institution-id><institution>Department of Public Health and Biostatistics Center,</institution><institution>China Medical University,</institution></institution-wrap>Taichung, Taiwan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17701259</idno><idno type="pmc">7089371</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089371</idno><idno type="RBID">PMC:7089371</idno><idno type="doi">10.1007/s11538-007-9245-6</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000332</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">On the Role of Asymptomatic Infection in Transmission Dynamics of Infectious Diseases</title><author><name sortKey="Hsu, Sze Bi" sort="Hsu, Sze Bi" uniqKey="Hsu S" first="Sze-Bi" last="Hsu">Sze-Bi Hsu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38348.34</institution-id><institution-id institution-id-type="ISNI">0000000405320580</institution-id><institution>Department of Mathematics,</institution><institution>National Tsing-Hua University,</institution></institution-wrap>Hsinchu, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Ying Hen" sort="Hsieh, Ying Hen" uniqKey="Hsieh Y" first="Ying-Hen" last="Hsieh">Ying-Hen Hsieh</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.254145.3</institution-id><institution-id institution-id-type="ISNI">0000000100836092</institution-id><institution>Department of Public Health and Biostatistics Center,</institution><institution>China Medical University,</institution></institution-wrap>Taichung, Taiwan</nlm:aff></affiliation></author></analytic><series><title level="j">Bulletin of Mathematical Biology</title><idno type="ISSN">0092-8240</idno><idno type="eISSN">1522-9602</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We propose a compartmental disease transmission model with an asymptomatic (or subclinical) infective class to study the role of asymptomatic infection in the transmission dynamics of infectious diseases with asymptomatic infectives, e.g., influenza. Analytical results are obtained using the respective ratios of susceptible, exposed (incubating), and asymptomatic classes to the clinical symptomatic infective class. Conditions are given for bistability of equilibria to occur, where trajectories with distinct initial values could result in either a major outbreak where the disease spreads to the whole population or a lesser outbreak where some members of the population remain uninfected. This dynamic behavior did not arise in a SARS model without asymptomatic infective class studied by Hsu and Hsieh (SIAM J. Appl. Math. 66(2), 627–647, <xref ref-type="bibr" rid="CR12">2006</xref>). Hence, this illustrates that depending on the initial states, control of a disease outbreak with asymptomatic infections may involve more than simply reducing the reproduction number. Moreover, the presence of asymptomatic infections could result in either a positive or negative impact on the outbreak, depending on different sets of conditions on the parameters, as illustrated with numerical simulations. Biological interpretations of the analytical and numerical results are also given.
</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arino, J" uniqKey="Arino J">J. Arino</name></author><author><name sortKey="Brauer, F" uniqKey="Brauer F">F. Brauer</name></author><author><name sortKey="Van Den Driessche, P" uniqKey="Van Den Driessche P">P. van den Driessche</name></author><author><name sortKey="Watmough, J" uniqKey="Watmough J">J. Watmough</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, D M" uniqKey="Bell D">D.M. Bell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coppell, W A" uniqKey="Coppell W">W.A. Coppell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diekmann, O" uniqKey="Diekmann O">O. Diekmann</name></author><author><name sortKey="Heesterbeek, J A P" uniqKey="Heesterbeek J">J.A.P. Heesterbeek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eccles, R" uniqKey="Eccles R">R. Eccles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S. Cauchemez</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S. Riley</name></author><author><name sortKey="Meeyai, A" uniqKey="Meeyai A">A. Meeyai</name></author><author><name sortKey="Iamsirithaworn, S" uniqKey="Iamsirithaworn S">S. Iamsirithaworn</name></author><author><name sortKey="Burke, D S" uniqKey="Burke D">D.S. Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name></author><author><name sortKey="Cajka, J C" uniqKey="Cajka J">J.C. Cajka</name></author><author><name sortKey="Cooley, P C" uniqKey="Cooley P">P.C. Cooley</name></author><author><name sortKey="Burke, D S" uniqKey="Burke D">D.S. Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Germann, T C" uniqKey="Germann T">T.C. Germann</name></author><author><name sortKey="Kadau, K" uniqKey="Kadau K">K. Kadau</name></author><author><name sortKey="Longini, I M" uniqKey="Longini I">I.M. Longini</name></author><author><name sortKey="Macken, C A" uniqKey="Macken C">C.A. Macken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graat, J M" uniqKey="Graat J">J.M. Graat</name></author><author><name sortKey="Schouten, E G" uniqKey="Schouten E">E.G. Schouten</name></author><author><name sortKey="Heijnen, M L" uniqKey="Heijnen M">M.L. Heijnen</name></author><author><name sortKey="Kok, F J" uniqKey="Kok F">F.J. Kok</name></author><author><name sortKey="Pallast, E G" uniqKey="Pallast E">E.G. Pallast</name></author><author><name sortKey="De Greeff, S C" uniqKey="De Greeff S">S.C. de Greeff</name></author><author><name sortKey="Dorigo Zetsma, J W" uniqKey="Dorigo Zetsma J">J.W. Dorigo-Zetsma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsieh, Y H" uniqKey="Hsieh Y">Y.-H. Hsieh</name></author><author><name sortKey="Van Den Driessche, P" uniqKey="Van Den Driessche P">P. van den Driessche</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, S B" uniqKey="Hsu S">S.B. Hsu</name></author><author><name sortKey="Hsieh, Y H" uniqKey="Hsieh Y">Y.-H. Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longini, I M" uniqKey="Longini I">I.M. Longini</name></author><author><name sortKey="Halloran, M E" uniqKey="Halloran M">M.E. Halloran</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A. Nizam</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longini, I M" uniqKey="Longini I">I.M. Longini</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A. Nizam</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S. Xu</name></author><author><name sortKey="Ungchusak, K" uniqKey="Ungchusak K">K. Ungchusak</name></author><author><name sortKey="Hanshaoworakul, W" uniqKey="Hanshaoworakul W">W. Hanshaoworakul</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, A S" uniqKey="Monto A">A.S. Monto</name></author><author><name sortKey="Gunn, R A" uniqKey="Gunn R">R.A. Gunn</name></author><author><name sortKey="Bandyk, M G" uniqKey="Bandyk M">M.G. Bandyk</name></author><author><name sortKey="King, C L" uniqKey="King C">C.L. King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nafta, I" uniqKey="Nafta I">I. Nafta</name></author><author><name sortKey="Turcanu, A G" uniqKey="Turcanu A">A.G. Turcanu</name></author><author><name sortKey="Braun, I" uniqKey="Braun I">I. Braun</name></author><author><name sortKey="Companetz, W" uniqKey="Companetz W">W. Companetz</name></author><author><name sortKey="Simionescu, A" uniqKey="Simionescu A">A. Simionescu</name></author><author><name sortKey="Birt, E" uniqKey="Birt E">E. Birt</name></author><author><name sortKey="Florea, V" uniqKey="Florea V">V. Florea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oker Blom, N" uniqKey="Oker Blom N">N. Oker-Blom</name></author><author><name sortKey="Hovi, T" uniqKey="Hovi T">T. Hovi</name></author><author><name sortKey="Leinikki, P" uniqKey="Leinikki P">P. Leinikki</name></author><author><name sortKey="Palosuo, T" uniqKey="Palosuo T">T. Palosuo</name></author><author><name sortKey="Pettersson, R" uniqKey="Pettersson R">R. Pettersson</name></author><author><name sortKey="Suni, J" uniqKey="Suni J">J. Suni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pettersson, R F" uniqKey="Pettersson R">R.F. Pettersson</name></author><author><name sortKey="Hellstrom, P E" uniqKey="Hellstrom P">P.E. Hellstrom</name></author><author><name sortKey="Penttinen, K" uniqKey="Penttinen K">K. Penttinen</name></author><author><name sortKey="Pyhala, R" uniqKey="Pyhala R">R. Pyhala</name></author><author><name sortKey="Tokola, O" uniqKey="Tokola O">O. Tokola</name></author><author><name sortKey="Vartio, T" uniqKey="Vartio T">T. Vartio</name></author><author><name sortKey="Visakorpi, R" uniqKey="Visakorpi R">R. Visakorpi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quarles, J M" uniqKey="Quarles J">J.M. Quarles</name></author><author><name sortKey="Couch, R B" uniqKey="Couch R">R.B. Couch</name></author><author><name sortKey="Cate, T R" uniqKey="Cate T">T.R. Cate</name></author><author><name sortKey="Goswick, C B" uniqKey="Goswick C">C.B. Goswick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stilianakis, N I" uniqKey="Stilianakis N">N.I. Stilianakis</name></author><author><name sortKey="Perelson, A S" uniqKey="Perelson A">A.S. Perelson</name></author><author><name sortKey="Hayden, F G" uniqKey="Hayden F">F.G. Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, R G" uniqKey="Webster R">R.G. Webster</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Bull Math Biol</journal-id><journal-id journal-id-type="iso-abbrev">Bull. Math. Biol</journal-id><journal-title-group><journal-title>Bulletin of Mathematical Biology</journal-title></journal-title-group><issn pub-type="ppub">0092-8240</issn><issn pub-type="epub">1522-9602</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17701259</article-id><article-id pub-id-type="pmc">7089371</article-id><article-id pub-id-type="publisher-id">9245</article-id><article-id pub-id-type="doi">10.1007/s11538-007-9245-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>On the Role of Asymptomatic Infection in Transmission Dynamics of Infectious Diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Sze-Bi</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Hsieh</surname><given-names>Ying-Hen</given-names></name><address><phone>886-4-24713907</phone><fax>886-4-24713907</fax><email>hsieh@amath.nchu.edu.tw</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.38348.34</institution-id><institution-id institution-id-type="ISNI">0000000405320580</institution-id><institution>Department of Mathematics,</institution><institution>National Tsing-Hua University,</institution></institution-wrap>Hsinchu, Taiwan</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.254145.3</institution-id><institution-id institution-id-type="ISNI">0000000100836092</institution-id><institution>Department of Public Health and Biostatistics Center,</institution><institution>China Medical University,</institution></institution-wrap>Taichung, Taiwan</aff></contrib-group><pub-date pub-type="epub"><day>15</day><month>8</month><year>2007</year></pub-date><pub-date pub-type="ppub"><year>2008</year></pub-date><volume>70</volume><issue>1</issue><fpage>134</fpage><lpage>155</lpage><history><date date-type="received"><day>9</day><month>10</month><year>2006</year></date><date date-type="accepted"><day>24</day><month>5</month><year>2007</year></date></history><permissions><copyright-statement>© Society for Mathematical Biology 2007</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>We propose a compartmental disease transmission model with an asymptomatic (or subclinical) infective class to study the role of asymptomatic infection in the transmission dynamics of infectious diseases with asymptomatic infectives, e.g., influenza. Analytical results are obtained using the respective ratios of susceptible, exposed (incubating), and asymptomatic classes to the clinical symptomatic infective class. Conditions are given for bistability of equilibria to occur, where trajectories with distinct initial values could result in either a major outbreak where the disease spreads to the whole population or a lesser outbreak where some members of the population remain uninfected. This dynamic behavior did not arise in a SARS model without asymptomatic infective class studied by Hsu and Hsieh (SIAM J. Appl. Math. 66(2), 627–647, <xref ref-type="bibr" rid="CR12">2006</xref>). Hence, this illustrates that depending on the initial states, control of a disease outbreak with asymptomatic infections may involve more than simply reducing the reproduction number. Moreover, the presence of asymptomatic infections could result in either a positive or negative impact on the outbreak, depending on different sets of conditions on the parameters, as illustrated with numerical simulations. Biological interpretations of the analytical and numerical results are also given.
</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Influenza</kwd><kwd>Asymptomatic infection</kwd><kwd>Basic reproduction number</kwd><kwd>Bistability</kwd><kwd>Threshold asymptomatic fraction</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Society for Mathematical Biology 2008</meta-value></custom-meta></custom-meta-group></article-meta></front><back><ref-list id="Bib1"><title>References</title><ref id="CR1"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arino</surname><given-names>J.</given-names></name><name><surname>Brauer</surname><given-names>F.</given-names></name><name><surname>van den Driessche</surname><given-names>P.</given-names></name><name><surname>Watmough</surname><given-names>J.</given-names></name><name><surname>Wu</surname><given-names>J.</given-names></name></person-group><article-title>Simple models for containment of a pandemic</article-title><source>J. R. Soc. Interface</source><year>2006</year><volume>3</volume><fpage>453</fpage><lpage>457</lpage><pub-id pub-id-type="doi">10.1098/rsif.2006.0112</pub-id><pub-id pub-id-type="pmid">16849273</pub-id></element-citation></ref><ref id="CR2"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bell</surname><given-names>D.M.</given-names></name><collab>World Health Organization Writing Group</collab></person-group><article-title>Nonpharmaceutical interventions for pandemic influenza, international measures</article-title><source>Emerg. Infect. Dis.</source><year>2006</year><volume>12</volume><issue>1</issue><fpage>81</fpage><lpage>87</lpage><pub-id pub-id-type="pmid">16494722</pub-id></element-citation></ref><ref id="CR3"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>P.K.</given-names></name></person-group><article-title>Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997</article-title><source>Clin. Infect. Dis.</source><year>2002</year><volume>34</volume><issue>Suppl. 2</issue><fpage>S58</fpage><lpage>S64</lpage><pub-id pub-id-type="doi">10.1086/338820</pub-id><pub-id pub-id-type="pmid">11938498</pub-id></element-citation></ref><ref id="CR4"><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Coppell</surname><given-names>W.A.</given-names></name></person-group><source>Stability and Asymptotic Behavior of Solutions of Differential Equations</source><year>1965</year><publisher-loc>Boston</publisher-loc><publisher-name>Heath</publisher-name></element-citation></ref><ref id="CR5"><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Diekmann</surname><given-names>O.</given-names></name><name><surname>Heesterbeek</surname><given-names>J.A.P.</given-names></name></person-group><source>Mathematical Epidemiology of Infectious Diseases: Model Building, Analysis and Interpretation</source><year>2000</year><publisher-loc>New York</publisher-loc><publisher-name>Wiley</publisher-name></element-citation></ref><ref id="CR6"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eccles</surname><given-names>R.</given-names></name></person-group><article-title>Asymptomatic spread of flu is not proved</article-title><source>Br. Med. J.</source><year>2005</year><volume>331</volume><issue>7525</issue><fpage>1145</fpage><pub-id pub-id-type="doi">10.1136/bmj.331.7525.1145</pub-id></element-citation></ref><ref id="CR7"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferguson</surname><given-names>N.M.</given-names></name><name><surname>Cummings</surname><given-names>D.A.</given-names></name><name><surname>Cauchemez</surname><given-names>S.</given-names></name><name><surname>Fraser</surname><given-names>C.</given-names></name><name><surname>Riley</surname><given-names>S.</given-names></name><name><surname>Meeyai</surname><given-names>A.</given-names></name><name><surname>Iamsirithaworn</surname><given-names>S.</given-names></name><name><surname>Burke</surname><given-names>D.S.</given-names></name></person-group><article-title>Strategies for containing an emerging influenza pandemic in Southeast Asia</article-title><source>Nature</source><year>2005</year><volume>437</volume><fpage>209</fpage><lpage>214</lpage><pub-id pub-id-type="doi">10.1038/nature04017</pub-id><pub-id pub-id-type="pmid">16079797</pub-id></element-citation></ref><ref id="CR8"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferguson</surname><given-names>N.M.</given-names></name><name><surname>Cummings</surname><given-names>D.A.</given-names></name><name><surname>Fraser</surname><given-names>C.</given-names></name><name><surname>Cajka</surname><given-names>J.C.</given-names></name><name><surname>Cooley</surname><given-names>P.C.</given-names></name><name><surname>Burke</surname><given-names>D.S.</given-names></name></person-group><article-title>Strategies for mitigating an influenza pandemic</article-title><source>Proc. Natl. Acad. Sci. U.S.A.</source><year>2006</year><volume>103</volume><issue>15</issue><fpage>5935</fpage><lpage>5940</lpage><pub-id pub-id-type="doi">10.1073/pnas.0601266103</pub-id><pub-id pub-id-type="pmid">16585506</pub-id></element-citation></ref><ref id="CR9"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Germann</surname><given-names>T.C.</given-names></name><name><surname>Kadau</surname><given-names>K.</given-names></name><name><surname>Longini</surname><given-names>I.M.</given-names><suffix>Jr.</suffix></name><name><surname>Macken</surname><given-names>C.A.</given-names></name></person-group><article-title>Mitigation strategies for pandemic influenza in the United States</article-title><source>Proc. Natl. Acad. Sci. U.S.A.</source><year>2006</year><volume>103</volume><fpage>5935</fpage><lpage>5940</lpage><pub-id pub-id-type="doi">10.1073/pnas.0601266103</pub-id><pub-id pub-id-type="pmid">16585506</pub-id></element-citation></ref><ref id="CR10"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Graat</surname><given-names>J.M.</given-names></name><name><surname>Schouten</surname><given-names>E.G.</given-names></name><name><surname>Heijnen</surname><given-names>M.L.</given-names></name><name><surname>Kok</surname><given-names>F.J.</given-names></name><name><surname>Pallast</surname><given-names>E.G.</given-names></name><name><surname>de Greeff</surname><given-names>S.C.</given-names></name><name><surname>Dorigo-Zetsma</surname><given-names>J.W.</given-names></name></person-group><article-title>A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection</article-title><source>J. Clin. Epidemiol.</source><year>2003</year><volume>56</volume><issue>12</issue><fpage>1218</fpage><lpage>1223</lpage><pub-id pub-id-type="doi">10.1016/S0895-4356(03)00171-9</pub-id><pub-id pub-id-type="pmid">14680673</pub-id></element-citation></ref><ref id="CR11"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hsieh</surname><given-names>Y.-H.</given-names></name><name><surname>van den Driessche</surname><given-names>P.</given-names></name><name><surname>Wang</surname><given-names>L.</given-names></name></person-group><article-title>A multi-patch model for spatial spread of disease: impact of travel between patches</article-title><source>Bull. Math. Biol.</source><year>2007</year><volume>69</volume><issue>4</issue><fpage>1355</fpage><lpage>1375</lpage><pub-id pub-id-type="doi">10.1007/s11538-006-9169-6</pub-id><pub-id pub-id-type="pmid">17318677</pub-id></element-citation></ref><ref id="CR12"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hsu</surname><given-names>S.B.</given-names></name><name><surname>Hsieh</surname><given-names>Y.-H.</given-names></name></person-group><article-title>Modeling intervention measures and public response during SARS outbreak</article-title><source>SIAM J. Appl. Math.</source><year>2006</year><volume>66</volume><issue>2</issue><fpage>627</fpage><lpage>647</lpage><pub-id pub-id-type="doi">10.1137/040615547</pub-id></element-citation></ref><ref id="CR13"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Longini</surname><given-names>I.M.</given-names></name><name><surname>Halloran</surname><given-names>M.E.</given-names></name><name><surname>Nizam</surname><given-names>A.</given-names></name><name><surname>Yang</surname><given-names>Y.</given-names></name></person-group><article-title>Containing pandemic influenza with antiviral agents</article-title><source>Am. J. Epidemiol.</source><year>2004</year><volume>159</volume><fpage>623</fpage><lpage>633</lpage><pub-id pub-id-type="doi">10.1093/aje/kwh092</pub-id><pub-id pub-id-type="pmid">15033640</pub-id></element-citation></ref><ref id="CR14"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Longini</surname><given-names>I.M.</given-names></name><name><surname>Nizam</surname><given-names>A.</given-names></name><name><surname>Xu</surname><given-names>S.</given-names></name><name><surname>Ungchusak</surname><given-names>K.</given-names></name><name><surname>Hanshaoworakul</surname><given-names>W.</given-names></name><name><surname>Cummings</surname><given-names>D.A.</given-names></name><etal></etal></person-group><article-title>Containing pandemic influenza at the source</article-title><source>Science</source><year>2005</year><volume>309</volume><fpage>1083</fpage><lpage>1087</lpage><pub-id pub-id-type="doi">10.1126/science.1115717</pub-id><pub-id pub-id-type="pmid">16079251</pub-id></element-citation></ref><ref id="CR15"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Monto</surname><given-names>A.S.</given-names></name><name><surname>Gunn</surname><given-names>R.A.</given-names></name><name><surname>Bandyk</surname><given-names>M.G.</given-names></name><name><surname>King</surname><given-names>C.L.</given-names></name></person-group><article-title>Prevention of Russian influenza by amantadine</article-title><source>J. Am. Med. Assoc.</source><year>1979</year><volume>241</volume><fpage>1003</fpage><lpage>1007</lpage><pub-id pub-id-type="doi">10.1001/jama.241.10.1003</pub-id></element-citation></ref><ref id="CR16"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nafta</surname><given-names>I.</given-names></name><name><surname>Turcanu</surname><given-names>A.G.</given-names></name><name><surname>Braun</surname><given-names>I.</given-names></name><name><surname>Companetz</surname><given-names>W.</given-names></name><name><surname>Simionescu</surname><given-names>A.</given-names></name><name><surname>Birt</surname><given-names>E.</given-names></name><name><surname>Florea</surname><given-names>V.</given-names></name></person-group><article-title>Administration of amantadine for the prevention of Hong Kong influenza</article-title><source>Bull. World Health. Organ.</source><year>1970</year><volume>42</volume><fpage>423</fpage><lpage>427</lpage><pub-id pub-id-type="pmid">5310209</pub-id></element-citation></ref><ref id="CR17"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oker-Blom</surname><given-names>N.</given-names></name><name><surname>Hovi</surname><given-names>T.</given-names></name><name><surname>Leinikki</surname><given-names>P.</given-names></name><name><surname>Palosuo</surname><given-names>T.</given-names></name><name><surname>Pettersson</surname><given-names>R.</given-names></name><name><surname>Suni</surname><given-names>J.</given-names></name></person-group><article-title>Protection of man from natural infection with influenza A2 Hong Kong virus by amantadine: a controlled field trial</article-title><source>Br. Med. J.</source><year>1970</year><volume>3</volume><fpage>676</fpage><lpage>678</lpage><pub-id pub-id-type="doi">10.1136/bmj.3.5724.676</pub-id><pub-id pub-id-type="pmid">4919024</pub-id></element-citation></ref><ref id="CR18"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pettersson</surname><given-names>R.F.</given-names></name><name><surname>Hellstrom</surname><given-names>P.E.</given-names></name><name><surname>Penttinen</surname><given-names>K.</given-names></name><name><surname>Pyhala</surname><given-names>R.</given-names></name><name><surname>Tokola</surname><given-names>O.</given-names></name><name><surname>Vartio</surname><given-names>T.</given-names></name><name><surname>Visakorpi</surname><given-names>R.</given-names></name></person-group><article-title>Evaluation of amantadine in the prophylaxis of influenza A (H1N1) virus infection: a controlled field trial among young adults and high-risk patients</article-title><source>J. Infect. Dis.</source><year>1980</year><volume>142</volume><fpage>377</fpage><lpage>383</lpage><pub-id pub-id-type="pmid">7003032</pub-id></element-citation></ref><ref id="CR19"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Quarles</surname><given-names>J.M.</given-names></name><name><surname>Couch</surname><given-names>R.B.</given-names></name><name><surname>Cate</surname><given-names>T.R.</given-names></name><name><surname>Goswick</surname><given-names>C.B.</given-names></name></person-group><article-title>Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza</article-title><source>Antiviral. Res.</source><year>1981</year><volume>1</volume><fpage>149</fpage><lpage>155</lpage><pub-id pub-id-type="doi">10.1016/0166-3542(81)90003-6</pub-id><pub-id pub-id-type="pmid">7337431</pub-id></element-citation></ref><ref id="CR20"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stilianakis</surname><given-names>N.I.</given-names></name><name><surname>Perelson</surname><given-names>A.S.</given-names></name><name><surname>Hayden</surname><given-names>F.G.</given-names></name></person-group><article-title>Emergence of drug resistance during an influenza epidemic: insights from a mathematical model</article-title><source>J. Infect. Dis.</source><year>1998</year><volume>177</volume><issue>4</issue><fpage>863</fpage><lpage>873</lpage><pub-id pub-id-type="pmid">9534957</pub-id></element-citation></ref><ref id="CR21"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Webster</surname><given-names>R.G.</given-names></name></person-group><article-title>Wet markets—a continuing source of severe acute respiratory syndrome and influenza?</article-title><source>Lancet</source><year>2004</year><volume>363</volume><issue>9404</issue><fpage>234</fpage><lpage>236</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(03)15329-9</pub-id><pub-id pub-id-type="pmid">14738798</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0003320 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0003320 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |