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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changing epidemiological patterns of HIV and AIDS in China in the post-SARS era identified by the nationwide surveillance system</title><author><name sortKey="Liu, Zhenqiu" sort="Liu, Zhenqiu" uniqKey="Liu Z" first="Zhenqiu" last="Liu">Zhenqiu Liu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 5341</institution-id><institution-id institution-id-type="GRID">grid.452350.5</institution-id><institution>Fudan University Taizhou Institute of Health Sciences,</institution></institution-wrap>Taizhou, China</nlm:aff></affiliation></author><author><name sortKey="Shi, Oumin" sort="Shi, Oumin" uniqKey="Shi O" first="Oumin" last="Shi">Oumin Shi</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.452847.8</institution-id><institution>Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University,</institution></institution-wrap>Shenzhen, China</nlm:aff></affiliation></author><author><name sortKey="Yan, Qiong" sort="Yan, Qiong" uniqKey="Yan Q" first="Qiong" last="Yan">Qiong Yan</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Child and Maternal Health, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Fang, Qiwen" sort="Fang, Qiwen" uniqKey="Fang Q" first="Qiwen" last="Fang">Qiwen Fang</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Zuo, Jialu" sort="Zuo, Jialu" uniqKey="Zuo J" first="Jialu" last="Zuo">Jialu Zuo</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yue" sort="Chen, Yue" uniqKey="Chen Y" first="Yue" last="Chen">Yue Chen</name><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2182 2255</institution-id><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>School of Epidemiology and Public Health Faculty of Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Canada</nlm:aff></affiliation></author><author><name sortKey="Chen, Xingdong" sort="Chen, Xingdong" uniqKey="Chen X" first="Xingdong" last="Chen">Xingdong Chen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 5341</institution-id><institution-id institution-id-type="GRID">grid.452350.5</institution-id><institution>Fudan University Taizhou Institute of Health Sciences,</institution></institution-wrap>Taizhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Human Phenome Institute, Fudan University,</institution></institution-wrap>825 Zhangheng Road, Shanghai, 201203 China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Tiejun" sort="Zhang, Tiejun" uniqKey="Zhang T" first="Tiejun" last="Zhang">Tiejun Zhang</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30587142</idno><idno type="pmc">6307199</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307199</idno><idno type="RBID">PMC:6307199</idno><idno type="doi">10.1186/s12879-018-3551-5</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000306</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Changing epidemiological patterns of HIV and AIDS in China in the post-SARS era identified by the nationwide surveillance system</title><author><name sortKey="Liu, Zhenqiu" sort="Liu, Zhenqiu" uniqKey="Liu Z" first="Zhenqiu" last="Liu">Zhenqiu Liu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 5341</institution-id><institution-id institution-id-type="GRID">grid.452350.5</institution-id><institution>Fudan University Taizhou Institute of Health Sciences,</institution></institution-wrap>Taizhou, China</nlm:aff></affiliation></author><author><name sortKey="Shi, Oumin" sort="Shi, Oumin" uniqKey="Shi O" first="Oumin" last="Shi">Oumin Shi</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.452847.8</institution-id><institution>Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University,</institution></institution-wrap>Shenzhen, China</nlm:aff></affiliation></author><author><name sortKey="Yan, Qiong" sort="Yan, Qiong" uniqKey="Yan Q" first="Qiong" last="Yan">Qiong Yan</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Child and Maternal Health, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Fang, Qiwen" sort="Fang, Qiwen" uniqKey="Fang Q" first="Qiwen" last="Fang">Qiwen Fang</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Zuo, Jialu" sort="Zuo, Jialu" uniqKey="Zuo J" first="Jialu" last="Zuo">Jialu Zuo</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yue" sort="Chen, Yue" uniqKey="Chen Y" first="Yue" last="Chen">Yue Chen</name><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2182 2255</institution-id><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>School of Epidemiology and Public Health Faculty of Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Canada</nlm:aff></affiliation></author><author><name sortKey="Chen, Xingdong" sort="Chen, Xingdong" uniqKey="Chen X" first="Xingdong" last="Chen">Xingdong Chen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 5341</institution-id><institution-id institution-id-type="GRID">grid.452350.5</institution-id><institution>Fudan University Taizhou Institute of Health Sciences,</institution></institution-wrap>Taizhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Human Phenome Institute, Fudan University,</institution></institution-wrap>825 Zhangheng Road, Shanghai, 201203 China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Tiejun" sort="Zhang, Tiejun" uniqKey="Zhang T" first="Tiejun" last="Zhang">Tiejun Zhang</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">China has made substantial progress in tackling its HIV and AIDS epidemic. But the changing patterns of HIV and AIDS incidence based on the longitudinal observation data were rarely studied.</p></sec><sec><title>Methods</title><p id="Par2">The reporting incidence (RI) and mortality data on HIV and AIDS in China covering 31 provinces from 2004 to 2014 were collected from the Chinese Public Health Science Data Center. To decompose the time-series data, Empirical Mode Decomposition (EMD) was applied to properly describe the trends of HIV and AIDS incidence. A mathematical model was used to estimate the relative change of incidence among provinces and age groups.</p></sec><sec><title>Results</title><p id="Par3">A total of 483,010 newly HIV infections and 214,205 AIDS cases were reported between 2004 and 2014 nationwide. HIV infection increased from 13,258 in 2004 (RI 1.02 per 100,000 person years) to 74,048 in 2014 (RI 5.46 per 100,000). The number of AIDS cases increased from 3054 in 2004 (RI 0.23 per 100,000) to 45,145 in 2014 (RI 3.33 per 100,000). The overall relative changes for HIV infection and AIDS incidence were 1.11 (95% confidence interval [CI] 1.10–1.13) and 1.28 (95% CI 1.23–1.33), respectively. The relative increase for HIV and AIDS RI was higher in northwest provinces while lower in Henan, Xinjiang, Guangxi and Yunnan. The overall relative changes for HIV infection were 1.12 (95% CI 1.11–1.14) in males and 1.10 (95% CI 1.06–1.13) in females. For AIDS RI, the relative increases were 1.31 (95% CI 1.26–1.36) in males and 1.22 (95% CI 1.17–1.28) in females. The lowest relative increase was detected among young adults, while the largest relative increase (odds ratio [OR] > 1.30) was detected in people aged 55 years or above.</p></sec><sec><title>Conclusions</title><p id="Par4">HIV and AIDS showed an increasing trend in China from 2004 to 2014, respectively, but the epidemic tended to be under control among provinces and young people that used to have a high HIV and AIDS incidence. Northwest China and older people could be new “hop-spots” for HIV and AIDS risk.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Sullivan, Sg" uniqKey="Sullivan S">SG Sullivan</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Rotheram Borus, Mj" uniqKey="Rotheram Borus M">MJ Rotheram-Borus</name></author><author><name sortKey="Detels, R" uniqKey="Detels R">R Detels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Mb" uniqKey="Huang M">MB Huang</name></author><author><name sortKey="Ye, L" uniqKey="Ye L">L Ye</name></author><author><name sortKey="Liang, By" uniqKey="Liang B">BY Liang</name></author><author><name sortKey="Ning, Cy" uniqKey="Ning C">CY Ning</name></author><author><name sortKey="Roth, Ww" uniqKey="Roth W">WW Roth</name></author><author><name sortKey="Jiang, Jj" uniqKey="Jiang J">JJ Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, N" uniqKey="He N">N He</name></author><author><name sortKey="Detels, R" uniqKey="Detels R">R Detels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Lu, F" uniqKey="Lu F">F Lu</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Poundstone, K" uniqKey="Poundstone K">K Poundstone</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Xu, P" uniqKey="Xu P">P Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mao, Y" uniqKey="Mao Y">Y Mao</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Poundstone, K" uniqKey="Poundstone K">K Poundstone</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Qin, Q" uniqKey="Qin Q">Q Qin</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Chin, Dp" uniqKey="Chin D">DP Chin</name></author><author><name sortKey="Koplan, Jp" uniqKey="Koplan J">JP Koplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ne" uniqKey="Huang N">NE Huang</name></author><author><name sortKey="Hu, K" uniqKey="Hu K">K Hu</name></author><author><name sortKey="Yang, Ac" uniqKey="Yang A">AC Yang</name></author><author><name sortKey="Chang, Hc" uniqKey="Chang H">HC Chang</name></author><author><name sortKey="Jia, D" uniqKey="Jia D">D Jia</name></author><author><name sortKey="Liang, Wk" uniqKey="Liang W">WK Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Jx" uniqKey="Huang J">JX Huang</name></author><author><name sortKey="Xia, Zg" uniqKey="Xia Z">ZG Xia</name></author><author><name sortKey="Zhou, Ss" uniqKey="Zhou S">SS Zhou</name></author><author><name sortKey="Pu, Xj" uniqKey="Pu X">XJ Pu</name></author><author><name sortKey="Hu, Mg" uniqKey="Hu M">MG Hu</name></author><author><name sortKey="Huang, Dc" uniqKey="Huang D">DC Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ott, Jj" uniqKey="Ott J">JJ Ott</name></author><author><name sortKey="Horn, J" uniqKey="Horn J">J Horn</name></author><author><name sortKey="Krause, G" uniqKey="Krause G">G Krause</name></author><author><name sortKey="Mikolajczyk, Rt" uniqKey="Mikolajczyk R">RT Mikolajczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clegg, Lx" uniqKey="Clegg L">LX Clegg</name></author><author><name sortKey="Hankey, Bf" uniqKey="Hankey B">BF Hankey</name></author><author><name sortKey="Tiwari, R" uniqKey="Tiwari R">R Tiwari</name></author><author><name sortKey="Feuer, Ej" uniqKey="Feuer E">EJ Feuer</name></author><author><name sortKey="Edwards, Bk" uniqKey="Edwards B">BK Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, B" uniqKey="Shao B">B Shao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Yu, L" uniqKey="Yu L">L Yu</name></author><author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name></author><author><name sortKey="Chang, M" uniqKey="Chang M">M Chang</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Es" uniqKey="Yu E">ES Yu</name></author><author><name sortKey="Xie, Q" uniqKey="Xie Q">Q Xie</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name></author><author><name sortKey="Chan, Ll" uniqKey="Chan L">LL Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Chow, Ep" uniqKey="Chow E">EP Chow</name></author><author><name sortKey="Jing, J" uniqKey="Jing J">J Jing</name></author><author><name sortKey="Zhuang, X" uniqKey="Zhuang X">X Zhuang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="He, M" uniqKey="He M">M He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, Zc" uniqKey="Dai Z">ZC Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, S" uniqKey="Qian S">S Qian</name></author><author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name></author><author><name sortKey="Xing, J" uniqKey="Xing J">J Xing</name></author><author><name sortKey="Qin, Q" uniqKey="Qin Q">Q Qin</name></author><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name></author><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name></author><author><name sortKey="Mcgoogan, Jm" uniqKey="Mcgoogan J">JM McGoogan</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Rou, K" uniqKey="Rou K">K Rou</name></author><author><name sortKey="Cui, H" uniqKey="Cui H">H Cui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Dou, Z" uniqKey="Dou Z">Z Dou</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, H" uniqKey="Yi H">H Yi</name></author><author><name sortKey="Lau, Jt" uniqKey="Lau J">JT Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, D" uniqKey="Yin D">D Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Sun, G" uniqKey="Sun G">G Sun</name></author><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, Y" uniqKey="Zeng Y">Y Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Li, Jz" uniqKey="Li J">JZ Li</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name></author><author><name sortKey="Abdullah, As" uniqKey="Abdullah A">AS Abdullah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, By" uniqKey="Zhu B">BY Zhu</name></author><author><name sortKey="Bu, J" uniqKey="Bu J">J Bu</name></author><author><name sortKey="Huang, Py" uniqKey="Huang P">PY Huang</name></author><author><name sortKey="Zhou, Zg" uniqKey="Zhou Z">ZG Zhou</name></author><author><name sortKey="Yin, Yp" uniqKey="Yin Y">YP Yin</name></author><author><name sortKey="Chen, Xs" uniqKey="Chen X">XS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longo, B" uniqKey="Longo B">B Longo</name></author><author><name sortKey="Camoni, L" uniqKey="Camoni L">L Camoni</name></author><author><name sortKey="Boros, S" uniqKey="Boros S">S Boros</name></author><author><name sortKey="Suligoi, B" uniqKey="Suligoi B">B Suligoi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Negin, J" uniqKey="Negin J">J Negin</name></author><author><name sortKey="Cumming, Rg" uniqKey="Cumming R">RG Cumming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, J" uniqKey="Xing J">J Xing</name></author><author><name sortKey="Li, Yg" uniqKey="Li Y">YG Li</name></author><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name></author><author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name></author><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name></author><author><name sortKey="Ding, G" uniqKey="Ding G">G Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name></author><author><name sortKey="Bu, K" uniqKey="Bu K">K Bu</name></author><author><name sortKey="Mahapatra, T" uniqKey="Mahapatra T">T Mahapatra</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author><author><name sortKey="Ortblad, Kf" uniqKey="Ortblad K">KF Ortblad</name></author><author><name sortKey="Guinovart, C" uniqKey="Guinovart C">C Guinovart</name></author><author><name sortKey="Lim, Ss" uniqKey="Lim S">SS Lim</name></author><author><name sortKey="Wolock, Tm" uniqKey="Wolock T">TM Wolock</name></author><author><name sortKey="Roberts, Da" uniqKey="Roberts D">DA Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortblad, Kf" uniqKey="Ortblad K">KF Ortblad</name></author><author><name sortKey="Lozano, R" uniqKey="Lozano R">R Lozano</name></author><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavoschi, L" uniqKey="Tavoschi L">L Tavoschi</name></author><author><name sortKey="Gomes Dias, J" uniqKey="Gomes Dias J">J Gomes Dias</name></author><author><name sortKey="Pharris, A" uniqKey="Pharris A">A Pharris</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30587142</article-id><article-id pub-id-type="pmc">6307199</article-id><article-id pub-id-type="publisher-id">3551</article-id><article-id pub-id-type="doi">10.1186/s12879-018-3551-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Changing epidemiological patterns of HIV and AIDS in China in the post-SARS era identified by the nationwide surveillance system</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Zhenqiu</given-names></name><address><email>zhenqiuliu@outlook.com</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Oumin</given-names></name><address><email>shioumin@sina.com</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Yan</surname><given-names>Qiong</given-names></name><address><email>16211020068@fudan.edu.cn</email></address><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Fang</surname><given-names>Qiwen</given-names></name><address><email>16211020001@fudan.edu.cn</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zuo</surname><given-names>Jialu</given-names></name><address><email>jialuzuo@126.com</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yue</given-names></name><address><email>Yue.Chen@uottawa.ca</email></address><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Chen</surname><given-names>Xingdong</given-names></name><address><email>xingdongchen@fudan.edu.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff8">8</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5244-6894</contrib-id><name><surname>Zhang</surname><given-names>Tiejun</given-names></name><address><phone>+86-21-54237410</phone><email>tjzhang@shmu.edu.cn</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Epidemiology, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 313X</institution-id><institution-id institution-id-type="GRID">grid.419897.a</institution-id><institution>Key Laboratory of Public Health Safety (Fudan University), Ministry of Education,</institution></institution-wrap>Shanghai, China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 5341</institution-id><institution-id institution-id-type="GRID">grid.452350.5</institution-id><institution>Fudan University Taizhou Institute of Health Sciences,</institution></institution-wrap>Taizhou, China</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.452847.8</institution-id><institution>Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University,</institution></institution-wrap>Shenzhen, China</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Department of Child and Maternal Health, School of Public Health,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, China</aff><aff id="Aff7"><label>7</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2182 2255</institution-id><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>School of Epidemiology and Public Health Faculty of Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Canada</aff><aff id="Aff8"><label>8</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Human Phenome Institute, Fudan University,</institution></institution-wrap>825 Zhangheng Road, Shanghai, 201203 China</aff></contrib-group><pub-date pub-type="epub"><day>27</day><month>12</month><year>2018</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>12</month><year>2018</year></pub-date><pub-date pub-type="collection"><year>2018</year></pub-date><volume>18</volume><elocation-id>700</elocation-id><history><date date-type="received"><day>18</day><month>10</month><year>2017</year></date><date date-type="accepted"><day>23</day><month>11</month><year>2018</year></date></history><permissions><copyright-statement>© The Author(s). 2018</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">China has made substantial progress in tackling its HIV and AIDS epidemic. But the changing patterns of HIV and AIDS incidence based on the longitudinal observation data were rarely studied.</p></sec><sec><title>Methods</title><p id="Par2">The reporting incidence (RI) and mortality data on HIV and AIDS in China covering 31 provinces from 2004 to 2014 were collected from the Chinese Public Health Science Data Center. To decompose the time-series data, Empirical Mode Decomposition (EMD) was applied to properly describe the trends of HIV and AIDS incidence. A mathematical model was used to estimate the relative change of incidence among provinces and age groups.</p></sec><sec><title>Results</title><p id="Par3">A total of 483,010 newly HIV infections and 214,205 AIDS cases were reported between 2004 and 2014 nationwide. HIV infection increased from 13,258 in 2004 (RI 1.02 per 100,000 person years) to 74,048 in 2014 (RI 5.46 per 100,000). The number of AIDS cases increased from 3054 in 2004 (RI 0.23 per 100,000) to 45,145 in 2014 (RI 3.33 per 100,000). The overall relative changes for HIV infection and AIDS incidence were 1.11 (95% confidence interval [CI] 1.10–1.13) and 1.28 (95% CI 1.23–1.33), respectively. The relative increase for HIV and AIDS RI was higher in northwest provinces while lower in Henan, Xinjiang, Guangxi and Yunnan. The overall relative changes for HIV infection were 1.12 (95% CI 1.11–1.14) in males and 1.10 (95% CI 1.06–1.13) in females. For AIDS RI, the relative increases were 1.31 (95% CI 1.26–1.36) in males and 1.22 (95% CI 1.17–1.28) in females. The lowest relative increase was detected among young adults, while the largest relative increase (odds ratio [OR] > 1.30) was detected in people aged 55 years or above.</p></sec><sec><title>Conclusions</title><p id="Par4">HIV and AIDS showed an increasing trend in China from 2004 to 2014, respectively, but the epidemic tended to be under control among provinces and young people that used to have a high HIV and AIDS incidence. Northwest China and older people could be new “hop-spots” for HIV and AIDS risk.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>HIV and AIDS</kwd><kwd>China</kwd><kwd>Surveillance</kwd><kwd>Incidence</kwd><kwd>Epidemiology</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/100007219</institution-id><institution>Natural Science Foundation of Shanghai</institution></institution-wrap></funding-source><award-id>17ZR1401400</award-id><principal-award-recipient><name><surname>Zhang</surname><given-names>Tiejun</given-names></name></principal-award-recipient></award-group></funding-group><funding-group><award-group><funding-source><institution>Ministry of Education of China</institution></funding-source><award-id>20120071120050</award-id><principal-award-recipient><name><surname>Zhang</surname><given-names>Tiejun</given-names></name></principal-award-recipient></award-group></funding-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100001809</institution-id><institution>National Natural Science Foundation of China</institution></institution-wrap></funding-source><award-id>81772170, 81502870</award-id><principal-award-recipient><name><surname>Zhang</surname><given-names>Tiejun</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2018</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Background</title><p id="Par15">Although great efforts have been made by Chinese government over the last three decades, HIV and AIDS remains an important public health concern in China [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>]. In 2014, more than half a million people living with HIV and 0.2 million AIDS cases were reported, and there were more than 0.1 million new HIV infections [<xref ref-type="bibr" rid="CR3">3</xref>]. Since the first AIDS case was reported in early 1980’s, China had initiated a set of measures to combat this emerging health problem. HIV and AIDS surveillance started in 1985. In 1995, the China Ministry of Health and the National Center for AIDS established 42 national sentinel sites in 23 of the 31 provinces [<xref ref-type="bibr" rid="CR4">4</xref>]. However, the system had issues related to its accessibility and accuracy, which hampered timely understanding of the HIV and AIDS epidemic pattern and effectiveness of HIV and AIDS prevention measures.</p><p id="Par16">The outbreak of severe acute respiratory syndromes (SARS) in 2003 revealed some shortcomings of China’s infectious disease prevention system and triggered a rapid mobilization of public health policies for a broader range of health challenges. In particular, the HIV response has been strengthened by an influx of new funds and political support such as the “Four Free and One Care” policy [<xref ref-type="bibr" rid="CR5">5</xref>]. A web-based HIV reporting system was established in 2005 and integrated the HIV and AIDS surveillance system [<xref ref-type="bibr" rid="CR6">6</xref>], which provides a unique opportunity to comprehensively understand the epidemiological features of HIV and AIDS in China.</p><p id="Par17">According to a recent study based on data collected from a routine infectious disease reporting system, ~ 20% (10/45) infectious diseases showed a significantly increasing trend in incidence from 2004 to 2013. HIV infection showed the fastest growth with annual percentage change of 16.3% in reporting incidence [<xref ref-type="bibr" rid="CR7">7</xref>], but the study did not provide province-specific and age-specific results.</p><p id="Par18">To better understand the epidemiological characteristics of HIV and AIDS in China, we used the surveillance data, by province, sex, and age, to determine the temporal trend of HIV and AIDS incidence in the country from 2004 to 2014, and the changing patterns of HIV and AIDS incidence across provinces and age groups. Moreover, we collected the mortality data to assess the HIV and AIDS disease burden in the same period. All these will assist evidence-based and region-specific planning and evaluation of the effectiveness of current treatment and prevention strategies, as well as the assessment of future tendency and subsequent allocation of limited health resources.</p></sec><sec id="Sec2"><title>Methods</title><sec id="Sec3"><title>Data collection</title><p id="Par19">A routine reporting system for selected infectious diseases covered 31 provinces in mainland China was established by the Chinese government in 1950s [<xref ref-type="bibr" rid="CR8">8</xref>]. It has become a web-based system since 2003. The number of notifiable infectious diseases in this system increased from 18 before 1978 to 39 after 2003. The notifiable infectious diseases were divided into Classes A, B and C. According to the Infectious Disease Prevention Act, all epidemic reports are time-sensitive. All Class A infectious diseases as well as pulmonary anthrax and SARS in Class B should be reported through the system within 2 h after diagnosis, and other disease in Class B and Class C infectious diseases should be reported within 24 h after diagnosis. As a result, the date of diagnosis and reporting is the same day. We extracted HIV and AIDS data from 2004 and 2014 from the Science Data Center of Public Health (<ext-link ext-link-type="uri" xlink:href="http://www.phsciencedata.cn">http://www.phsciencedata.cn</ext-link>). AIDS patients in our study were those who had a previous HIV diagnosis, which had been identified or not, and then progressed to late stage.</p></sec><sec id="Sec4"><title>Statistical analysis</title><sec id="Sec5"><title>Incident trend decomposition</title><p id="Par20">Empirical mode decomposition (EMD), an adaptive model for non-liner and non-stationary time series data [<xref ref-type="bibr" rid="CR9">9</xref>], was used to identify the temporal trend of HIV and AIDS incidence from 2004 to 2014. The EMD method decomposed original data into several oscillatory components, corresponding to some physical phenomenon underlying the data, and the residue of decomposition is the unbiased surrogate of the true trend of the data [<xref ref-type="bibr" rid="CR10">10</xref>]. The physical phenomenon varied across different scenarios and therefore hardly to be specified here. For example, if the data were time series of HIV incidence, the physical phenomenon included the effect size of infected people, the using rate of condom, and the HIV/AIDS polices etc.</p></sec><sec id="Sec6"><title>Patterns of time changes in incidence and mortality of HIV and AIDS</title><p id="Par21">In order to investigate the changing patterns of HIV and AIDS epidemic and to specify a mathematical model that allows comparisons among sexes, different provinces and age groups [<xref ref-type="bibr" rid="CR11">11</xref>], we processed the original incidence and mortality data with a logit transformation and then assessed secular changes via polynomial and spline models (in our surveillance system, the incidence and mortality rate was calculated by population as denominator). As linear trends were observed in most provinces and age groups, a linear model was applied for incidence data on the logit scale. Relative changes in HIV and AIDS incidence or mortality were presented by odds ratio (OR) as compared with 2004. In addition, we also calculated average annual percentage change (AAPC) in HIV and AIDS RIs [<xref ref-type="bibr" rid="CR12">12</xref>]. All analyses were conducted using R (version 3.3.3).</p><p id="Par22">In the current analysis, “HIV infection” referred to the presence of HIV infection at the time of reporting. “AIDS” cases were newly diagnosed AIDS patients.</p></sec></sec></sec><sec id="Sec7"><title>Results</title><sec id="Sec8"><title>Temporal trends of HIV and AIDS incidence</title><p id="Par23">During the period of 2004–2014, a total of 483,010 newly HIV infections and 214,205 AIDS cases were reported nationwide. Reported HIV infection cases increased from 13,258 in 2004 (RI: 1.02 per 100,000) to 74,048 in 2014 (RI = 5.46 per 100,000). Reported AIDS cases increased from 3054 in 2004 (RI = 0.23 per 100,000) to 45,145 in 2014 (RI = 3.33 per 100,000). The overall relative changes in incidence measured by OR were 1.11 (95% CI 1.10–1.13) for HIV and 1.28 (95% CI 1.23–1.33) for AIDS, respectively. The increase for HIV infection incidence was in a linear fashion. For AIDS incidence, the linear increase was smaller for the period of 2004–2009, with a relative change of 1.06 (95% CI 1.03–1.09), it was larger between 2010 and 2013, with a relative change of 1.44 (95% CI 1.37–1.50). The incidence of reported AIDS was plateaued in 2014 (Fig. <xref rid="Fig1" ref-type="fig">1</xref>).<fig id="Fig1"><label>Fig. 1</label><caption><p>Monthly incidence of HIV and AIDS in China from 2004 to 2014. The gray smooth lines plotted in Fig. 1 were obtained from residues of EMD. (<bold>a</bold>: HIV monthly incidence from Jan, 2004 to Dec, 2014; <bold>b</bold>: AIDS monthly incidence from Jan, 2004 to Dec, 2014)</p></caption><graphic xlink:href="12879_2018_3551_Fig1_HTML" id="MO1"></graphic></fig></p></sec><sec id="Sec9"><title>Changing patterns of HIV and AIDS incidence according to each province</title><p id="Par24">The distributions of HIV infection and AIDS varied geographically in China (Fig. <xref rid="Fig2" ref-type="fig">2</xref>; Figs. <xref rid="Fig1" ref-type="fig">1</xref> and <xref rid="Fig2" ref-type="fig">2</xref> in Appendix). An increasing trend for both HIV infection and AIDS RIs was observed in all provinces from 2004 to 2014 (OR > 1.00) (Table <xref rid="Tab1" ref-type="table">1</xref>; Fig. <xref rid="Fig3" ref-type="fig">3</xref>). In 2004, four provinces including Yunnan, Guangxi, Xinjiang and Henan, had the highest HIV incidence, and accounted for 56.1% of all newly HIV infections (Fig. <xref rid="Fig2" ref-type="fig">2</xref>), with the ORs being 1.13 (95% CI 1.09–1.16), 1.06 (95% CI 1.03–1.08), 1.03 (95% CI 1.01–1.05) and 1.06 (95% CI 1.02–1.10), respectively. In 2014, four provinces with the highest HIV incidence were Xinjiang, Yunnan, Sichuan (OR = 1.21, 95% CI 1.15–1.28) and Chongqing (OR = 1.20, 95% CI 1.16–1.25), and the incidence was all above 14.0 per 100,000. The highest relative increase in the incidence of HIV infection occurred in Shaanxi (OR = 1.40, 95% CI 1.33–1.47), Qinghai (OR = 1.41, 95% CI 1.33–1.49) and Inner Mongolia (OR = 1.38, 95% CI 1.33–1.44), which were all located in North and Northwest China.<fig id="Fig2"><label>Fig. 2</label><caption><p>The distribution of HIV and AIDS cases by province in 2004 and 2014</p></caption><graphic xlink:href="12879_2018_3551_Fig2_HTML" id="MO2"></graphic></fig><table-wrap id="Tab1"><label>Table 1</label><caption><p>The relative change of HIV and AIDS incidence in each province in China from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Region</th><th rowspan="2">Province</th><th rowspan="2">HIV incidence in 2004 (/10^5)</th><th colspan="3">Relative Changes of HIV incidence</th><th rowspan="2">AIDS incidence in 2004 (/10^5)</th><th colspan="3">Relative Changes of AIDS incidence</th></tr><tr><th>OR</th><th colspan="2">95%CI</th><th>OR</th><th colspan="2">95%CI</th></tr></thead><tbody><tr><td></td><td>ALL</td><td>1.02</td><td>1.11</td><td>1.10</td><td>1.13</td><td>0.23</td><td>1.28</td><td>1.23</td><td>1.33</td></tr><tr><td rowspan="5">North</td><td>Beijing</td><td>1.38</td><td>1.18</td><td>1.14</td><td>1.22</td><td>0.48</td><td>1.32</td><td>1.20</td><td>1.45</td></tr><tr><td>Tianjin</td><td>0.37</td><td>1.26</td><td>1.18</td><td>1.33</td><td>0.00</td><td>1.09</td><td>1.07</td><td>1.12</td></tr><tr><td>Hebei</td><td>0.08</td><td>1.28</td><td>1.24</td><td>1.31</td><td>0.04</td><td>1.29</td><td>1.20</td><td>1.37</td></tr><tr><td>Shanxi</td><td>0.12</td><td>1.14</td><td>1.09</td><td>1.18</td><td>0.11</td><td>1.16</td><td>1.09</td><td>1.23</td></tr><tr><td>Inner Mongolia</td><td>0.05</td><td>1.38</td><td>1.33</td><td>1.44</td><td>0.03</td><td>1.40</td><td>1.25</td><td>1.56</td></tr><tr><td rowspan="3">Northeast</td><td>Liaoning</td><td>0.11</td><td>1.34</td><td>1.29</td><td>1.40</td><td>0.04</td><td>1.48</td><td>1.40</td><td>1.58</td></tr><tr><td>Jilin</td><td>0.23</td><td>1.22</td><td>1.17</td><td>1.28</td><td>0.06</td><td>1.43</td><td>1.38</td><td>1.49</td></tr><tr><td>Heilongjiang</td><td>0.11</td><td>1.35</td><td>1.30</td><td>1.41</td><td>0.04</td><td>1.42</td><td>1.37</td><td>1.47</td></tr><tr><td rowspan="7">East</td><td>Shanghai</td><td>1.62</td><td>1.06</td><td>1.02</td><td>1.10</td><td>0.19</td><td>1.34</td><td>1.24</td><td>1.46</td></tr><tr><td>Jiangsu</td><td>0.17</td><td>1.30</td><td>1.25</td><td>1.35</td><td>0.05</td><td>1.41</td><td>1.33</td><td>1.48</td></tr><tr><td>Zhejiang</td><td>0.39</td><td>1.24</td><td>1.19</td><td>1.28</td><td>0.06</td><td>1.47</td><td>1.42</td><td>1.53</td></tr><tr><td>Anhui</td><td>0.05</td><td>1.13</td><td>1.05</td><td>1.21</td><td>0.01</td><td>1.23</td><td>1.13</td><td>1.33</td></tr><tr><td>Fujian</td><td>0.40</td><td>1.27</td><td>1.23</td><td>1.32</td><td>0.14</td><td>1.32</td><td>1.28</td><td>1.36</td></tr><tr><td>Jiangxi</td><td>0.14</td><td>1.26</td><td>1.20</td><td>1.32</td><td>0.08</td><td>1.35</td><td>1.30</td><td>1.40</td></tr><tr><td>Shandong</td><td>0.03</td><td>1.20</td><td>1.14</td><td>1.27</td><td>0.03</td><td>1.32</td><td>1.20</td><td>1.45</td></tr><tr><td rowspan="3">Central</td><td>Henan</td><td>2.06</td><td>1.06</td><td>1.02</td><td>1.10</td><td>1.36</td><td>1.03</td><td>1.01</td><td>1.05</td></tr><tr><td>Hubei</td><td>0.93</td><td>1.22</td><td>1.19</td><td>1.24</td><td>0.41</td><td>1.21</td><td>1.14</td><td>1.28</td></tr><tr><td>Hunan</td><td>0.57</td><td>1.13</td><td>1.10</td><td>1.15</td><td>0.14</td><td>1.33</td><td>1.28</td><td>1.38</td></tr><tr><td rowspan="3">South</td><td>Guangdong</td><td>1.94</td><td>1.04</td><td>1.01</td><td>1.06</td><td>0.26</td><td>1.25</td><td>1.20</td><td>1.31</td></tr><tr><td>Guangxi</td><td>2.90</td><td>1.06</td><td>1.03</td><td>1.08</td><td>0.70</td><td>1.26</td><td>1.19</td><td>1.34</td></tr><tr><td>Hainan</td><td>1.31</td><td>1.19</td><td>1.16</td><td>1.22</td><td>0.05</td><td>1.38</td><td>1.23</td><td>1.55</td></tr><tr><td rowspan="5">Southwest</td><td>Chongqing</td><td>0.71</td><td>1.20</td><td>1.16</td><td>1.25</td><td>0.11</td><td>1.62</td><td>1.54</td><td>1.70</td></tr><tr><td>Sichuan</td><td>0.89</td><td>1.21</td><td>1.15</td><td>1.28</td><td>0.06</td><td>1.64</td><td>1.54</td><td>1.75</td></tr><tr><td>Guizhou</td><td>1.93</td><td>1.17</td><td>1.13</td><td>1.21</td><td>0.01</td><td>1.63</td><td>1.46</td><td>1.82</td></tr><tr><td>Yunnan</td><td>8.39</td><td>1.13</td><td>1.09</td><td>1.16</td><td>0.68</td><td>1.33</td><td>1.23</td><td>1.44</td></tr><tr><td>Tibet</td><td>0.00</td><td>1.23</td><td>1.16</td><td>1.35</td><td>0.00</td><td>1.36</td><td>1.26</td><td>1.47</td></tr><tr><td rowspan="5">Northwest</td><td>Shaanxi</td><td>0.09</td><td>1.40</td><td>1.33</td><td>1.47</td><td>0.05</td><td>1.43</td><td>1.37</td><td>1.50</td></tr><tr><td>Gansu</td><td>0.07</td><td>1.29</td><td>1.23</td><td>1.34</td><td>0.04</td><td>1.40</td><td>1.21</td><td>1.61</td></tr><tr><td>Qinghai</td><td>0.17</td><td>1.41</td><td>1.33</td><td>1.49</td><td>0.13</td><td>1.40</td><td>1.27</td><td>1.54</td></tr><tr><td>Ningxia</td><td>0.14</td><td>1.22</td><td>1.18</td><td>1.26</td><td>0.00</td><td>1.06</td><td>1.04</td><td>1.08</td></tr><tr><td>Xinjiang</td><td>2.84</td><td>1.03</td><td>1.01</td><td>1.05</td><td>0.10</td><td>1.36</td><td>1.24</td><td>1.50</td></tr></tbody></table></table-wrap><fig id="Fig3"><label>Fig. 3</label><caption><p>The relative change (odds ratio) of HIV and AIDS incidences in China from 2004 to 2014. (The maps were derived from <italic>ggmap</italic> package in R program. BJ: Beijing, TJ: Tianjin, HB: Hebei, NMG: Inner Mongolia, SX: Shanxi, HLJ: Heilongjiang, JL: Jilin, LN: Liaoning, SD: Shandong, JS: Jiangsu, SH: Shanghai, ZJ: Zhejiang, AH: Anhui, FJ: Fujian, JX: Jiangxi, GD: Guangdong, GX: Guangxi, HN: Hainan, YN: Yunnan, GZ: Guizhou, XZ: Tibet, SC: Sichuan, CQ: Chongqing, HU: Hunan, HE: Hubei, HA: Henan, SA: Shaanxi, GS: Gansu, NX: Ningxia, QH: Qinghai, XJ: Xinjiang)</p></caption><graphic xlink:href="12879_2018_3551_Fig3_HTML" id="MO3"></graphic></fig></p><p id="Par25">In 2004, Henan, Guangxi, Yunnan and Beijing had the top 4 AIDS incidence rates (Fig. <xref rid="Fig1" ref-type="fig">1</xref> in Appendix). Henan was the only province where AIDS incidence exceeded 1.0 per 100,000 from 2004 to 2014, but had the lowest relative increase (OR = 1.03, 95%CI 1.01–1.05). In 2014, Guangxi, Yunnan, Chongqing and Sichuan, all in Southwest China, had the highest AIDS incidence rates (Fig. <xref rid="Fig2" ref-type="fig">2</xref>; Fig. <xref rid="Fig1" ref-type="fig">1</xref> in Appendix). Sichuan had the largest relative increase (OR = 1.64, 95% CI 1.54–1.75), followed by Guizhou (OR = 1.63, 95% CI 1.46–1.82) and Chongqing (OR = 1.62, 95% CI 1.54–1.70), which were all in Southwest China (Table <xref rid="Tab1" ref-type="table">1</xref>; Fig. <xref rid="Fig3" ref-type="fig">3</xref>).</p></sec><sec id="Sec10"><title>Changing patterns of HIV and AIDS incidence stratified by age</title><p id="Par26">The age-specific incidences of HIV infection and AIDS changed over time. In 2004, adults aged 25–34 years accounted for 36.04% of all new HIV infections and 54.78% of all new diagnosed AIDS cases. In 2014, the corresponding proportions were 22.58 and 30.69%, respectively. However, the numbers of newly infected HIV and diagnosed AIDS cases unexpectedly increased among people aged 55 years or above between 2004 and 2014 (Fig. <xref rid="Fig4" ref-type="fig">4</xref>). In order to further investigate the HIV and AIDS changing patterns associated with age, we divided age into 18 groups stratified by gender.<fig id="Fig4"><label>Fig. 4</label><caption><p>The distribution of HIV and AIDS cases by age in 2004 and 2014</p></caption><graphic xlink:href="12879_2018_3551_Fig4_HTML" id="MO4"></graphic></fig></p><p id="Par27">The overall relative changes of reported HIV incidence among males and females were 1.12 (95% CI 1.11–1.14) and 1.10 (95% CI 1.06–1.13), respectively. Males and females had a similar changing pattern of HIV incidence (Table <xref rid="Tab2" ref-type="table">2</xref>). Most age groups experienced an increase in HIV infection from 2004 to 2014 (Fig. <xref rid="Fig5" ref-type="fig">5</xref>).<table-wrap id="Tab2"><label>Table 2</label><caption><p>The relative change of HIV incidence in different age group in China from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Age group</th><th colspan="4">Relative Change</th><th>Male</th><th colspan="3">Relative Change</th><th>Female</th><th colspan="3">Relative Change</th></tr><tr><th>HIV incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th>HIV incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th>HIV incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th></tr></thead><tbody><tr><td>All</td><td>0.99</td><td>1.12</td><td>1.10</td><td>1.13</td><td>1.46</td><td>1.12</td><td>1.11</td><td>1.14</td><td>0.51</td><td>1.10</td><td>1.06</td><td>1.13</td></tr><tr><td>0-</td><td>0.15</td><td>1.07</td><td>1.01</td><td>1.12</td><td>0.16</td><td>1.06</td><td>1.01</td><td>1.10</td><td>0.14</td><td>1.07</td><td>1.01</td><td>1.14</td></tr><tr><td>5-</td><td>0.08</td><td>1.10</td><td>1.05</td><td>1.15</td><td>0.09</td><td>1.09</td><td>1.04</td><td>1.14</td><td>0.06</td><td>1.11</td><td>1.04</td><td>1.17</td></tr><tr><td>10-</td><td>0.06</td><td>1.04</td><td>0.99</td><td>1.08</td><td>0.07</td><td>1.00</td><td>0.95</td><td>1.06</td><td>0.04</td><td>1.10</td><td>1.06</td><td>1.14</td></tr><tr><td>15-</td><td>0.38</td><td>1.18</td><td>1.16</td><td>1.20</td><td>0.45</td><td>1.23</td><td>1.19</td><td>1.26</td><td>0.29</td><td>1.09</td><td>1.06</td><td>1.12</td></tr><tr><td>20-</td><td>1.33</td><td>1.12</td><td>1.10</td><td>1.14</td><td>1.88</td><td>1.17</td><td>1.15</td><td>1.19</td><td>0.76</td><td>1.02</td><td>0.97</td><td>1.08</td></tr><tr><td>25-</td><td>2.86</td><td>1.07</td><td>1.05</td><td>1.08</td><td>4.35</td><td>1.08</td><td>1.06</td><td>1.10</td><td>1.36</td><td>1.03</td><td>0.99</td><td>1.07</td></tr><tr><td>30-</td><td>3.21</td><td>1.02</td><td>1.01</td><td>1.04</td><td>5.02</td><td>1.02</td><td>1.00</td><td>1.05</td><td>1.33</td><td>1.03</td><td>0.99</td><td>1.06</td></tr><tr><td>35-</td><td>1.84</td><td>1.06</td><td>1.04</td><td>1.08</td><td>2.81</td><td>1.06</td><td>1.04</td><td>1.07</td><td>0.81</td><td>1.08</td><td>1.03</td><td>1.13</td></tr><tr><td>40-</td><td>1.02</td><td>1.14</td><td>1.12</td><td>1.17</td><td>1.49</td><td>1.14</td><td>1.12</td><td>1.16</td><td>0.52</td><td>1.16</td><td>1.12</td><td>1.19</td></tr><tr><td>45-</td><td>0.62</td><td>1.26</td><td>1.22</td><td>1.29</td><td>0.91</td><td>1.25</td><td>1.22</td><td>1.28</td><td>0.32</td><td>1.29</td><td>1.24</td><td>1.33</td></tr><tr><td>50-</td><td>0.55</td><td>1.25</td><td>1.22</td><td>1.28</td><td>0.67</td><td>1.26</td><td>1.23</td><td>1.29</td><td>0.41</td><td>1.24</td><td>1.21</td><td>1.26</td></tr><tr><td>55-</td><td>0.23</td><td>1.33</td><td>1.28</td><td>1.38</td><td>0.28</td><td>1.33</td><td>1.28</td><td>1.38</td><td>0.19</td><td>1.34</td><td>1.29</td><td>1.39</td></tr><tr><td>60-</td><td>0.17</td><td>1.37</td><td>1.31</td><td>1.43</td><td>0.24</td><td>1.35</td><td>1.30</td><td>1.40</td><td>0.10</td><td>1.42</td><td>1.34</td><td>1.50</td></tr><tr><td>65-</td><td>0.18</td><td>1.38</td><td>1.31</td><td>1.46</td><td>0.28</td><td>1.38</td><td>1.30</td><td>1.47</td><td>0.06</td><td>1.38</td><td>1.32</td><td>1.45</td></tr><tr><td>70-</td><td>0.12</td><td>1.37</td><td>1.29</td><td>1.45</td><td>0.20</td><td>1.36</td><td>1.29</td><td>1.44</td><td>0.04</td><td>1.40</td><td>1.31</td><td>1.51</td></tr><tr><td>75-</td><td>0.07</td><td>1.41</td><td>1.30</td><td>1.52</td><td>0.13</td><td>1.40</td><td>1.30</td><td>1.51</td><td>0.02</td><td>1.50</td><td>1.32</td><td>1.70</td></tr><tr><td>80-</td><td>0.04</td><td>1.42</td><td>1.32</td><td>1.54</td><td>0.07</td><td>1.42</td><td>1.32</td><td>1.53</td><td>0.01</td><td>1.49</td><td>1.32</td><td>1.68</td></tr><tr><td>85-</td><td>0.25</td><td>1.17</td><td>1.01</td><td>1.36</td><td>0.56</td><td>1.22</td><td>1.07</td><td>1.38</td><td>0.06</td><td>1.00</td><td>0.96</td><td>1.02</td></tr></tbody></table></table-wrap><fig id="Fig5"><label>Fig. 5</label><caption><p>The relative change (odds ratio) of HIV and AIDS incidence in each age group stratified by gender from 2004 to 2014. (※: <italic>p</italic> < 0.05)</p></caption><graphic xlink:href="12879_2018_3551_Fig5_HTML" id="MO5"></graphic></fig></p><p id="Par28">In males, the highest incidence of HIV infection in 2004 was found in people aged 30–34 years (5.02 per 100,000), but the relative increase was low (OR = 1.02, 95% CI 1.00–1.05, <italic>p</italic> = 0.027). The largest relative increase was observed in men aged 80–84 (OR = 1.42, 95% CI 1.32–1.53), albeit the lowest incidence in 2004 (0.07 per 100,000). The highest incidence of HIV infection in 2004 was found in women aged 25–29 years (1.36 per 100,000), but the incidence remained stable in the study period (OR = 1.03, 95% CI 0.99–1.07). The highest relative increase was detected in women aged 75–79 (OR = 1.50, 95% CI 1.32–1.70) with the HIV infection incidence being 0.02 per 100,000 in 2004.</p><p id="Par29">For AIDS incidence, the relative increases in males and females were 1.31 (95% CI 1.26–1.36) and 1.22 (95% CI 1.17–1.28), respectively (Table <xref rid="Tab3" ref-type="table">3</xref>; Fig. <xref rid="Fig5" ref-type="fig">5</xref>). All age groups except the age group of 10–14 years showed an increasing trend. In 2004, the highest AIDS incidence was found in people aged 30–34 years in both genders, but the relative increase was low for both males (OR = 1.23, 95% CI 1.16–1.29) and females (OR = 1.16, 95% CI 1.11–1.23). The largest relative increase was observed in older people (age ≥ 55 years) for both sexes. In males, the largest OR was observed in the age group of 80–84 years (OR = 1.57, 95% CI 1.48–1.67). In females, the largest OR was detected in the age group of 70–74 years (OR = 1.49, 95% CI 1.41–1.58).<table-wrap id="Tab3"><label>Table 3</label><caption><p>The relative change of AIDS incidence in different age group in China from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Age group</th><th>Both sex</th><th colspan="3">Relative Change</th><th>Male</th><th colspan="3">Relative Change</th><th>Female</th><th colspan="3">Relative Change</th></tr><tr><th>AIDS incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th>AIDS incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th>AIDS incidence in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th></tr></thead><tbody><tr><td>All</td><td>0.23</td><td>1.28</td><td>1.23</td><td>1.34</td><td>0.29</td><td>1.31</td><td>1.26</td><td>1.36</td><td>0.16</td><td>1.22</td><td>1.17</td><td>1.28</td></tr><tr><td>0-</td><td>0.04</td><td>1.15</td><td>1.06</td><td>1.25</td><td>0.05</td><td>1.14</td><td>1.05</td><td>1.23</td><td>0.02</td><td>1.17</td><td>1.08</td><td>1.27</td></tr><tr><td>5-</td><td>0.04</td><td>1.12</td><td>1.07</td><td>1.18</td><td>0.05</td><td>1.12</td><td>1.06</td><td>1.18</td><td>0.03</td><td>1.12</td><td>1.05</td><td>1.20</td></tr><tr><td>10-</td><td>0.03</td><td>0.96</td><td>0.89</td><td>1.04</td><td>0.03</td><td>0.92</td><td>0.85</td><td>0.99</td><td>0.02</td><td>1.03</td><td>0.94</td><td>1.14</td></tr><tr><td>15-</td><td>0.02</td><td>1.35</td><td>1.24</td><td>1.47</td><td>0.02</td><td>1.39</td><td>1.28</td><td>1.50</td><td>0.01</td><td>1.30</td><td>1.18</td><td>1.43</td></tr><tr><td>20-</td><td>0.10</td><td>1.38</td><td>1.29</td><td>1.47</td><td>0.11</td><td>1.47</td><td>1.35</td><td>1.59</td><td>0.08</td><td>1.26</td><td>1.18</td><td>1.34</td></tr><tr><td>25-</td><td>0.39</td><td>1.27</td><td>1.19</td><td>1.35</td><td>0.54</td><td>1.30</td><td>1.20</td><td>1.40</td><td>0.24</td><td>1.21</td><td>1.14</td><td>1.28</td></tr><tr><td>30-</td><td>0.65</td><td>1.21</td><td>1.15</td><td>1.27</td><td>0.88</td><td>1.23</td><td>1.16</td><td>1.29</td><td>0.41</td><td>1.16</td><td>1.11</td><td>1.23</td></tr><tr><td>35-</td><td>0.51</td><td>1.22</td><td>1.17</td><td>1.27</td><td>0.64</td><td>1.24</td><td>1.20</td><td>1.29</td><td>0.38</td><td>1.15</td><td>1.10</td><td>1.20</td></tr><tr><td>40-</td><td>0.40</td><td>1.26</td><td>1.22</td><td>1.30</td><td>0.48</td><td>1.29</td><td>1.25</td><td>1.33</td><td>0.32</td><td>1.19</td><td>1.15</td><td>1.24</td></tr><tr><td>45-</td><td>0.25</td><td>1.36</td><td>1.32</td><td>1.40</td><td>0.31</td><td>1.38</td><td>1.34</td><td>1.42</td><td>0.19</td><td>1.30</td><td>1.25</td><td>1.35</td></tr><tr><td>50-</td><td>0.27</td><td>1.29</td><td>1.25</td><td>1.32</td><td>0.33</td><td>1.32</td><td>1.29</td><td>1.35</td><td>0.20</td><td>1.22</td><td>1.17</td><td>1.27</td></tr><tr><td>55-</td><td>0.13</td><td>1.38</td><td>1.34</td><td>1.43</td><td>0.17</td><td>1.40</td><td>1.35</td><td>1.45</td><td>0.09</td><td>1.35</td><td>1.30</td><td>1.40</td></tr><tr><td>60-</td><td>0.12</td><td>1.44</td><td>1.37</td><td>1.51</td><td>0.16</td><td>1.46</td><td>1.38</td><td>1.53</td><td>0.06</td><td>1.40</td><td>1.33</td><td>1.48</td></tr><tr><td>65-</td><td>0.08</td><td>1.47</td><td>1.41</td><td>1.53</td><td>0.13</td><td>1.48</td><td>1.42</td><td>1.55</td><td>0.02</td><td>1.43</td><td>1.37</td><td>1.49</td></tr><tr><td>70-</td><td>0.07</td><td>1.50</td><td>1.41</td><td>1.60</td><td>0.12</td><td>1.50</td><td>1.41</td><td>1.61</td><td>0.01</td><td>1.49</td><td>1.41</td><td>1.58</td></tr><tr><td>75-</td><td>0.03</td><td>1.54</td><td>1.44</td><td>1.64</td><td>0.05</td><td>1.56</td><td>1.46</td><td>1.66</td><td>0.01</td><td>1.42</td><td>1.31</td><td>1.54</td></tr><tr><td>80-</td><td>0.01</td><td>1.58</td><td>1.49</td><td>1.68</td><td>0.02</td><td>1.57</td><td>1.48</td><td>1.67</td><td>0.00</td><td>1.12</td><td>1.06</td><td>1.18</td></tr><tr><td>85-</td><td>0.01</td><td>1.45</td><td>1.31</td><td>1.60</td><td>0.04</td><td>1.45</td><td>1.32</td><td>1.58</td><td>0.00</td><td>1.05</td><td>1.02</td><td>1.10</td></tr></tbody></table></table-wrap></p></sec><sec id="Sec11"><title>Changing patterns of HIV and AIDS mortality</title><p id="Par30">Overall, the mortality rate for HIV and AIDS in China was increasing (Fig. <xref rid="Fig3" ref-type="fig">3</xref> and Table <xref rid="Tab1" ref-type="table">1</xref> in Appendix). The relative increase was 1.29 (95% CI 1.18–1.40) nationwide. Geographically, the largest OR was found in Xinjiang (OR = 1.64, 95% CI 1.37–1.97). Henan was the only province where HIV and AIDS mortality remained stable from 2004 to 2014 (OR = 1.07, 95% CI 0.96–1.19). Moreover, HIV and AIDS mortality showed an increasing trend among all age groups except for the age group of 20–24 years in both genders (Table <xref rid="Tab2" ref-type="table">2</xref> in Appendix).</p><p id="Par31">The results of AAPC were presented in Tables <xref rid="Tab3" ref-type="table">3</xref>, <xref rid="Tab4" ref-type="table">4</xref>, <xref rid="Tab5" ref-type="table">5</xref> and <xref rid="Tab6" ref-type="table">6</xref> in Appendix. No significant difference was detected.</p></sec></sec><sec id="Sec12"><title>Discussion</title><p id="Par32">Since the first report of HIV and AIDS case in China, the HIV and AIDS epidemic has been changing both geographically and temporally [<xref ref-type="bibr" rid="CR13">13</xref>–<xref ref-type="bibr" rid="CR19">19</xref>]. In this study, we provided a comprehensive overview of HIV and AIDS epidemic in China, and assessed secular changes among provinces and age groups for the period of 2004–2014. The lowest relative increase of HIV and AIDS incidence was detected in provinces with a high HIV and AIDS incidence in 2004. Some Northwestern provinces such as Qinghai and Shaanxi had the strongest relative increase of HIV and AIDS incidence. In addition, young men and women aged 20–34 years who had the highest HIV and AIDS incidence in 2004 experienced the lowest relative increase during the study period. Older men and women (age ≥ 55 years) showed the largest increase of HIV and AIDS incidence.</p><p id="Par33">The HIV and AIDS surveillance/reporting system has been improving, which may explain part of the observed increases of HIV and AIDS incidence and mortality. China has more than 1800 sentinel sites for HIV and AIDS surveillance [<xref ref-type="bibr" rid="CR15">15</xref>]. The counseling and testing services have been continuously strengthened. By the end of 2014, there were 455 HIV testing and confirmation labs and 25,762 screening labs in China, covering 96.5% of the country [<xref ref-type="bibr" rid="CR20">20</xref>], and 21,210 medical and health institutions conducted ~ 130 million person-times of HIV antibody tests, increasing from 84 million in 2011 [<xref ref-type="bibr" rid="CR20">20</xref>].</p><p id="Par34">China has achieved a substantial progress in combatting with HIV and AIDS. For instance, AIDS incidence showed a plateau after 2013, which might imply a near-future decrease of AIDS cases with the persistent expansion of availability of highly active anti-retroviral therapy (HAART) [<xref ref-type="bibr" rid="CR21">21</xref>]. Also, the control of HIV and AIDS epidemic in Henan, Xinjiang, Guangxi and Yunnan might be an indication for the effectiveness of preventive strategies and measures after the SARS outbreak, and these areas used to be the “hot-spots” of HIV and AIDS in China [<xref ref-type="bibr" rid="CR22">22</xref>].</p><p id="Par35">In the first two decades of HIV and AIDS era in China, Henan, Guangxi, Yunnan and Xinjiang had high HIV and AIDS prevalence [<xref ref-type="bibr" rid="CR23">23</xref>], but had different transmission modes. After dramatically cracking down the illegal blood trade in Henan [<xref ref-type="bibr" rid="CR24">24</xref>, <xref ref-type="bibr" rid="CR25">25</xref>], HIV and AIDS incidence showed the lowest relative change there. Guangxi and Yunnan are close to the “Golden Triangle” in Burma, where intravenous drug use was once the major source of HIV transmission, but unprotected sex was found to be a main source of HIV transmission recently [<xref ref-type="bibr" rid="CR26">26</xref>, <xref ref-type="bibr" rid="CR27">27</xref>]. In this study, Guangxi and Yunnan had a relatively slow increasing trend for both HIV infection and AIDS incidence, which might ascribe to substantial targeted endeavors combating HIV and AIDS in the last decade. A similar changing pattern was observed in Xinjiang, where the HIV and AIDS incidence was high in 2004, but the relative increase was low during the study period.</p><p id="Par36">However, it should be noted that some new HIV and AIDS “hot-spots” including Sichuan and Chongqing have appeared recently according to our analyses. Additionally, Inner Mongolia, Qinghai and Shaanxi showed great relative increases in the HIV and AIDS incidence. We should pay much more attention to the prevention and control of HIV and AIDS in these provinces.</p><p id="Par37">There were also substantial changes in HIV and AIDS incidence associated with age. Men and women aged 20–34 years had the lowest relative increase, while those aged 55 years or above had the highest relative increase. The results suggested the effectiveness of measures that focused on young adults but also indicated a potential upsurge of HIV and AIDS epidemic among older people. Globally, previous evidence has suggested a considerable burden of HIV and AIDS among older adults [<xref ref-type="bibr" rid="CR28">28</xref>–<xref ref-type="bibr" rid="CR30">30</xref>]. Thus, it is important to further investigate the risk factors of HIV infection and to prioritize the prevention and control of HIV and AIDS among older adults.</p><p id="Par38">Surprisingly, an increased mortality of HIV and AIDS was detected in the present study. We speculate that the increase of HIV and AIDS mortality may be partially explained by the accumulation of AIDS cases, since the cumulative AIDS-related mortality rates significantly increased over time after diagnosis [<xref ref-type="bibr" rid="CR31">31</xref>]. Meanwhile, the inadequate provision of treatment services and difficulty with adherence were also likely to contribute to the increased mortality, particularly before 2003. Therefore, the accumulation in HIV infections and improved survival time among AIDS patients could result in an increasing burden of HIV and AIDS [<xref ref-type="bibr" rid="CR32">32</xref>, <xref ref-type="bibr" rid="CR33">33</xref>].</p><p id="Par39">Some limitations of our study should be mentioned. First, since the data were retrieved from a passive surveillance system, there might be some under reporting, especially during earlier years of the system. Second, the incidence could also be underestimated because of ascertainment bias by self-selection that individuals at high risk of HIV and AIDS were more reluctant to screening. Third, the increase of HIV and AIDS reporting incidence among older adults might be ascribed to the detection of long-standing infections, though more investigations should be warranted in the near future. Finally, key affected populations (e.g. the men who have sex with men) have not been particularized in our study due to the inaccessibility of corresponding surveillance data.</p><p id="Par40">Estimation of the incidence of most infectious diseases is challenging, because infection might have occurred several years before symptoms arise or a diagnosis is made [<xref ref-type="bibr" rid="CR34">34</xref>, <xref ref-type="bibr" rid="CR35">35</xref>]. Fortunately, the surveillance data can serve as good proxy to quantify the temporal trends of infectious diseases. The China Information System for Disease Control and Prevention (CISDCP) is currently the largest web-based surveillance system in the world, and it stores the nationwide validated reporting data daily. Despite these challenges, our analysis is based on a large sample of people diagnosed with HIV and AIDS across 31 provinces and over 11 years, which strengthens the reliability of our findings.</p></sec><sec id="Sec13"><title>Conclusions</title><p id="Par41">We used a longitudinal surveillance dataset spanning 11 years in China to investigate changes in the epidemiological characteristics of HIV and AIDS after SARS outbreak. HIV and AIDS incidence showed a significant increasing trend in the last decade, but the epidemic has been well controlled among provinces where the HIV and AIDS incidence were high, and among young adults. However, the major findings also highlight the unmet need for HIV and AIDS prevention efforts and call for a beforehand measure to prevent the emergency among certain provinces and elderly people.</p></sec></body><back><app-group><app id="App1"><sec id="Sec14"><title>Appendix</title><p id="Par48"><fig id="Fig6"><label>Fig. 6</label><caption><p>The HIV and AIDS incidence in China in 2004 and 2014</p></caption><graphic position="anchor" xlink:href="12879_2018_3551_Fig6_HTML" id="MO6"></graphic></fig></p><p id="Par49"><fig id="Fig7"><label>Fig. 7</label><caption><p>The incidence of HIV and AIDS in each province stratified by regions in China from 2004 to 2014. (<bold>a</bold>: HIV incidence in China at province level; <bold>b</bold>: AIDS incidence in China at province level)</p></caption><graphic position="anchor" xlink:href="12879_2018_3551_Fig7_HTML" id="MO7"></graphic></fig></p><p id="Par50"><fig id="Fig8"><label>Fig. 8</label><caption><p>The HIV and AIDS mortality in China in 2004 and 2014</p></caption><graphic position="anchor" xlink:href="12879_2018_3551_Fig8_HTML" id="MO8"></graphic></fig></p><p id="Par51"><fig id="Fig9"><label>Fig. 9</label><caption><p>The relative change of mortality rate of HIV and AIDS in China at provincial level from 2004 to 2014</p></caption><graphic position="anchor" xlink:href="12879_2018_3551_Fig9_HTML" id="MO9"></graphic></fig></p><p id="Par52"><table-wrap id="Tab4"><label>Table 4</label><caption><p>The relative change of mortality rate of HIV and AIDS in China at province level from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Province</th><th>Mortality in 2004</th><th>Mortality rate in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th><italic>P</italic> value</th></tr></thead><tbody><tr><td>All</td><td>741</td><td>0.0570</td><td>1.29</td><td>1.18</td><td>1.40</td><td>< 0.001</td></tr><tr><td>Beijing</td><td>71</td><td>0.0135</td><td>1.23</td><td>1.15</td><td>1.32</td><td>< 0.001</td></tr><tr><td>Tianjin</td><td>0</td><td>0</td><td>1.19</td><td>1.16</td><td>1.23</td><td>< 0.001</td></tr><tr><td>Hebei</td><td>27</td><td>0.0088</td><td>1.24</td><td>1.08</td><td>1.42</td><td>0.0067</td></tr><tr><td>Shanxi</td><td>37</td><td>0.0060</td><td>1.07</td><td>1.02</td><td>1.12</td><td>0.013</td></tr><tr><td>Inner Mongolia</td><td>8</td><td>0.0126</td><td>1.24</td><td>1.12</td><td>1.38</td><td>0.002</td></tr><tr><td>Liaoning</td><td>15</td><td>0.0192</td><td>1.35</td><td>1.26</td><td>1.44</td><td>< 0.001</td></tr><tr><td>Jilin</td><td>16</td><td>0.0338</td><td>1.35</td><td>1.28</td><td>1.42</td><td>< 0.001</td></tr><tr><td>Heilongjiang</td><td>14</td><td>0.0133</td><td>1.29</td><td>1.23</td><td>1.36</td><td>< 0.001</td></tr><tr><td>Shanghai</td><td>25</td><td>0.0299</td><td>1.17</td><td>1.09</td><td>1.25</td><td>0.001</td></tr><tr><td>Jiangsu</td><td>35</td><td>0.0304</td><td>1.25</td><td>1.21</td><td>1.29</td><td>< 0.001</td></tr><tr><td>Zhejiang</td><td>28</td><td>0.0213</td><td>1.31</td><td>1.23</td><td>1.40</td><td>< 0.001</td></tr><tr><td>Anhui</td><td>6</td><td>0.0031</td><td>1.17</td><td>1.09</td><td>1.25</td><td>< 0.001</td></tr><tr><td>Fujian</td><td>52</td><td>0.0584</td><td>1.20</td><td>1.10</td><td>1.31</td><td>0.002</td></tr><tr><td>Jiangxi</td><td>34</td><td>0.0560</td><td>1.19</td><td>1.14</td><td>1.24</td><td>< 0.001</td></tr><tr><td>Shandong</td><td>31</td><td>0.0153</td><td>1.15</td><td>1.11</td><td>1.20</td><td>< 0.001</td></tr><tr><td>Henan</td><td>1315</td><td>0.2022</td><td>1.07</td><td>0.96</td><td>1.19</td><td>0.206</td></tr><tr><td>Hubei</td><td>248</td><td>0.1598</td><td>1.15</td><td>1.09</td><td>1.21</td><td>< 0.001</td></tr><tr><td>Hunan</td><td>9</td><td>0.0689</td><td>1.33</td><td>1.24</td><td>1.44</td><td>< 0.001</td></tr><tr><td>Guangdong</td><td>205</td><td>0.0629</td><td>1.29</td><td>1.18</td><td>1.40</td><td>< 0.001</td></tr><tr><td>Guangxi</td><td>341</td><td>0.1091</td><td>1.53</td><td>1.35</td><td>1.73</td><td>< 0.001</td></tr><tr><td>Hainan</td><td>4</td><td>0.0123</td><td>1.49</td><td>1.24</td><td>1.79</td><td>0.0011</td></tr><tr><td>Chongqing</td><td>34</td><td>0.0383</td><td>1.51</td><td>1.35</td><td>1.67</td><td>< 0.001</td></tr><tr><td>Sichuan</td><td>56</td><td>0.0252</td><td>1.53</td><td>1.35</td><td>1.73</td><td>< 0.001</td></tr><tr><td>Guizhou</td><td>5</td><td>0.0078</td><td>1.56</td><td>1.27</td><td>1.90</td><td>0.001</td></tr><tr><td>Yunnan</td><td>298</td><td>0.2411</td><td>1.37</td><td>1.20</td><td>1.57</td><td>< 0.001</td></tr><tr><td>Tibet</td><td>0</td><td>0</td><td>1.09</td><td>1.06</td><td>1.15</td><td>< 0.001</td></tr><tr><td>Shaanxi</td><td>17</td><td>0.0219</td><td>1.34</td><td>1.20</td><td>1.50</td><td>< 0.001</td></tr><tr><td>Gansu</td><td>11</td><td>0.0383</td><td>1.27</td><td>1.15</td><td>1.39</td><td>< 0.001</td></tr><tr><td>Qinghai</td><td>7</td><td>0.0185</td><td>1.26</td><td>1.22</td><td>1.30</td><td>< 0.001</td></tr><tr><td>Ningxia</td><td>0</td><td>0</td><td>1.22</td><td>1.18</td><td>1.26</td><td>< 0.001</td></tr><tr><td>Xinjiang</td><td>18</td><td>0.0269</td><td>1.64</td><td>1.37</td><td>1.97</td><td>< 0.001</td></tr></tbody></table></table-wrap></p><p id="Par53"><table-wrap id="Tab5"><label>Table 5</label><caption><p>The relative change of mortality rate of HIV and AIDS in each age group in China from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>age group</th><th>Mortality in 2004</th><th>Mortality rate in 2004 (/10^5)</th><th>OR</th><th colspan="2">95%CI</th><th><italic>P</italic> value</th></tr></thead><tbody><tr><td colspan="7">Male</td></tr><tr><td> 1 to 4</td><td>3</td><td>0.0505</td><td>1.05</td><td>1.03</td><td>1.07</td><td>< 0.001</td></tr><tr><td> 5 to 9</td><td>5</td><td>0.0080</td><td>1.10</td><td>1.08</td><td>1.12</td><td>< 0.001</td></tr><tr><td> 10 to 14</td><td>4</td><td>0.0061</td><td>1.17</td><td>1.15</td><td>1.18</td><td>< 0.001</td></tr><tr><td> 15 to 19</td><td>4</td><td>0.0076</td><td>1.19</td><td>1.16</td><td>1.22</td><td>< 0.001</td></tr><tr><td> 20 to 24</td><td>21</td><td>0.0438</td><td>0.98</td><td>0.97</td><td>1.00</td><td>0.072</td></tr><tr><td> 25 to 29</td><td>70</td><td>0.1162</td><td>1.02</td><td>1.00</td><td>1.04</td><td>0.033</td></tr><tr><td> 30 to 34</td><td>106</td><td>0.1622</td><td>1.04</td><td>1.03</td><td>1.06</td><td>< 0.001</td></tr><tr><td> 35 to 39</td><td>102</td><td>0.1817</td><td>1.08</td><td>1.06</td><td>1.10</td><td>< 0.001</td></tr><tr><td> 40 to 44</td><td>82</td><td>0.1941</td><td>1.09</td><td>1.07</td><td>1.11</td><td>< 0.001</td></tr><tr><td> 45 to 49</td><td>36</td><td>0.0819</td><td>1.08</td><td>1.05</td><td>1.11</td><td>< 0.001</td></tr><tr><td> 50 to 54</td><td>31</td><td>0.0945</td><td>1.08</td><td>1.06</td><td>1.11</td><td>< 0.001</td></tr><tr><td> 55 to 59</td><td>22</td><td>0.0914</td><td>1.07</td><td>1.04</td><td>1.10</td><td>< 0.001</td></tr><tr><td> 60 to 64</td><td>14</td><td>0.0655</td><td>1.07</td><td>1.05</td><td>1.10</td><td>< 0.001</td></tr><tr><td> 65 to 69</td><td>8</td><td>0.0456</td><td>1.07</td><td>1.05</td><td>1.10</td><td>< 0.001</td></tr><tr><td> 70 to 74</td><td>5</td><td>0.0402</td><td>1.07</td><td>1.04</td><td>1.10</td><td>< 0.001</td></tr><tr><td> 75 to 79</td><td>0</td><td>0</td><td>1.07</td><td>1.04</td><td>1.09</td><td>< 0.001</td></tr><tr><td> 80 plus</td><td>0</td><td>0</td><td>1.08</td><td>1.05</td><td>1.11</td><td>< 0.001</td></tr><tr><td colspan="7">Female</td></tr><tr><td> 1 to 4</td><td>3</td><td>0.0096</td><td>1.05</td><td>1.03</td><td>1.07</td><td>< 0.001</td></tr><tr><td> 5 to 9</td><td>2</td><td>0.0048</td><td>1.10</td><td>1.09</td><td>1.12</td><td>< 0.001</td></tr><tr><td> 10 to 14</td><td>4</td><td>0.0067</td><td>1.17</td><td>1.15</td><td>1.18</td><td>< 0.001</td></tr><tr><td> 15 to 19</td><td>4</td><td>0.0080</td><td>1.17</td><td>1.13</td><td>1.21</td><td>< 0.001</td></tr><tr><td> 20 to 24</td><td>14</td><td>0.0300</td><td>0.99</td><td>0.97</td><td>1.01</td><td>0.3653</td></tr><tr><td> 25 to 29</td><td>36</td><td>0.0628</td><td>1.03</td><td>1.01</td><td>1.06</td><td>0.006</td></tr><tr><td> 30 to 34</td><td>46</td><td>0.0743</td><td>1.06</td><td>1.04</td><td>1.08</td><td>< 0.001</td></tr><tr><td> 35 to 39</td><td>48</td><td>0.0906</td><td>1.09</td><td>1.07</td><td>1.12</td><td>< 0.001</td></tr><tr><td> 40 to 44</td><td>20</td><td>0.0513</td><td>1.10</td><td>1.07</td><td>1.13</td><td>< 0.001</td></tr><tr><td> 45 to 49</td><td>16</td><td>0.0385</td><td>1.09</td><td>1.05</td><td>1.12</td><td>< 0.001</td></tr><tr><td> 50 to 54</td><td>20</td><td>0.0656</td><td>1.09</td><td>1.05</td><td>1.12</td><td>< 0.001</td></tr><tr><td> 55 to 59</td><td>7</td><td>0.0313</td><td>1.06</td><td>1.02</td><td>1.11</td><td>0.010</td></tr><tr><td> 60 to 64</td><td>5</td><td>0.0250</td><td>1.07</td><td>1.03</td><td>1.11</td><td>0.003</td></tr><tr><td> 65 to 69</td><td>1</td><td>0.0058</td><td>1.08</td><td>1.04</td><td>1.12</td><td>0.002</td></tr><tr><td> 70 to 74</td><td>1</td><td>0.0076</td><td>1.08</td><td>1.03</td><td>1.12</td><td>0.003</td></tr><tr><td> 75 to 79</td><td>0</td><td>0</td><td>1.08</td><td>1.04</td><td>1.12</td><td>0.002</td></tr><tr><td> 80 plus</td><td>0</td><td>0</td><td>1.08</td><td>1.04</td><td>1.12</td><td>0.002</td></tr></tbody></table></table-wrap></p><p id="Par54"><table-wrap id="Tab6"><label>Table 6</label><caption><p>The annual average annual percentage change (AAPC) of HIV and AIDS reporting incidence (RI) at province level from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Province</th><th>AAPC in HIV RI<break></break>NO. (95% CI)</th><th>AAPC in AIDS RI<break></break>NO. (95% CI)</th></tr></thead><tbody><tr><td>all</td><td>46.63(39.60,54.01)</td><td>20.57(-0.28,45.77)</td></tr><tr><td>Beijing</td><td>147.72(110.96,190.89)</td><td>19.10(0.30,41.43)</td></tr><tr><td>Tianjin</td><td>32.77(26.79,39.04)</td><td>8.86(-0.03,18.55)</td></tr><tr><td>Hebei</td><td>11.21(7.41,15.15)</td><td>2.86(-0.20,6.02)</td></tr><tr><td>Shanxi</td><td>16.01(10.88,21.37)</td><td>3.53(-1.09,8.36)</td></tr><tr><td>Inner Mongolia</td><td>21.87(15.70,28.37)</td><td>2.67(-0.30,5.72)</td></tr><tr><td>Liaoning</td><td>48.83(34.92,64.18)</td><td>8.16(-0.07,17.07)</td></tr><tr><td>Jilin</td><td>22.82(12.82,33.71)</td><td>7.98(0.52,15.98)</td></tr><tr><td>Heilongjiang</td><td>27.90(18.92,37.55)</td><td>5.80(0.17,11.74)</td></tr><tr><td>Shanghai</td><td>31.74(15.58,50.17)</td><td>18.80(1.11,39.59)</td></tr><tr><td>Jiangsu</td><td>31.83(23.62,40.59)</td><td>9.46(0.11,19.68)</td></tr><tr><td>Zhejiang</td><td>48.81(41.75,56.23)</td><td>15.29(0.90,31.72)</td></tr><tr><td>Anhui</td><td>14.08(6.97,21.66)</td><td>7.94(-1.55,18.33)</td></tr><tr><td>Fujian</td><td>34.19(21.69,47.97)</td><td>7.78(0.61,15.45)</td></tr><tr><td>Jiangxi</td><td>25.97(17.85,34.65)</td><td>10.12(0.20,21.03)</td></tr><tr><td>Shandong</td><td>11.35(7.77,15.05)</td><td>2.01(-0.07,4.14)</td></tr><tr><td>Henan</td><td>9.33(0.54,18.89)</td><td>3.81(-10.34,20.20)</td></tr><tr><td>Hubei</td><td>21.84(14.15,30.04)</td><td>8.98(-0.02,18.79)</td></tr><tr><td>Hunan</td><td>35.62(26.70,45.16)</td><td>21.15(0.08,46.66)</td></tr><tr><td>Guangdong</td><td>22.10(2.44,45.54)</td><td>18.22(-0.63,40.64)</td></tr><tr><td>Guangxi</td><td>111.12(-3.85,363.55)</td><td>180.62(-3.28,714.22)</td></tr><tr><td>Hainan</td><td>27.20(17.94,37.19)</td><td>10.71(-0.29,22.92)</td></tr><tr><td>Chongqing</td><td>241.88(170.14,332.67)</td><td>51.08(1.99,123.80)</td></tr><tr><td>Sichuan</td><td>283.60(215.28,366.71)</td><td>61.17(2.05,154.52)</td></tr><tr><td>Guizhou</td><td>114.41(67.61,174.28)</td><td>33.31(-0.38,78.40)</td></tr><tr><td>Yunnan</td><td>88.25(8.93,225.32)</td><td>123.90(-1.14,407.08)</td></tr><tr><td>Tibet</td><td>27.84(20.80,35.30)</td><td>2.63(-1.38,6.80)</td></tr><tr><td>Shaanxi</td><td>37.19(24.99,50.57)</td><td>7.85(0.06,16.24)</td></tr><tr><td>Gansu</td><td>17.47(11.90,23.32)</td><td>3.93(-0.08,8.11)</td></tr><tr><td>Qinghai</td><td>46.85(32.59,62.65)</td><td>10.04(-0.14,21.27)</td></tr><tr><td>Ningxia</td><td>28.86(21.83,36.30)</td><td>5.49(-0.37,11.70)</td></tr><tr><td>Xinjiang</td><td>228.15(27.38,745.38)</td><td>79.93(-7.84,251.29)</td></tr></tbody></table></table-wrap></p><p id="Par55"><table-wrap id="Tab7"><label>Table 7</label><caption><p>The average annual percentage change (AAPC) of HIV and AIDS reporting incidence in each age group from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Age group</th><th>AAPC in HIV RI<break></break>NO. (95% CI)</th><th>AAPC in AIDS RI<break></break>NO. (95% CI)</th></tr></thead><tbody><tr><td>1 to 4</td><td>5.79 (0.00,11.93)</td><td>2.71 (0.51,4.96)</td></tr><tr><td>5 to 9</td><td>4.61 (1.91,7.38)</td><td>2.12 (0.49,3.78)</td></tr><tr><td>10 to 14</td><td>0.78 (0.45,1.12)</td><td>0.40 (−0.29,1.11)</td></tr><tr><td>15 to 19</td><td>24.45 (17.49,31.83)</td><td>6.76 (2.90,10.76)</td></tr><tr><td>20 to 24</td><td>60.06 (40.85,81.89)</td><td>28.14 (13.20,45.05)</td></tr><tr><td>25 to 29</td><td>75.35 (19.60,157.10)</td><td>61.30 (28.23,102.89)</td></tr><tr><td>30 to 34</td><td>80.53 (31.84,147.21)</td><td>82.41 (42.28,133.85)</td></tr><tr><td>35 to 39</td><td>56.80 (36.34,80.34)</td><td>62.72 (34.71,96.55)</td></tr><tr><td>40 to 44</td><td>50.36 (43.08,58.00)</td><td>49.90 (28.89,74.33)</td></tr><tr><td>45 to 49</td><td>50.08 (41.38,59.31)</td><td>45.32 (32.90,58.90)</td></tr><tr><td>50 to 54</td><td>44.83 (29.59,61.86)</td><td>40.75 (20.70,64.13)</td></tr><tr><td>55 to 59</td><td>47.61 (36.81,59.25)</td><td>42.10 (26.14,60.09)</td></tr><tr><td>60 to 64</td><td>61.19 (49.18,74.17)</td><td>51.79 (32.37,74.05)</td></tr><tr><td>65 to 69</td><td>70.77 (55.94,87.00)</td><td>56.32 (32.97,83.78)</td></tr><tr><td>70 to 74</td><td>63.51 (49.86,78.40)</td><td>47.27 (29.78,67.10)</td></tr><tr><td>75 to 79</td><td>49.70 (40.50,59.51)</td><td>31.66 (20.64,43.70)</td></tr><tr><td>80 plus</td><td>34.71 (24.19,46.12)</td><td>16.94 (11.66,22.46)</td></tr></tbody></table></table-wrap></p><p id="Par56"><table-wrap id="Tab8"><label>Table 8</label><caption><p>The average annual percentage change (AAPC) of AIDS reporting mortality (RM) at province level from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Province</th><th>AAPC in AIDS RM<break></break>NO. (95% CI)</th></tr></thead><tbody><tr><td>All</td><td>9.87 (8.60,11.15)</td></tr><tr><td>Beijing</td><td>1.97 (1.52,2.41)</td></tr><tr><td>Tianjin</td><td>2.25 (1.78,2.72)</td></tr><tr><td>Hebei</td><td>1.15 (0.67,1.63)</td></tr><tr><td>Shanxi</td><td>1.54 (0.66,2.43)</td></tr><tr><td>Inner Mongolia</td><td>0.92 (0.51,1.33)</td></tr><tr><td>Liaoning</td><td>2.52 (1.78,3.26)</td></tr><tr><td>Jilin</td><td>3.90 (2.75,5.07)</td></tr><tr><td>Heilongjiang</td><td>2.03 (1.63,2.43)</td></tr><tr><td>Shanghai</td><td>1.39 (0.96,1.83)</td></tr><tr><td>Jiangsu</td><td>2.65 (2.03,3.28)</td></tr><tr><td>Zhejiang</td><td>3.19 (2.71,3.66)</td></tr><tr><td>Anhui</td><td>3.34 (2.45,4.24)</td></tr><tr><td>Fujian</td><td>2.53 (1.33,3.75)</td></tr><tr><td>Jiangxi</td><td>3.70 (3.24,4.17)</td></tr><tr><td>Shandong</td><td>0.63 (0.46,0.80)</td></tr><tr><td>Henan</td><td>9.64 (−2.30,23.05)</td></tr><tr><td>Hubei</td><td>3.79 (2.94,4.64)</td></tr><tr><td>Hunan</td><td>11.00 (9.52,12.51)</td></tr><tr><td>Guangdong</td><td>7.93 (6.76,9.12)</td></tr><tr><td>Guangxi</td><td>103.49 (71.17,141.90)</td></tr><tr><td>Hainan</td><td>7.27 (6.12,8.44)</td></tr><tr><td>Chongqing</td><td>18.05 (14.34,21.88)</td></tr><tr><td>Sichuan</td><td>22.59 (18.48,26.84)</td></tr><tr><td>Guizhou</td><td>14.34 (11.83,16.91)</td></tr><tr><td>Yunnan</td><td>49.13 (41.35,57.33)</td></tr><tr><td>Tibet</td><td>1.08 (0.30,1.87)</td></tr><tr><td>Shaanxi</td><td>2.29 (1.76,2.82)</td></tr><tr><td>Gansu</td><td>1.50 (0.99,2.02)</td></tr><tr><td>Qinghai</td><td>3.38 (1.65,5.13)</td></tr><tr><td>Ningxia</td><td>2.50 (2.01,2.99)</td></tr><tr><td>Xinjiang</td><td>35.99 (28.49,43.93)</td></tr></tbody></table></table-wrap></p><p id="Par57"><table-wrap id="Tab9"><label>Table 9</label><caption><p>The average annual percentage change (AAPC) of AIDS reporting mortality (RM) by age groups from 2004 to 2014</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Age group</th><th>AAPC in AIDS RM<break></break>NO. (95% CI)</th></tr></thead><tbody><tr><td>1 to 4</td><td>0.72 (−0.15,1.59)</td></tr><tr><td>5 to 9</td><td>0.89 (0.34,1.44)</td></tr><tr><td>10 to 14</td><td>0.57 (0.01,1.12)</td></tr><tr><td>15 to 19</td><td>0.84 (0.55,1.12)</td></tr><tr><td>20 to 24</td><td>0.46 (0.09,0.84)</td></tr><tr><td>25 to 29</td><td>0.32 (−0.07,0.72)</td></tr><tr><td>30 to 34</td><td>0.45 (0.21,0.70)</td></tr><tr><td>35 to 39</td><td>0.44 (0.03,0.85)</td></tr><tr><td>40 to 44</td><td>0.24 (0.01,0.47)</td></tr><tr><td>45 to 49</td><td>1.15 (0.83,1.48)</td></tr><tr><td>50 to 54</td><td>4.93 (3.94,5.93)</td></tr><tr><td>55 to 59</td><td>13.11 (10.57,15.71)</td></tr><tr><td>60 to 64</td><td>20.44 (16.06,24.99)</td></tr><tr><td>65 to 69</td><td>16.78 (13.47,20.18)</td></tr><tr><td>70 to 74</td><td>13.19 (11.31,15.10)</td></tr><tr><td>75 to 79</td><td>11.80 (9.51,14.13)</td></tr><tr><td>80 plus</td><td>11.47 (9.45,13.52)</td></tr></tbody></table></table-wrap></p></sec></app></app-group><glossary><title>Abbreviations</title><def-list><def-item><term>AAPC</term><def><p id="Par5">Average annual percentage change</p></def></def-item><def-item><term>AIDS</term><def><p id="Par6">Acquired immune deficiency syndrome</p></def></def-item><def-item><term>CI</term><def><p id="Par7">Confidence interval</p></def></def-item><def-item><term>CISDCP</term><def><p id="Par8">The China Information System for Disease Control and Prevention</p></def></def-item><def-item><term>EMD</term><def><p id="Par9">Empirical mode decomposition</p></def></def-item><def-item><term>HAART</term><def><p id="Par10">Highly active anti-retroviral therapy</p></def></def-item><def-item><term>HIV</term><def><p id="Par11">Human immunodeficiency virus</p></def></def-item><def-item><term>OR</term><def><p id="Par12">Odds ratio</p></def></def-item><def-item><term>RI</term><def><p id="Par13">Reporting incidence</p></def></def-item><def-item><term>SARS</term><def><p id="Par14">Severe acute respiratory syndromes</p></def></def-item></def-list></glossary><ack><title>Acknowledgements</title><p>Not applicable.</p><sec id="FPar1"><title>Funding</title><p id="Par42">This work was supported by the National Natural Science Foundation of China (grant numbers: 81772170, 81502870); the National Key Research and Development program of China (grant number: 2017YFC0907002, 2017YFC0907501, 2017YFC211700); the key basic research grants from Science and Technology Commission of Shanghai Municipality (grant number: 16JC1400500); the International S&T Cooperation Program of China (grant number: 2015DFE32790); and Shanghai Municipal Science and Technology Major Project (2017SHZDZX01).</p></sec><sec id="FPar2" sec-type="data-availability"><title>Availability of data and materials</title><p id="Par43">The incidence and mortality data on HIV and AIDS in China covering 31 provinces from 2004 to 2014 were collected from the Chinese Public Health Science Data Center (<ext-link ext-link-type="uri" xlink:href="http://www.phsciencedata.cn">http://www.phsciencedata.cn</ext-link>).</p></sec></ack><notes notes-type="author-contribution"><title>Authors’ contributions</title><p>TZ, YC and XC contributed to the study design; OS, QY and QF contributed to the data collection; ZL, OS and JZ contributed to the data analyses, interpretations and writing of the manuscript. All authors contributed to the manuscript proof. All authors read and approved the final manuscript.</p></notes><notes><title>Ethics approval and consent to participate</title><p id="Par44">This study was undertaken with the retrospective analysis of data collected from the Chinese Public Health Science Data Center, and the data used in the analysis were anonymized and no additional contact was made with patients to obtain further information as a part of this study, therefore, no ethical approval was required.</p></notes><notes><title>Consent for publication</title><p id="Par45">Not applicable.</p></notes><notes notes-type="COI-statement"><title>Competing interests</title><p id="Par46">The authors declare that they have no competing interests.</p></notes><notes><title>Publisher’s Note</title><p id="Par47">Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></notes><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><mixed-citation publication-type="other">Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117–71.</mixed-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>Z</given-names></name><name><surname>Sullivan</surname><given-names>SG</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Rotheram-Borus</surname><given-names>MJ</given-names></name><name><surname>Detels</surname><given-names>R</given-names></name></person-group><article-title>Evolution of China's response to HIV/AIDS</article-title><source>Lancet</source><year>2007</year><volume>369</volume><issue>9562</issue><fpage>679</fpage><lpage>690</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(07)60315-8</pub-id><pub-id pub-id-type="pmid">17321313</pub-id></element-citation></ref><ref id="CR3"><label>3.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>MB</given-names></name><name><surname>Ye</surname><given-names>L</given-names></name><name><surname>Liang</surname><given-names>BY</given-names></name><name><surname>Ning</surname><given-names>CY</given-names></name><name><surname>Roth</surname><given-names>WW</given-names></name><name><surname>Jiang</surname><given-names>JJ</given-names></name><etal></etal></person-group><article-title>Characterizing the HIV/AIDS epidemic in the United States and China</article-title><source>Int J Environ Res Public Health</source><year>2015</year><volume>13</volume><issue>1</issue><fpage>ijerph13010030</fpage><pub-id pub-id-type="doi">10.3390/ijerph13010030</pub-id><pub-id pub-id-type="pmid">26703667</pub-id></element-citation></ref><ref id="CR4"><label>4.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>He</surname><given-names>N</given-names></name><name><surname>Detels</surname><given-names>R</given-names></name></person-group><article-title>The HIV epidemic in China: history, response, and challenge</article-title><source>Cell Res</source><year>2005</year><volume>15</volume><issue>11–12</issue><fpage>825</fpage><lpage>832</lpage><pub-id pub-id-type="doi">10.1038/sj.cr.7290354</pub-id><pub-id pub-id-type="pmid">16354555</pub-id></element-citation></ref><ref id="CR5"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sun</surname><given-names>X</given-names></name><name><surname>Lu</surname><given-names>F</given-names></name><name><surname>Wu</surname><given-names>Z</given-names></name><name><surname>Poundstone</surname><given-names>K</given-names></name><name><surname>Zeng</surname><given-names>G</given-names></name><name><surname>Xu</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Evolution of information-driven HIV/AIDS policies in China</article-title><source>Int J Epidemiol</source><year>2010</year><volume>39</volume><issue>Suppl 2</issue><fpage>ii4</fpage><lpage>i13</lpage><pub-id pub-id-type="pmid">21113036</pub-id></element-citation></ref><ref id="CR6"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mao</surname><given-names>Y</given-names></name><name><surname>Wu</surname><given-names>Z</given-names></name><name><surname>Poundstone</surname><given-names>K</given-names></name><name><surname>Wang</surname><given-names>C</given-names></name><name><surname>Qin</surname><given-names>Q</given-names></name><name><surname>Ma</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Development of a unified web-based national HIV/AIDS information system in China</article-title><source>Int J Epidemiol</source><year>2010</year><volume>39</volume><issue>Suppl 2</issue><fpage>ii79</fpage><lpage>ii89</lpage><pub-id pub-id-type="pmid">21113041</pub-id></element-citation></ref><ref id="CR7"><label>7.</label><mixed-citation publication-type="other">Yang S, Wu J, Ding C, Cui Y, Zhou Y, Li Y, et al. Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study. Lancet Infect Dis. 2017;17(7):716–25.</mixed-citation></ref><ref id="CR8"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Jin</surname><given-names>S</given-names></name><name><surname>Wu</surname><given-names>Z</given-names></name><name><surname>Chin</surname><given-names>DP</given-names></name><name><surname>Koplan</surname><given-names>JP</given-names></name><etal></etal></person-group><article-title>Emergence and control of infectious diseases in China</article-title><source>Lancet</source><year>2008</year><volume>372</volume><issue>9649</issue><fpage>1598</fpage><lpage>1605</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(08)61365-3</pub-id><pub-id pub-id-type="pmid">18930534</pub-id></element-citation></ref><ref id="CR9"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>NE</given-names></name><name><surname>Hu</surname><given-names>K</given-names></name><name><surname>Yang</surname><given-names>AC</given-names></name><name><surname>Chang</surname><given-names>HC</given-names></name><name><surname>Jia</surname><given-names>D</given-names></name><name><surname>Liang</surname><given-names>WK</given-names></name><etal></etal></person-group><article-title>On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data</article-title><source>Philos Trans A Math Phys Eng Sci</source><year>2016</year><volume>374</volume><issue>2065</issue><fpage>20150206</fpage><pub-id pub-id-type="doi">10.1098/rsta.2015.0206</pub-id><pub-id pub-id-type="pmid">26953180</pub-id></element-citation></ref><ref id="CR10"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>JX</given-names></name><name><surname>Xia</surname><given-names>ZG</given-names></name><name><surname>Zhou</surname><given-names>SS</given-names></name><name><surname>Pu</surname><given-names>XJ</given-names></name><name><surname>Hu</surname><given-names>MG</given-names></name><name><surname>Huang</surname><given-names>DC</given-names></name><etal></etal></person-group><article-title>Spatio-temporal analysis of malaria vectors in national malaria surveillance sites in China</article-title><source>Parasit Vectors</source><year>2015</year><volume>8</volume><fpage>146</fpage><pub-id pub-id-type="doi">10.1186/s13071-015-0741-5</pub-id><pub-id pub-id-type="pmid">25888910</pub-id></element-citation></ref><ref id="CR11"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ott</surname><given-names>JJ</given-names></name><name><surname>Horn</surname><given-names>J</given-names></name><name><surname>Krause</surname><given-names>G</given-names></name><name><surname>Mikolajczyk</surname><given-names>RT</given-names></name></person-group><article-title>Time trends of chronic HBV infection over prior decades - a global analysis</article-title><source>J Hepatol</source><year>2017</year><volume>66</volume><issue>1</issue><fpage>48</fpage><lpage>54</lpage><pub-id pub-id-type="doi">10.1016/j.jhep.2016.08.013</pub-id><pub-id pub-id-type="pmid">27592304</pub-id></element-citation></ref><ref id="CR12"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Clegg</surname><given-names>LX</given-names></name><name><surname>Hankey</surname><given-names>BF</given-names></name><name><surname>Tiwari</surname><given-names>R</given-names></name><name><surname>Feuer</surname><given-names>EJ</given-names></name><name><surname>Edwards</surname><given-names>BK</given-names></name></person-group><article-title>Estimating average annual per cent change in trend analysis</article-title><source>Stat Med</source><year>2009</year><volume>28</volume><issue>29</issue><fpage>3670</fpage><lpage>3682</lpage><pub-id pub-id-type="doi">10.1002/sim.3733</pub-id><pub-id pub-id-type="pmid">19856324</pub-id></element-citation></ref><ref id="CR13"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shao</surname><given-names>B</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Yu</surname><given-names>L</given-names></name><name><surname>Wang</surname><given-names>K</given-names></name><name><surname>Chang</surname><given-names>M</given-names></name><name><surname>Wang</surname><given-names>B</given-names></name><etal></etal></person-group><article-title>The HIV/AIDS epidemic characteristics in a northeast province of China--men who have sex with men have made a tremendous contribution to the growth of the HIV epidemic</article-title><source>J Inf Secur</source><year>2014</year><volume>68</volume><issue>3</issue><fpage>273</fpage><lpage>280</lpage></element-citation></ref><ref id="CR14"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>ES</given-names></name><name><surname>Xie</surname><given-names>Q</given-names></name><name><surname>Zhang</surname><given-names>K</given-names></name><name><surname>Lu</surname><given-names>P</given-names></name><name><surname>Chan</surname><given-names>LL</given-names></name></person-group><article-title>HIV infection and AIDS in China, 1985 through 1994</article-title><source>Am J Public Health</source><year>1996</year><volume>86</volume><issue>8</issue><fpage>1116</fpage><lpage>1122</lpage><pub-id pub-id-type="doi">10.2105/AJPH.86.8_Pt_1.1116</pub-id><pub-id pub-id-type="pmid">8712271</pub-id></element-citation></ref><ref id="CR15"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>L</given-names></name><name><surname>Chow</surname><given-names>EP</given-names></name><name><surname>Jing</surname><given-names>J</given-names></name><name><surname>Zhuang</surname><given-names>X</given-names></name><name><surname>Li</surname><given-names>X</given-names></name><name><surname>He</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>HIV prevalence in China: integration of surveillance data and a systematic review</article-title><source>Lancet Infect Dis</source><year>2013</year><volume>13</volume><issue>11</issue><fpage>955</fpage><lpage>963</lpage><pub-id pub-id-type="doi">10.1016/S1473-3099(13)70245-7</pub-id><pub-id pub-id-type="pmid">24107261</pub-id></element-citation></ref><ref id="CR16"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dai</surname><given-names>ZC</given-names></name></person-group><article-title>AIDS prevention and control in China</article-title><source>Chin Med J</source><year>1991</year><volume>104</volume><issue>10</issue><fpage>795</fpage><lpage>798</lpage><pub-id pub-id-type="pmid">1752138</pub-id></element-citation></ref><ref id="CR17"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qian</surname><given-names>S</given-names></name><name><surname>Guo</surname><given-names>W</given-names></name><name><surname>Xing</surname><given-names>J</given-names></name><name><surname>Qin</surname><given-names>Q</given-names></name><name><surname>Ding</surname><given-names>Z</given-names></name><name><surname>Chen</surname><given-names>F</given-names></name><etal></etal></person-group><article-title>Diversity of HIV/AIDS epidemic in China: a result from hierarchical clustering analysis and spatial autocorrelation analysis</article-title><source>AIDS</source><year>2014</year><volume>28</volume><issue>12</issue><fpage>1805</fpage><lpage>1813</lpage><pub-id pub-id-type="doi">10.1097/QAD.0000000000000323</pub-id><pub-id pub-id-type="pmid">24906111</pub-id></element-citation></ref><ref id="CR18"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Guo</surname><given-names>W</given-names></name><name><surname>Li</surname><given-names>D</given-names></name><name><surname>Ding</surname><given-names>Z</given-names></name><name><surname>McGoogan</surname><given-names>JM</given-names></name><name><surname>Wang</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>HIV epidemic among drug users in China: 1995-2011</article-title><source>Addiction</source><year>2015</year><volume>110</volume><issue>Suppl 1</issue><fpage>20</fpage><lpage>28</lpage><pub-id pub-id-type="doi">10.1111/add.12779</pub-id><pub-id pub-id-type="pmid">25533861</pub-id></element-citation></ref><ref id="CR19"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>Z</given-names></name><name><surname>Rou</surname><given-names>K</given-names></name><name><surname>Cui</surname><given-names>H</given-names></name></person-group><article-title>The HIV/AIDS epidemic in China: history, current strategies and future challenges</article-title><source>AIDS Educ Prev</source><year>2004</year><volume>16</volume><issue>3 Suppl A</issue><fpage>7</fpage><lpage>17</lpage><pub-id pub-id-type="doi">10.1521/aeap.16.3.5.7.35521</pub-id><pub-id pub-id-type="pmid">15262561</pub-id></element-citation></ref><ref id="CR20"><label>20.</label><mixed-citation publication-type="other">Unaids: 2015 China AIDS Response Progress Report. (Available at <ext-link ext-link-type="uri" xlink:href="http://www.unaids.org.cn/en/index/Document_view.asp?id=874">http://www.unaids.org.cn/en/index/Document_view.asp?id=874</ext-link>).</mixed-citation></ref><ref id="CR21"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>F</given-names></name><name><surname>Dou</surname><given-names>Z</given-names></name><name><surname>Ma</surname><given-names>Y</given-names></name><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Zhao</surname><given-names>Y</given-names></name><name><surname>Zhao</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study</article-title><source>Lancet Infect Dis</source><year>2011</year><volume>11</volume><issue>7</issue><fpage>516</fpage><lpage>524</lpage><pub-id pub-id-type="doi">10.1016/S1473-3099(11)70097-4</pub-id><pub-id pub-id-type="pmid">21600849</pub-id></element-citation></ref><ref id="CR22"><label>22.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yi</surname><given-names>H</given-names></name><name><surname>Lau</surname><given-names>JT</given-names></name></person-group><article-title>Emerging issues, challenges and aspirations in the HIV/AIDS epidemic in China</article-title><source>Public Health</source><year>2011</year><volume>125</volume><issue>5</issue><fpage>257</fpage><lpage>259</lpage><pub-id pub-id-type="doi">10.1016/j.puhe.2011.01.012</pub-id><pub-id pub-id-type="pmid">21349560</pub-id></element-citation></ref><ref id="CR23"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yin</surname><given-names>D</given-names></name></person-group><article-title>Against the HIV / AIDS epidemic</article-title><source>China Integration</source><year>1998</year><volume>57</volume><fpage>29</fpage><lpage>31</lpage></element-citation></ref><ref id="CR24"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>N</given-names></name><name><surname>Wang</surname><given-names>Z</given-names></name><name><surname>Sun</surname><given-names>D</given-names></name><name><surname>Zhu</surname><given-names>Q</given-names></name><name><surname>Sun</surname><given-names>G</given-names></name><name><surname>Yang</surname><given-names>W</given-names></name><etal></etal></person-group><article-title>HIV among plasma donors and other high-risk groups in Henan, China</article-title><source>J Acquir Immune Defic Syndr</source><year>2010</year><volume>53</volume><issue>Suppl 1</issue><fpage>S41</fpage><lpage>S47</lpage><pub-id pub-id-type="doi">10.1097/QAI.0b013e3181c7d717</pub-id><pub-id pub-id-type="pmid">20104109</pub-id></element-citation></ref><ref id="CR25"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zeng</surname><given-names>Y</given-names></name></person-group><article-title>AIDS prevention and control</article-title><source>Chin J Exp Clin Virol</source><year>2007</year><volume>21</volume><fpage>1</fpage></element-citation></ref><ref id="CR26"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>J</given-names></name><name><surname>Jiang</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>JZ</given-names></name><name><surname>Yang</surname><given-names>X</given-names></name><name><surname>Deng</surname><given-names>W</given-names></name><name><surname>Abdullah</surname><given-names>AS</given-names></name><etal></etal></person-group><article-title>Prevalence and correlates of sexual risk behaviors among drug users in western China: implications for HIV transmission</article-title><source>AIDS Res Hum Retrovir</source><year>2013</year><volume>29</volume><issue>4</issue><fpage>673</fpage><lpage>680</lpage><pub-id pub-id-type="doi">10.1089/aid.2012.0272</pub-id><pub-id pub-id-type="pmid">23210514</pub-id></element-citation></ref><ref id="CR27"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname><given-names>BY</given-names></name><name><surname>Bu</surname><given-names>J</given-names></name><name><surname>Huang</surname><given-names>PY</given-names></name><name><surname>Zhou</surname><given-names>ZG</given-names></name><name><surname>Yin</surname><given-names>YP</given-names></name><name><surname>Chen</surname><given-names>XS</given-names></name><etal></etal></person-group><article-title>Epidemiology of sexually transmitted infections, HIV, and related high-risk behaviors among female sex workers in Guangxi Autonomous Region, China</article-title><source>Jpn J Infect Dis</source><year>2012</year><volume>65</volume><issue>1</issue><fpage>75</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">22274163</pub-id></element-citation></ref><ref id="CR28"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Longo</surname><given-names>B</given-names></name><name><surname>Camoni</surname><given-names>L</given-names></name><name><surname>Boros</surname><given-names>S</given-names></name><name><surname>Suligoi</surname><given-names>B</given-names></name></person-group><article-title>Increasing proportion of AIDS diagnoses among older adults in Italy</article-title><source>AIDS Patient Care STDs</source><year>2008</year><volume>22</volume><issue>5</issue><fpage>365</fpage><lpage>371</lpage><pub-id pub-id-type="doi">10.1089/apc.2007.0168</pub-id><pub-id pub-id-type="pmid">18435593</pub-id></element-citation></ref><ref id="CR29"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Negin</surname><given-names>J</given-names></name><name><surname>Cumming</surname><given-names>RG</given-names></name></person-group><article-title>HIV infection in older adults in sub-Saharan Africa: extrapolating prevalence from existing data</article-title><source>Bull World Health Organ</source><year>2010</year><volume>88</volume><issue>11</issue><fpage>847</fpage><lpage>853</lpage><pub-id pub-id-type="doi">10.2471/BLT.10.076349</pub-id><pub-id pub-id-type="pmid">21076566</pub-id></element-citation></ref><ref id="CR30"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xing</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>YG</given-names></name><name><surname>Tang</surname><given-names>W</given-names></name><name><surname>Guo</surname><given-names>W</given-names></name><name><surname>Ding</surname><given-names>Z</given-names></name><name><surname>Ding</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>HIV/AIDS epidemic among older adults in China during 2005-2012: results from trend and spatial analysis</article-title><source>Clin Infect Dis</source><year>2014</year><volume>59</volume><issue>2</issue><fpage>e53</fpage><lpage>e60</lpage><pub-id pub-id-type="doi">10.1093/cid/ciu214</pub-id><pub-id pub-id-type="pmid">24700658</pub-id></element-citation></ref><ref id="CR31"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>M</given-names></name><name><surname>Tang</surname><given-names>W</given-names></name><name><surname>Bu</surname><given-names>K</given-names></name><name><surname>Mahapatra</surname><given-names>T</given-names></name><name><surname>Zhang</surname><given-names>X</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Mortality among people living with HIV and AIDS in China: implications for enhancing linkage</article-title><source>Sci Rep</source><year>2016</year><volume>6</volume><fpage>28005</fpage><pub-id pub-id-type="doi">10.1038/srep28005</pub-id><pub-id pub-id-type="pmid">27324204</pub-id></element-citation></ref><ref id="CR32"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murray</surname><given-names>CJ</given-names></name><name><surname>Ortblad</surname><given-names>KF</given-names></name><name><surname>Guinovart</surname><given-names>C</given-names></name><name><surname>Lim</surname><given-names>SS</given-names></name><name><surname>Wolock</surname><given-names>TM</given-names></name><name><surname>Roberts</surname><given-names>DA</given-names></name><etal></etal></person-group><article-title>Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the global burden of disease study 2013</article-title><source>Lancet</source><year>2014</year><volume>384</volume><issue>9947</issue><fpage>1005</fpage><lpage>1070</lpage><pub-id pub-id-type="doi">10.1016/s0140-6736(14)60844-8</pub-id><pub-id pub-id-type="pmid">25059949</pub-id></element-citation></ref><ref id="CR33"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ortblad</surname><given-names>KF</given-names></name><name><surname>Lozano</surname><given-names>R</given-names></name><name><surname>Murray</surname><given-names>CJ</given-names></name></person-group><article-title>The burden of HIV: insights from the global burden of disease study 2010</article-title><source>Aids</source><year>2013</year><volume>27</volume><issue>13</issue><fpage>2003</fpage><lpage>2017</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e328362ba67</pub-id><pub-id pub-id-type="pmid">23660576</pub-id></element-citation></ref><ref id="CR34"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tavoschi</surname><given-names>L</given-names></name><name><surname>Gomes Dias</surname><given-names>J</given-names></name><name><surname>Pharris</surname><given-names>A</given-names></name></person-group><article-title>New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004-15: an analysis of surveillance data</article-title><source>Lancet HIV</source><year>2017</year><volume>4</volume><issue>11</issue><fpage>e514</fpage><lpage>ee21</lpage><pub-id pub-id-type="doi">10.1016/s2352-3018(17)30155-8</pub-id><pub-id pub-id-type="pmid">28967582</pub-id></element-citation></ref><ref id="CR35"><label>35.</label><mixed-citation publication-type="other">Liu Z, Yang Q, Shi O, Ye W, Chen X, Zhang T. The epidemiology of hepatitis B and hepatitis C infections in China from 2004 to 2014: an observational population-based study. J Viral Hepat. 2018;25(12):1543–54. 10.1111/jvh.12938.</mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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