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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Review of economic evaluations of mask and respirator use for protection against respiratory infection transmission</title>
<author><name sortKey="Mukerji, Shohini" sort="Mukerji, Shohini" uniqKey="Mukerji S" first="Shohini" last="Mukerji">Shohini Mukerji</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Macintyre, C Raina" sort="Macintyre, C Raina" uniqKey="Macintyre C" first="C. Raina" last="Macintyre">C. Raina Macintyre</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Newall, Anthony T" sort="Newall, Anthony T" uniqKey="Newall A" first="Anthony T." last="Newall">Anthony T. Newall</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26462473</idno>
<idno type="pmc">4605092</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605092</idno>
<idno type="RBID">PMC:4605092</idno>
<idno type="doi">10.1186/s12879-015-1167-6</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000305</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000305</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Review of economic evaluations of mask and respirator use for protection against respiratory infection transmission</title>
<author><name sortKey="Mukerji, Shohini" sort="Mukerji, Shohini" uniqKey="Mukerji S" first="Shohini" last="Mukerji">Shohini Mukerji</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Macintyre, C Raina" sort="Macintyre, C Raina" uniqKey="Macintyre C" first="C. Raina" last="Macintyre">C. Raina Macintyre</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Newall, Anthony T" sort="Newall, Anthony T" uniqKey="Newall A" first="Anthony T." last="Newall">Anthony T. Newall</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">There has been increasing debate surrounding mask and respirator interventions to control respiratory infection transmission in both healthcare and community settings. As decision makers are considering the recommendations they should evaluate how to provide the most efficient protection strategies with minimum costs. The aim of this review is to identify and evaluate the existing economic evaluation literature in this area and to offer advice on how future evaluations on this topic should be conducted.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">We searched the Scopus database for all literature on economic evaluation of mask or respirator use to control respiratory infection transmission. Reference lists from the identified studies were also manually searched. Seven studies met our inclusion criteria from the initial 806 studies identified by the search strategy and our manual search.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">Five studies considered interventions for seasonal and/or pandemic influenza, with one also considering SARS (Severe Acute Respiratory Syndrome). The other two studies focussed on tuberculosis transmission control interventions. The settings and methodologies of the studies varied greatly. No low-middle income settings were identified. Only one of the reviewed studies cited clinical evidence to inform their mask/respirator intervention effectiveness parameters. Mask and respirator interventions were generally reported by the study authors to be cost saving or cost-effective when compared to no intervention or other control measures, however the evaluations had important limitations.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">Given the large cost differential between masks and respirators, there is a need for more comprehensive economic evaluations to compare the relative costs and benefits of these interventions in situations and settings where alternative options are potentially applicable. There are at present insufficient well conducted cost-effectiveness studies to inform decision-makers on the value for money of alternative mask/respirator options.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Fineberg, Hv" uniqKey="Fineberg H">HV Fineberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carrasco, Lr" uniqKey="Carrasco L">LR Carrasco</name>
</author>
<author><name sortKey="Lee, Vj" uniqKey="Lee V">VJ Lee</name>
</author>
<author><name sortKey="Chen, Mi" uniqKey="Chen M">MI Chen</name>
</author>
<author><name sortKey="Matchar, Db" uniqKey="Matchar D">DB Matchar</name>
</author>
<author><name sortKey="Thompson, Jp" uniqKey="Thompson J">JP Thompson</name>
</author>
<author><name sortKey="Cook, Ar" uniqKey="Cook A">AR Cook</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chughtai, Aa" uniqKey="Chughtai A">AA Chughtai</name>
</author>
<author><name sortKey="Seale, H" uniqKey="Seale H">H Seale</name>
</author>
<author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR Macintyre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weber, A" uniqKey="Weber A">A Weber</name>
</author>
<author><name sortKey="Willeke, K" uniqKey="Willeke K">K Willeke</name>
</author>
<author><name sortKey="Marchioni, R" uniqKey="Marchioni R">R Marchioni</name>
</author>
<author><name sortKey="Myojo, T" uniqKey="Myojo T">T Myojo</name>
</author>
<author><name sortKey="Mckay, R" uniqKey="Mckay R">R McKay</name>
</author>
<author><name sortKey="Donnelly, J" uniqKey="Donnelly J">J Donnelly</name>
</author>
<author><name sortKey="Liebhaber, F" uniqKey="Liebhaber F">F Liebhaber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shine, Ki" uniqKey="Shine K">KI Shine</name>
</author>
<author><name sortKey="Rogers, B" uniqKey="Rogers B">B Rogers</name>
</author>
<author><name sortKey="Goldfrank, Lr" uniqKey="Goldfrank L">LR Goldfrank</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Larson, E" uniqKey="Larson E">E Larson</name>
</author>
<author><name sortKey="Liverman, Ct" uniqKey="Liverman C">CT Liverman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tracht, Sm" uniqKey="Tracht S">SM Tracht</name>
</author>
<author><name sortKey="Del Valle, Sy" uniqKey="Del Valle S">SY Del Valle</name>
</author>
<author><name sortKey="Edwards, Bk" uniqKey="Edwards B">BK Edwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dan, Yy" uniqKey="Dan Y">YY Dan</name>
</author>
<author><name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name>
</author>
<author><name sortKey="Sim, J" uniqKey="Sim J">J Sim</name>
</author>
<author><name sortKey="Lim, J" uniqKey="Lim J">J Lim</name>
</author>
<author><name sortKey="Hsu, Ly" uniqKey="Hsu L">LY Hsu</name>
</author>
<author><name sortKey="Chow, Wl" uniqKey="Chow W">WL Chow</name>
</author>
<author><name sortKey="Fisher, Da" uniqKey="Fisher D">DA Fisher</name>
</author>
<author><name sortKey="Wong, Ys" uniqKey="Wong Y">YS Wong</name>
</author>
<author><name sortKey="Ho, Ky" uniqKey="Ho K">KY Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Velasco, Rp" uniqKey="Velasco R">RP Velasco</name>
</author>
<author><name sortKey="Praditsitthikorn, N" uniqKey="Praditsitthikorn N">N Praditsitthikorn</name>
</author>
<author><name sortKey="Wichmann, K" uniqKey="Wichmann K">K Wichmann</name>
</author>
<author><name sortKey="Mohara, A" uniqKey="Mohara A">A Mohara</name>
</author>
<author><name sortKey="Kotirum, S" uniqKey="Kotirum S">S Kotirum</name>
</author>
<author><name sortKey="Tantivess, S" uniqKey="Tantivess S">S Tantivess</name>
</author>
<author><name sortKey="Vallenas, C" uniqKey="Vallenas C">C Vallenas</name>
</author>
<author><name sortKey="Harmanci, H" uniqKey="Harmanci H">H Harmanci</name>
</author>
<author><name sortKey="Teerawattananon, Y" uniqKey="Teerawattananon Y">Y Teerawattananon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burnham, J" uniqKey="Burnham J">J Burnham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kellerman, Se" uniqKey="Kellerman S">SE Kellerman</name>
</author>
<author><name sortKey="Tokars, Ji" uniqKey="Tokars J">JI Tokars</name>
</author>
<author><name sortKey="Jarvis, Wr" uniqKey="Jarvis W">WR Jarvis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rivera, P" uniqKey="Rivera P">P Rivera</name>
</author>
<author><name sortKey="Louther, J" uniqKey="Louther J">J Louther</name>
</author>
<author><name sortKey="Mohr, J" uniqKey="Mohr J">J Mohr</name>
</author>
<author><name sortKey="Campbell, A" uniqKey="Campbell A">A Campbell</name>
</author>
<author><name sortKey="Dehovitz, J" uniqKey="Dehovitz J">J DeHovitz</name>
</author>
<author><name sortKey="Sepkowitz, Ka" uniqKey="Sepkowitz K">KA Sepkowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christie, Cd" uniqKey="Christie C">CD Christie</name>
</author>
<author><name sortKey="Glover, Am" uniqKey="Glover A">AM Glover</name>
</author>
<author><name sortKey="Willke, Mj" uniqKey="Willke M">MJ Willke</name>
</author>
<author><name sortKey="Marx, Ml" uniqKey="Marx M">ML Marx</name>
</author>
<author><name sortKey="Reising, Sf" uniqKey="Reising S">SF Reising</name>
</author>
<author><name sortKey="Hutchinson, Nm" uniqKey="Hutchinson N">NM Hutchinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hogg, W" uniqKey="Hogg W">W Hogg</name>
</author>
<author><name sortKey="Huston, P" uniqKey="Huston P">P Huston</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adal, Ka" uniqKey="Adal K">KA Adal</name>
</author>
<author><name sortKey="Anglim, Am" uniqKey="Anglim A">AM Anglim</name>
</author>
<author><name sortKey="Palumbo, Cl" uniqKey="Palumbo C">CL Palumbo</name>
</author>
<author><name sortKey="Titus, Mg" uniqKey="Titus M">MG Titus</name>
</author>
<author><name sortKey="Coyner, Bj" uniqKey="Coyner B">BJ Coyner</name>
</author>
<author><name sortKey="Farr, Bm" uniqKey="Farr B">BM Farr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cahill, Bp" uniqKey="Cahill B">BP Cahill</name>
</author>
<author><name sortKey="Collins, Rd" uniqKey="Collins R">RD Collins</name>
</author>
<author><name sortKey="Jurko, Rc" uniqKey="Jurko R">RC Jurko</name>
</author>
<author><name sortKey="Zivic, Tr" uniqKey="Zivic T">TR Zivic</name>
</author>
<author><name sortKey="Crowther, Kg" uniqKey="Crowther K">KG Crowther</name>
</author>
<author><name sortKey="Haimes, Yy" uniqKey="Haimes Y">YY Haimes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name>
</author>
<author><name sortKey="Liao, Cm" uniqKey="Liao C">CM Liao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Rm" uniqKey="Jones R">RM Jones</name>
</author>
<author><name sortKey="Adida, E" uniqKey="Adida E">E Adida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nettleman, Md" uniqKey="Nettleman M">MD Nettleman</name>
</author>
<author><name sortKey="Fredrickson, M" uniqKey="Fredrickson M">M Fredrickson</name>
</author>
<author><name sortKey="Good, Nl" uniqKey="Good N">NL Good</name>
</author>
<author><name sortKey="Hunter, Sa" uniqKey="Hunter S">SA Hunter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tom, Ld" uniqKey="Tom L">LD Tom</name>
</author>
<author><name sortKey="Zaid, C" uniqKey="Zaid C">C Zaid</name>
</author>
<author><name sortKey="Richard, C" uniqKey="Richard C">C Richard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diel, R" uniqKey="Diel R">R Diel</name>
</author>
<author><name sortKey="Loddenkemper, R" uniqKey="Loddenkemper R">R Loddenkemper</name>
</author>
<author><name sortKey="Nienhaus, A" uniqKey="Nienhaus A">A Nienhaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aiello, Ae" uniqKey="Aiello A">AE Aiello</name>
</author>
<author><name sortKey="Murray, Gf" uniqKey="Murray G">GF Murray</name>
</author>
<author><name sortKey="Perez, V" uniqKey="Perez V">V Perez</name>
</author>
<author><name sortKey="Coulborn, Rm" uniqKey="Coulborn R">RM Coulborn</name>
</author>
<author><name sortKey="Davis, Bm" uniqKey="Davis B">BM Davis</name>
</author>
<author><name sortKey="Uddin, M" uniqKey="Uddin M">M Uddin</name>
</author>
<author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name>
</author>
<author><name sortKey="Waterman, Sh" uniqKey="Waterman S">SH Waterman</name>
</author>
<author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loeb, M" uniqKey="Loeb M">M Loeb</name>
</author>
<author><name sortKey="Dafoe, N" uniqKey="Dafoe N">N Dafoe</name>
</author>
<author><name sortKey="Mahony, J" uniqKey="Mahony J">J Mahony</name>
</author>
<author><name sortKey="John, M" uniqKey="John M">M John</name>
</author>
<author><name sortKey="Sarabia, A" uniqKey="Sarabia A">A Sarabia</name>
</author>
<author><name sortKey="Glavin, V" uniqKey="Glavin V">V Glavin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Seale, H" uniqKey="Seale H">H Seale</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Rahman, B" uniqKey="Rahman B">B Rahman</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Newall, At" uniqKey="Newall A">AT Newall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bollinger, N" uniqKey="Bollinger N">N Bollinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balazy, A" uniqKey="Balazy A">A Balazy</name>
</author>
<author><name sortKey="Toivola, M" uniqKey="Toivola M">M Toivola</name>
</author>
<author><name sortKey="Adhikari, A" uniqKey="Adhikari A">A Adhikari</name>
</author>
<author><name sortKey="Sivasubramani, Sk" uniqKey="Sivasubramani S">SK Sivasubramani</name>
</author>
<author><name sortKey="Reponen, T" uniqKey="Reponen T">T Reponen</name>
</author>
<author><name sortKey="Grinshpun, Sa" uniqKey="Grinshpun S">SA Grinshpun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mugford, M" uniqKey="Mugford M">M Mugford</name>
</author>
<author><name sortKey="Donaldson, C" uniqKey="Donaldson C">C Donaldson</name>
</author>
<author><name sortKey="Vale, L" uniqKey="Vale L">L Vale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seet, Rcs" uniqKey="Seet R">RCS Seet</name>
</author>
<author><name sortKey="Lim, Ech" uniqKey="Lim E">ECH Lim</name>
</author>
<author><name sortKey="Oh, Vms" uniqKey="Oh V">VMS Oh</name>
</author>
<author><name sortKey="Ong, Bkc" uniqKey="Ong B">BKC Ong</name>
</author>
<author><name sortKey="Goh, Kt" uniqKey="Goh K">KT Goh</name>
</author>
<author><name sortKey="Fisher, Da" uniqKey="Fisher D">DA Fisher</name>
</author>
<author><name sortKey="Ho, Ky" uniqKey="Ho K">KY Ho</name>
</author>
<author><name sortKey="Yeoh, Kg" uniqKey="Yeoh K">KG Yeoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name>
</author>
<author><name sortKey="Liao, Cm" uniqKey="Liao C">CM Liao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aiello, Ae" uniqKey="Aiello A">AE Aiello</name>
</author>
<author><name sortKey="Perez, V" uniqKey="Perez V">V Perez</name>
</author>
<author><name sortKey="Coulborn, Rm" uniqKey="Coulborn R">RM Coulborn</name>
</author>
<author><name sortKey="Davis, Bm" uniqKey="Davis B">BM Davis</name>
</author>
<author><name sortKey="Uddin, M" uniqKey="Uddin M">M Uddin</name>
</author>
<author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name>
</author>
<author><name sortKey="Cheng, Cky" uniqKey="Cheng C">CKY Cheng</name>
</author>
<author><name sortKey="Fung, Rop" uniqKey="Fung R">ROP Fung</name>
</author>
<author><name sortKey="Wai, W" uniqKey="Wai W">W Wai</name>
</author>
<author><name sortKey="Sin, J" uniqKey="Sin J">J Sin</name>
</author>
<author><name sortKey="Seto, Wh" uniqKey="Seto W">WH Seto</name>
</author>
<author><name sortKey="Yung, R" uniqKey="Yung R">R Yung</name>
</author>
<author><name sortKey="Chu, Dws" uniqKey="Chu D">DWS Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Seale, H" uniqKey="Seale H">H Seale</name>
</author>
<author><name sortKey="Dwyer, De" uniqKey="Dwyer D">DE Dwyer</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Pang, X" uniqKey="Pang X">X Pang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maclntyre, Cr" uniqKey="Maclntyre C">CR Maclntyre</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Dwyer, De" uniqKey="Dwyer D">DE Dwyer</name>
</author>
<author><name sortKey="Seale, H" uniqKey="Seale H">H Seale</name>
</author>
<author><name sortKey="Cheung, P" uniqKey="Cheung P">P Cheung</name>
</author>
<author><name sortKey="Browne, G" uniqKey="Browne G">G Browne</name>
</author>
<author><name sortKey="Fasher, M" uniqKey="Fasher M">M Fasher</name>
</author>
<author><name sortKey="Wood, J" uniqKey="Wood J">J Wood</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Booy, R" uniqKey="Booy R">R Booy</name>
</author>
<author><name sortKey="Ferguson, N" uniqKey="Ferguson N">N Ferguson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Larson, El" uniqKey="Larson E">EL Larson</name>
</author>
<author><name sortKey="Ferng, Yh" uniqKey="Ferng Y">YH Ferng</name>
</author>
<author><name sortKey="Wong Mcloughlin, J" uniqKey="Wong Mcloughlin J">J Wong-McLoughlin</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Haber, M" uniqKey="Haber M">M Haber</name>
</author>
<author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molinari, Nam" uniqKey="Molinari N">NAM Molinari</name>
</author>
<author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name>
</author>
<author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name>
</author>
<author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name>
</author>
<author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, M" uniqKey="Drummond M">M Drummond</name>
</author>
<author><name sortKey="Sculpher, Mj" uniqKey="Sculpher M">MJ Sculpher</name>
</author>
<author><name sortKey="Torrance, Gw" uniqKey="Torrance G">GW Torrance</name>
</author>
<author><name sortKey="O Rien, Bj" uniqKey="O Rien B">BJ O’Brien</name>
</author>
<author><name sortKey="Stoddart, Gl" uniqKey="Stoddart G">GL Stoddart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seale, H" uniqKey="Seale H">H Seale</name>
</author>
<author><name sortKey="Corbett, S" uniqKey="Corbett S">S Corbett</name>
</author>
<author><name sortKey="Dwyer, De" uniqKey="Dwyer D">DE Dwyer</name>
</author>
<author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chor, Jsy" uniqKey="Chor J">JSY Chor</name>
</author>
<author><name sortKey="Pada, Sk" uniqKey="Pada S">SK Pada</name>
</author>
<author><name sortKey="Stephenson, I" uniqKey="Stephenson I">I Stephenson</name>
</author>
<author><name sortKey="Goggins, Wb" uniqKey="Goggins W">WB Goggins</name>
</author>
<author><name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name>
</author>
<author><name sortKey="Medina, M" uniqKey="Medina M">M Medina</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Leung, Tf" uniqKey="Leung T">TF Leung</name>
</author>
<author><name sortKey="Ngai, Klk" uniqKey="Ngai K">KLK Ngai</name>
</author>
<author><name sortKey="Law, Sk" uniqKey="Law S">SK Law</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgess, A" uniqKey="Burgess A">A Burgess</name>
</author>
<author><name sortKey="Horii, M" uniqKey="Horii M">M Horii</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Csk" uniqKey="Tang C">CSK Tang</name>
</author>
<author><name sortKey="Wong, Cy" uniqKey="Wong C">CY Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferng, Yh" uniqKey="Ferng Y">YH Ferng</name>
</author>
<author><name sortKey="Wong Mcloughlin, J" uniqKey="Wong Mcloughlin J">J Wong-McLoughlin</name>
</author>
<author><name sortKey="Barrett, A" uniqKey="Barrett A">A Barrett</name>
</author>
<author><name sortKey="Currie, L" uniqKey="Currie L">L Currie</name>
</author>
<author><name sortKey="Larson, E" uniqKey="Larson E">E Larson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Jtf" uniqKey="Lau J">JTF Lau</name>
</author>
<author><name sortKey="Griffiths, S" uniqKey="Griffiths S">S Griffiths</name>
</author>
<author><name sortKey="Au, Dwh" uniqKey="Au D">DWH Au</name>
</author>
<author><name sortKey="Choi, Kc" uniqKey="Choi K">KC Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Jtf" uniqKey="Lau J">JTF Lau</name>
</author>
<author><name sortKey="Griffiths, S" uniqKey="Griffiths S">S Griffiths</name>
</author>
<author><name sortKey="Choi, K" uniqKey="Choi K">K Choi</name>
</author>
<author><name sortKey="Lin, C" uniqKey="Lin C">C Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chia, Se" uniqKey="Chia S">SE Chia</name>
</author>
<author><name sortKey="Koh, D" uniqKey="Koh D">D Koh</name>
</author>
<author><name sortKey="Fones, C" uniqKey="Fones C">C Fones</name>
</author>
<author><name sortKey="Qian, F" uniqKey="Qian F">F Qian</name>
</author>
<author><name sortKey="Ng, V" uniqKey="Ng V">V Ng</name>
</author>
<author><name sortKey="Tan, Bh" uniqKey="Tan B">BH Tan</name>
</author>
<author><name sortKey="Wong, Ks" uniqKey="Wong K">KS Wong</name>
</author>
<author><name sortKey="Chew, Wm" uniqKey="Chew W">WM Chew</name>
</author>
<author><name sortKey="Tang, Hk" uniqKey="Tang H">HK Tang</name>
</author>
<author><name sortKey="Ng, W" uniqKey="Ng W">W Ng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name>
</author>
<author><name sortKey="Del Mar, C" uniqKey="Del Mar C">C Del Mar</name>
</author>
<author><name sortKey="Dooley, L" uniqKey="Dooley L">L Dooley</name>
</author>
<author><name sortKey="Ferroni, E" uniqKey="Ferroni E">E Ferroni</name>
</author>
<author><name sortKey="Al Ansary, La" uniqKey="Al Ansary L">LA Al-ansary</name>
</author>
<author><name sortKey="Bawazeer, Ga" uniqKey="Bawazeer G">GA Bawazeer</name>
</author>
<author><name sortKey="Van Driel, Ml" uniqKey="Van Driel M">ML Van Driel</name>
</author>
<author><name sortKey="Foxlee, R" uniqKey="Foxlee R">R Foxlee</name>
</author>
<author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A Rivetti</name>
</author>
<author><name sortKey="Al Ansary, La" uniqKey="Al Ansary L">LA Al-Ansary</name>
</author>
<author><name sortKey="Van Driel, Ml" uniqKey="Van Driel M">ML van Driel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name>
</author>
<author><name sortKey="Del Mar, C" uniqKey="Del Mar C">C Del Mar</name>
</author>
<author><name sortKey="Dooley, L" uniqKey="Dooley L">L Dooley</name>
</author>
<author><name sortKey="Ferroni, E" uniqKey="Ferroni E">E Ferroni</name>
</author>
<author><name sortKey="Al Ansary, La" uniqKey="Al Ansary L">LA Al-Ansary</name>
</author>
<author><name sortKey="Bawazeer, Ga" uniqKey="Bawazeer G">GA Bawazeer</name>
</author>
<author><name sortKey="Van Driel, Ml" uniqKey="Van Driel M">ML van Driel</name>
</author>
<author><name sortKey="Nair, S" uniqKey="Nair S">S Nair</name>
</author>
<author><name sortKey="Foxlee, R" uniqKey="Foxlee R">R Foxlee</name>
</author>
<author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A Rivetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bin Reza, F" uniqKey="Bin Reza F">F Bin-Reza</name>
</author>
<author><name sortKey="Lopez Chavarrias, V" uniqKey="Lopez Chavarrias V">V Lopez Chavarrias</name>
</author>
<author><name sortKey="Nicoll, A" uniqKey="Nicoll A">A Nicoll</name>
</author>
<author><name sortKey="Chamberland, Me" uniqKey="Chamberland M">ME Chamberland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Sa" uniqKey="Lee S">SA Lee</name>
</author>
<author><name sortKey="Grinshpun, Sa" uniqKey="Grinshpun S">SA Grinshpun</name>
</author>
<author><name sortKey="Reponen, T" uniqKey="Reponen T">T Reponen</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id>
<journal-title-group><journal-title>BMC Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2334</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26462473</article-id>
<article-id pub-id-type="pmc">4605092</article-id>
<article-id pub-id-type="publisher-id">1167</article-id>
<article-id pub-id-type="doi">10.1186/s12879-015-1167-6</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Review of economic evaluations of mask and respirator use for protection against respiratory infection transmission</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Mukerji</surname>
<given-names>Shohini</given-names>
</name>
<address><email>s.mukerji@unsw.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>MacIntyre</surname>
<given-names>C. Raina</given-names>
</name>
<address><email>r.macintyre@unsw.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Newall</surname>
<given-names>Anthony T.</given-names>
</name>
<address><email>a.newall@unsw.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.1005.4</institution-id>
<institution-id institution-id-type="ISNI">0000000449020432</institution-id>
<institution>School of Public Health and Community Medicine, Faculty of Medicine,</institution>
<institution>University of New South Wales,</institution>
</institution-wrap>
Sydney, NSW Australia</aff>
</contrib-group>
<pub-date pub-type="epub"><day>13</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>15</volume>
<elocation-id>413</elocation-id>
<history><date date-type="received"><day>5</day>
<month>2</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>30</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© Mukerji et al. 2015</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p id="Par1">There has been increasing debate surrounding mask and respirator interventions to control respiratory infection transmission in both healthcare and community settings. As decision makers are considering the recommendations they should evaluate how to provide the most efficient protection strategies with minimum costs. The aim of this review is to identify and evaluate the existing economic evaluation literature in this area and to offer advice on how future evaluations on this topic should be conducted.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">We searched the Scopus database for all literature on economic evaluation of mask or respirator use to control respiratory infection transmission. Reference lists from the identified studies were also manually searched. Seven studies met our inclusion criteria from the initial 806 studies identified by the search strategy and our manual search.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">Five studies considered interventions for seasonal and/or pandemic influenza, with one also considering SARS (Severe Acute Respiratory Syndrome). The other two studies focussed on tuberculosis transmission control interventions. The settings and methodologies of the studies varied greatly. No low-middle income settings were identified. Only one of the reviewed studies cited clinical evidence to inform their mask/respirator intervention effectiveness parameters. Mask and respirator interventions were generally reported by the study authors to be cost saving or cost-effective when compared to no intervention or other control measures, however the evaluations had important limitations.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">Given the large cost differential between masks and respirators, there is a need for more comprehensive economic evaluations to compare the relative costs and benefits of these interventions in situations and settings where alternative options are potentially applicable. There are at present insufficient well conducted cost-effectiveness studies to inform decision-makers on the value for money of alternative mask/respirator options.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Respirator</kwd>
<kwd>Facemask</kwd>
<kwd>Economic evaluation</kwd>
<kwd>Cost-effectiveness</kwd>
<kwd>Influenza</kwd>
<kwd>Tuberculosis</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body><sec id="Sec1"><title>Background</title>
<p id="Par10">Both the World Health Organisation (WHO) and the Centre for Disease Control (CDC) guidelines recommend the use of a mask in low-risk settings and a respirator in high-risk settings (e.g. during aerosol generating procedures) to protect healthcare workers (HCWs) from seasonal influenza [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR2">2</xref>
]. The use of a respirator at all times is also advised for HCWs caring for patients with suspected infectious tuberculosis [<xref ref-type="bibr" rid="CR3">3</xref>
, <xref ref-type="bibr" rid="CR4">4</xref>
]. These measures are important to protect HCWs as well as to reduce the spread of respiratory infections within hospitals. This can help to reduce both the costs associated with HCW absenteeism and the costs of nosocomial infections.</p>
<p id="Par11">Mask/respirator availability may also prove crucial in the context of newly emerging respiratory infections, particularly as some diseases such as SARS (Severe Acute Respiratory Syndrome) and MERS-CoV (Middle East Respiratory Syndrome Coronavirus) may initially have no vaccine or treatment available, leaving non-pharmaceutical measures as the only available protection for HCWs. For other diseases such as pandemic influenza, reliance on vaccines for protection is not always possible due to time delays in vaccine development, manufacturing and distribution [<xref ref-type="bibr" rid="CR5">5</xref>
]. Furthermore, the stockpiling of relatively expensive antivirals for influenza pandemics may not be cost-effective in low and middle income settings [<xref ref-type="bibr" rid="CR6">6</xref>
].</p>
<p id="Par12">In the absence of standardised mask/respirator nomenclature [<xref ref-type="bibr" rid="CR7">7</xref>
], we will use the term ‘mask’ to indicate standard surgical masks, also referred to as “medical masks” in some countries. These are not specially engineered to protect the wearer from aerosol transmission of droplet nuclei and viral particles [<xref ref-type="bibr" rid="CR8">8</xref>
, <xref ref-type="bibr" rid="CR9">9</xref>
]. ‘Respirator’ will be used to denote all personal protective facemasks engineered for filtration and fit to prevent the transmission of respiratory viruses and aerosol droplets. Several air purifying respirators that filter the inhaled air through filtering materials are available for use by HCWs [<xref ref-type="bibr" rid="CR10">10</xref>
], these include: N95, HEPA (high-efficiency particulate air), PARP (powered air purifying respirator), DM (dust-mist) and DMF (dust-mist-fume).</p>
<p id="Par13">There are substantial differences in cost between different mask/respirator options. These cost differences may be an important determinant in the development of country specific mask/respirator guidelines for HCWs. For example, the more costly PARP is only recommended in the guidelines for high income countries [<xref ref-type="bibr" rid="CR7">7</xref>
]. Many countries’ guidelines recommend fit testing and training sessions for respirator use, but contain limited descriptions of what this should entail [<xref ref-type="bibr" rid="CR7">7</xref>
]. Fit testing can be qualitative or quantitative, with the latter being more expensive and adding a substantial cost to respirator use but not to mask use, which does not require fit testing [<xref ref-type="bibr" rid="CR10">10</xref>
].</p>
<p id="Par14">Two studies evaluating mask/respirator use [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR12">12</xref>
] were included in a previous economic review of influenza pandemic measures [<xref ref-type="bibr" rid="CR13">13</xref>
]. There are a small but growing number of economic evaluations for masks/respirators. The aim of this review is to identify and evaluate this existing literature and offer advice on how future evaluations on this topic should be conducted.</p>
</sec>
<sec id="Sec2"><title>Methods</title>
<p id="Par15">The Scopus database was searched for all English-language literature on the economic evaluation of mask or respirator use for the control of respiratory infection transmission. Scopus includes 100 % coverage of both MEDLINE and EMBASE [<xref ref-type="bibr" rid="CR14">14</xref>
]. The majority of the relevant literature identified in the initial Scopus search included influenza or tuberculosis as either the single focus or one of the diseases to control. For this reason, these terms (influenza OR tuberculosis) were used in <italic>addition</italic>
to the generic terms related to infection and transmission, i.e. they did not prevent the identification of articles focused on other infectious respiratory diseases. The final search strategy contained publications until the 1st of August 2014, and used the search terms (as keyword, title or abstract): ‘facemask*’ (or ‘mask*’ or ‘respirator’ or ‘N95’ or ‘non$pharm*’ or ‘{personal protect*}’) AND ‘economic*’ (or ‘cost*’) AND ‘infect*’ (or ‘transmi*’ or ‘influenza’ or ‘tuberculosis’).</p>
<p id="Par16">The 806 results from this initial Scopus search were screened (Fig. <xref rid="Fig1" ref-type="fig">1</xref>
). The abstracts of these articles were reviewed on the basis of whether they were economic evaluations (e.g. cost-effectiveness, cost-utility or cost-benefit studies), and whether the intervention being evaluated involved masks and/or respirators as a strategy to prevent the transmission of respiratory infections. From this process, 112 full text articles were considered potentially relevant and their full texts were further reviewed for eligibility. Of these, only six were confirmed to be economic evaluations of mask or respirator infection control interventions. One additional study by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] was identified from the reference list of a systematic review [<xref ref-type="bibr" rid="CR13">13</xref>
]. These were the main studies used in our qualitative synthesis. Four other costing studies [<xref ref-type="bibr" rid="CR15">15</xref>
–<xref ref-type="bibr" rid="CR18">18</xref>
] have been published but these examined the cost of the intervention only and were not classified as full economic evaluations (i.e. they did not examine the health impacts or the cost savings from prevented illness). Data from the included studies was independently extracted intro a spread sheet by SM and this was reviewed by ATN. Disagreements were resolved by discussion between these authors.<fig id="Fig1"><label>Fig. 1</label>
<caption><p>Flow diagram for study inclusion</p>
</caption>
<graphic xlink:href="12879_2015_1167_Fig1_HTML" id="d29e357"></graphic>
</fig>
</p>
</sec>
<sec id="Sec3"><title>Results</title>
<sec id="Sec4"><title>Description of economic evaluations identified</title>
<p id="Par17">Seven economic evaluations of mask/respirator use in the control of respiratory infections were identified (Table <xref rid="Tab1" ref-type="table">1</xref>
) [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR19">19</xref>
–<xref ref-type="bibr" rid="CR23">23</xref>
]. These studies varied widely in their settings and methodologies. The studies by Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
] and Nettleman et al. [<xref ref-type="bibr" rid="CR23">23</xref>
] were published in 1994 and were on tuberculosis in healthcare settings. Five others (published post 2008) were focused on seasonal or pandemic influenza [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
–<xref ref-type="bibr" rid="CR22">22</xref>
]. One of these by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] also considered a SARS scenario. Other than this study, to date, no other mask/respirator economic evaluations have been identified that focus on SARS, MERS-CoV or other respiratory viruses (other than influenza). There were also no economic evaluation studies identified on mask or respirator use to prevent transmission of Ebola.<table-wrap id="Tab1"><label>Table 1</label>
<caption><p>Descriptive and methodological details of identified mask and respirator economic evaluations</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th>First author, year, setting</th>
<th>Jones and Adida, 2013 [<xref ref-type="bibr" rid="CR22">22</xref>
], European contact rates</th>
<th>Chen and Liao, 2013 [<xref ref-type="bibr" rid="CR21">21</xref>
], Taiwan</th>
<th>Tracht et al, 2012 [<xref ref-type="bibr" rid="CR11">11</xref>
], USA</th>
<th>Dan et al, 2009 [<xref ref-type="bibr" rid="CR12">12</xref>
], Singapore</th>
<th>Cahill et al, 2008 [<xref ref-type="bibr" rid="CR20">20</xref>
], USA</th>
<th>Adal et al, 1994 [<xref ref-type="bibr" rid="CR19">19</xref>
], USA</th>
<th>Nettleman et al, 1994 [<xref ref-type="bibr" rid="CR23">23</xref>
], USA</th>
</tr>
</thead>
<tbody><tr><td>Infection(s)</td>
<td>Influenza epidemic</td>
<td>Seasonal influenza</td>
<td>Influenza A(H1N1)pdm09</td>
<td>Influenza A(H1N1)pdm09, SARS, 1918 Spanish influenza</td>
<td>Influenza A(H1N1)pdm09</td>
<td>TB</td>
<td>TB</td>
</tr>
<tr><td>Mask(s) used</td>
<td>N95</td>
<td>Surgical mask</td>
<td>N95</td>
<td>N95</td>
<td>N95, surgical mask</td>
<td>Isolation mask, respirators: DM, HEPA with/without disposable filter</td>
<td>Surgical cup mask, respirators: DM, DMF, HEPA</td>
</tr>
<tr><td>Mask intervention</td>
<td>1 mask/person/day for duration of epidemic (90 days). Assumed respirator use begins when 0.05 % population infected</td>
<td>Surgical mask use and natural ventilation</td>
<td>N95 respirator use by a varied % of the population for the duration of pandemic, starting when 0.001 % symptomatic</td>
<td>Green 0: no intervention, Green 1: PPE for HCWs in contact with suspected cases, Yellow: full PPE for HCWs in high risk contact, Orange: PPE for HCWs in contact with medium risk</td>
<td>Monthly stockpiling and use for duration of pandemic</td>
<td>HCW program: respirators, fit testing and HCW medical evaluation</td>
<td>HCW program: 20 masks/8 h shift for HCWs visiting patients in isolation</td>
</tr>
<tr><td>Mask intervention effectiveness</td>
<td>Baseline effectiveness was 50 %. Intervention estimated to reduce probability of infection to 30 % or 70 % of baseline, depending on person-to-person contact rates</td>
<td>Not explicitly reported</td>
<td>Intervention estimated to be 50 % effective in decreasing susceptibility and 20 % effective for reducing infectivity</td>
<td>Exposure reductions of 50, 80 and 90 % with intervention. A 5 % failure despite use of protective equipment and isolation measures</td>
<td>Probability of transmission in 5 min encounter (varied for different % compliance for masks)</td>
<td>Not reported</td>
<td>Assumed respirator would prevent 25 % of HCW exposure to TB</td>
</tr>
<tr><td>Source of effectiveness data</td>
<td>Estimate derived from respirator assigned protective factor (APF = 10) [<xref ref-type="bibr" rid="CR29">29</xref>
]. This was adjusted for estimated lack of training, compliance and mask quality to give APF = 2 (i.e. mask 50 % effective)</td>
<td>Based on assumptions from previous study Chen et al. 2008 [<xref ref-type="bibr" rid="CR33">33</xref>
] where mask efficacies are assumed to be 60 %, 70 %, 80 %, or 95 % and are combined in the model with other control measures</td>
<td>Laboratory data, Lee et al. 2008 [<xref ref-type="bibr" rid="CR52">52</xref>
], and a randomised control trial by Aiello et al. 2010 [<xref ref-type="bibr" rid="CR26">26</xref>
] that found hand hygiene and facemask together were 35-51 % effective but not facemask use alone</td>
<td>No data cited for exposure reduction, these are assumptions. Failure rate estimate from a hospital simulation study Seet et al. 2009 [<xref ref-type="bibr" rid="CR32">32</xref>
]</td>
<td>Laboratory data from Balazy et al. 2006 [<xref ref-type="bibr" rid="CR30">30</xref>
] used to build particle transmission model</td>
<td>Reported none available</td>
<td>Reported none available</td>
</tr>
<tr><td>Type of economic evaluation</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
<td>Cost-effectiveness analysis</td>
</tr>
<tr><td>Perspective</td>
<td>Policy developer view</td>
<td>Not stated</td>
<td>Not stated</td>
<td>Healthcare institution</td>
<td>Not stated</td>
<td>Not stated</td>
<td>Not stated</td>
</tr>
<tr><td>Primary outcome measure</td>
<td>Total costs of intervention</td>
<td>Unit cost per person, per year</td>
<td>Net savings compared to no intervention</td>
<td>Incremental increase in cost per death averted</td>
<td>Productivity loss to economy from absenteeism</td>
<td>Cost of respirator use per case prevented and per life saved</td>
<td>Minimum estimates of cost per life saved and cost per death averted</td>
</tr>
<tr><td>Intervention outcome measures</td>
<td>Cases</td>
<td>Cases</td>
<td>Cases, deaths, hospitalisations</td>
<td>Cases, deaths</td>
<td>Deaths, hospitalisation, outpatient visits, absenteeism</td>
<td>HCW PPD test conversion rates</td>
<td>Patients isolated for suspected TB, confirmed cases pulmonary TB in patients and active pulmonary TB in HCWs</td>
</tr>
</tbody>
</table>
<table-wrap-foot><p><italic>PPE</italic>
personal protective equipment, <italic>PPD</italic>
positive protein derivative skin test, <italic>TB</italic>
tuberculosis, <italic>HCW</italic>
healthcare worker, <italic>SARS</italic>
severe acute respiratory syndrome, <italic>HEPA</italic>
high-efficiency particulate air, <italic>PARP</italic>
powered air purifying respirator, <italic>DM</italic>
dust-mist, <italic>DMF</italic>
dust-mist-fume</p>
</table-wrap-foot>
</table-wrap>
</p>
<p id="Par18">The interventions evaluated by the studies included N95 respirators [<xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
], HEPA, DM and DMF respirators [<xref ref-type="bibr" rid="CR19">19</xref>
, <xref ref-type="bibr" rid="CR23">23</xref>
], and surgical masks [<xref ref-type="bibr" rid="CR19">19</xref>
–<xref ref-type="bibr" rid="CR21">21</xref>
, <xref ref-type="bibr" rid="CR23">23</xref>
]. Amongst the studies that focused on influenza, two of the five, by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] and Chen and Liao [<xref ref-type="bibr" rid="CR21">21</xref>
], integrated mask/respirator use in a scenario in conjunction with other non-pharmaceutical control measures e.g. natural ventilation [<xref ref-type="bibr" rid="CR21">21</xref>
] or isolation measures [<xref ref-type="bibr" rid="CR12">12</xref>
], as opposed to evaluating the use of masks/respirators exclusively. This makes it difficult to assess to what degree the mask/respirator aspect of the intervention is driving the cost-effectiveness, or if the results are more attributable to the other control measures included.</p>
<p id="Par19">The settings of the evaluated studies varied more broadly for the influenza studies than for those on tuberculosis. Three of the five influenza studies were in a community setting [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. Of the others, one considered control measures for both the community and hospital setting [<xref ref-type="bibr" rid="CR12">12</xref>
] and the last was set in a primary school [<xref ref-type="bibr" rid="CR21">21</xref>
]. All of the seven identified studies were set in the USA or other developed countries, limiting the generalisability of the findings, e.g. for decision making in low resource settings. The lack of studies in low resource settings has been cited as one of the major impediments to the use of cost-effectiveness analysis for pandemic influenza preparedness planning in this context [<xref ref-type="bibr" rid="CR24">24</xref>
].</p>
</sec>
<sec id="Sec5"><title>Intervention outcome measures</title>
<p id="Par20">Four of the five influenza studies included the number of infection cases as one of the outcome measures of intervention effectiveness (Table <xref rid="Tab1" ref-type="table">1</xref>
) [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR21">21</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. The remaining influenza study quantified and reported the consequences of infection on other outcomes e.g. prevented deaths, hospitalisations, outpatient visits and absenteeism [<xref ref-type="bibr" rid="CR20">20</xref>
].</p>
<p id="Par21">Both tuberculosis studies measured conversion rates of newly positive protein derivative tests in HCWs at study hospitals [<xref ref-type="bibr" rid="CR19">19</xref>
, <xref ref-type="bibr" rid="CR23">23</xref>
]. A positive test indicates a 5–10 % chance that the individual will develop active tuberculosis in their lifetime [<xref ref-type="bibr" rid="CR25">25</xref>
]. One of the two studies also estimated the number of patients isolated for known tuberculosis per month, confirmed pulmonary tuberculosis cases in patients in the past year and active cases of pulmonary tuberculosis in HCWs in the last 5 years [<xref ref-type="bibr" rid="CR23">23</xref>
]. This additional information provided a more complete measure of the impact of the intervention.</p>
</sec>
<sec id="Sec6"><title>Cost-effectiveness outcomes</title>
<p id="Par22">Only three [<xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR19">19</xref>
, <xref ref-type="bibr" rid="CR23">23</xref>
] of the seven studies reported results as cost per unit of effect. The evaluation by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] of influenza and SARS reported an incremental cost per death averted [<xref ref-type="bibr" rid="CR12">12</xref>
]. The other two were the tuberculosis studies, with one reporting the cost to prevent a single occupational case of tuberculosis in the next 41 years [<xref ref-type="bibr" rid="CR19">19</xref>
] and the other reporting the cost per tuberculosis case prevented and the cost per life saved [<xref ref-type="bibr" rid="CR23">23</xref>
]. Two of the pandemic influenza studies evaluating combinations of interventions in the community concluded that mask/respirator interventions were cost saving in a pandemic setting [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. The first estimated substantial net savings if 10 % of the population had worn N95 respirators during influenza A(H1N1)pdm09, assuming an effectiveness of 20 % [<xref ref-type="bibr" rid="CR11">11</xref>
]. The second estimated that surgical mask use at 60 % compliance would yield savings of $US100-250 million, far exceeding the estimated intervention cost of $US20 million [<xref ref-type="bibr" rid="CR20">20</xref>
]. The influenza modelling studies by Jones and Adida [<xref ref-type="bibr" rid="CR22">22</xref>
] focused on demonstrating the feasibility of the methods rather than reporting key economic results. The influenza study by Chen and Liao [<xref ref-type="bibr" rid="CR21">21</xref>
] calculated a cost per individual to implement control measures, but limited the inclusion of costs to intervention and outpatient treatments costs.</p>
</sec>
<sec id="Sec7"><title>Mask and respirator effectiveness or “strategy impact”</title>
<p id="Par23">Approaches to incorporate intervention effectiveness amongst the seven studies varied (Table <xref rid="Tab1" ref-type="table">1</xref>
). Both of the tuberculosis evaluations by Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
] and Nettleman et al. [<xref ref-type="bibr" rid="CR23">23</xref>
] reported that no efficacy studies were available and thus no specific measures of mask or respirator effectiveness were included in their evaluations. Nettleman et al. [<xref ref-type="bibr" rid="CR23">23</xref>
] assumed that in a best case scenario, HEPA respirators would prevent 25 % of HCW exposure to tuberculosis, but no data was cited to support this estimate. Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
] implicitly assumed that all HCW cases of tuberculosis that may have been acquired from patients in isolation with active tuberculosis would be prevented by the intervention.</p>
<p id="Par24">Of the five influenza studies, Tracht et al. [<xref ref-type="bibr" rid="CR11">11</xref>
] was the only study that attempted to utilise clinical efficacy data. They obtained this from a randomised trial in a university residence setting [<xref ref-type="bibr" rid="CR26">26</xref>
] that found a significant decrease (35–51 %) in influenza-like illness if hand hygiene and medical masks were used together compared to a control, but no difference for medical mask use alone. Tracht et al. [<xref ref-type="bibr" rid="CR11">11</xref>
] uses this result to estimate N95 respirator use provides a 50 % decrease in susceptibility to influenza A(H1N1)pdm09. This may not be robust as the clinical trial measured different outcomes (i.e. influenza-like illness, not influenza A(H1N1)pdm09 cases) and it assumes there is no difference between the efficacy of medical masks and N95 respirators based on the findings of Loeb et al. [<xref ref-type="bibr" rid="CR27">27</xref>
], although other trials have found evidence that there is a difference [<xref ref-type="bibr" rid="CR28">28</xref>
]. The study by Jones and Adida [<xref ref-type="bibr" rid="CR22">22</xref>
] derived efficacy estimates from the assigned protective factor (APF) measure for N95 respirators released by the National Institute for Occupational Safety and Health [<xref ref-type="bibr" rid="CR29">29</xref>
]. The APF is estimated from laboratory testing completed by this organisation, including laboratory testing of the quantitative measure of fit when the respirators are fit tested to ensure a protective seal around the wearer’s face. Cahill et al. [<xref ref-type="bibr" rid="CR20">20</xref>
] also used efficacy estimates from laboratory investigation data [<xref ref-type="bibr" rid="CR30">30</xref>
]. These estimates may have limited applicability to measuring real-world effectiveness [<xref ref-type="bibr" rid="CR31">31</xref>
]. Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] estimated baseline intervention effectiveness rates of 50, 80 and 90 % as protective equipment (including masks) and isolation precautions were increased. They did not cite data to support these estimates, however a 5 % failure rate where transmission still occurs despite the use of protective equipment and isolation measures, was obtained from a hospital simulation study [<xref ref-type="bibr" rid="CR32">32</xref>
]. Chen and Liao [<xref ref-type="bibr" rid="CR21">21</xref>
] applied a relative efficacy estimate of masks in combination with other control measures which was developed in a previous modelling study that did not cite supporting data for efficacy input assumptions [<xref ref-type="bibr" rid="CR33">33</xref>
]. Other than Tracht et al. [<xref ref-type="bibr" rid="CR11">11</xref>
], none of the analyses used intervention effectiveness estimates from clinical trials such as the mask/respirator randomised trials that have been published to date on interventions in community and healthcare settings [<xref ref-type="bibr" rid="CR26">26</xref>
–<xref ref-type="bibr" rid="CR28">28</xref>
, <xref ref-type="bibr" rid="CR34">34</xref>
–<xref ref-type="bibr" rid="CR38">38</xref>
].</p>
</sec>
<sec id="Sec8"><title>Costs</title>
<p id="Par25">Only two of the seven evaluations, by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] and Jones and Adida et al. [<xref ref-type="bibr" rid="CR22">22</xref>
], explicitly stated the economic perspective from which they had conducted their evaluation, these being a policy developer view [<xref ref-type="bibr" rid="CR22">22</xref>
] and the healthcare institution perspective [<xref ref-type="bibr" rid="CR12">12</xref>
]. On the basis of costs included and excluded, four of the seven studies are most aligned with healthcare payer perspectives [<xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR19">19</xref>
, <xref ref-type="bibr" rid="CR21">21</xref>
, <xref ref-type="bibr" rid="CR23">23</xref>
] and the remaining three with a societal perspective [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
] (e.g. they included some form of productivity costs). Both tuberculosis evaluations by Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
] and Nettleman et al. [<xref ref-type="bibr" rid="CR23">23</xref>
], considered costs from a healthcare provider perspective, reflecting the objective of preventing the burden of nosocomial cases in HCWs and patients. The influenza studies [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
] more frequently applied a societal perspective, consistent with the substantial economic impact of productivity losses due to influenza absenteeism [<xref ref-type="bibr" rid="CR39">39</xref>
].</p>
<p id="Par26">The reporting of costs included in the evaluations was often not transparent. One evaluation by Dan et al. [<xref ref-type="bibr" rid="CR12">12</xref>
] identified the omission of the indirect costs of lost revenue from the cancellation of elective surgeries, decreased outpatient attendance, lost clinical teaching time and administration costs of senior staff meetings. These costs were not discussed in other influenza modelling studies where they may have been relevant [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. The tuberculosis studies by Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
] and Nettleman et al. [<xref ref-type="bibr" rid="CR23">23</xref>
] relied on hospital databases for the number of masks/respirators used, and multiplied this by unit costs to calculate total costs. Administration costs were most thoroughly reported in the tuberculosis study by Adal et al. [<xref ref-type="bibr" rid="CR19">19</xref>
], which included staff program planning time and staff medical evaluation time.</p>
<p id="Par27">All of the studies that estimated a cost per case, included the cost of infected individuals [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
–<xref ref-type="bibr" rid="CR22">22</xref>
]. For example, one influenza modelling study by Jones and Adida [<xref ref-type="bibr" rid="CR22">22</xref>
] assumed a fixed average cost for each infection. This may not always be an ideal method to cost resources used as the cost of an average case may vary amongst patients [<xref ref-type="bibr" rid="CR40">40</xref>
]. Tracht et al. [<xref ref-type="bibr" rid="CR11">11</xref>
] allocated a separate average hospital cost per day due to influenza A(H1N1)pdm09 infections for three age groups.</p>
</sec>
<sec id="Sec9"><title>Approaches to model adherence to interventions</title>
<p id="Par28">Three of the studies evaluating the intervention in the community included the impact of compliance [<xref ref-type="bibr" rid="CR11">11</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. These included simple approaches, as used by Cahill et al. [<xref ref-type="bibr" rid="CR20">20</xref>
] of assessing 60 and 100 % adherence scenarios, as well as by Jones and Adida [<xref ref-type="bibr" rid="CR22">22</xref>
] where an estimate of 50 % compliance was assumed. Tracht et al. [<xref ref-type="bibr" rid="CR11">11</xref>
] conducted a more thorough sensitivity analysis by dividing the population into three age groups and testing three scenarios with different proportions of compliance in each group. No study attempted to use compliance rates from real-world investigations such as clinical trials [<xref ref-type="bibr" rid="CR28">28</xref>
, <xref ref-type="bibr" rid="CR36">36</xref>
].</p>
</sec>
</sec>
<sec id="Sec10"><title>Discussion</title>
<p id="Par30">There were a relatively small number of economic evaluations of mask/respirator use that met the inclusion criteria and no existing studies were found that address the cost-effectiveness of these interventions in low-middle income countries. The seven evaluations identified have limited utility to advise decision makers on the value for money that masks and respirators offer compared with other health spending choices. This is due to the reporting of results in the form of intermediate outcomes (e.g. case prevented) and the analysis of combinations of masks/respirators with other protection measures in evaluations [<xref ref-type="bibr" rid="CR12">12</xref>
, <xref ref-type="bibr" rid="CR21">21</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. There was also limited inclusion of clinical data to inform the effectiveness estimates and the impact of intervention compliance in the identified studies. Compliance has major implications for a mask/respirator intervention targeting HCWs [<xref ref-type="bibr" rid="CR9">9</xref>
]. For example, obtaining high adherence in HCWs has not been feasible in some high-income countries such as Australia [<xref ref-type="bibr" rid="CR41">41</xref>
]. Variation in HCW mask/respirator compliance has been observed between countries, such as the lower rates seen in UK hospitals compared to Hong Kong and Singapore during influenza A(H1N1)pdm09 [<xref ref-type="bibr" rid="CR42">42</xref>
]. Mask/respirator adherence is primarily driven by perceived susceptibility to the infectious disease threats present [<xref ref-type="bibr" rid="CR43">43</xref>
–<xref ref-type="bibr" rid="CR48">48</xref>
].</p>
<sec id="Sec11"><title>What clinical evidence is there on comparative mask and respirator effectiveness?</title>
<p id="Par31">Only one of the reviewed studies [<xref ref-type="bibr" rid="CR11">11</xref>
] cited clinical evidence to support their mask/respirator intervention effectiveness parameters. However, there is a growing body of research in this area. An initial systematic review on the topic reported pooled efficacy measures from case control studies for N95 respirators and medical masks of 91 and 68 % respectively for the prevention of respiratory viruses [<xref ref-type="bibr" rid="CR49">49</xref>
]. A weakness of this initial review was that the case control studies included in the meta-analysis focused exclusively on SARS [<xref ref-type="bibr" rid="CR50">50</xref>
]. As a consequence, it should not be assumed that the conclusions of this meta-analysis are necessarily true for influenza or other respiratory infections [<xref ref-type="bibr" rid="CR51">51</xref>
].</p>
<p id="Par32">The updated edition of this review concluded that there was no evidence of a significant difference in effectiveness between N95 respirators and medical masks [<xref ref-type="bibr" rid="CR50">50</xref>
]. However, this conclusion was heavily influenced by a single cluster randomised trial by Loeb et al. [<xref ref-type="bibr" rid="CR27">27</xref>
] that compared N95 respirators and medical masks, both used selectively in high-risk situations. This trial contained only 446 HCWs and may have been underpowered to detect a difference between the arms [<xref ref-type="bibr" rid="CR28">28</xref>
]. Two larger trials not included in this review have been published [<xref ref-type="bibr" rid="CR28">28</xref>
, <xref ref-type="bibr" rid="CR36">36</xref>
]. One of these by Macintyre et al. [<xref ref-type="bibr" rid="CR28">28</xref>
], involving 1669 HCWs, found significantly greater protective efficacy for continuous N95 use when compared to continuous medical mask use, but no evidence that selective N95 use was superior to continuous medical mask use for the prevention of clinical respiratory illness [<xref ref-type="bibr" rid="CR28">28</xref>
].</p>
</sec>
<sec id="Sec12"><title>Limitations</title>
<p id="Par33">The limitations of the review include the restriction to English language articles used in the search of the Scopus database. Further potential limitations are that the identification and screening process was carried out predominantly by one of the authors (SM). Finally, the limited number of studies identified for inclusion made it difficult to make general conclusions about cost-effectiveness.</p>
</sec>
<sec id="Sec13"><title>Recommendations</title>
<p id="Par34">One key recommendation is that future economic analyses should attempt to apply clinical mask/respirator efficacy data, preferably from clinical trials, where this data is deemed applicable to the infectious agent, intervention and setting, rather than using estimations derived from expert opinion or laboratory testing studies [<xref ref-type="bibr" rid="CR31">31</xref>
]. In some cases this may not be possible, for example, it is not appropriate to extrapolate clinical trial results for respiratory viruses to tuberculosis and for ethical reasons, randomised trial data cannot be collected on the effectiveness of a respirator intervention in HCWs for tuberculosis prevention. While the use of other types of efficacy data applied in the studies identified by this review have limitations, the results of the studies may still have validity. However, the underlying assumptions made in the analyses do need to be carefully considered.</p>
<p id="Par35">Although economic evaluations have been conducted for the use of mask/respirator strategies in HCWs for tuberculosis, the way these evaluations should be used to inform policy needs to be carefully considered. Cost-effectiveness criteria should only be one part of the decision making process for any intervention and there may be specific cases where this factor should be given less weight. Economic evaluations would be of less relevance to a decision maker in situations and settings where a respirator would be used regardless of its cost-effectiveness, but they may be more useful in evaluating situations where these devices are not currently recommended in a given setting.</p>
<p id="Par36">Future evaluations should report their results in such a way that would allow them to be easily compared to other non-pharmaceutical or pharmaceutical interventions (e.g. cost per quality-adjusted life year (QALY) gained). If an evaluation fails to report results in an appropriate format, this limits its use for decision making as it means that the value of mask/respirator interventions cannot be compared with spending on healthcare interventions targeted at other diseases [<xref ref-type="bibr" rid="CR40">40</xref>
]. However, in some cases the use of intermediate outcomes (e.g. cases prevented) can still be useful for comparing alternative ways of reducing specific infection events. This may provide useful information to decision makers.</p>
<p id="Par37">Future analysts may also want to consider whether masks/respirators are cost-effective for use by HCWs in the seasonal influenza context, or if they are only cost-effective in extreme pandemic scenarios which may necessitate a stockpiled supply of masks/respirators.</p>
</sec>
</sec>
<sec id="Sec14"><title>Conclusions</title>
<p id="Par38">Although the WHO and the CDC recommend that HCWs use masks for low-risk influenza exposure and respirators for high-risk influenza or tuberculosis exposure [<xref ref-type="bibr" rid="CR1">1</xref>
–<xref ref-type="bibr" rid="CR4">4</xref>
], there is currently a lack of economic evidence to support these recommendations. Further robust economic evaluations on mask/respirator interventions are needed.</p>
</sec>
</body>
<back><glossary><title>Abbreviations</title>
<def-list><def-item><term>HCW</term>
<def><p id="Par5">Healthcare worker</p>
</def>
</def-item>
<def-item><term>HEPA</term>
<def><p id="Par6">High-efficiency particulate air</p>
</def>
</def-item>
<def-item><term>PARP</term>
<def><p id="Par7">Powered air purifying respirator</p>
</def>
</def-item>
<def-item><term>DM</term>
<def><p id="Par8">Dust-mist</p>
</def>
</def-item>
<def-item><term>DMF</term>
<def><p id="Par9">Dust-mist-fume</p>
</def>
</def-item>
</def-list>
</glossary>
<fn-group><fn><p><bold>Competing interests</bold>
</p>
<p>RM receives funding from influenza vaccine manufacturers GSK and CSL Biotherapies for investigator-driven research. She has also been on advisory boards for Wyeth, GSK and Merck.</p>
</fn>
<fn><p><bold>Authors’ contributions</bold>
</p>
<p>ATN and RM initiated the study. ATN and SM developed the search strategy and selection criteria. SM carried out the systematic review and drafted the initial manuscript. ATN assisted with the interpretation of economic data. RM assisted with the interpretation of available efficacy data. All authors contributed to revising the manuscript and read and approved the final manuscript.</p>
</fn>
</fn-group>
<ack><title>Acknowledgements</title>
<p>No funding was provided for this study and there are no additional individuals (who are not named authors) or organisations that provided assistance.</p>
</ack>
<ref-list id="Bib1"><title>References</title>
<ref id="CR1"><label>1.</label>
<mixed-citation publication-type="other">Prevention Strategies for Seasonal Influenza in Healthcare Settings. <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.htm">http://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.htm</ext-link>
. Accessed on 4 Sept 2014.</mixed-citation>
</ref>
<ref id="CR2"><label>2.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><collab>World Health Organization</collab>
</person-group>
<source>Infection prevention and control of epidemic-and pandemic-prone acute respiratory infections in health care</source>
<year>2014</year>
<publisher-loc>Geneva</publisher-loc>
<publisher-name>World Health Organization</publisher-name>
</element-citation>
</ref>
<ref id="CR3"><label>3.</label>
<mixed-citation publication-type="other">Respiratory Protection in Health-Care Settings. <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/tb/publications/factsheets/prevention/rphcs.htm">http://www.cdc.gov/tb/publications/factsheets/prevention/rphcs.htm</ext-link>
. Accessed on 4 Sept 2014.</mixed-citation>
</ref>
<ref id="CR4"><label>4.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><collab>World Health Organization</collab>
</person-group>
<source>WHO policy on TB infection control in health-care facilities, congregate settings and households</source>
<year>2009</year>
<publisher-loc>Canberra</publisher-loc>
<publisher-name>World Health Organization</publisher-name>
</element-citation>
</ref>
<ref id="CR5"><label>5.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fineberg</surname>
<given-names>HV</given-names>
</name>
</person-group>
<article-title>Pandemic preparedness and response — Lessons from the H1N1 Influenza of 2009</article-title>
<source>N Engl J Med</source>
<year>2014</year>
<volume>370</volume>
<fpage>1335</fpage>
<lpage>42</lpage>
<pub-id pub-id-type="doi">10.1056/NEJMra1208802</pub-id>
<pub-id pub-id-type="pmid">24693893</pub-id>
</element-citation>
</ref>
<ref id="CR6"><label>6.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carrasco</surname>
<given-names>LR</given-names>
</name>
<name><surname>Lee</surname>
<given-names>VJ</given-names>
</name>
<name><surname>Chen</surname>
<given-names>MI</given-names>
</name>
<name><surname>Matchar</surname>
<given-names>DB</given-names>
</name>
<name><surname>Thompson</surname>
<given-names>JP</given-names>
</name>
<name><surname>Cook</surname>
<given-names>AR</given-names>
</name>
</person-group>
<article-title>Strategies for antiviral stockpiling for future influenza pandemics: a global epidemic-economic perspective</article-title>
<source>J R Soc Interface</source>
<year>2011</year>
<volume>8</volume>
<fpage>1307</fpage>
<lpage>13</lpage>
<pub-id pub-id-type="doi">10.1098/rsif.2010.0715</pub-id>
<pub-id pub-id-type="pmid">21296791</pub-id>
</element-citation>
</ref>
<ref id="CR7"><label>7.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chughtai</surname>
<given-names>AA</given-names>
</name>
<name><surname>Seale</surname>
<given-names>H</given-names>
</name>
<name><surname>Macintyre</surname>
<given-names>CR</given-names>
</name>
</person-group>
<article-title>Availability, consistency and evidence-base of policies and guidelines on the use of mask and respirator to protect hospital health care workers: a global analysis</article-title>
<source>BMC Res Notes</source>
<year>2013</year>
<volume>6</volume>
<fpage>216</fpage>
<pub-id pub-id-type="doi">10.1186/1756-0500-6-216</pub-id>
<pub-id pub-id-type="pmid">23725338</pub-id>
</element-citation>
</ref>
<ref id="CR8"><label>8.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weber</surname>
<given-names>A</given-names>
</name>
<name><surname>Willeke</surname>
<given-names>K</given-names>
</name>
<name><surname>Marchioni</surname>
<given-names>R</given-names>
</name>
<name><surname>Myojo</surname>
<given-names>T</given-names>
</name>
<name><surname>McKay</surname>
<given-names>R</given-names>
</name>
<name><surname>Donnelly</surname>
<given-names>J</given-names>
</name>
<name><surname>Liebhaber</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Aerosol penetration and leakage characteristics of masks used in the health care industry</article-title>
<source>Am J Infect Control</source>
<year>1993</year>
<volume>21</volume>
<fpage>167</fpage>
<lpage>73</lpage>
<pub-id pub-id-type="doi">10.1016/0196-6553(93)90027-2</pub-id>
<pub-id pub-id-type="pmid">8239046</pub-id>
</element-citation>
</ref>
<ref id="CR9"><label>9.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shine</surname>
<given-names>KI</given-names>
</name>
<name><surname>Rogers</surname>
<given-names>B</given-names>
</name>
<name><surname>Goldfrank</surname>
<given-names>LR</given-names>
</name>
</person-group>
<article-title>Novel H1N1 influenza and respiratory protection for health care workers</article-title>
<source>N Engl J Med</source>
<year>2009</year>
<volume>361</volume>
<fpage>1823</fpage>
<lpage>5</lpage>
<pub-id pub-id-type="doi">10.1056/NEJMp0908437</pub-id>
<pub-id pub-id-type="pmid">19797278</pub-id>
</element-citation>
</ref>
<ref id="CR10"><label>10.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Larson</surname>
<given-names>E</given-names>
</name>
<name><surname>Liverman</surname>
<given-names>CT</given-names>
</name>
</person-group>
<source>Institute of Medicine (IOM) National Academy of Sciences: preventing transmission of pandemic influenza and other viral respiratory diseases: personal protective equipment for healthcare personnel update 201</source>
<year>2010</year>
<publisher-loc>Washington</publisher-loc>
<publisher-name>The National Academies Pres</publisher-name>
</element-citation>
</ref>
<ref id="CR11"><label>11.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tracht</surname>
<given-names>SM</given-names>
</name>
<name><surname>Del Valle</surname>
<given-names>SY</given-names>
</name>
<name><surname>Edwards</surname>
<given-names>BK</given-names>
</name>
</person-group>
<article-title>Economic analysis of the use of facemasks during pandemic (H1N1) 2009</article-title>
<source>J Theor Biol</source>
<year>2012</year>
<volume>300</volume>
<fpage>161</fpage>
<lpage>72</lpage>
<pub-id pub-id-type="doi">10.1016/j.jtbi.2012.01.032</pub-id>
<pub-id pub-id-type="pmid">22300798</pub-id>
</element-citation>
</ref>
<ref id="CR12"><label>12.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dan</surname>
<given-names>YY</given-names>
</name>
<name><surname>Tambyah</surname>
<given-names>PA</given-names>
</name>
<name><surname>Sim</surname>
<given-names>J</given-names>
</name>
<name><surname>Lim</surname>
<given-names>J</given-names>
</name>
<name><surname>Hsu</surname>
<given-names>LY</given-names>
</name>
<name><surname>Chow</surname>
<given-names>WL</given-names>
</name>
<name><surname>Fisher</surname>
<given-names>DA</given-names>
</name>
<name><surname>Wong</surname>
<given-names>YS</given-names>
</name>
<name><surname>Ho</surname>
<given-names>KY</given-names>
</name>
</person-group>
<article-title>Cost-effectiveness analysis of hospital infection control response to an epidemic respiratory virus threat</article-title>
<source>Emerg Infect Dis</source>
<year>2009</year>
<volume>15</volume>
<fpage>1909</fpage>
<pub-id pub-id-type="doi">10.3201/eid1512.090902</pub-id>
<pub-id pub-id-type="pmid">19961669</pub-id>
</element-citation>
</ref>
<ref id="CR13"><label>13.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Velasco</surname>
<given-names>RP</given-names>
</name>
<name><surname>Praditsitthikorn</surname>
<given-names>N</given-names>
</name>
<name><surname>Wichmann</surname>
<given-names>K</given-names>
</name>
<name><surname>Mohara</surname>
<given-names>A</given-names>
</name>
<name><surname>Kotirum</surname>
<given-names>S</given-names>
</name>
<name><surname>Tantivess</surname>
<given-names>S</given-names>
</name>
<name><surname>Vallenas</surname>
<given-names>C</given-names>
</name>
<name><surname>Harmanci</surname>
<given-names>H</given-names>
</name>
<name><surname>Teerawattananon</surname>
<given-names>Y</given-names>
</name>
</person-group>
<article-title>Systematic review of economic evaluations of preparedness strategies and interventions against influenza pandemics</article-title>
<source>PLoS One</source>
<year>2012</year>
<volume>7</volume>
<fpage>e30333</fpage>
<pub-id pub-id-type="doi">10.1371/journal.pone.0030333</pub-id>
<pub-id pub-id-type="pmid">22393352</pub-id>
</element-citation>
</ref>
<ref id="CR14"><label>14.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burnham</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Scopus database: a review</article-title>
<source>Biomed Digit Libr</source>
<year>2006</year>
<volume>3</volume>
<fpage>1</fpage>
<pub-id pub-id-type="doi">10.1186/1742-5581-3-1</pub-id>
<pub-id pub-id-type="pmid">16522216</pub-id>
</element-citation>
</ref>
<ref id="CR15"><label>15.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kellerman</surname>
<given-names>SE</given-names>
</name>
<name><surname>Tokars</surname>
<given-names>JI</given-names>
</name>
<name><surname>Jarvis</surname>
<given-names>WR</given-names>
</name>
</person-group>
<article-title>The costs of healthcare worker respiratory protection and fit- testing programs</article-title>
<source>Infect Control Hosp Epidemiol</source>
<year>1998</year>
<volume>19</volume>
<fpage>629</fpage>
<lpage>34</lpage>
<pub-id pub-id-type="doi">10.2307/30141524</pub-id>
<pub-id pub-id-type="pmid">9778158</pub-id>
</element-citation>
</ref>
<ref id="CR16"><label>16.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rivera</surname>
<given-names>P</given-names>
</name>
<name><surname>Louther</surname>
<given-names>J</given-names>
</name>
<name><surname>Mohr</surname>
<given-names>J</given-names>
</name>
<name><surname>Campbell</surname>
<given-names>A</given-names>
</name>
<name><surname>DeHovitz</surname>
<given-names>J</given-names>
</name>
<name><surname>Sepkowitz</surname>
<given-names>KA</given-names>
</name>
</person-group>
<article-title>Does a cheaper mask save money? The cost of implementing a respiratory personal protective equipment program</article-title>
<source>Infect Control Hosp Epidemiol</source>
<year>1997</year>
<volume>18</volume>
<fpage>24</fpage>
<lpage>7</lpage>
<pub-id pub-id-type="doi">10.2307/30141959</pub-id>
<pub-id pub-id-type="pmid">9013242</pub-id>
</element-citation>
</ref>
<ref id="CR17"><label>17.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Christie</surname>
<given-names>CD</given-names>
</name>
<name><surname>Glover</surname>
<given-names>AM</given-names>
</name>
<name><surname>Willke</surname>
<given-names>MJ</given-names>
</name>
<name><surname>Marx</surname>
<given-names>ML</given-names>
</name>
<name><surname>Reising</surname>
<given-names>SF</given-names>
</name>
<name><surname>Hutchinson</surname>
<given-names>NM</given-names>
</name>
</person-group>
<article-title>Containment of pertussis in the regional pediatric hospital during the Greater Cincinnati epidemic of 1993</article-title>
<source>Infect Control Hosp Epidemiol</source>
<year>1995</year>
<volume>16</volume>
<fpage>556</fpage>
<lpage>63</lpage>
<pub-id pub-id-type="doi">10.2307/30141094</pub-id>
<pub-id pub-id-type="pmid">8568199</pub-id>
</element-citation>
</ref>
<ref id="CR18"><label>18.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hogg</surname>
<given-names>W</given-names>
</name>
<name><surname>Huston</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>Controlling droplet-transmitted respiratory infections: best practices and cost</article-title>
<source>Can Fam Physician</source>
<year>2006</year>
<volume>52</volume>
<fpage>1229</fpage>
<lpage>32</lpage>
<pub-id pub-id-type="pmid">17279182</pub-id>
</element-citation>
</ref>
<ref id="CR19"><label>19.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adal</surname>
<given-names>KA</given-names>
</name>
<name><surname>Anglim</surname>
<given-names>AM</given-names>
</name>
<name><surname>Palumbo</surname>
<given-names>CL</given-names>
</name>
<name><surname>Titus</surname>
<given-names>MG</given-names>
</name>
<name><surname>Coyner</surname>
<given-names>BJ</given-names>
</name>
<name><surname>Farr</surname>
<given-names>BM</given-names>
</name>
</person-group>
<article-title>The use of high-efficiency particulate air-filter respirators to protect hospital workers from tuberculosis -- a cost-effectiveness analysis</article-title>
<source>N Engl J Med</source>
<year>1994</year>
<volume>331</volume>
<fpage>169</fpage>
<lpage>73</lpage>
<pub-id pub-id-type="doi">10.1056/NEJM199407213310306</pub-id>
<pub-id pub-id-type="pmid">8008031</pub-id>
</element-citation>
</ref>
<ref id="CR20"><label>20.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Cahill</surname>
<given-names>BP</given-names>
</name>
<name><surname>Collins</surname>
<given-names>RD</given-names>
</name>
<name><surname>Jurko</surname>
<given-names>RC</given-names>
</name>
<name><surname>Zivic</surname>
<given-names>TR</given-names>
</name>
<name><surname>Crowther</surname>
<given-names>KG</given-names>
</name>
<name><surname>Haimes</surname>
<given-names>YY</given-names>
</name>
</person-group>
<article-title>Collaborative risk-based preparedness for pandemic influenza in southeastern Virginia</article-title>
<source>Proceedings of the 2008 IEEE Systems and Information Engineering Design Symposium, University of Virginia, Charlottesville</source>
<year>2008</year>
<fpage>323</fpage>
<lpage>8</lpage>
</element-citation>
</ref>
<ref id="CR21"><label>21.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>SC</given-names>
</name>
<name><surname>Liao</surname>
<given-names>CM</given-names>
</name>
</person-group>
<article-title>Cost-effectiveness of influenza control measures: a dynamic transmission model-based analysis</article-title>
<source>Epidemiol Infect</source>
<year>2013</year>
<volume>141</volume>
<fpage>2581</fpage>
<lpage>94</lpage>
<pub-id pub-id-type="doi">10.1017/S0950268813000423</pub-id>
<pub-id pub-id-type="pmid">23481024</pub-id>
</element-citation>
</ref>
<ref id="CR22"><label>22.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jones</surname>
<given-names>RM</given-names>
</name>
<name><surname>Adida</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>Selecting nonpharmaceutical interventions for influenza</article-title>
<source>Risk Anal</source>
<year>2013</year>
<volume>33</volume>
<fpage>1473</fpage>
<lpage>88</lpage>
<pub-id pub-id-type="doi">10.1111/j.1539-6924.2012.01938.x</pub-id>
<pub-id pub-id-type="pmid">23231621</pub-id>
</element-citation>
</ref>
<ref id="CR23"><label>23.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nettleman</surname>
<given-names>MD</given-names>
</name>
<name><surname>Fredrickson</surname>
<given-names>M</given-names>
</name>
<name><surname>Good</surname>
<given-names>NL</given-names>
</name>
<name><surname>Hunter</surname>
<given-names>SA</given-names>
</name>
</person-group>
<article-title>Tuberculosis control strategies: the cost of particulate respirators</article-title>
<source>Ann Intern Med</source>
<year>1994</year>
<volume>121</volume>
<fpage>37</fpage>
<lpage>40</lpage>
<pub-id pub-id-type="doi">10.7326/0003-4819-121-1-199407010-00007</pub-id>
<pub-id pub-id-type="pmid">8198346</pub-id>
</element-citation>
</ref>
<ref id="CR24"><label>24.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tom</surname>
<given-names>LD</given-names>
</name>
<name><surname>Zaid</surname>
<given-names>C</given-names>
</name>
<name><surname>Richard</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Cost- effectiveness analysis of pandemic influenza preparedness: what’s missing?</article-title>
<source>Bull World Health Organ</source>
<year>2012</year>
<volume>90</volume>
<fpage>940</fpage>
<pub-id pub-id-type="doi">10.2471/BLT.12.109025</pub-id>
<pub-id pub-id-type="pmid">23284200</pub-id>
</element-citation>
</ref>
<ref id="CR25"><label>25.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Diel</surname>
<given-names>R</given-names>
</name>
<name><surname>Loddenkemper</surname>
<given-names>R</given-names>
</name>
<name><surname>Nienhaus</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Predictive value of interferon-γ release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis</article-title>
<source>Chest</source>
<year>2012</year>
<volume>142</volume>
<fpage>63</fpage>
<lpage>75</lpage>
<pub-id pub-id-type="doi">10.1378/chest.11-3157</pub-id>
<pub-id pub-id-type="pmid">22490872</pub-id>
</element-citation>
</ref>
<ref id="CR26"><label>26.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aiello</surname>
<given-names>AE</given-names>
</name>
<name><surname>Murray</surname>
<given-names>GF</given-names>
</name>
<name><surname>Perez</surname>
<given-names>V</given-names>
</name>
<name><surname>Coulborn</surname>
<given-names>RM</given-names>
</name>
<name><surname>Davis</surname>
<given-names>BM</given-names>
</name>
<name><surname>Uddin</surname>
<given-names>M</given-names>
</name>
<name><surname>Shay</surname>
<given-names>DK</given-names>
</name>
<name><surname>Waterman</surname>
<given-names>SH</given-names>
</name>
<name><surname>Monto</surname>
<given-names>AS</given-names>
</name>
</person-group>
<article-title>Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial</article-title>
<source>J Infect Dis</source>
<year>2010</year>
<volume>201</volume>
<fpage>491</fpage>
<lpage>8</lpage>
<pub-id pub-id-type="doi">10.1086/650396</pub-id>
<pub-id pub-id-type="pmid">20088690</pub-id>
</element-citation>
</ref>
<ref id="CR27"><label>27.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loeb</surname>
<given-names>M</given-names>
</name>
<name><surname>Dafoe</surname>
<given-names>N</given-names>
</name>
<name><surname>Mahony</surname>
<given-names>J</given-names>
</name>
<name><surname>John</surname>
<given-names>M</given-names>
</name>
<name><surname>Sarabia</surname>
<given-names>A</given-names>
</name>
<name><surname>Glavin</surname>
<given-names>V</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Surgical mask vs n95 respirator for preventing influenza among health care workers: a randomized trial</article-title>
<source>JAMA</source>
<year>2009</year>
<volume>302</volume>
<fpage>1865</fpage>
<lpage>71</lpage>
<pub-id pub-id-type="doi">10.1001/jama.2009.1466</pub-id>
<pub-id pub-id-type="pmid">19797474</pub-id>
</element-citation>
</ref>
<ref id="CR28"><label>28.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>MacIntyre</surname>
<given-names>CR</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Q</given-names>
</name>
<name><surname>Seale</surname>
<given-names>H</given-names>
</name>
<name><surname>Yang</surname>
<given-names>P</given-names>
</name>
<name><surname>Shi</surname>
<given-names>W</given-names>
</name>
<name><surname>Gao</surname>
<given-names>Z</given-names>
</name>
<name><surname>Rahman</surname>
<given-names>B</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y</given-names>
</name>
<name><surname>Wang</surname>
<given-names>X</given-names>
</name>
<name><surname>Newall</surname>
<given-names>AT</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A randomized clinical trial of three options for N95 respirators and medical masks in health workers</article-title>
<source>Am J Respir Crit Care Med</source>
<year>2013</year>
<volume>187</volume>
<fpage>960</fpage>
<lpage>6</lpage>
<pub-id pub-id-type="doi">10.1164/rccm.201207-1164OC</pub-id>
<pub-id pub-id-type="pmid">23413265</pub-id>
</element-citation>
</ref>
<ref id="CR29"><label>29.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Bollinger</surname>
<given-names>N</given-names>
</name>
</person-group>
<article-title>NIOSH respirator selection logic</article-title>
<source>Book NIOSH respirator selection logic NIOSH publications dissemination</source>
<year>2004</year>
</element-citation>
</ref>
<ref id="CR30"><label>30.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Balazy</surname>
<given-names>A</given-names>
</name>
<name><surname>Toivola</surname>
<given-names>M</given-names>
</name>
<name><surname>Adhikari</surname>
<given-names>A</given-names>
</name>
<name><surname>Sivasubramani</surname>
<given-names>SK</given-names>
</name>
<name><surname>Reponen</surname>
<given-names>T</given-names>
</name>
<name><surname>Grinshpun</surname>
<given-names>SA</given-names>
</name>
</person-group>
<article-title>Do N95 respirators provide 95 % protection level against airborne viruses, and how adequate are surgical masks?</article-title>
<source>Am J Infect Control</source>
<year>2006</year>
<volume>34</volume>
<fpage>51</fpage>
<lpage>7</lpage>
<pub-id pub-id-type="doi">10.1016/j.ajic.2005.08.018</pub-id>
<pub-id pub-id-type="pmid">16490606</pub-id>
</element-citation>
</ref>
<ref id="CR31"><label>31.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Mugford</surname>
<given-names>M</given-names>
</name>
<name><surname>Donaldson</surname>
<given-names>C</given-names>
</name>
<name><surname>Vale</surname>
<given-names>L</given-names>
</name>
</person-group>
<source>Evidence-based health economics: from effectiveness to efficiency in systematic review</source>
<year>2002</year>
<publisher-loc>London</publisher-loc>
<publisher-name>BMJ</publisher-name>
</element-citation>
</ref>
<ref id="CR32"><label>32.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seet</surname>
<given-names>RCS</given-names>
</name>
<name><surname>Lim</surname>
<given-names>ECH</given-names>
</name>
<name><surname>Oh</surname>
<given-names>VMS</given-names>
</name>
<name><surname>Ong</surname>
<given-names>BKC</given-names>
</name>
<name><surname>Goh</surname>
<given-names>KT</given-names>
</name>
<name><surname>Fisher</surname>
<given-names>DA</given-names>
</name>
<name><surname>Ho</surname>
<given-names>KY</given-names>
</name>
<name><surname>Yeoh</surname>
<given-names>KG</given-names>
</name>
</person-group>
<article-title>Readiness exercise to combat avian influenza</article-title>
<source>QJM</source>
<year>2009</year>
<volume>102</volume>
<fpage>133</fpage>
<lpage>7</lpage>
<pub-id pub-id-type="doi">10.1093/qjmed/hcn159</pub-id>
<pub-id pub-id-type="pmid">19073645</pub-id>
</element-citation>
</ref>
<ref id="CR33"><label>33.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>SC</given-names>
</name>
<name><surname>Liao</surname>
<given-names>CM</given-names>
</name>
</person-group>
<article-title>Modelling control measures to reduce the impact of pandemic influenza among schoolchildren</article-title>
<source>Epidemiol Infect</source>
<year>2008</year>
<volume>136</volume>
<fpage>1035</fpage>
<lpage>45</lpage>
<pub-id pub-id-type="doi">10.1017/S0950268807009284</pub-id>
<pub-id pub-id-type="pmid">17850689</pub-id>
</element-citation>
</ref>
<ref id="CR34"><label>34.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aiello</surname>
<given-names>AE</given-names>
</name>
<name><surname>Perez</surname>
<given-names>V</given-names>
</name>
<name><surname>Coulborn</surname>
<given-names>RM</given-names>
</name>
<name><surname>Davis</surname>
<given-names>BM</given-names>
</name>
<name><surname>Uddin</surname>
<given-names>M</given-names>
</name>
<name><surname>Monto</surname>
<given-names>AS</given-names>
</name>
</person-group>
<article-title>Facemasks, hand hygiene, and influenza among young adults: a randomized intervention trial</article-title>
<source>PLoS One</source>
<year>2012</year>
<volume>7</volume>
<fpage>e29744</fpage>
<pub-id pub-id-type="doi">10.1371/journal.pone.0029744</pub-id>
<pub-id pub-id-type="pmid">22295066</pub-id>
</element-citation>
</ref>
<ref id="CR35"><label>35.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cowling</surname>
<given-names>BJ</given-names>
</name>
<name><surname>Chan</surname>
<given-names>KH</given-names>
</name>
<name><surname>Fang</surname>
<given-names>VJ</given-names>
</name>
<name><surname>Cheng</surname>
<given-names>CKY</given-names>
</name>
<name><surname>Fung</surname>
<given-names>ROP</given-names>
</name>
<name><surname>Wai</surname>
<given-names>W</given-names>
</name>
<name><surname>Sin</surname>
<given-names>J</given-names>
</name>
<name><surname>Seto</surname>
<given-names>WH</given-names>
</name>
<name><surname>Yung</surname>
<given-names>R</given-names>
</name>
<name><surname>Chu</surname>
<given-names>DWS</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial</article-title>
<source>Ann Intern Med</source>
<year>2009</year>
<volume>151</volume>
<fpage>437</fpage>
<lpage>46</lpage>
<pub-id pub-id-type="doi">10.7326/0003-4819-151-7-200910060-00142</pub-id>
<pub-id pub-id-type="pmid">19652172</pub-id>
</element-citation>
</ref>
<ref id="CR36"><label>36.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>MacIntyre</surname>
<given-names>CR</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Q</given-names>
</name>
<name><surname>Cauchemez</surname>
<given-names>S</given-names>
</name>
<name><surname>Seale</surname>
<given-names>H</given-names>
</name>
<name><surname>Dwyer</surname>
<given-names>DE</given-names>
</name>
<name><surname>Yang</surname>
<given-names>P</given-names>
</name>
<name><surname>Shi</surname>
<given-names>W</given-names>
</name>
<name><surname>Gao</surname>
<given-names>Z</given-names>
</name>
<name><surname>Pang</surname>
<given-names>X</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A cluster randomized clinical trial comparing fit-tested and non-fit-tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers</article-title>
<source>Influenza Other Respir Viruses</source>
<year>2011</year>
<volume>5</volume>
<fpage>170</fpage>
<lpage>9</lpage>
<pub-id pub-id-type="doi">10.1111/j.1750-2659.2011.00198.x</pub-id>
<pub-id pub-id-type="pmid">21477136</pub-id>
</element-citation>
</ref>
<ref id="CR37"><label>37.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Maclntyre</surname>
<given-names>CR</given-names>
</name>
<name><surname>Cauchemez</surname>
<given-names>S</given-names>
</name>
<name><surname>Dwyer</surname>
<given-names>DE</given-names>
</name>
<name><surname>Seale</surname>
<given-names>H</given-names>
</name>
<name><surname>Cheung</surname>
<given-names>P</given-names>
</name>
<name><surname>Browne</surname>
<given-names>G</given-names>
</name>
<name><surname>Fasher</surname>
<given-names>M</given-names>
</name>
<name><surname>Wood</surname>
<given-names>J</given-names>
</name>
<name><surname>Gao</surname>
<given-names>Z</given-names>
</name>
<name><surname>Booy</surname>
<given-names>R</given-names>
</name>
<name><surname>Ferguson</surname>
<given-names>N</given-names>
</name>
</person-group>
<article-title>Face mask use and control of respiratory virus transmission in households</article-title>
<source>Emerg Infect Dis</source>
<year>2009</year>
<volume>15</volume>
<fpage>233</fpage>
<lpage>41</lpage>
<pub-id pub-id-type="doi">10.3201/eid1502.081166</pub-id>
<pub-id pub-id-type="pmid">19193267</pub-id>
</element-citation>
</ref>
<ref id="CR38"><label>38.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Larson</surname>
<given-names>EL</given-names>
</name>
<name><surname>Ferng</surname>
<given-names>YH</given-names>
</name>
<name><surname>Wong-McLoughlin</surname>
<given-names>J</given-names>
</name>
<name><surname>Wang</surname>
<given-names>S</given-names>
</name>
<name><surname>Haber</surname>
<given-names>M</given-names>
</name>
<name><surname>Morse</surname>
<given-names>SS</given-names>
</name>
</person-group>
<article-title>Impact of non-pharmaceutical interventions on URIs and influenza in crowded, urban households</article-title>
<source>Public Health Rep</source>
<year>2010</year>
<volume>125</volume>
<fpage>178</fpage>
<lpage>91</lpage>
<pub-id pub-id-type="pmid">20297744</pub-id>
</element-citation>
</ref>
<ref id="CR39"><label>39.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Molinari</surname>
<given-names>NAM</given-names>
</name>
<name><surname>Ortega-Sanchez</surname>
<given-names>IR</given-names>
</name>
<name><surname>Messonnier</surname>
<given-names>ML</given-names>
</name>
<name><surname>Thompson</surname>
<given-names>WW</given-names>
</name>
<name><surname>Wortley</surname>
<given-names>PM</given-names>
</name>
<name><surname>Weintraub</surname>
<given-names>E</given-names>
</name>
<name><surname>Bridges</surname>
<given-names>CB</given-names>
</name>
</person-group>
<article-title>The annual impact of seasonal influenza in the US: measuring disease burden and costs</article-title>
<source>Vaccine</source>
<year>2007</year>
<volume>25</volume>
<fpage>5086</fpage>
<lpage>96</lpage>
<pub-id pub-id-type="doi">10.1016/j.vaccine.2007.03.046</pub-id>
<pub-id pub-id-type="pmid">17544181</pub-id>
</element-citation>
</ref>
<ref id="CR40"><label>40.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Drummond</surname>
<given-names>M</given-names>
</name>
<name><surname>Sculpher</surname>
<given-names>MJ</given-names>
</name>
<name><surname>Torrance</surname>
<given-names>GW</given-names>
</name>
<name><surname>O’Brien</surname>
<given-names>BJ</given-names>
</name>
<name><surname>Stoddart</surname>
<given-names>GL</given-names>
</name>
</person-group>
<source>Methods for the economic evaluation of health care programmes</source>
<year>2005</year>
<edition>3</edition>
<publisher-loc>Oxford</publisher-loc>
<publisher-name>Oxford University Press</publisher-name>
</element-citation>
</ref>
<ref id="CR41"><label>41.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seale</surname>
<given-names>H</given-names>
</name>
<name><surname>Corbett</surname>
<given-names>S</given-names>
</name>
<name><surname>Dwyer</surname>
<given-names>DE</given-names>
</name>
<name><surname>MacIntyre</surname>
<given-names>CR</given-names>
</name>
</person-group>
<article-title>Feasibility exercise to evaluate the use of particulate respirators by emergency department staff during the 2007 influenza season</article-title>
<source>Infect Control Hosp Epidemiol</source>
<year>2009</year>
<volume>30</volume>
<fpage>710</fpage>
<lpage>2</lpage>
<pub-id pub-id-type="doi">10.1086/599254</pub-id>
<pub-id pub-id-type="pmid">19496650</pub-id>
</element-citation>
</ref>
<ref id="CR42"><label>42.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chor</surname>
<given-names>JSY</given-names>
</name>
<name><surname>Pada</surname>
<given-names>SK</given-names>
</name>
<name><surname>Stephenson</surname>
<given-names>I</given-names>
</name>
<name><surname>Goggins</surname>
<given-names>WB</given-names>
</name>
<name><surname>Tambyah</surname>
<given-names>PA</given-names>
</name>
<name><surname>Medina</surname>
<given-names>M</given-names>
</name>
<name><surname>Lee</surname>
<given-names>N</given-names>
</name>
<name><surname>Leung</surname>
<given-names>TF</given-names>
</name>
<name><surname>Ngai</surname>
<given-names>KLK</given-names>
</name>
<name><surname>Law</surname>
<given-names>SK</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Differences in the compliance with hospital infection control practices during the 2009 influenza H1N1 pandemic in three countries</article-title>
<source>J Hosp Infect</source>
<year>2012</year>
<volume>81</volume>
<fpage>98</fpage>
<lpage>103</lpage>
<pub-id pub-id-type="doi">10.1016/j.jhin.2012.04.003</pub-id>
<pub-id pub-id-type="pmid">22560251</pub-id>
</element-citation>
</ref>
<ref id="CR43"><label>43.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burgess</surname>
<given-names>A</given-names>
</name>
<name><surname>Horii</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Risk, ritual and health responsibilisation: Japan’s ‘safety blanket’ of surgical face mask-wearing</article-title>
<source>Sociol Health Illn</source>
<year>2012</year>
<volume>34</volume>
<fpage>1184</fpage>
<lpage>98</lpage>
<pub-id pub-id-type="doi">10.1111/j.1467-9566.2012.01466.x</pub-id>
<pub-id pub-id-type="pmid">22443378</pub-id>
</element-citation>
</ref>
<ref id="CR44"><label>44.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tang</surname>
<given-names>CSK</given-names>
</name>
<name><surname>Wong</surname>
<given-names>CY</given-names>
</name>
</person-group>
<article-title>Factors influencing the wearing of facemasks to prevent the severe acute respiratory syndrome among adult Chinese in Hong Kong</article-title>
<source>Prev Med</source>
<year>2004</year>
<volume>39</volume>
<fpage>1187</fpage>
<lpage>93</lpage>
<pub-id pub-id-type="doi">10.1016/j.ypmed.2004.04.032</pub-id>
<pub-id pub-id-type="pmid">15539054</pub-id>
</element-citation>
</ref>
<ref id="CR45"><label>45.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferng</surname>
<given-names>YH</given-names>
</name>
<name><surname>Wong-McLoughlin</surname>
<given-names>J</given-names>
</name>
<name><surname>Barrett</surname>
<given-names>A</given-names>
</name>
<name><surname>Currie</surname>
<given-names>L</given-names>
</name>
<name><surname>Larson</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>Barriers to mask wearing for influenza-like illnesses among urban hispanic households</article-title>
<source>Public Health Nurs</source>
<year>2011</year>
<volume>28</volume>
<fpage>13</fpage>
<lpage>23</lpage>
<pub-id pub-id-type="doi">10.1111/j.1525-1446.2010.00918.x</pub-id>
<pub-id pub-id-type="pmid">21198810</pub-id>
</element-citation>
</ref>
<ref id="CR46"><label>46.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lau</surname>
<given-names>JTF</given-names>
</name>
<name><surname>Griffiths</surname>
<given-names>S</given-names>
</name>
<name><surname>Au</surname>
<given-names>DWH</given-names>
</name>
<name><surname>Choi</surname>
<given-names>KC</given-names>
</name>
</person-group>
<article-title>Changes in knowledge, perceptions, preventive behaviours and psychological responses in the pre-community outbreak phase of the H1N1 epidemic</article-title>
<source>Epidemiol Infect</source>
<year>2011</year>
<volume>139</volume>
<fpage>80</fpage>
<lpage>90</lpage>
<pub-id pub-id-type="doi">10.1017/S0950268810001925</pub-id>
<pub-id pub-id-type="pmid">20800008</pub-id>
</element-citation>
</ref>
<ref id="CR47"><label>47.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lau</surname>
<given-names>JTF</given-names>
</name>
<name><surname>Griffiths</surname>
<given-names>S</given-names>
</name>
<name><surname>Choi</surname>
<given-names>K</given-names>
</name>
<name><surname>Lin</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Prevalence of preventive behaviors and associated factors during early phase of the H1N1 influenza epidemic</article-title>
<source>Am J Infect Control</source>
<year>2010</year>
<volume>38</volume>
<fpage>374</fpage>
<lpage>80</lpage>
<pub-id pub-id-type="doi">10.1016/j.ajic.2010.03.002</pub-id>
<pub-id pub-id-type="pmid">20569849</pub-id>
</element-citation>
</ref>
<ref id="CR48"><label>48.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chia</surname>
<given-names>SE</given-names>
</name>
<name><surname>Koh</surname>
<given-names>D</given-names>
</name>
<name><surname>Fones</surname>
<given-names>C</given-names>
</name>
<name><surname>Qian</surname>
<given-names>F</given-names>
</name>
<name><surname>Ng</surname>
<given-names>V</given-names>
</name>
<name><surname>Tan</surname>
<given-names>BH</given-names>
</name>
<name><surname>Wong</surname>
<given-names>KS</given-names>
</name>
<name><surname>Chew</surname>
<given-names>WM</given-names>
</name>
<name><surname>Tang</surname>
<given-names>HK</given-names>
</name>
<name><surname>Ng</surname>
<given-names>W</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Appropriate use of personal protective equipment among healthcare workers in public sector hospitals and primary healthcare polyclinics during the SARS outbreak in Singapore</article-title>
<source>Occup Environ Med</source>
<year>2005</year>
<volume>62</volume>
<fpage>473</fpage>
<lpage>7</lpage>
<pub-id pub-id-type="doi">10.1136/oem.2004.015024</pub-id>
<pub-id pub-id-type="pmid">15961624</pub-id>
</element-citation>
</ref>
<ref id="CR49"><label>49.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jefferson</surname>
<given-names>T</given-names>
</name>
<name><surname>Del Mar</surname>
<given-names>C</given-names>
</name>
<name><surname>Dooley</surname>
<given-names>L</given-names>
</name>
<name><surname>Ferroni</surname>
<given-names>E</given-names>
</name>
<name><surname>Al-ansary</surname>
<given-names>LA</given-names>
</name>
<name><surname>Bawazeer</surname>
<given-names>GA</given-names>
</name>
<name><surname>Van Driel</surname>
<given-names>ML</given-names>
</name>
<name><surname>Foxlee</surname>
<given-names>R</given-names>
</name>
<name><surname>Rivetti</surname>
<given-names>A</given-names>
</name>
<name><surname>Al-Ansary</surname>
<given-names>LA</given-names>
</name>
<name><surname>van Driel</surname>
<given-names>ML</given-names>
</name>
</person-group>
<article-title>Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review</article-title>
<source>BMJ</source>
<year>2009</year>
<volume>339</volume>
<fpage>b3675</fpage>
<pub-id pub-id-type="doi">10.1136/bmj.b3675</pub-id>
<pub-id pub-id-type="pmid">19773323</pub-id>
</element-citation>
</ref>
<ref id="CR50"><label>50.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jefferson</surname>
<given-names>T</given-names>
</name>
<name><surname>Del Mar</surname>
<given-names>C</given-names>
</name>
<name><surname>Dooley</surname>
<given-names>L</given-names>
</name>
<name><surname>Ferroni</surname>
<given-names>E</given-names>
</name>
<name><surname>Al-Ansary</surname>
<given-names>LA</given-names>
</name>
<name><surname>Bawazeer</surname>
<given-names>GA</given-names>
</name>
<name><surname>van Driel</surname>
<given-names>ML</given-names>
</name>
<name><surname>Nair</surname>
<given-names>S</given-names>
</name>
<name><surname>Foxlee</surname>
<given-names>R</given-names>
</name>
<name><surname>Rivetti</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Physical interventions to interrupt or reduce the spread of respiratory viruses: a Cochrane review</article-title>
<source>Health Technol Assess (Winch Eng)</source>
<year>2010</year>
<volume>14</volume>
<fpage>347</fpage>
<lpage>476</lpage>
</element-citation>
</ref>
<ref id="CR51"><label>51.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bin-Reza</surname>
<given-names>F</given-names>
</name>
<name><surname>Lopez Chavarrias</surname>
<given-names>V</given-names>
</name>
<name><surname>Nicoll</surname>
<given-names>A</given-names>
</name>
<name><surname>Chamberland</surname>
<given-names>ME</given-names>
</name>
</person-group>
<article-title>The use of masks and respirators to prevent transmission of influenza: a systematic review of the scientific evidence</article-title>
<source>Influenza Other Respir Viruses</source>
<year>2012</year>
<volume>6</volume>
<fpage>257</fpage>
<lpage>67</lpage>
<pub-id pub-id-type="doi">10.1111/j.1750-2659.2011.00307.x</pub-id>
<pub-id pub-id-type="pmid">22188875</pub-id>
</element-citation>
</ref>
<ref id="CR52"><label>52.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname>
<given-names>SA</given-names>
</name>
<name><surname>Grinshpun</surname>
<given-names>SA</given-names>
</name>
<name><surname>Reponen</surname>
<given-names>T</given-names>
</name>
</person-group>
<article-title>Respiratory performance offered by N95 respirators and surgical masks: human subject evaluation with NaCl aerosol representing bacterial and viral particle size range</article-title>
<source>Ann Occup Hyg</source>
<year>2008</year>
<volume>52</volume>
<fpage>177</fpage>
<lpage>85</lpage>
<pub-id pub-id-type="doi">10.1093/annhyg/men005</pub-id>
<pub-id pub-id-type="pmid">18326870</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
</pmc>
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