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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of HLA class I with severe acute respiratory syndrome coronavirus infection</title><author><name sortKey="Lin, Marie" sort="Lin, Marie" uniqKey="Lin M" first="Marie" last="Lin">Marie Lin</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Tseng, Hsiang Kuang" sort="Tseng, Hsiang Kuang" uniqKey="Tseng H" first="Hsiang-Kuang" last="Tseng">Hsiang-Kuang Tseng</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Trejaut, Jean A" sort="Trejaut, Jean A" uniqKey="Trejaut J" first="Jean A" last="Trejaut">Jean A. Trejaut</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lee, Hui Lin" sort="Lee, Hui Lin" uniqKey="Lee H" first="Hui-Lin" last="Lee">Hui-Lin Lee</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Loo, Jun Hun" sort="Loo, Jun Hun" uniqKey="Loo J" first="Jun-Hun" last="Loo">Jun-Hun Loo</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chu, Chen Chung" sort="Chu, Chen Chung" uniqKey="Chu C" first="Chen-Chung" last="Chu">Chen-Chung Chu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Pei Jan" sort="Chen, Pei Jan" uniqKey="Chen P" first="Pei-Jan" last="Chen">Pei-Jan Chen</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Su, Ying Wen" sort="Su, Ying Wen" uniqKey="Su Y" first="Ying-Wen" last="Su">Ying-Wen Su</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lim, Ken Hong" sort="Lim, Ken Hong" uniqKey="Lim K" first="Ken Hong" last="Lim">Ken Hong Lim</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Tsai, Zen Uong" sort="Tsai, Zen Uong" uniqKey="Tsai Z" first="Zen-Uong" last="Tsai">Zen-Uong Tsai</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Ruey Yi" sort="Lin, Ruey Yi" uniqKey="Lin R" first="Ruey-Yi" last="Lin">Ruey-Yi Lin</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.416849.6</institution-id><institution>Taipei Municipal Hoping Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Ruey Shiung" sort="Lin, Ruey Shiung" uniqKey="Lin R" first="Ruey-Shiung" last="Lin">Ruey-Shiung Lin</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000000405460241</institution-id><institution>Institute of Preventive Medicine,</institution><institution>National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Huang, Chun Hsiung" sort="Huang, Chun Hsiung" uniqKey="Huang C" first="Chun-Hsiung" last="Huang">Chun-Hsiung Huang</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Office of Director,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">12969506</idno><idno type="pmc">212558</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212558</idno><idno type="RBID">PMC:212558</idno><idno type="doi">10.1186/1471-2350-4-9</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">000063</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of HLA class I with severe acute respiratory syndrome coronavirus infection</title><author><name sortKey="Lin, Marie" sort="Lin, Marie" uniqKey="Lin M" first="Marie" last="Lin">Marie Lin</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Tseng, Hsiang Kuang" sort="Tseng, Hsiang Kuang" uniqKey="Tseng H" first="Hsiang-Kuang" last="Tseng">Hsiang-Kuang Tseng</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Trejaut, Jean A" sort="Trejaut, Jean A" uniqKey="Trejaut J" first="Jean A" last="Trejaut">Jean A. Trejaut</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lee, Hui Lin" sort="Lee, Hui Lin" uniqKey="Lee H" first="Hui-Lin" last="Lee">Hui-Lin Lee</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Loo, Jun Hun" sort="Loo, Jun Hun" uniqKey="Loo J" first="Jun-Hun" last="Loo">Jun-Hun Loo</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chu, Chen Chung" sort="Chu, Chen Chung" uniqKey="Chu C" first="Chen-Chung" last="Chu">Chen-Chung Chu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Pei Jan" sort="Chen, Pei Jan" uniqKey="Chen P" first="Pei-Jan" last="Chen">Pei-Jan Chen</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Su, Ying Wen" sort="Su, Ying Wen" uniqKey="Su Y" first="Ying-Wen" last="Su">Ying-Wen Su</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lim, Ken Hong" sort="Lim, Ken Hong" uniqKey="Lim K" first="Ken Hong" last="Lim">Ken Hong Lim</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Tsai, Zen Uong" sort="Tsai, Zen Uong" uniqKey="Tsai Z" first="Zen-Uong" last="Tsai">Zen-Uong Tsai</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Ruey Yi" sort="Lin, Ruey Yi" uniqKey="Lin R" first="Ruey-Yi" last="Lin">Ruey-Yi Lin</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.416849.6</institution-id><institution>Taipei Municipal Hoping Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Ruey Shiung" sort="Lin, Ruey Shiung" uniqKey="Lin R" first="Ruey-Shiung" last="Lin">Ruey-Shiung Lin</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000000405460241</institution-id><institution>Institute of Preventive Medicine,</institution><institution>National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Huang, Chun Hsiung" sort="Huang, Chun Hsiung" uniqKey="Huang C" first="Chun-Hsiung" last="Huang">Chun-Hsiung Huang</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Office of Director,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Medical Genetics</title><idno type="eISSN">1471-2350</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The human leukocyte antigen (HLA) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many health care workers were infected. In an effort to establish a screening program for high risk personal, the distribution of HLA class I and II alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to SARS coronavirus infection.</p></sec><sec><title>Methods</title><p>HLA-class I and II allele typing by PCR-SSOP was performed on 37 cases of probable SARS, 28 fever patients excluded later as probable SARS, and 101 non-infected health care workers who were exposed or possibly exposed to SARS coronavirus. An additional control set of 190 normal healthy unrelated Taiwanese was also used in the analysis.</p></sec><sec><title>Results</title><p>Woolf and Haldane Odds ratio (OR) and corrected P-value (Pc) obtained from two tails Fisher exact test were used to show susceptibility of HLA class I or class II alleles with coronavirus infection. At first, when analyzing infected SARS patients and high risk health care workers groups, HLA-B*4601 (OR = 2.08, <italic>P</italic> = 0.04, <italic>Pc</italic> = n.s.) and HLA-B*5401 (OR = 5.44, <italic>P</italic> = 0.02, <italic>Pc</italic> = n.s.) appeared as the most probable elements that may be favoring SARS coronavirus infection. After selecting only a "severe cases" patient group from the infected "probable SARS" patient group and comparing them with the high risk health care workers group, the severity of SARS was shown to be significantly associated with HLA-B*4601 (<italic>P</italic> = 0.0008 or <italic>Pc</italic> = 0.0279).</p></sec><sec><title>Conclusions</title><p>Densely populated regions with genetically related southern Asian populations appear to be more affected by the spreading of SARS infection. Up until recently, no probable SARS patients were reported among Taiwan indigenous peoples who are genetically distinct from the Taiwanese general population, have no HLA-B* 4601 and have high frequency of HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the "Probable SARS infected" patient group, a further significant increase of the allele was seen in the "Severe cases" patient group. These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. Independent studies are needed to test these results.</p></sec></div></front></TEI><pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Med Genet</journal-id><journal-id journal-id-type="iso-abbrev">BMC Med. Genet</journal-id><journal-title-group><journal-title>BMC Medical Genetics</journal-title></journal-title-group><issn pub-type="epub">1471-2350</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">12969506</article-id><article-id pub-id-type="pmc">212558</article-id><article-id pub-id-type="publisher-id">35</article-id><article-id pub-id-type="doi">10.1186/1471-2350-4-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Association of HLA class I with severe acute respiratory syndrome coronavirus infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Marie</given-names></name><address><email>marilin@ms2.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Hsiang-Kuang</given-names></name><address><email>drtseng@anet.net.tw</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Trejaut</surname><given-names>Jean A</given-names></name><address><email>jtrejaut@ms1.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Hui-Lin</given-names></name><address><email>leehl@ms1.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Loo</surname><given-names>Jun-Hun</given-names></name><address><email>junhun@ms1.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Chen-Chung</given-names></name><address><email>chucc@ms1.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Pei-Jan</given-names></name><address><email>g8640@ms13.hinet.net</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Su</surname><given-names>Ying-Wen</given-names></name><address><email>yingwen_su@yahoo.com.tw</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Ken Hong</given-names></name><address><email>khlim@seed.net.tw</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Tsai</surname><given-names>Zen-Uong</given-names></name><address><email>tsaizu@ms1.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Ruey-Yi</given-names></name><address><email>lin-8424@mail.hoping.gov.tw</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Ruey-Shiung</given-names></name><address><email>rueyshiung@yahoo.com</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Huang</surname><given-names>Chun-Hsiung</given-names></name><address><email>chhuang@ms2.mmh.org.tw</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Transfusion Medicine Laboratory,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Department of Internal Medicine,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.416849.6</institution-id><institution>Taipei Municipal Hoping Hospital,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000000405460241</institution-id><institution>Institute of Preventive Medicine,</institution><institution>National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id><institution-id institution-id-type="ISNI">000000040573007X</institution-id><institution>Office of Director,</institution><institution>Mackay Memorial Hospital,</institution></institution-wrap>Taipei, Taiwan</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>9</month><year>2003</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>9</month><year>2003</year></pub-date><pub-date pub-type="collection"><year>2003</year></pub-date><volume>4</volume><elocation-id>9</elocation-id><history><date date-type="received"><day>26</day><month>6</month><year>2003</year></date><date date-type="accepted"><day>12</day><month>9</month><year>2003</year></date></history><permissions><copyright-statement>© Lin et al; licensee BioMed Central Ltd. 2003, This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>The human leukocyte antigen (HLA) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many health care workers were infected. In an effort to establish a screening program for high risk personal, the distribution of HLA class I and II alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to SARS coronavirus infection.</p></sec><sec><title>Methods</title><p>HLA-class I and II allele typing by PCR-SSOP was performed on 37 cases of probable SARS, 28 fever patients excluded later as probable SARS, and 101 non-infected health care workers who were exposed or possibly exposed to SARS coronavirus. An additional control set of 190 normal healthy unrelated Taiwanese was also used in the analysis.</p></sec><sec><title>Results</title><p>Woolf and Haldane Odds ratio (OR) and corrected P-value (Pc) obtained from two tails Fisher exact test were used to show susceptibility of HLA class I or class II alleles with coronavirus infection. At first, when analyzing infected SARS patients and high risk health care workers groups, HLA-B*4601 (OR = 2.08, <italic>P</italic> = 0.04, <italic>Pc</italic> = n.s.) and HLA-B*5401 (OR = 5.44, <italic>P</italic> = 0.02, <italic>Pc</italic> = n.s.) appeared as the most probable elements that may be favoring SARS coronavirus infection. After selecting only a "severe cases" patient group from the infected "probable SARS" patient group and comparing them with the high risk health care workers group, the severity of SARS was shown to be significantly associated with HLA-B*4601 (<italic>P</italic> = 0.0008 or <italic>Pc</italic> = 0.0279).</p></sec><sec><title>Conclusions</title><p>Densely populated regions with genetically related southern Asian populations appear to be more affected by the spreading of SARS infection. Up until recently, no probable SARS patients were reported among Taiwan indigenous peoples who are genetically distinct from the Taiwanese general population, have no HLA-B* 4601 and have high frequency of HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the "Probable SARS infected" patient group, a further significant increase of the allele was seen in the "Severe cases" patient group. These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. Independent studies are needed to test these results.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Human Leukocyte Antigen</kwd><kwd>Health Care Worker</kwd><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Human Leukocyte Antigen Class</kwd><kwd>Severe Acute Respiratory Syndrome</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2003</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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|area= SrasV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |