Epidemiologic Clues to SARS Origin in China
Identifieur interne : 001676 ( Pmc/Checkpoint ); précédent : 001675; suivant : 001677Epidemiologic Clues to SARS Origin in China
Auteurs : Rui-Heng Xu [République populaire de Chine] ; Jian-Feng He [République populaire de Chine] ; Meirion R. Evans [Royaume-Uni] ; Guo-Wen Peng [République populaire de Chine] ; Hume E. Field [Australie] ; De-Wen Yu [République populaire de Chine] ; Chin-Kei Lee [Australie] ; Hui-Min Luo [République populaire de Chine] ; Wei-Sheng Lin [République populaire de Chine] ; Peng Lin [République populaire de Chine] ; Ling-Hui Li [République populaire de Chine] ; Wen-Jia Liang [République populaire de Chine] ; Jin-Yan Lin [République populaire de Chine] ; Alan Schnur [République populaire de Chine]Source :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2004.
Abstract
An epidemic of severe acute respiratory syndrome (SARS) began in Foshan municipality, Guangdong Province, China, in November 2002. We studied SARS case reports through April 30, 2003, including data from case investigations and a case series analysis of index cases. A total of 1,454 clinically confirmed cases (and 55 deaths) occurred; the epidemic peak was in the first week of February 2003. Healthcare workers accounted for 24% of cases. Clinical signs and symptoms differed between children (<18 years) and older persons (>65 years). Several observations support the hypothesis of a wild animal origin for SARS. Cases apparently occurred independently in at least five different municipalities; early case-patients were more likely than later patients to report living near a produce market (odds ratio undefined; lower 95% confidence interval 2.39) but not near a farm; and 9 (39%) of 23 early patients, including 6 who lived or worked in Foshan, were food handlers with probable animal contact.
Url:
DOI: 10.3201/eid1006.030852
PubMed: 15207054
PubMed Central: 3323155
Affiliations:
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wicri:level="1"><nlm:aff id="aff5">Australian National University, Canberra, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Hui Min" sort="Luo, Hui Min" uniqKey="Luo H" first="Hui-Min" last="Luo">Hui-Min Luo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lin, Wei Sheng" sort="Lin, Wei Sheng" uniqKey="Lin W" first="Wei-Sheng" last="Lin">Wei-Sheng Lin</name><affiliation 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Ling Hui" sort="Li, Ling Hui" uniqKey="Li L" first="Ling-Hui" last="Li">Ling-Hui Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liang, Wen Jia" sort="Liang, Wen Jia" uniqKey="Liang W" first="Wen-Jia" last="Liang">Wen-Jia Liang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement 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China</title><author><name sortKey="Xu, Rui Heng" sort="Xu, Rui Heng" uniqKey="Xu R" first="Rui-Heng" last="Xu">Rui-Heng Xu</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="He, Jian Feng" sort="He, Jian Feng" uniqKey="He J" first="Jian-Feng" last="He">Jian-Feng He</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Evans, Meirion R" sort="Evans, Meirion R" uniqKey="Evans M" first="Meirion R." last="Evans">Meirion R. Evans</name><affiliation wicri:level="1"><nlm:aff id="aff2">University of Wales College of Medicine, Cardiff, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Wales College of Medicine, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Public Health Service for Wales, Cardiff, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Public Health Service for Wales, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Guo Wen" sort="Peng, Guo Wen" uniqKey="Peng G" first="Guo-Wen" last="Peng">Guo-Wen Peng</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Field, Hume E" sort="Field, Hume E" uniqKey="Field H" first="Hume E" last="Field">Hume E. Field</name><affiliation wicri:level="1"><nlm:aff id="aff4">Animal Research Institute, Brisbane, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Animal Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Yu, De Wen" sort="Yu, De Wen" uniqKey="Yu D" first="De-Wen" last="Yu">De-Wen Yu</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lee, Chin Kei" sort="Lee, Chin Kei" uniqKey="Lee C" first="Chin-Kei" last="Lee">Chin-Kei Lee</name><affiliation wicri:level="1"><nlm:aff id="aff5">Australian National University, Canberra, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Hui Min" sort="Luo, Hui Min" uniqKey="Luo H" first="Hui-Min" last="Luo">Hui-Min Luo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lin, Wei Sheng" sort="Lin, Wei Sheng" uniqKey="Lin W" first="Wei-Sheng" last="Lin">Wei-Sheng Lin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lin, Peng" sort="Lin, Peng" uniqKey="Lin P" first="Peng" last="Lin">Peng Lin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Ling Hui" sort="Li, Ling Hui" uniqKey="Li L" first="Ling-Hui" last="Li">Ling-Hui Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liang, Wen Jia" sort="Liang, Wen Jia" uniqKey="Liang W" first="Wen-Jia" last="Liang">Wen-Jia Liang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lin, Jin Yan" sort="Lin, Jin Yan" uniqKey="Lin J" first="Jin-Yan" last="Lin">Jin-Yan Lin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Province Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Schnur, Alan" sort="Schnur, Alan" uniqKey="Schnur A" first="Alan" last="Schnur">Alan Schnur</name><affiliation wicri:level="3"><nlm:aff id="aff6">World Health Organization, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>World Health Organization, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>An epidemic of severe acute respiratory syndrome (SARS) began in Foshan municipality, Guangdong Province, China, in November 2002. We studied SARS case reports through April 30, 2003, including data from case investigations and a case series analysis of index cases. A total of 1,454 clinically confirmed cases (and 55 deaths) occurred; the epidemic peak was in the first week of February 2003. Healthcare workers accounted for 24% of cases. Clinical signs and symptoms differed between children (<18 years) and older persons (>65 years). Several observations support the hypothesis of a wild animal origin for SARS. Cases apparently occurred independently in at least five different municipalities; early case-patients were more likely than later patients to report living near a produce market (odds ratio undefined; lower 95% confidence interval 2.39) but not near a farm; and 9 (39%) of 23 early patients, including 6 who lived or worked in Foshan, were food handlers with probable animal contact.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15207054</article-id><article-id pub-id-type="pmc">3323155</article-id><article-id pub-id-type="publisher-id">03-0852</article-id><article-id pub-id-type="doi">10.3201/eid1006.030852</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Epidemiologic Clues to SARS Origin in China</article-title><alt-title alt-title-type="running-head">SARS Origin in China</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Rui-Heng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Jian-Feng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Evans</surname><given-names>Meirion R.</given-names></name><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="aff" rid="aff3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Peng</surname><given-names>Guo-Wen</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Field</surname><given-names>Hume E</given-names></name><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>De-Wen</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Chin-Kei</given-names></name><xref ref-type="aff" rid="aff5">¶</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Hui-Min</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Wei-Sheng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Peng</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Ling-Hui</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Wen-Jia</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Jin-Yan</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Schnur</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="aff6">#</xref><xref ref-type="fn" rid="FN1"><sup>1</sup></xref></contrib><aff id="aff1"><label>*</label>Guangdong Province Center for Disease Control and Prevention, Guangzhou, China;</aff><aff id="aff2"><label>†</label>University of Wales College of Medicine, Cardiff, United Kingdom;</aff><aff id="aff3"><label>‡</label>National Public Health Service for Wales, Cardiff, United Kingdom;</aff><aff id="aff4"><label>§</label>Animal Research Institute, Brisbane, Australia;</aff><aff id="aff5"><label>¶</label>Australian National University, Canberra, Australia;</aff><aff id="aff6"><label>#</label>World Health Organization, Beijing, China</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Meirion Evans, Communicable Disease Surveillance Centre, National Public Health Service for Wales, Abton House, Cardiff CF14 3QX, UK; fax: +44 2920 521987; email: <email xlink:href="meirion.evans@nphs.wales.nhs.uk">meirion.evans@nphs.wales.nhs.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2004</year></pub-date><volume>10</volume><issue>6</issue><fpage>1030</fpage><lpage>1037</lpage><abstract><p>An epidemic of severe acute respiratory syndrome (SARS) began in Foshan municipality, Guangdong Province, China, in November 2002. We studied SARS case reports through April 30, 2003, including data from case investigations and a case series analysis of index cases. A total of 1,454 clinically confirmed cases (and 55 deaths) occurred; the epidemic peak was in the first week of February 2003. Healthcare workers accounted for 24% of cases. Clinical signs and symptoms differed between children (<18 years) and older persons (>65 years). Several observations support the hypothesis of a wild animal origin for SARS. Cases apparently occurred independently in at least five different municipalities; early case-patients were more likely than later patients to report living near a produce market (odds ratio undefined; lower 95% confidence interval 2.39) but not near a farm; and 9 (39%) of 23 early patients, including 6 who lived or worked in Foshan, were food handlers with probable animal contact.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>SARS</kwd><kwd>pneumonia, community-acquired infections, disease outbreaks, zoonoses, China</kwd><kwd>communicable diseases, emerging, child, aged</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Xu, Rui Heng" sort="Xu, Rui Heng" uniqKey="Xu R" first="Rui-Heng" last="Xu">Rui-Heng Xu</name></region><name sortKey="He, Jian Feng" sort="He, Jian Feng" uniqKey="He J" first="Jian-Feng" last="He">Jian-Feng He</name><name sortKey="Li, Ling Hui" sort="Li, Ling Hui" uniqKey="Li L" first="Ling-Hui" last="Li">Ling-Hui Li</name><name sortKey="Liang, Wen Jia" sort="Liang, Wen Jia" uniqKey="Liang W" first="Wen-Jia" last="Liang">Wen-Jia Liang</name><name sortKey="Lin, Jin Yan" sort="Lin, Jin Yan" uniqKey="Lin J" first="Jin-Yan" last="Lin">Jin-Yan Lin</name><name sortKey="Lin, Peng" sort="Lin, Peng" uniqKey="Lin P" first="Peng" last="Lin">Peng Lin</name><name sortKey="Lin, Wei Sheng" sort="Lin, Wei Sheng" uniqKey="Lin W" first="Wei-Sheng" last="Lin">Wei-Sheng Lin</name><name sortKey="Luo, Hui Min" sort="Luo, Hui Min" uniqKey="Luo H" first="Hui-Min" last="Luo">Hui-Min Luo</name><name sortKey="Peng, Guo Wen" sort="Peng, Guo Wen" uniqKey="Peng G" first="Guo-Wen" last="Peng">Guo-Wen Peng</name><name sortKey="Schnur, Alan" sort="Schnur, Alan" uniqKey="Schnur A" first="Alan" last="Schnur">Alan Schnur</name><name sortKey="Yu, De Wen" sort="Yu, De Wen" uniqKey="Yu D" first="De-Wen" last="Yu">De-Wen Yu</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Evans, Meirion R" sort="Evans, Meirion R" uniqKey="Evans M" first="Meirion R." last="Evans">Meirion R. Evans</name></noRegion><name sortKey="Evans, Meirion R" sort="Evans, Meirion R" uniqKey="Evans M" first="Meirion R." last="Evans">Meirion R. Evans</name></country><country name="Australie"><noRegion><name sortKey="Field, Hume E" sort="Field, Hume E" uniqKey="Field H" first="Hume E" last="Field">Hume E. Field</name></noRegion><name sortKey="Lee, Chin Kei" sort="Lee, Chin Kei" uniqKey="Lee C" first="Chin-Kei" last="Lee">Chin-Kei Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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