Nucleocapsid Protein as Early Diagnostic Marker for SARS
Identifieur interne : 001582 ( Pmc/Checkpoint ); précédent : 001581; suivant : 001583Nucleocapsid Protein as Early Diagnostic Marker for SARS
Auteurs : Xiao-Yan Che [République populaire de Chine] ; Wei Hao [République populaire de Chine] ; Yadi Wang [République populaire de Chine] ; Biao Di [République populaire de Chine] ; Kai Yin [République populaire de Chine] ; Yin-Chao Xu [République populaire de Chine] ; Chang-Sen Feng [République populaire de Chine] ; Zhuo-Yue Wan [République populaire de Chine] ; Vincent C. C. Cheng [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine]Source :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2004.
Abstract
Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.
Url:
DOI: 10.3201/eid1011.040516
PubMed: 15550204
PubMed Central: 3329003
Affiliations:
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C." last="Cheng">Vincent C. C. Cheng</name><affiliation wicri:level="1"><nlm:aff id="aff4">The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff4">The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative 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uniqKey="Che X" first="Xiao-Yan" last="Che">Xiao-Yan Che</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Hao, Wei" sort="Hao, Wei" uniqKey="Hao W" first="Wei" last="Hao">Wei Hao</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Yadi" sort="Wang, Yadi" uniqKey="Wang Y" first="Yadi" last="Wang">Yadi Wang</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Di, Biao" sort="Di, Biao" uniqKey="Di B" first="Biao" last="Di">Biao Di</name><affiliation wicri:level="3"><nlm:aff id="aff2">Center for Disease Control and Prevention of Guangzhou, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Disease Control and Prevention of Guangzhou, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Yin, Kai" sort="Yin, Kai" uniqKey="Yin K" first="Kai" last="Yin">Kai Yin</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xu, Yin Chao" sort="Xu, Yin Chao" uniqKey="Xu Y" first="Yin-Chao" last="Xu">Yin-Chao Xu</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Feng, Chang Sen" sort="Feng, Chang Sen" uniqKey="Feng C" first="Chang-Sen" last="Feng">Chang-Sen Feng</name><affiliation wicri:level="3"><nlm:aff id="aff1">First Military Medical University, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Military Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name><affiliation wicri:level="3"><nlm:aff id="aff3">Center for Disease Control and Prevention of Guangdong Province, Guangzhou, People's Republic of China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Disease Control and Prevention of Guangdong Province, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><affiliation wicri:level="1"><nlm:aff id="aff4">The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff4">The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15550204</article-id><article-id pub-id-type="pmc">3329003</article-id><article-id pub-id-type="publisher-id">04-0516</article-id><article-id pub-id-type="doi">10.3201/eid1011.040516</article-id><article-categories><subj-group subj-group-type="heading"><subject>Dispatch</subject></subj-group><subj-group subj-group-type="article-type"><subject>Dispatch</subject></subj-group></article-categories><title-group><article-title>Nucleocapsid Protein as Early Diagnostic Marker for SARS</article-title><alt-title alt-title-type="running-head">Nucleocapsid Protein as Early Diagnostic Marker for SARS</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Che</surname><given-names>Xiao-Yan</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hao</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yadi</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Di</surname><given-names>Biao</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Kai</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Yin-Chao</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Chang-Sen</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Wan</surname><given-names>Zhuo-Yue</given-names></name><xref ref-type="aff" rid="aff3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Vincent C.C.</given-names></name><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Kwok-Yung</given-names></name><xref ref-type="aff" rid="aff4">§</xref></contrib><aff id="aff1"><label>*</label>First Military Medical University, Guangzhou, People's Republic of China;</aff><aff id="aff2"><label>†</label>Center for Disease Control and Prevention of Guangzhou, Guangzhou, People's Republic of China;</aff><aff id="aff3"><label>‡</label>Center for Disease Control and Prevention of Guangdong Province, Guangzhou, People's Republic of China;</aff><aff id="aff4"><label>§</label>The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Xiao-Yan Che, Center of Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, People’s Republic of China; fax: 86-2061643592; email: <email xlink:href="linche@pub.guangzhou.gd.cn">linche@pub.guangzhou.gd.cn</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2004</year></pub-date><volume>10</volume><issue>11</issue><fpage>1947</fpage><lpage>1949</lpage><abstract><p>Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>SARS-CoV</kwd><kwd>nucleocapsid protein, monoclonal antibody, enzyme-linked immunosorbent assay, early diagnosis, severe acute respiratory syndrome, dispatch</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Che, Xiao Yan" sort="Che, Xiao Yan" uniqKey="Che X" first="Xiao-Yan" last="Che">Xiao-Yan Che</name></region><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><name sortKey="Di, Biao" sort="Di, Biao" uniqKey="Di B" first="Biao" last="Di">Biao Di</name><name sortKey="Feng, Chang Sen" sort="Feng, Chang Sen" uniqKey="Feng C" first="Chang-Sen" last="Feng">Chang-Sen Feng</name><name sortKey="Hao, Wei" sort="Hao, Wei" uniqKey="Hao W" first="Wei" last="Hao">Wei Hao</name><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name><name sortKey="Wang, Yadi" sort="Wang, Yadi" uniqKey="Wang Y" first="Yadi" last="Wang">Yadi Wang</name><name sortKey="Xu, Yin Chao" sort="Xu, Yin Chao" uniqKey="Xu Y" first="Yin-Chao" last="Xu">Yin-Chao Xu</name><name sortKey="Yin, Kai" sort="Yin, Kai" uniqKey="Yin K" first="Kai" last="Yin">Kai Yin</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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