Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
Identifieur interne : 001578 ( Pmc/Checkpoint ); précédent : 001577; suivant : 001579Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
Auteurs : Yanqing Ding ; Li He ; Qingling Zhang ; Zhongxi Huang ; Xiaoyan Che ; Jinlin Hou ; Huijun Wang ; Hong Shen ; Liwen Qiu ; Zhuguo Li ; Jian Geng ; Junjie Cai ; Huixia Han ; Xin Li ; Wei Kang ; Desheng Weng ; Ping Liang ; Shibo JiangSource :
- The Journal of Pathology [ 0022-3417 ] ; 2004.
Abstract
We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and
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DOI: 10.1002/path.1560
PubMed: NONE
PubMed Central: 7167761
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sortKey="Che, Xiaoyan" sort="Che, Xiaoyan" uniqKey="Che X" first="Xiaoyan" last="Che">Xiaoyan Che</name><affiliation><nlm:aff id="af2"></nlm:aff></affiliation></author><author><name sortKey="Hou, Jinlin" sort="Hou, Jinlin" uniqKey="Hou J" first="Jinlin" last="Hou">Jinlin Hou</name><affiliation><nlm:aff id="af3"></nlm:aff></affiliation></author><author><name sortKey="Wang, Huijun" sort="Wang, Huijun" uniqKey="Wang H" first="Huijun" last="Wang">Huijun Wang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Shen, Hong" sort="Shen, Hong" uniqKey="Shen H" first="Hong" last="Shen">Hong Shen</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Qiu, Liwen" sort="Qiu, Liwen" uniqKey="Qiu L" first="Liwen" last="Qiu">Liwen Qiu</name><affiliation><nlm:aff id="af3"></nlm:aff></affiliation></author><author><name sortKey="Li, Zhuguo" sort="Li, Zhuguo" uniqKey="Li Z" first="Zhuguo" last="Li">Zhuguo Li</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Geng, Jian" sort="Geng, Jian" uniqKey="Geng J" first="Jian" last="Geng">Jian Geng</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Cai, Junjie" sort="Cai, Junjie" uniqKey="Cai J" first="Junjie" last="Cai">Junjie Cai</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Han, Huixia" sort="Han, Huixia" uniqKey="Han H" first="Huixia" last="Han">Huixia Han</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Li, Xin" sort="Li, Xin" uniqKey="Li X" first="Xin" last="Li">Xin Li</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Kang, Wei" sort="Kang, Wei" uniqKey="Kang W" first="Wei" last="Kang">Wei Kang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Weng, Desheng" sort="Weng, Desheng" uniqKey="Weng D" first="Desheng" last="Weng">Desheng Weng</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Liang, Ping" sort="Liang, Ping" uniqKey="Liang P" first="Ping" last="Liang">Ping Liang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="af4"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7167761</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167761</idno><idno type="RBID">PMC:7167761</idno><idno type="doi">10.1002/path.1560</idno><idno type="pmid">NONE</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">001208</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001208</idno><idno 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last="Zhang">Qingling Zhang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Huang, Zhongxi" sort="Huang, Zhongxi" uniqKey="Huang Z" first="Zhongxi" last="Huang">Zhongxi Huang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Che, Xiaoyan" sort="Che, Xiaoyan" uniqKey="Che X" first="Xiaoyan" last="Che">Xiaoyan Che</name><affiliation><nlm:aff id="af2"></nlm:aff></affiliation></author><author><name sortKey="Hou, Jinlin" sort="Hou, Jinlin" uniqKey="Hou J" first="Jinlin" last="Hou">Jinlin Hou</name><affiliation><nlm:aff id="af3"></nlm:aff></affiliation></author><author><name sortKey="Wang, Huijun" sort="Wang, Huijun" uniqKey="Wang H" first="Huijun" last="Wang">Huijun Wang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Shen, Hong" sort="Shen, Hong" uniqKey="Shen H" first="Hong" last="Shen">Hong Shen</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Qiu, Liwen" sort="Qiu, Liwen" uniqKey="Qiu L" first="Liwen" last="Qiu">Liwen Qiu</name><affiliation><nlm:aff id="af3"></nlm:aff></affiliation></author><author><name sortKey="Li, Zhuguo" sort="Li, Zhuguo" uniqKey="Li Z" first="Zhuguo" last="Li">Zhuguo Li</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Geng, Jian" sort="Geng, Jian" uniqKey="Geng J" first="Jian" last="Geng">Jian Geng</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Cai, Junjie" sort="Cai, Junjie" uniqKey="Cai J" first="Junjie" last="Cai">Junjie Cai</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Han, Huixia" sort="Han, Huixia" uniqKey="Han H" first="Huixia" last="Han">Huixia Han</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Li, Xin" sort="Li, Xin" uniqKey="Li X" first="Xin" last="Li">Xin Li</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Kang, Wei" sort="Kang, Wei" uniqKey="Kang W" first="Wei" last="Kang">Wei Kang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Weng, Desheng" sort="Weng, Desheng" uniqKey="Weng D" first="Desheng" last="Weng">Desheng Weng</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Liang, Ping" sort="Liang, Ping" uniqKey="Liang P" first="Ping" last="Liang">Ping Liang</name><affiliation><nlm:aff id="af1"></nlm:aff></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="af4"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Pathology</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and <italic>in situ</italic> hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J. Pathol</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1096-9896</journal-id><journal-id journal-id-type="publisher-id">PATH</journal-id><journal-title-group><journal-title>The Journal of Pathology</journal-title></journal-title-group><issn pub-type="ppub">0022-3417</issn><issn pub-type="epub">1096-9896</issn><publisher><publisher-name>John Wiley & Sons, Ltd.</publisher-name><publisher-loc>Chichester, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7167761</article-id><article-id pub-id-type="doi">10.1002/path.1560</article-id><article-id pub-id-type="publisher-id">PATH1560</article-id><article-categories><subj-group subj-group-type="overline"><subject>Rapid Communication</subject></subj-group><subj-group subj-group-type="heading"><subject>Rapid Communications</subject></subj-group></article-categories><title-group><article-title>Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways</article-title><alt-title alt-title-type="right-running-head">Organ distribution of SARS‐CoV</alt-title></title-group><contrib-group><contrib id="au1" contrib-type="author" corresp="yes"><name><surname>Ding</surname><given-names>Yanqing</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref><address><email>dyq@fimmu.com</email></address></contrib><contrib id="au2" contrib-type="author"><name><surname>He</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au3" contrib-type="author"><name><surname>Zhang</surname><given-names>Qingling</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au4" contrib-type="author"><name><surname>Huang</surname><given-names>Zhongxi</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au5" contrib-type="author"><name><surname>Che</surname><given-names>Xiaoyan</given-names></name><xref ref-type="aff" rid="af2"><sup>2</sup></xref></contrib><contrib id="au6" contrib-type="author"><name><surname>Hou</surname><given-names>Jinlin</given-names></name><xref ref-type="aff" rid="af3"><sup>3</sup></xref></contrib><contrib id="au7" contrib-type="author"><name><surname>Wang</surname><given-names>Huijun</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au8" contrib-type="author"><name><surname>Shen</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au9" contrib-type="author"><name><surname>Qiu</surname><given-names>Liwen</given-names></name><xref ref-type="aff" rid="af3"><sup>3</sup></xref></contrib><contrib id="au10" contrib-type="author"><name><surname>Li</surname><given-names>Zhuguo</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au11" contrib-type="author"><name><surname>Geng</surname><given-names>Jian</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au12" contrib-type="author"><name><surname>Cai</surname><given-names>Junjie</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au13" contrib-type="author"><name><surname>Han</surname><given-names>Huixia</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au14" contrib-type="author"><name><surname>Li</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au15" contrib-type="author"><name><surname>Kang</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au16" contrib-type="author"><name><surname>Weng</surname><given-names>Desheng</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au17" contrib-type="author"><name><surname>Liang</surname><given-names>Ping</given-names></name><xref ref-type="aff" rid="af1"><sup>1</sup></xref></contrib><contrib id="au18" contrib-type="author" corresp="yes"><name><surname>Jiang</surname><given-names>Shibo</given-names></name><xref ref-type="aff" rid="af4"><sup>4</sup></xref><address><email>sjiang@nybloodcenter.org</email></address></contrib></contrib-group><aff id="af1"><label><sup>1</sup></label>Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, China</aff><aff id="af2"><label><sup>2</sup></label>Department of Infectious Diseases, Nan Fang Hospital, First Military Medical University, Guangzhou, China</aff><aff id="af3"><label><sup>3</sup></label>Centre Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou, China</aff><aff id="af4"><label><sup>4</sup></label>Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, USA</aff><author-notes><corresp id="correspondenceTo"><label>*</label>Yanqing Ding, Department of Pathology, First Military Medical University, Guangzhou 5101515, China.<break></break>Shibo Jiang, Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.<break></break></corresp></author-notes><pub-date pub-type="epub"><day>07</day><month>5</month><year>2004</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2004</year></pub-date><volume>203</volume><issue>2</issue><issue-id pub-id-type="doi">10.1002/path.v203:2</issue-id><fpage>622</fpage><lpage>630</lpage><history><date date-type="received"><day>14</day><month>1</month><year>2004</year></date><date date-type="rev-recd"><day>08</day><month>2</month><year>2004</year></date><date date-type="accepted"><day>12</day><month>2</month><year>2004</year></date></history><permissions><copyright-statement content-type="article-copyright">Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</copyright-statement><license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:PATH-203-622.pdf"></self-uri><abstract><title>Abstract</title><p>We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and <italic>in situ</italic> hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</p></abstract><kwd-group kwd-group-type="author-generated"><kwd id="kwd1">SARS</kwd><kwd id="kwd2">SARS‐CoV</kwd><kwd id="kwd3">distribution</kwd><kwd id="kwd4">detection</kwd><kwd id="kwd5">pathogenesis</kwd><kwd id="kwd6">transmission</kwd></kwd-group><funding-group><award-group id="funding-0001"><funding-source>Chinese National Foundation of Natural Sciences</funding-source><award-id>30340015</award-id></award-group><award-group id="funding-0002"><funding-source>Military Foundation of Medical Science</funding-source><award-id>03F016‐2</award-id></award-group><award-group id="funding-0003"><funding-source>Foundation of Natural Sciences of Guangdong Province</funding-source><award-id>GD2003‐80</award-id></award-group></funding-group><counts><fig-count count="3"></fig-count><table-count count="1"></table-count><ref-count count="31"></ref-count><page-count count="9"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>June 2004</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Cai, Junjie" sort="Cai, Junjie" uniqKey="Cai J" first="Junjie" last="Cai">Junjie Cai</name><name sortKey="Che, Xiaoyan" sort="Che, Xiaoyan" uniqKey="Che X" first="Xiaoyan" last="Che">Xiaoyan Che</name><name sortKey="Ding, Yanqing" sort="Ding, Yanqing" uniqKey="Ding Y" first="Yanqing" last="Ding">Yanqing Ding</name><name sortKey="Geng, Jian" sort="Geng, Jian" uniqKey="Geng J" first="Jian" last="Geng">Jian Geng</name><name sortKey="Han, Huixia" sort="Han, Huixia" uniqKey="Han H" first="Huixia" last="Han">Huixia Han</name><name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name><name sortKey="Hou, Jinlin" sort="Hou, Jinlin" uniqKey="Hou J" first="Jinlin" last="Hou">Jinlin Hou</name><name sortKey="Huang, Zhongxi" sort="Huang, Zhongxi" uniqKey="Huang Z" first="Zhongxi" last="Huang">Zhongxi Huang</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Kang, Wei" sort="Kang, Wei" uniqKey="Kang W" first="Wei" last="Kang">Wei Kang</name><name sortKey="Li, Xin" sort="Li, Xin" uniqKey="Li X" first="Xin" last="Li">Xin Li</name><name sortKey="Li, Zhuguo" sort="Li, Zhuguo" uniqKey="Li Z" first="Zhuguo" last="Li">Zhuguo Li</name><name sortKey="Liang, Ping" sort="Liang, Ping" uniqKey="Liang P" first="Ping" last="Liang">Ping Liang</name><name sortKey="Qiu, Liwen" sort="Qiu, Liwen" uniqKey="Qiu L" first="Liwen" last="Qiu">Liwen Qiu</name><name sortKey="Shen, Hong" sort="Shen, Hong" uniqKey="Shen H" first="Hong" last="Shen">Hong Shen</name><name sortKey="Wang, Huijun" sort="Wang, Huijun" uniqKey="Wang H" first="Huijun" last="Wang">Huijun Wang</name><name sortKey="Weng, Desheng" sort="Weng, Desheng" uniqKey="Weng D" first="Desheng" last="Weng">Desheng Weng</name><name sortKey="Zhang, Qingling" sort="Zhang, Qingling" uniqKey="Zhang Q" first="Qingling" last="Zhang">Qingling Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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