The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases
Identifieur interne : 001441 ( Pmc/Checkpoint ); précédent : 001440; suivant : 001442The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases
Auteurs : Bun Sheng [Hong Kong] ; Sammy Kin Wing Cheng [Hong Kong] ; Kwok Kwong Lau [Hong Kong] ; Ho Lun Li [Hong Kong] ; Eric Lok Yiu Chan [Hong Kong]Source :
- European Psychiatry [ 0924-9338 ] ; 2004.
Abstract
Url:
DOI: 10.1016/j.eurpsy.2004.06.023
PubMed: 15935422
PubMed Central: 7135192
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases</title>
<author><name sortKey="Sheng, Bun" sort="Sheng, Bun" uniqKey="Sheng B" first="Bun" last="Sheng">Bun Sheng</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon</wicri:regionArea>
<wicri:noRegion>Kowloon</wicri:noRegion>
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<author><name sortKey="Wing Cheng, Sammy Kin" sort="Wing Cheng, Sammy Kin" uniqKey="Wing Cheng S" first="Sammy Kin" last="Wing Cheng">Sammy Kin Wing Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="AFF2">Consultation and Liaison Psychiatry Team and Clinical Psychology Service Unit, Kwai Chung Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Consultation and Liaison Psychiatry Team and Clinical Psychology Service Unit, Kwai Chung Hospital</wicri:regionArea>
<wicri:noRegion>Kwai Chung Hospital</wicri:noRegion>
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<author><name sortKey="Lau, Kwok Kwong" sort="Lau, Kwok Kwong" uniqKey="Lau K" first="Kwok Kwong" last="Lau">Kwok Kwong Lau</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
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<author><name sortKey="Li, Ho Lun" sort="Li, Ho Lun" uniqKey="Li H" first="Ho Lun" last="Li">Ho Lun Li</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon</wicri:regionArea>
<wicri:noRegion>Kowloon</wicri:noRegion>
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<author><name sortKey="Yiu Chan, Eric Lok" sort="Yiu Chan, Eric Lok" uniqKey="Yiu Chan E" first="Eric Lok" last="Yiu Chan">Eric Lok Yiu Chan</name>
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<country xml:lang="fr">Hong Kong</country>
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<wicri:noRegion>Caritas Medical Centre</wicri:noRegion>
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<series><title level="j">European Psychiatry</title>
<idno type="ISSN">0924-9338</idno>
<idno type="eISSN">1778-3585</idno>
<imprint><date when="2004">2004</date>
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<front><div type="abstract" xml:lang="en"><p><italic><bold>Objective. –</bold>
</italic>
To evaluate the effects of disease severity, corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients, both during acute and convalescent phases.</p>
<p><italic><bold>Subjects and methods. –</bold>
</italic>
Self-administered mail questionnaires survey to 308 SARS patients after discharging from hospital. Both patients and their families were asked about symptoms related to various neuropsychiatric domains, and the questions covered both acute and convalescent phases.</p>
<p><italic><bold>Results. –</bold>
</italic>
Among the 102 (33%) valid replies, 65% had strong symptoms in convalescent phase as indicated by GHQ28 score ≥ 5. In multiple linear regression analysis, use of pulse steroid and total dosages of pulse steroid during hospitalisation were predictive for anxiety-depression, psychosis and behavioural symptoms in acute phase, the effects persisted in convalescent phase. Disease severity had direct correlation with symptoms in all neuropsychiatric domains at acute phase and anxiety-depression and cognition at convalescent phase. Health care workers had more neuropsychiatric complaints in both phases. Severity of symptoms, corticosteroids and social factors explained about half of the variances (<italic>R</italic>
<sup>2</sup>
= 52) in anxiety-depression at acute phase and 33% at convalescent phase.</p>
<p><italic><bold>Conclusion. –</bold>
</italic>
Severe disease, high dose corticosteroids and being health care workers were independent predictors of neuropsychiatric complaints in both acute and convalescent phases.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur Psychiatry</journal-id>
<journal-id journal-id-type="iso-abbrev">Eur. Psychiatry</journal-id>
<journal-title-group><journal-title>European Psychiatry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0924-9338</issn>
<issn pub-type="epub">1778-3585</issn>
<publisher><publisher-name>Elsevier SAS.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">15935422</article-id>
<article-id pub-id-type="pmc">7135192</article-id>
<article-id pub-id-type="publisher-id">S0924-9338(04)00154-3</article-id>
<article-id pub-id-type="doi">10.1016/j.eurpsy.2004.06.023</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sheng</surname>
<given-names>Bun</given-names>
</name>
<email>shengbun@hotmail.com</email>
<xref rid="AFF1" ref-type="aff">a</xref>
<xref rid="COR1" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wing Cheng</surname>
<given-names>Sammy Kin</given-names>
</name>
<xref rid="AFF2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lau</surname>
<given-names>Kwok Kwong</given-names>
</name>
<xref rid="AFF1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Ho Lun</given-names>
</name>
<xref rid="AFF1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yiu Chan</surname>
<given-names>Eric Lok</given-names>
</name>
<xref rid="AFF3" ref-type="aff">c</xref>
</contrib>
</contrib-group>
<aff id="AFF1"><label>a</label>
Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong</aff>
<aff id="AFF2"><label>b</label>
Consultation and Liaison Psychiatry Team and Clinical Psychology Service Unit, Kwai Chung Hospital, Hong Kong</aff>
<aff id="AFF3"><label>c</label>
Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong</aff>
<author-notes><corresp id="COR1"><label>*</label>
Corresponding author. <email>shengbun@hotmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>16</day>
<month>9</month>
<year>2004</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>5</month>
<year>2005</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>9</month>
<year>2004</year>
</pub-date>
<volume>20</volume>
<issue>3</issue>
<fpage>236</fpage>
<lpage>242</lpage>
<history><date date-type="received"><day>12</day>
<month>11</month>
<year>2003</year>
</date>
<date date-type="rev-recd"><day>11</day>
<month>5</month>
<year>2004</year>
</date>
<date date-type="accepted"><day>11</day>
<month>5</month>
<year>2004</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2004 Elsevier SAS. All rights reserved.</copyright-statement>
<copyright-year>2004</copyright-year>
<copyright-holder>Elsevier SAS</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract><p><italic><bold>Objective. –</bold>
</italic>
To evaluate the effects of disease severity, corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients, both during acute and convalescent phases.</p>
<p><italic><bold>Subjects and methods. –</bold>
</italic>
Self-administered mail questionnaires survey to 308 SARS patients after discharging from hospital. Both patients and their families were asked about symptoms related to various neuropsychiatric domains, and the questions covered both acute and convalescent phases.</p>
<p><italic><bold>Results. –</bold>
</italic>
Among the 102 (33%) valid replies, 65% had strong symptoms in convalescent phase as indicated by GHQ28 score ≥ 5. In multiple linear regression analysis, use of pulse steroid and total dosages of pulse steroid during hospitalisation were predictive for anxiety-depression, psychosis and behavioural symptoms in acute phase, the effects persisted in convalescent phase. Disease severity had direct correlation with symptoms in all neuropsychiatric domains at acute phase and anxiety-depression and cognition at convalescent phase. Health care workers had more neuropsychiatric complaints in both phases. Severity of symptoms, corticosteroids and social factors explained about half of the variances (<italic>R</italic>
<sup>2</sup>
= 52) in anxiety-depression at acute phase and 33% at convalescent phase.</p>
<p><italic><bold>Conclusion. –</bold>
</italic>
Severe disease, high dose corticosteroids and being health care workers were independent predictors of neuropsychiatric complaints in both acute and convalescent phases.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Severe acute respiratory syndrome</kwd>
<kwd>Steroids</kwd>
<kwd>Health care workers</kwd>
<kwd>Mental disorders</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Hong Kong</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Sheng, Bun" sort="Sheng, Bun" uniqKey="Sheng B" first="Bun" last="Sheng">Bun Sheng</name>
</noRegion>
<name sortKey="Lau, Kwok Kwong" sort="Lau, Kwok Kwong" uniqKey="Lau K" first="Kwok Kwong" last="Lau">Kwok Kwong Lau</name>
<name sortKey="Li, Ho Lun" sort="Li, Ho Lun" uniqKey="Li H" first="Ho Lun" last="Li">Ho Lun Li</name>
<name sortKey="Wing Cheng, Sammy Kin" sort="Wing Cheng, Sammy Kin" uniqKey="Wing Cheng S" first="Sammy Kin" last="Wing Cheng">Sammy Kin Wing Cheng</name>
<name sortKey="Yiu Chan, Eric Lok" sort="Yiu Chan, Eric Lok" uniqKey="Yiu Chan E" first="Eric Lok" last="Yiu Chan">Eric Lok Yiu Chan</name>
</country>
</tree>
</affiliations>
</record>
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