From genome to antivirals: SARS as a test tube
Identifieur interne : 001334 ( Pmc/Checkpoint ); précédent : 001333; suivant : 001335From genome to antivirals: SARS as a test tube
Auteurs : Yossef Kliger ; Erez Y. Levanon ; Doron GerberSource :
- Drug Discovery Today [ 1359-6446 ] ; 2005.
Abstract
The severe acute respiratory syndrome epidemic brought into the spotlight the need for rapid development of effective antiviral drugs against newly emerging viruses.
Url:
DOI: 10.1016/S1359-6446(04)03320-3
PubMed: 15749283
PubMed Central: 7128434
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7128434Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">From genome to antivirals: SARS as a test tube</title><author><name sortKey="Kliger, Yossef" sort="Kliger, Yossef" uniqKey="Kliger Y" first="Yossef" last="Kliger">Yossef Kliger</name></author><author><name sortKey="Levanon, Erez Y" sort="Levanon, Erez Y" uniqKey="Levanon E" first="Erez Y." last="Levanon">Erez Y. Levanon</name></author><author><name sortKey="Gerber, Doron" sort="Gerber, Doron" uniqKey="Gerber D" first="Doron" last="Gerber">Doron Gerber</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15749283</idno><idno type="pmc">7128434</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128434</idno><idno type="RBID">PMC:7128434</idno><idno type="doi">10.1016/S1359-6446(04)03320-3</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001747</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001747</idno><idno type="wicri:Area/Pmc/Curation">001747</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001747</idno><idno type="wicri:Area/Pmc/Checkpoint">001334</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001334</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">From genome to antivirals: SARS as a test tube</title><author><name sortKey="Kliger, Yossef" sort="Kliger, Yossef" uniqKey="Kliger Y" first="Yossef" last="Kliger">Yossef Kliger</name></author><author><name sortKey="Levanon, Erez Y" sort="Levanon, Erez Y" uniqKey="Levanon E" first="Erez Y." last="Levanon">Erez Y. Levanon</name></author><author><name sortKey="Gerber, Doron" sort="Gerber, Doron" uniqKey="Gerber D" first="Doron" last="Gerber">Doron Gerber</name></author></analytic><series><title level="j">Drug Discovery Today</title><idno type="ISSN">1359-6446</idno><idno type="eISSN">1878-5832</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome epidemic brought into the spotlight the need for rapid development of effective antiviral drugs against newly emerging viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vabret, A" uniqKey="Vabret A">A. Vabret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sainz, B" uniqKey="Sainz B">B. Sainz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujii, T" uniqKey="Fujii T">T. Fujii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barre Sinoussi, F" uniqKey="Barre Sinoussi F">F. Barre-Sinoussi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallo, R C" uniqKey="Gallo R">R.C. Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muesing, M A" uniqKey="Muesing M">M.A. Muesing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richman, D D" uniqKey="Richman D">D.D. Richman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, T" uniqKey="Matthews T">T. Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berger, B" uniqKey="Berger B">B. Berger</name></author><author><name sortKey="Singh, M" uniqKey="Singh M">M. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, M" uniqKey="Singh M">M. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klatzmann, D" uniqKey="Klatzmann D">D. Klatzmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalgleish, A G" uniqKey="Dalgleish A">A.G. Dalgleish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alkhatib, G" uniqKey="Alkhatib G">G. Alkhatib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samson, M" uniqKey="Samson M">M. Samson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huentelman, M J" uniqKey="Huentelman M">M.J. Huentelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeffers, S A" uniqKey="Jeffers S">S.A. Jeffers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallo, S A" uniqKey="Gallo S">S.A. Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallo, S A" uniqKey="Gallo S">S.A. Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reeves, J D" uniqKey="Reeves J">J.D. Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reeves, J D" uniqKey="Reeves J">J.D. Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremblay, C L" uniqKey="Tremblay C">C.L. Tremblay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremblay, C L" uniqKey="Tremblay C">C.L. Tremblay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagashima, K A" uniqKey="Nagashima K">K.A. Nagashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blumenthal, R" uniqKey="Blumenthal R">R. Blumenthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittal, A" uniqKey="Mittal A">A. Mittal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittal, A" uniqKey="Mittal A">A. Mittal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markosyan, R M" uniqKey="Markosyan R">R.M. Markosyan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markosyan, R M" uniqKey="Markosyan R">R.M. Markosyan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, M L" uniqKey="Ng M">M.L. Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kliger, Y" uniqKey="Kliger Y">Y. Kliger</name></author><author><name sortKey="Levanon, E Y" uniqKey="Levanon E">E.Y. Levanon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, K" uniqKey="Yuan K">K. Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simmons, G" uniqKey="Simmons G">G. Simmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingallinella, P" uniqKey="Ingallinella P">P. Ingallinella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tripet, B" uniqKey="Tripet B">B. Tripet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pastey, M K" uniqKey="Pastey M">M.K. Pastey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, J A" uniqKey="Tanner J">J.A. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koolen, M J" uniqKey="Koolen M">M.J. Koolen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takamura, K" uniqKey="Takamura K">K. Takamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisht, H" uniqKey="Bisht H">H. Bisht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccaffrey, A P" uniqKey="Mccaffrey A">A.P. McCaffrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X W" uniqKey="Zhang X">X.W. Zhang</name></author><author><name sortKey="Yap, Y L" uniqKey="Yap Y">Y.L. Yap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sledz, C A" uniqKey="Sledz C">C.A. Sledz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Opalinska, J B" uniqKey="Opalinska J">J.B. Opalinska</name></author><author><name sortKey="Gewirtz, A M" uniqKey="Gewirtz A">A.M. Gewirtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, S H" uniqKey="Yeh S">S.H. Yeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chinese, S M E C" uniqKey="Chinese S">S.M.E.C. Chinese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Grotthuss, M" uniqKey="Von Grotthuss M">M. von Grotthuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivanov, K A" uniqKey="Ivanov K">K.A. Ivanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, R Y" uniqKey="Kao R">R.Y. Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leong, H N" uniqKey="Leong H">H.N. Leong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W K" uniqKey="Wang W">W.K. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hillisch, A" uniqKey="Hillisch A">A. Hillisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, R Y" uniqKey="Kao R">R.Y. Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blanchard, J E" uniqKey="Blanchard J">J.E. Blanchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N. Yamamoto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Drug Discov Today</journal-id><journal-id journal-id-type="iso-abbrev">Drug Discov. Today</journal-id><journal-title-group><journal-title>Drug Discovery Today</journal-title></journal-title-group><issn pub-type="ppub">1359-6446</issn><issn pub-type="epub">1878-5832</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15749283</article-id><article-id pub-id-type="pmc">7128434</article-id><article-id pub-id-type="publisher-id">S1359-6446(04)03320-3</article-id><article-id pub-id-type="doi">10.1016/S1359-6446(04)03320-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>From genome to antivirals: SARS as a test tube</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kliger</surname><given-names>Yossef</given-names></name><email>kliger@compugen.co.il</email></contrib><contrib contrib-type="author"><name><surname>Levanon</surname><given-names>Erez Y.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gerber</surname><given-names>Doron</given-names></name></contrib></contrib-group><aff>Compugen, 72 Pinchas Rosen, Tel Aviv 69512, Israel</aff><pub-date pub-type="pmc-release"><day>2</day><month>3</month><year>2005</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>1</day><month>3</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>2</day><month>3</month><year>2005</year></pub-date><volume>10</volume><issue>5</issue><fpage>345</fpage><lpage>352</lpage><permissions><copyright-statement>Copyright © 2005 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="teaser"><p>The severe acute respiratory syndrome epidemic brought into the spotlight the need for rapid development of effective antiviral drugs against newly emerging viruses.</p></abstract><abstract><p>The severe acute respiratory syndrome (SARS) epidemic brought into the spotlight the need for rapid development of effective anti-viral drugs against newly emerging viruses. Researchers have leveraged the 20-year battle against AIDS into a variety of possible treatments for SARS. Most prominently, based solely on viral genome information, silencers of viral genes, viral-enzyme blockers and viral-entry inhibitors were suggested as potential therapeutic agents for SARS. In particular, inhibitors of viral entry, comprising therapeutic peptides, were based on the recently launched anti-HIV drug enfuvirtide. This could represent one of the most direct routes from genome sequencing to the discovery of antiviral drugs.</p></abstract><kwd-group><title>Keywords</title><kwd>HIV</kwd><kwd>Entry inhibitors</kwd><kwd>RNA polymerase</kwd><kwd>Membrane fusion</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Gerber, Doron" sort="Gerber, Doron" uniqKey="Gerber D" first="Doron" last="Gerber">Doron Gerber</name><name sortKey="Kliger, Yossef" sort="Kliger, Yossef" uniqKey="Kliger Y" first="Yossef" last="Kliger">Yossef Kliger</name><name sortKey="Levanon, Erez Y" sort="Levanon, Erez Y" uniqKey="Levanon E" first="Erez Y." last="Levanon">Erez Y. Levanon</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001334 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001334 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7128434
|texte= From genome to antivirals: SARS as a test tube
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:15749283" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |