Genetic lesions within the 3a gene of SARS-CoV
Identifieur interne : 001332 ( Pmc/Checkpoint ); précédent : 001331; suivant : 001333Genetic lesions within the 3a gene of SARS-CoV
Auteurs : Timothy Hp Tan [Singapour] ; Timothy Barkham [Singapour] ; Burtram C. Fielding [Singapour] ; Chih-Fong Chou [Singapour] ; Shuo Shen [Singapour] ; Seng Gee Lim [Singapour] ; Wanjin Hong [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Virology Journal [ 1743-422X ] ; 2005.
Abstract
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
The online version of this article (doi:10.1186/1743-422X-2-51) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1743-422X-2-51
PubMed: 15963240
PubMed Central: 1183252
Affiliations:
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We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-2-51) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vega, Vb" uniqKey="Vega V">VB Vega</name></author><author><name sortKey="Ruan, Y" uniqKey="Ruan Y">Y Ruan</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lee, Wh" uniqKey="Lee W">WH Lee</name></author><author><name sortKey="Wei, Cl" uniqKey="Wei C">CL Wei</name></author><author><name sortKey="Se Thoe, Sy" uniqKey="Se Thoe S">SY Se-Thoe</name></author><author><name sortKey="Tang, Kf" uniqKey="Tang K">KF Tang</name></author><author><name sortKey="Zhang, T" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virol J</journal-id><journal-id journal-id-type="iso-abbrev">Virol. J</journal-id><journal-title-group><journal-title>Virology Journal</journal-title></journal-title-group><issn pub-type="epub">1743-422X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15963240</article-id><article-id pub-id-type="pmc">1183252</article-id><article-id pub-id-type="publisher-id">66</article-id><article-id pub-id-type="doi">10.1186/1743-422X-2-51</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject></subj-group></article-categories><title-group><article-title>Genetic lesions within the 3a gene of SARS-CoV</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Tan</surname><given-names>Timothy HP</given-names></name><address><email>ttan@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Barkham</surname><given-names>Timothy</given-names></name><address><email>Timothy_Barkham@ttsh.com.sg</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fielding</surname><given-names>Burtram C</given-names></name><address><email>fieldingbc@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Chih-Fong</given-names></name><address><email>mcbccf@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Shuo</given-names></name><address><email>shenshuo@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Seng Gee</given-names></name><address><email>sglim@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hong</surname><given-names>Wanjin</given-names></name><address><email>mcbhwj@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Yee-Joo</given-names></name><address><email>mcbtanyj@imcb.a-star.edu.sg</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.418812.6</institution-id><institution>Institute of Molecular and Cell Biology,</institution></institution-wrap>College Station, 61 Biopolis Drive, 138673 Singapore</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.240988.f</institution-id><institution>Tan Tock Seng Hospital,</institution></institution-wrap>College Station, 11 Jalan Tan Tock Seng, 308433 Singapore</aff></contrib-group><pub-date pub-type="epub"><day>20</day><month>6</month><year>2005</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>6</month><year>2005</year></pub-date><pub-date pub-type="collection"><year>2005</year></pub-date><volume>2</volume><elocation-id>51</elocation-id><history><date date-type="received"><day>09</day><month>5</month><year>2005</year></date><date date-type="accepted"><day>20</day><month>6</month><year>2005</year></date></history><permissions><copyright-statement>© Tan et al; licensee BioMed Central Ltd. 2005</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-2-51) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Frameshift Mutation</kwd><kwd>Infectious Bronchitis Virus</kwd><kwd>Human Respiratory Syncytial Virus</kwd><kwd>Severe Acute Respiratory Syndrome Coronavirus</kwd><kwd>Polymerase Chain Reaction Error</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2005</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Tan, Timothy Hp" sort="Tan, Timothy Hp" uniqKey="Tan T" first="Timothy Hp" last="Tan">Timothy Hp Tan</name></noRegion><name sortKey="Barkham, Timothy" sort="Barkham, Timothy" uniqKey="Barkham T" first="Timothy" last="Barkham">Timothy Barkham</name><name sortKey="Chou, Chih Fong" sort="Chou, Chih Fong" uniqKey="Chou C" first="Chih-Fong" last="Chou">Chih-Fong Chou</name><name sortKey="Fielding, Burtram C" sort="Fielding, Burtram C" uniqKey="Fielding B" first="Burtram C" last="Fielding">Burtram C. Fielding</name><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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