Nasopharyngeal Shedding of Severe Acute Respiratory Syndrome—Associated Coronavirus Is Associated with Genetic Polymorphisms
Identifieur interne : 001093 ( Pmc/Checkpoint ); précédent : 001092; suivant : 001094Nasopharyngeal Shedding of Severe Acute Respiratory Syndrome—Associated Coronavirus Is Associated with Genetic Polymorphisms
Auteurs : Wei-Ju Chen [Taïwan] ; Jyh-Yuan Yang [Taïwan] ; Jih-Hui Lin [Taïwan] ; Cathy S. J. Fann [Taïwan] ; Valeriy Osyetrov [Taïwan] ; Chwan-Chuen King [Taïwan] ; Yi-Ming Arthur Chen ; Hsiao-Ling Chang [Taïwan] ; Hung-Wei Kuo [Taïwan] ; Fong Liao [Taïwan] ; Mei-Shang Ho [Taïwan]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2006.
Abstract
Url:
DOI: 10.1086/503843
PubMed: 16652313
PubMed Central: 7107974
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nasopharyngeal Shedding of Severe Acute Respiratory Syndrome—Associated Coronavirus Is Associated with Genetic Polymorphisms</title><author><name sortKey="Chen, Wei Ju" sort="Chen, Wei Ju" uniqKey="Chen W" first="Wei-Ju" last="Chen">Wei-Ju Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Fann, Cathy S J" sort="Fann, Cathy S J" uniqKey="Fann C" first="Cathy S. J." last="Fann">Cathy S. J. Fann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Osyetrov, Valeriy" sort="Osyetrov, Valeriy" uniqKey="Osyetrov V" first="Valeriy" last="Osyetrov">Valeriy Osyetrov</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Graduate Institute of Epidemiology, National Taiwan University</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Chang, Hsiao Ling" sort="Chang, Hsiao Ling" uniqKey="Chang H" first="Hsiao-Ling" last="Chang">Hsiao-Ling Chang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Kuo, Hung Wei" sort="Kuo, Hung Wei" uniqKey="Kuo H" first="Hung-Wei" last="Kuo">Hung-Wei Kuo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Liao, Fong" sort="Liao, Fong" uniqKey="Liao F" first="Fong" last="Liao">Fong Liao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Graduate Institute of Epidemiology, National Taiwan University</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16652313</idno><idno type="pmc">7107974</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107974</idno><idno type="RBID">PMC:7107974</idno><idno type="doi">10.1086/503843</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000F03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F03</idno><idno type="wicri:Area/Pmc/Curation">000F03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F03</idno><idno type="wicri:Area/Pmc/Checkpoint">001093</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001093</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nasopharyngeal Shedding of Severe Acute Respiratory Syndrome—Associated Coronavirus Is Associated with Genetic Polymorphisms</title><author><name sortKey="Chen, Wei Ju" sort="Chen, Wei Ju" uniqKey="Chen W" first="Wei-Ju" last="Chen">Wei-Ju Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Fann, Cathy S J" sort="Fann, Cathy S J" uniqKey="Fann C" first="Cathy S. J." last="Fann">Cathy S. J. Fann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Osyetrov, Valeriy" sort="Osyetrov, Valeriy" uniqKey="Osyetrov V" first="Valeriy" last="Osyetrov">Valeriy Osyetrov</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Graduate Institute of Epidemiology, National Taiwan University</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Chang, Hsiao Ling" sort="Chang, Hsiao Ling" uniqKey="Chang H" first="Hsiao-Ling" last="Chang">Hsiao-Ling Chang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Kuo, Hung Wei" sort="Kuo, Hung Wei" uniqKey="Kuo H" first="Hung-Wei" last="Kuo">Hung-Wei Kuo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Liao, Fong" sort="Liao, Fong" uniqKey="Liao F" first="Fong" last="Liao">Fong Liao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Graduate Institute of Epidemiology, National Taiwan University</institution>,<addr-line>Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><bold><italic>Background</italic></bold>. A high initial or peak severe acute respiratory syndrome (SARS)—associated coronavirus (SARS-CoV) load in nasopharyngeal specimens was shown to be associated with a high mortality rate. Because all infected individuals were devoid of preeexisting protective immunity against SARS-CoV, the biological basis for the variable virus burdens in different patients remains elusive.</p><p><bold><italic>Methods</italic></bold>. The nationwide SARS database in Taiwan was analyzed, and genotyping of 281 single-nucleotide polymorphisms (SNPs) of 65 genes was performed for 94 patients with SARS, to identify SNPs for which distribution between patients with or without detectable nasopharyngeal shedding of SARS-CoV was biased.</p><p><bold><italic>Results</italic></bold>. Titers of SARS-CoV shed in nasopharyngeal specimens varied widely, ranging from nondetectable to 10<sup>8</sup> SARS-CoV RNA copies/mL, and they were correlated positively with a high mortality rate (<italic>P</italic> < .0001, by trend test) and with early death (i.e., death occurring within 2 weeks of the onset of illness) (<italic>P</italic> = .0015, by trend test). Virus shedding was found to be higher among male patients (<italic>P</italic> = .0014, by multivariate logistic regression) and among older patients (<italic>P</italic> = .015, by multivariate logistic regression). Detectable nasopharyngeal shedding of SARS-CoV was associated with polymorphic alleles of interleukins 18 (<italic>P</italic> = .014) and 1A (<italic>P</italic> = .031) and a member of NFκB complex (reticuloendotheliosis viral oncogene homolog B [<italic>RelB</italic>]) (<italic>P</italic> = .034), all of which are proinflammatory in nature, as well as the procoagulation molecule fibrinogen-like protein 2 (<italic>P</italic> = .008).</p><p><bold><italic>Conclusion</italic></bold>. The SARS-CoV load is a determinant of clinical outcomes of SARS, and it is associated with polymorphisms of genes involved in innate immunity, which might be regulated in an age- and sex-dependent manner. The findings of the present study provided leads to genes involved in the host response to SARS-CoV infection; if substantiated with functional studies, these findings may be applicable to other newly emerged respiratory viruses (e.g., the influenza pandemic strain).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Booth, Cm" uniqKey="Booth C">CM Booth</name></author><author><name sortKey="Matukas, Lm" uniqKey="Matukas L">LM Matukas</name></author><author><name sortKey="Tomlinson, Ga" uniqKey="Tomlinson G">GA Tomlinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rainer, Th" uniqKey="Rainer T">TH Rainer</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Ip, M" uniqKey="Ip M">M Ip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, Pt" uniqKey="Tsui P">PT Tsui</name></author><author><name sortKey="Kwok, Ml" uniqKey="Kwok M">ML Kwok</name></author><author><name sortKey="Yuen, H" uniqKey="Yuen H">H Yuen</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, Oy" uniqKey="Cheung O">OY Cheung</name></author><author><name sortKey="Chan, Jw" uniqKey="Chan J">JW Chan</name></author><author><name sortKey="Ng, Ck" uniqKey="Ng C">CK Ng</name></author><author><name sortKey="Koo, Ck" uniqKey="Koo C">CK Koo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Kt" uniqKey="Wong K">KT Wong</name></author><author><name sortKey="Antonio, Ge" uniqKey="Antonio G">GE Antonio</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Zhou, C" uniqKey="Zhou C">C Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Kj" uniqKey="Huang K">KJ Huang</name></author><author><name sortKey="Su, Ij" uniqKey="Su I">IJ Su</name></author><author><name sortKey="Theron, M" uniqKey="Theron M">M Theron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Ek" uniqKey="Ng E">EK Ng</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Chan, Kc" uniqKey="Chan K">KC Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Wk" uniqKey="Wang W">WK Wang</name></author><author><name sortKey="Chen, Sy" uniqKey="Chen S">SY Chen</name></author><author><name sortKey="Liu, Ij" uniqKey="Liu I">IJ Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Yq" uniqKey="Ding Y">YQ Ding</name></author><author><name sortKey="Wang, Hj" uniqKey="Wang H">HJ Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farcas, Ga" uniqKey="Farcas G">GA Farcas</name></author><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T Mazzulli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Ch" uniqKey="Wang C">CH Wang</name></author><author><name sortKey="Liu, Cy" uniqKey="Liu C">CY Liu</name></author><author><name sortKey="Wan, Yl" uniqKey="Wan Y">YL Wan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Leung, Ws" uniqKey="Leung W">WS Leung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T Mazzulli</name></author><author><name sortKey="Farcas, Ga" uniqKey="Farcas G">GA Farcas</name></author><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Hs" uniqKey="Wu H">HS Wu</name></author><author><name sortKey="Chiu, Sc" uniqKey="Chiu S">SC Chiu</name></author><author><name sortKey="Tseng, Tc" uniqKey="Tseng T">TC Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, M S" uniqKey="Ho M">M-S Ho</name></author><author><name sortKey="Chen, W J" uniqKey="Chen W">W-J Chen</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H-Y Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Wh" uniqKey="Pan W">WH Pan</name></author><author><name sortKey="Fann, Csj" uniqKey="Fann C">CSJ Fann</name></author><author><name sortKey="Wu, Jy" uniqKey="Wu J">JY Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wj" uniqKey="Chen W">WJ Chen</name></author><author><name sortKey="Fann, Csj" uniqKey="Fann C">CSJ Fann</name></author><author><name sortKey="Osyetrov, V" uniqKey="Osyetrov V">V Osyetrov</name></author><author><name sortKey="Ho, Ms" uniqKey="Ho M">MS Ho</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ott, J" uniqKey="Ott J">J Ott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephens, M" uniqKey="Stephens M">M Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinstock, Jv" uniqKey="Weinstock J">JV Weinstock</name></author><author><name sortKey="Blum, A" uniqKey="Blum A">A Blum</name></author><author><name sortKey="Metwali, A" uniqKey="Metwali A">A Metwali</name></author><author><name sortKey="Elliott, D" uniqKey="Elliott D">D Elliott</name></author><author><name sortKey="Arsenescu, R" uniqKey="Arsenescu R">R Arsenescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sareneva, T" uniqKey="Sareneva T">T Sareneva</name></author><author><name sortKey="Julkunen, I" uniqKey="Julkunen I">I Julkunen</name></author><author><name sortKey="Matikainen, S" uniqKey="Matikainen S">S Matikainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wickremasinghe, Mi" uniqKey="Wickremasinghe M">MI Wickremasinghe</name></author><author><name sortKey="Thomas, Lh" uniqKey="Thomas L">LH Thomas</name></author><author><name sortKey="Friedland, Js" uniqKey="Friedland J">JS Friedland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, S" uniqKey="Ghosh S">S Ghosh</name></author><author><name sortKey="May, Mj" uniqKey="May M">MJ May</name></author><author><name sortKey="Kopp, Eb" uniqKey="Kopp E">EB Kopp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trebilcock, Gu" uniqKey="Trebilcock G">GU Trebilcock</name></author><author><name sortKey="Ponnappan, U" uniqKey="Ponnappan U">U Ponnappan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allan, Sm" uniqKey="Allan S">SM Allan</name></author><author><name sortKey="Tyrrell, Pj" uniqKey="Tyrrell P">PJ Tyrrell</name></author><author><name sortKey="Rothwell, Nj" uniqKey="Rothwell N">NJ Rothwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Sluijs, Kf" uniqKey="Van Der Sluijs K">KF Van Der Sluijs</name></author><author><name sortKey="Van Elden, Lj" uniqKey="Van Elden L">LJ Van Elden</name></author><author><name sortKey="Arens, R" uniqKey="Arens R">R Arens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, P" uniqKey="Price P">P Price</name></author><author><name sortKey="James, I" uniqKey="James I">I James</name></author><author><name sortKey="Fernandez, S" uniqKey="Fernandez S">S Fernandez</name></author><author><name sortKey="French, Ma" uniqKey="French M">MA French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murakami, Y" uniqKey="Murakami Y">Y Murakami</name></author><author><name sortKey="Otsuki, M" uniqKey="Otsuki M">M Otsuki</name></author><author><name sortKey="Kusumoto, K" uniqKey="Kusumoto K">K Kusumoto</name></author><author><name sortKey="Takeuchi, S" uniqKey="Takeuchi S">S Takeuchi</name></author><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beagley, Kw" uniqKey="Beagley K">KW Beagley</name></author><author><name sortKey="Gockel, Cm" uniqKey="Gockel C">CM Gockel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morales Montor, J" uniqKey="Morales Montor J">J Morales-Montor</name></author><author><name sortKey="Chavarria, A" uniqKey="Chavarria A">A Chavarria</name></author><author><name sortKey="De Leon, Ma" uniqKey="De Leon M">MA De Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, R" uniqKey="Mo R">R Mo</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Grolleau Julius, A" uniqKey="Grolleau Julius A">A Grolleau-Julius</name></author><author><name sortKey="Murphy, Hs" uniqKey="Murphy H">HS Murphy</name></author><author><name sortKey="Richardson, Bc" uniqKey="Richardson B">BC Richardson</name></author><author><name sortKey="Yung, Rl" uniqKey="Yung R">RL Yung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karlberg, J" uniqKey="Karlberg J">J Karlberg</name></author><author><name sortKey="Chong, Ds" uniqKey="Chong D">DS Chong</name></author><author><name sortKey="Lai, Wy" uniqKey="Lai W">WY Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Da" uniqKey="Clark D">DA Clark</name></author><author><name sortKey="Foerster, K" uniqKey="Foerster K">K Foerster</name></author><author><name sortKey="Fung, L" uniqKey="Fung L">L Fung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, Ga" uniqKey="Levy G">GA Levy</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Ding, J" uniqKey="Ding J">J Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsden, Pa" uniqKey="Marsden P">PA Marsden</name></author><author><name sortKey="Ning, Q" uniqKey="Ning Q">Q Ning</name></author><author><name sortKey="Fung, Ls" uniqKey="Fung L">LS Fung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ning, Q" uniqKey="Ning Q">Q Ning</name></author><author><name sortKey="Lakatoo, S" uniqKey="Lakatoo S">S Lakatoo</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marazzi, S" uniqKey="Marazzi S">S Marazzi</name></author><author><name sortKey="Blum, S" uniqKey="Blum S">S Blum</name></author><author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stout, Rd" uniqKey="Stout R">RD Stout</name></author><author><name sortKey="Suttles, J" uniqKey="Suttles J">J Suttles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Hc" uniqKey="Yang H">HC Yang</name></author><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Hsu, Cl" uniqKey="Hsu C">CL Hsu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>The University of Chicago Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16652313</article-id><article-id pub-id-type="pmc">7107974</article-id><article-id pub-id-type="doi">10.1086/503843</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject><subj-group subj-group-type="category-toc-heading"><subject>Major Articles</subject></subj-group></subj-group></article-categories><title-group><article-title>Nasopharyngeal Shedding of Severe Acute Respiratory Syndrome—Associated Coronavirus Is Associated with Genetic Polymorphisms</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Wei-Ju</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Jyh-Yuan</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Jih-Hui</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fann</surname><given-names>Cathy S. J.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Osyetrov</surname><given-names>Valeriy</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>King</surname><given-names>Chwan-Chuen</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yi-Ming Arthur</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Hsiao-Ling</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>Hung-Wei</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Liao</surname><given-names>Fong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Mei-Shang</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="corresp" rid="cor1"></xref><pmc-comment>homs@ibms.sinica.edu.tw </pmc-comment>
</contrib></contrib-group><aff id="aff1"><label>1</label><institution>Institute of Biomedical Science, Academia Sinica</institution>,<addr-line>Taipei, Taiwan</addr-line></aff><aff id="aff2"><label>2</label><institution>Center for Disease Control</institution>,<addr-line>Taipei, Taiwan</addr-line></aff><aff id="aff3"><label>3</label><institution>Graduate Institute of Epidemiology, National Taiwan University</institution>,<addr-line>Taipei, Taiwan</addr-line></aff><aff id="aff4"><label>1</label><institution>Institute of Public Health, National Yang-Ming University</institution>,<addr-line>Taipei, Taiwan</addr-line></aff><author-notes><corresp id="cor1">Reprints or correspondence: Dr. Mei-Shang Ho, IBMS, Academia Sinica, Taipei, 11529 Taiwan (<email>homs@ibms.sinica.edu.tw</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>6</month><year>2006</year></pub-date><pub-date pub-type="epub" iso-8601-date="2006-06-01"><day>1</day><month>6</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2006</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>42</volume><issue>11</issue><fpage>1561</fpage><lpage>1569</lpage><history><date date-type="received"><day>5</day><month>12</month><year>2005</year></date><date date-type="accepted"><day>1</day><month>2</month><year>2006</year></date></history><permissions><copyright-statement>© 2006 by the Infectious Diseases Society of America</copyright-statement><copyright-year>2006</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="42-11-1561.pdf"></self-uri><abstract><title>Abstract</title><p><bold><italic>Background</italic></bold>. A high initial or peak severe acute respiratory syndrome (SARS)—associated coronavirus (SARS-CoV) load in nasopharyngeal specimens was shown to be associated with a high mortality rate. Because all infected individuals were devoid of preeexisting protective immunity against SARS-CoV, the biological basis for the variable virus burdens in different patients remains elusive.</p><p><bold><italic>Methods</italic></bold>. The nationwide SARS database in Taiwan was analyzed, and genotyping of 281 single-nucleotide polymorphisms (SNPs) of 65 genes was performed for 94 patients with SARS, to identify SNPs for which distribution between patients with or without detectable nasopharyngeal shedding of SARS-CoV was biased.</p><p><bold><italic>Results</italic></bold>. Titers of SARS-CoV shed in nasopharyngeal specimens varied widely, ranging from nondetectable to 10<sup>8</sup> SARS-CoV RNA copies/mL, and they were correlated positively with a high mortality rate (<italic>P</italic> < .0001, by trend test) and with early death (i.e., death occurring within 2 weeks of the onset of illness) (<italic>P</italic> = .0015, by trend test). Virus shedding was found to be higher among male patients (<italic>P</italic> = .0014, by multivariate logistic regression) and among older patients (<italic>P</italic> = .015, by multivariate logistic regression). Detectable nasopharyngeal shedding of SARS-CoV was associated with polymorphic alleles of interleukins 18 (<italic>P</italic> = .014) and 1A (<italic>P</italic> = .031) and a member of NFκB complex (reticuloendotheliosis viral oncogene homolog B [<italic>RelB</italic>]) (<italic>P</italic> = .034), all of which are proinflammatory in nature, as well as the procoagulation molecule fibrinogen-like protein 2 (<italic>P</italic> = .008).</p><p><bold><italic>Conclusion</italic></bold>. The SARS-CoV load is a determinant of clinical outcomes of SARS, and it is associated with polymorphisms of genes involved in innate immunity, which might be regulated in an age- and sex-dependent manner. The findings of the present study provided leads to genes involved in the host response to SARS-CoV infection; if substantiated with functional studies, these findings may be applicable to other newly emerged respiratory viruses (e.g., the influenza pandemic strain).</p></abstract></article-meta></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Chen, Wei Ju" sort="Chen, Wei Ju" uniqKey="Chen W" first="Wei-Ju" last="Chen">Wei-Ju Chen</name></noRegion><name sortKey="Chang, Hsiao Ling" sort="Chang, Hsiao Ling" uniqKey="Chang H" first="Hsiao-Ling" last="Chang">Hsiao-Ling Chang</name><name sortKey="Fann, Cathy S J" sort="Fann, Cathy S J" uniqKey="Fann C" first="Cathy S. J." last="Fann">Cathy S. J. Fann</name><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name><name sortKey="Kuo, Hung Wei" sort="Kuo, Hung Wei" uniqKey="Kuo H" first="Hung-Wei" last="Kuo">Hung-Wei Kuo</name><name sortKey="Liao, Fong" sort="Liao, Fong" uniqKey="Liao F" first="Fong" last="Liao">Fong Liao</name><name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name><name sortKey="Osyetrov, Valeriy" sort="Osyetrov, Valeriy" uniqKey="Osyetrov V" first="Valeriy" last="Osyetrov">Valeriy Osyetrov</name><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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