Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays
Identifieur interne : 001066 ( Pmc/Checkpoint ); précédent : 001065; suivant : 001067Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays
Auteurs : George Zahariadis ; Ted A. Gooley [États-Unis] ; Phyllis Ryall [Canada] ; Christine Hutchinson [Canada] ; Mary I. Latchford [Canada] ; Margaret A. Fearon [Canada] ; Frances B. Jamieson [Canada] ; Susan Richardson [Canada] ; Theodore Kuschak ; Barbara Mederski [Canada]Source :
- Canadian Respiratory Journal : Journal of the Canadian Thoracic Society [ 1198-2241 ] ; 2006.
Abstract
Severe acute respiratory syndrome (SARS) caused the first epidemic of the 21st century and continues to threaten the global community.
To assess the incidence of coinfection in patients confirmed to have SARS-associated coronavirus (SARS-CoV) infection, and thus, to determine the risk of ruling out SARS by ruling in another diagnosis.
The present report is a retrospective study evaluating the incidence and impact of laboratory-confirmed SARS-CoV and other pulmonary pathogens in 117 patients. These patients were evaluated in a Toronto, Ontario, community hospital identified as the epicentre for the second SARS outbreak.
Coinfection with other pulmonary pathogens occured in patients with SARS. Seventy-three per cent of the patient population evaluated had laboratory-confirmed SARS-CoV infection. Serology showing acute or recent
Diagnostic assays for well-recognized pulmonary pathogens have limitations, and ruling out SARS-CoV by ruling in another pulmonary pathogen carries significant risk. Despite positive serology for atypical pathogens, in a setting where clinical suspicion for SARS is high, specific tests for SARS should be performed to confirm or exclude a diagnosis.
Url:
PubMed: 16470249
PubMed Central: 2539008
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:2539008Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays</title><author><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name><affiliation><nlm:aff id="af1-0130017"> University of Alberta, Edmonton, Alberta</nlm:aff><wicri:noCountry code="subfield">Alberta</wicri:noCountry></affiliation></author><author><name sortKey="Gooley, Ted A" sort="Gooley, Ted A" uniqKey="Gooley T" first="Ted A" last="Gooley">Ted A. Gooley</name><affiliation wicri:level="2"><nlm:aff id="af2-0130017"> Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ryall, Phyllis" sort="Ryall, Phyllis" uniqKey="Ryall P" first="Phyllis" last="Ryall">Phyllis Ryall</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Hutchinson, Christine" sort="Hutchinson, Christine" uniqKey="Hutchinson C" first="Christine" last="Hutchinson">Christine Hutchinson</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Latchford, Mary I" sort="Latchford, Mary I" uniqKey="Latchford M" first="Mary I" last="Latchford">Mary I. Latchford</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Fearon, Margaret A" sort="Fearon, Margaret A" uniqKey="Fearon M" first="Margaret A" last="Fearon">Margaret A. Fearon</name><affiliation wicri:level="2"><nlm:aff id="af4-0130017"> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Jamieson, Frances B" sort="Jamieson, Frances B" uniqKey="Jamieson F" first="Frances B" last="Jamieson">Frances B. Jamieson</name><affiliation wicri:level="2"><nlm:aff id="af4-0130017"> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name><affiliation wicri:level="2"><nlm:aff id="af5-0130017"> The Hospital for Sick Children, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> The Hospital for Sick Children, Toronto</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af6-0130017"> University of Toronto, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> University of Toronto, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Kuschak, Theodore" sort="Kuschak, Theodore" uniqKey="Kuschak T" first="Theodore" last="Kuschak">Theodore Kuschak</name><affiliation><nlm:aff id="af7-0130017"> Health Canada National Microbiology Laboratory, Winnipeg, Manitoba</nlm:aff><wicri:noCountry code="subfield">Manitoba</wicri:noCountry></affiliation></author><author><name sortKey="Mederski, Barbara" sort="Mederski, Barbara" uniqKey="Mederski B" first="Barbara" last="Mederski">Barbara Mederski</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16470249</idno><idno type="pmc">2539008</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539008</idno><idno type="RBID">PMC:2539008</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000C47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C47</idno><idno type="wicri:Area/Pmc/Curation">000C47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C47</idno><idno type="wicri:Area/Pmc/Checkpoint">001066</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays</title><author><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name><affiliation><nlm:aff id="af1-0130017"> University of Alberta, Edmonton, Alberta</nlm:aff><wicri:noCountry code="subfield">Alberta</wicri:noCountry></affiliation></author><author><name sortKey="Gooley, Ted A" sort="Gooley, Ted A" uniqKey="Gooley T" first="Ted A" last="Gooley">Ted A. Gooley</name><affiliation wicri:level="2"><nlm:aff id="af2-0130017"> Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ryall, Phyllis" sort="Ryall, Phyllis" uniqKey="Ryall P" first="Phyllis" last="Ryall">Phyllis Ryall</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Hutchinson, Christine" sort="Hutchinson, Christine" uniqKey="Hutchinson C" first="Christine" last="Hutchinson">Christine Hutchinson</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Latchford, Mary I" sort="Latchford, Mary I" uniqKey="Latchford M" first="Mary I" last="Latchford">Mary I. Latchford</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Fearon, Margaret A" sort="Fearon, Margaret A" uniqKey="Fearon M" first="Margaret A" last="Fearon">Margaret A. Fearon</name><affiliation wicri:level="2"><nlm:aff id="af4-0130017"> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Jamieson, Frances B" sort="Jamieson, Frances B" uniqKey="Jamieson F" first="Frances B" last="Jamieson">Frances B. Jamieson</name><affiliation wicri:level="2"><nlm:aff id="af4-0130017"> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name><affiliation wicri:level="2"><nlm:aff id="af5-0130017"> The Hospital for Sick Children, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> The Hospital for Sick Children, Toronto</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af6-0130017"> University of Toronto, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> University of Toronto, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Kuschak, Theodore" sort="Kuschak, Theodore" uniqKey="Kuschak T" first="Theodore" last="Kuschak">Theodore Kuschak</name><affiliation><nlm:aff id="af7-0130017"> Health Canada National Microbiology Laboratory, Winnipeg, Manitoba</nlm:aff><wicri:noCountry code="subfield">Manitoba</wicri:noCountry></affiliation></author><author><name sortKey="Mederski, Barbara" sort="Mederski, Barbara" uniqKey="Mederski B" first="Barbara" last="Mederski">Barbara Mederski</name><affiliation wicri:level="2"><nlm:aff id="af3-0130017"> North York General Hospital, Toronto, Ontario</nlm:aff><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea> North York General Hospital, Toronto</wicri:cityArea></affiliation></author></analytic><series><title level="j">Canadian Respiratory Journal : Journal of the Canadian Thoracic Society</title><idno type="ISSN">1198-2241</idno><idno type="eISSN">1916-7245</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title><p>Severe acute respiratory syndrome (SARS) caused the first epidemic of the 21st century and continues to threaten the global community.</p></sec><sec><title>OBJECTIVE</title><p>To assess the incidence of coinfection in patients confirmed to have SARS-associated coronavirus (SARS-CoV) infection, and thus, to determine the risk of ruling out SARS by ruling in another diagnosis.</p></sec><sec><title>METHODS</title><p>The present report is a retrospective study evaluating the incidence and impact of laboratory-confirmed SARS-CoV and other pulmonary pathogens in 117 patients. These patients were evaluated in a Toronto, Ontario, community hospital identified as the epicentre for the second SARS outbreak.</p></sec><sec><title>RESULTS</title><p>Coinfection with other pulmonary pathogens occured in patients with SARS. Seventy-three per cent of the patient population evaluated had laboratory-confirmed SARS-CoV infection. Serology showing acute or recent <italic>Chlamydophila pneumoniae</italic> or <italic>Mycoplasma pneumoniae</italic> infection revealed an incidence of 30% and 9%, respectively, in those with SARS. These rates are similar to previously published studies on coinfection in pneumonia. All nucleic acid diagnostic assays were negative for <italic>C pneumoniae</italic> and <italic>M pneumoniae</italic> in respiratory samples from patients with SARS having serological evidence for these atypical pathogens.</p></sec><sec><title>CONCLUSIONS</title><p>Diagnostic assays for well-recognized pulmonary pathogens have limitations, and ruling out SARS-CoV by ruling in another pulmonary pathogen carries significant risk. Despite positive serology for atypical pathogens, in a setting where clinical suspicion for SARS is high, specific tests for SARS should be performed to confirm or exclude a diagnosis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can Respir J</journal-id><journal-id journal-id-type="publisher-id">PGI</journal-id><journal-title-group><journal-title>Canadian Respiratory Journal : Journal of the Canadian Thoracic Society</journal-title></journal-title-group><issn pub-type="ppub">1198-2241</issn><issn pub-type="epub">1916-7245</issn><publisher><publisher-name>Pulsus Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16470249</article-id><article-id pub-id-type="pmc">2539008</article-id><article-id pub-id-type="publisher-id">crj13017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zahariadis</surname><given-names>George</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af1-0130017">1</xref><xref ref-type="corresp" rid="c1-0130017"></xref></contrib><contrib contrib-type="author"><name><surname>Gooley</surname><given-names>Ted A</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="af2-0130017">2</xref></contrib><contrib contrib-type="author"><name><surname>Ryall</surname><given-names>Phyllis</given-names></name><degrees>RN</degrees><xref ref-type="aff" rid="af3-0130017">3</xref></contrib><contrib contrib-type="author"><name><surname>Hutchinson</surname><given-names>Christine</given-names></name><degrees>BScN</degrees><xref ref-type="aff" rid="af3-0130017">3</xref></contrib><contrib contrib-type="author"><name><surname>Latchford</surname><given-names>Mary I</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="af3-0130017">3</xref></contrib><contrib contrib-type="author"><name><surname>Fearon</surname><given-names>Margaret A</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af4-0130017">4</xref></contrib><contrib contrib-type="author"><name><surname>Jamieson</surname><given-names>Frances B</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af4-0130017">4</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Susan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af5-0130017">5</xref><xref ref-type="aff" rid="af6-0130017">6</xref></contrib><contrib contrib-type="author"><name><surname>Kuschak</surname><given-names>Theodore</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="af7-0130017">7</xref></contrib><contrib contrib-type="author"><name><surname>Mederski</surname><given-names>Barbara</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af3-0130017">3</xref></contrib></contrib-group><aff id="af1-0130017"><label>1</label> University of Alberta, Edmonton, Alberta</aff><aff id="af2-0130017"><label>2</label> Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="af3-0130017"><label>3</label> North York General Hospital, Toronto, Ontario</aff><aff id="af4-0130017"><label>4</label> Ministry of Health and Long-Term Care – Laboratories Branch, Toronto, Ontario</aff><aff id="af5-0130017"><label>5</label> The Hospital for Sick Children, Toronto, Ontario</aff><aff id="af6-0130017"><label>6</label> University of Toronto, Toronto, Ontario</aff><aff id="af7-0130017"><label>7</label> Health Canada National Microbiology Laboratory, Winnipeg, Manitoba</aff><author-notes><corresp id="c1-0130017">Correspondence: Dr George Zahariadis, University of Alberta and Provincial Laboratory for Public Health (Alberta), Walter MacKenzie Centre, Room 2B1.04, 8440 – 112 Street, Edmonton, Alberta T6G 2J2. Telephone 780-407-8975, fax 780-407-8961, e-mail
<email>georgez@ualberta.ca</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2006</year></pub-date><volume>13</volume><issue>1</issue><fpage>17</fpage><lpage>22</lpage><permissions><copyright-statement>© 2006, Pulsus Group Inc. All rights reserved</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract><sec><title>BACKGROUND</title><p>Severe acute respiratory syndrome (SARS) caused the first epidemic of the 21st century and continues to threaten the global community.</p></sec><sec><title>OBJECTIVE</title><p>To assess the incidence of coinfection in patients confirmed to have SARS-associated coronavirus (SARS-CoV) infection, and thus, to determine the risk of ruling out SARS by ruling in another diagnosis.</p></sec><sec><title>METHODS</title><p>The present report is a retrospective study evaluating the incidence and impact of laboratory-confirmed SARS-CoV and other pulmonary pathogens in 117 patients. These patients were evaluated in a Toronto, Ontario, community hospital identified as the epicentre for the second SARS outbreak.</p></sec><sec><title>RESULTS</title><p>Coinfection with other pulmonary pathogens occured in patients with SARS. Seventy-three per cent of the patient population evaluated had laboratory-confirmed SARS-CoV infection. Serology showing acute or recent <italic>Chlamydophila pneumoniae</italic> or <italic>Mycoplasma pneumoniae</italic> infection revealed an incidence of 30% and 9%, respectively, in those with SARS. These rates are similar to previously published studies on coinfection in pneumonia. All nucleic acid diagnostic assays were negative for <italic>C pneumoniae</italic> and <italic>M pneumoniae</italic> in respiratory samples from patients with SARS having serological evidence for these atypical pathogens.</p></sec><sec><title>CONCLUSIONS</title><p>Diagnostic assays for well-recognized pulmonary pathogens have limitations, and ruling out SARS-CoV by ruling in another pulmonary pathogen carries significant risk. Despite positive serology for atypical pathogens, in a setting where clinical suspicion for SARS is high, specific tests for SARS should be performed to confirm or exclude a diagnosis.</p></sec></abstract><trans-abstract xml:lang="fr"><sec><title>HISTORIQUE</title><p>Le syndrome respiratoire aigu sévère (SRAS) a causé la première épidémie du 21<sup>e</sup> siècle et continue de représenter une menace globale pour l’être humain.</p></sec><sec><title>OBJECTIF</title><p>Mesurer l’incidence des co-infections chez les patients avérés infectés par le coronavirus associé au SRAS (SRAS-coV) et déterminer ainsi s’il y a un risque à écarter un diagnostic de SRAS en faveur d’un autre diagnostic.</p></sec><sec><title>MÉTHODES</title><p>Le présent rapport décrit une étude rétrospective qui visait à évaluer l’incidence et l’impact du SRAS-coV et d’autres pathogènes pulmonaires confirmés en laboratoire chez 117 patients. Ces patients ont été examinés dans un hôpital communautaire de Toronto, en Ontario, identifié comme l’épicentre de la seconde éclosion de SRAS.</p></sec><sec><title>RÉSULTATS</title><p>La co-infection par d’autres pathogènes pulmonaires a été notée chez des patients victimes du SRAS. Soixante-treize pour cent de la population de patient évalués présentaient une infection à SRAS-coV, analyses de laboratoires à l’appui. Des épreuves sérologiques ont révélé la présence d’infections aiguës ou récentes à <italic>Chlamydophila pneumoniæ</italic> ou à <italic>Mycoplasma pneumoniæ</italic>, selon une incidence respective de 30 % et de 9 % chez les sujets atteints de SRAS. Ces taux font écho aux résultats enregistrés lors d’études publiées antérieurement sur la co-infection dans la pneumonie. Tous les tests diagnostiques reposant sur l’amplification génique de l’acide nucléique se sont révélés négatifs à l’égard de <italic>C pneumoniæ</italic> et de <italic>M pneumoniæ</italic> dans les spécimens respiratoires provenant de patients atteints de SRAS, alors que les épreuves sérologiques indiquaient la présence de ces pathogènes atypiques.</p></sec><sec><title>CONCLUSIONS</title><p>Les tests diagnostiques de dépistage des pathogènes respiratoires bien connus ont des limites et le fait d’écarter un diagnostic de SRAS-coV en faveur d’un autre pathogène pulmonaire comporte un risque important. Malgré les tests sérologiques positifs, dans un contexte clinique où on soupçonne fort l’implication du SRAS, des tests spécifiques de dépistage du SRAS doivent être effectués pour confirmer ou infirmer le diagnostic.</p></sec></trans-abstract><kwd-group><kwd>Coinfection</kwd><kwd>Coronavirus</kwd><kwd>Epidemic</kwd><kwd>Pneumonia</kwd><kwd>SARS</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li><li>Washington (État)</li></region></list><tree><noCountry><name sortKey="Kuschak, Theodore" sort="Kuschak, Theodore" uniqKey="Kuschak T" first="Theodore" last="Kuschak">Theodore Kuschak</name><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Gooley, Ted A" sort="Gooley, Ted A" uniqKey="Gooley T" first="Ted A" last="Gooley">Ted A. Gooley</name></region></country><country name="Canada"><region name="Ontario"><name sortKey="Ryall, Phyllis" sort="Ryall, Phyllis" uniqKey="Ryall P" first="Phyllis" last="Ryall">Phyllis Ryall</name></region><name sortKey="Fearon, Margaret A" sort="Fearon, Margaret A" uniqKey="Fearon M" first="Margaret A" last="Fearon">Margaret A. Fearon</name><name sortKey="Hutchinson, Christine" sort="Hutchinson, Christine" uniqKey="Hutchinson C" first="Christine" last="Hutchinson">Christine Hutchinson</name><name sortKey="Jamieson, Frances B" sort="Jamieson, Frances B" uniqKey="Jamieson F" first="Frances B" last="Jamieson">Frances B. Jamieson</name><name sortKey="Latchford, Mary I" sort="Latchford, Mary I" uniqKey="Latchford M" first="Mary I" last="Latchford">Mary I. Latchford</name><name sortKey="Mederski, Barbara" sort="Mederski, Barbara" uniqKey="Mederski B" first="Barbara" last="Mederski">Barbara Mederski</name><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001066 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001066 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:2539008
|texte= Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:16470249" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |