Treatment of Severe Acute Respiratory Syndrome With Glucosteroids
Identifieur interne : 001022 ( Pmc/Checkpoint ); précédent : 001021; suivant : 001023Treatment of Severe Acute Respiratory Syndrome With Glucosteroids
Auteurs : Rong-Chang Chen [République populaire de Chine] ; Xiao-Ping Tang [République populaire de Chine] ; Shou-Yong Tan [République populaire de Chine] ; Bi-Ling Liang [République populaire de Chine] ; Zhuo-Yue Wan [République populaire de Chine] ; Ji-Qian Fang [République populaire de Chine] ; Nanshan Zhong [République populaire de Chine]Source :
- Chest [ 0012-3692 ] ; 2006.
Abstract
To investigate the efficacy and safety profiles of corticosteroid therapy in severe acute respiratory syndrome (SARS) patients.
Four hundred one of 1,278 SARS cases treated in Guangzhou China between December 2002 and June 2003 fulfilled the diagnostic criteria issued by the World Health Organization for confirmed identification of SARS. Among them, the diagnosis of critical SARS was defined by criteria of SARS guidelines incorporated with a low oxygenation index (OI) [< 300 mm Hg]. Data of these patients retrieved from a database were retrospectively analyzed by logistic regression and Cox regression for the effect of corticosteroid therapy on death, hospitalization days, and complication presentation.
Among the 401 SARS patients studied, 147 of 249 noncritical patients (59.0%) received corticosteroids (mean daily dose, 105.3 ± 86.1 mg) [± SD], and all survived the disease; 121 of 152 critical patients (79.6%) received corticosteroids at a mean daily dose of 133.5 ± 102.3 mg, and 25 died. Analysis of these 401 confirmed cases did not show any benefits of corticosteroid on the death rate and hospitalization days. However, when focused on 152 critical SARS cases, factors correlated with these end points indicated by univariate analysis included use of corticosteroid, age, rigor at onset, secondary respiratory infections, pulmonary rales, grading of OI, and use of invasive ventilation. After adjustment for possible confounders, treatment with corticosteroid was shown contributing to lower overall mortality, instant mortality, and shorter hospitalization stay (p < 0.05). Incidence of complications was significantly associated with the need for invasive ventilation but not with use of corticosteroids.
This Guangzhou retrospective study revealed that proper use of corticosteroid in confirmed critical SARS resulted in lowered mortality and shorter hospitalization stay, and was not associated with significant secondary lower respiratory infection and other complications.
Url:
DOI: 10.1378/chest.129.6.1441
PubMed: 16778260
PubMed Central: 7094735
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7094735Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of Severe Acute Respiratory Syndrome With Glucosteroids</title><author><name sortKey="Chen, Rong Chang" sort="Chen, Rong Chang" uniqKey="Chen R" first="Rong-Chang" last="Chen">Rong-Chang Chen</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College</wicri:orgArea></affiliation></author><author><name sortKey="Tang, Xiao Ping" sort="Tang, Xiao Ping" uniqKey="Tang X" first="Xiao-Ping" last="Tang">Xiao-Ping Tang</name><affiliation wicri:level="3"><nlm:aff id="aff2">Guangzhou Municipal Hospital of Infective Disease, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Municipal Hospital of Infective Disease</wicri:orgArea></affiliation></author><author><name sortKey="Tan, Shou Yong" sort="Tan, Shou Yong" uniqKey="Tan S" first="Shou-Yong" last="Tan">Shou-Yong Tan</name><affiliation wicri:level="3"><nlm:aff id="aff3">Guangzhou Chest Hospital, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Chest Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Liang, Bi Ling" sort="Liang, Bi Ling" uniqKey="Liang B" first="Bi-Ling" last="Liang">Bi-Ling Liang</name><affiliation wicri:level="3"><nlm:aff id="aff4">Second Affiliated Hospital of Zhongshan University, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Second Affiliated Hospital of Zhongshan University</wicri:orgArea></affiliation></author><author><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name><affiliation wicri:level="3"><nlm:aff id="aff5">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangdong Provincial Center for Disease Control and Prevention</wicri:orgArea></affiliation></author><author><name sortKey="Fang, Ji Qian" sort="Fang, Ji Qian" uniqKey="Fang J" first="Ji-Qian" last="Fang">Ji-Qian Fang</name><affiliation wicri:level="3"><nlm:aff id="aff6">Zhongshan University School of Public Health, Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhongshan University School of Public Health, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College</wicri:orgArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16778260</idno><idno type="pmc">7094735</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094735</idno><idno type="RBID">PMC:7094735</idno><idno type="doi">10.1378/chest.129.6.1441</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000E82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E82</idno><idno type="wicri:Area/Pmc/Curation">000E82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E82</idno><idno type="wicri:Area/Pmc/Checkpoint">001022</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001022</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of Severe Acute Respiratory Syndrome With Glucosteroids</title><author><name sortKey="Chen, Rong Chang" sort="Chen, Rong Chang" uniqKey="Chen R" first="Rong-Chang" last="Chen">Rong-Chang Chen</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College</wicri:orgArea></affiliation></author><author><name sortKey="Tang, Xiao Ping" sort="Tang, Xiao Ping" uniqKey="Tang X" first="Xiao-Ping" last="Tang">Xiao-Ping Tang</name><affiliation wicri:level="3"><nlm:aff id="aff2">Guangzhou Municipal Hospital of Infective Disease, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Municipal Hospital of Infective Disease</wicri:orgArea></affiliation></author><author><name sortKey="Tan, Shou Yong" sort="Tan, Shou Yong" uniqKey="Tan S" first="Shou-Yong" last="Tan">Shou-Yong Tan</name><affiliation wicri:level="3"><nlm:aff id="aff3">Guangzhou Chest Hospital, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Chest Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Liang, Bi Ling" sort="Liang, Bi Ling" uniqKey="Liang B" first="Bi-Ling" last="Liang">Bi-Ling Liang</name><affiliation wicri:level="3"><nlm:aff id="aff4">Second Affiliated Hospital of Zhongshan University, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Second Affiliated Hospital of Zhongshan University</wicri:orgArea></affiliation></author><author><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name><affiliation wicri:level="3"><nlm:aff id="aff5">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangdong Provincial Center for Disease Control and Prevention</wicri:orgArea></affiliation></author><author><name sortKey="Fang, Ji Qian" sort="Fang, Ji Qian" uniqKey="Fang J" first="Ji-Qian" last="Fang">Ji-Qian Fang</name><affiliation wicri:level="3"><nlm:aff id="aff6">Zhongshan University School of Public Health, Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhongshan University School of Public Health, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name><affiliation wicri:level="3"><nlm:aff id="aff1">Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College</wicri:orgArea></affiliation></author></analytic><series><title level="j">Chest</title><idno type="ISSN">0012-3692</idno><idno type="eISSN">1931-3543</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Study objective</title><p>To investigate the efficacy and safety profiles of corticosteroid therapy in severe acute respiratory syndrome (SARS) patients.</p></sec><sec><title>Design</title><p>Four hundred one of 1,278 SARS cases treated in Guangzhou China between December 2002 and June 2003 fulfilled the diagnostic criteria issued by the World Health Organization for confirmed identification of SARS. Among them, the diagnosis of critical SARS was defined by criteria of SARS guidelines incorporated with a low oxygenation index (OI) [< 300 mm Hg]. Data of these patients retrieved from a database were retrospectively analyzed by logistic regression and Cox regression for the effect of corticosteroid therapy on death, hospitalization days, and complication presentation.</p></sec><sec><title>Results</title><p>Among the 401 SARS patients studied, 147 of 249 noncritical patients (59.0%) received corticosteroids (mean daily dose, 105.3 ± 86.1 mg) [± SD], and all survived the disease; 121 of 152 critical patients (79.6%) received corticosteroids at a mean daily dose of 133.5 ± 102.3 mg, and 25 died. Analysis of these 401 confirmed cases did not show any benefits of corticosteroid on the death rate and hospitalization days. However, when focused on 152 critical SARS cases, factors correlated with these end points indicated by univariate analysis included use of corticosteroid, age, rigor at onset, secondary respiratory infections, pulmonary rales, grading of OI, and use of invasive ventilation. After adjustment for possible confounders, treatment with corticosteroid was shown contributing to lower overall mortality, instant mortality, and shorter hospitalization stay (p < 0.05). Incidence of complications was significantly associated with the need for invasive ventilation but not with use of corticosteroids.</p></sec><sec><title>Conclusion</title><p>This Guangzhou retrospective study revealed that proper use of corticosteroid in confirmed critical SARS resulted in lowered mortality and shorter hospitalization stay, and was not associated with significant secondary lower respiratory infection and other complications.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="So, Lk" uniqKey="So L">LK So</name></author><author><name sortKey="Lau, Ac" uniqKey="Lau A">AC Lau</name></author><author><name sortKey="Yam, Ly" uniqKey="Yam L">LY Yam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Jc" uniqKey="Ho J">JC Ho</name></author><author><name sortKey="Ooi, Gc" uniqKey="Ooi G">GC Ooi</name></author><author><name sortKey="Mok, Ty" uniqKey="Mok T">TY Mok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meng, Qh" uniqKey="Meng Q">QH Meng</name></author><author><name sortKey="Dong, Pl" uniqKey="Dong P">PL Dong</name></author><author><name sortKey="Guo, Yb" uniqKey="Guo Y">YB Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, Jz" uniqKey="Xiao J">JZ Xiao</name></author><author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author><author><name sortKey="Joynt, Gm" uniqKey="Joynt G">GM Joynt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, K" uniqKey="Tsang K">K Tsang</name></author><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author><author><name sortKey="Lee, Wm" uniqKey="Lee W">WM Lee</name></author><author><name sortKey="Bressler, B" uniqKey="Bressler B">B Bressler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Eh" uniqKey="Wu E">EH Wu</name></author><author><name sortKey="Li, Gx" uniqKey="Li G">GX Li</name></author><author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Zg" uniqKey="Zheng Z">ZG Zheng</name></author><author><name sortKey="Chen, Rc" uniqKey="Chen R">RC Chen</name></author><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, J" uniqKey="Hong J">J Hong</name></author><author><name sortKey="Davis, Jm" uniqKey="Davis J">JM Davis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tian, Q" uniqKey="Tian Q">Q Tian</name></author><author><name sortKey="Liu, Yn" uniqKey="Liu Y">YN Liu</name></author><author><name sortKey="Xie, Lx" uniqKey="Xie L">LX Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Shao, Yx" uniqKey="Shao Y">YX Shao</name></author><author><name sortKey="Yi, Y" uniqKey="Yi Y">Y Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Rc" uniqKey="Chen R">RC Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Xw" uniqKey="Li X">XW Li</name></author><author><name sortKey="Jiang, Rm" uniqKey="Jiang R">RM Jiang</name></author><author><name sortKey="Guo, Jz" uniqKey="Guo J">JZ Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Chan, Kc" uniqKey="Chan K">KC Chan</name></author><author><name sortKey="Allen" uniqKey="Allen">Allen</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, Ot" uniqKey="Tsang O">OT Tsang</name></author><author><name sortKey="Chau, Tn" uniqKey="Chau T">TN Chau</name></author><author><name sortKey="Choi, Kw" uniqKey="Choi K">KW Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modig, J" uniqKey="Modig J">J Modig</name></author><author><name sortKey="Borg, T" uniqKey="Borg T">T Borg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luce, Jm" uniqKey="Luce J">JM Luce</name></author><author><name sortKey="Montgomery, Ab" uniqKey="Montgomery A">AB Montgomery</name></author><author><name sortKey="Marks, Jd" uniqKey="Marks J">JD Marks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author><author><name sortKey="Luce, Jm" uniqKey="Luce J">JM Luce</name></author><author><name sortKey="Sprung, Cl" uniqKey="Sprung C">CL Sprung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, Gu" uniqKey="Meduri G">GU Meduri</name></author><author><name sortKey="Tolley, Ea" uniqKey="Tolley E">EA Tolley</name></author><author><name sortKey="Chrousos, Gp" uniqKey="Chrousos G">GP Chrousos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinozaki, M" uniqKey="Shinozaki M">M Shinozaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, Gu" uniqKey="Meduri G">GU Meduri</name></author><author><name sortKey="Headley, S" uniqKey="Headley S">S Headley</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Kohler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Zhou, C" uniqKey="Zhou C">C Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Bm" uniqKey="Jones B">BM Jones</name></author><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Wong, Pc" uniqKey="Wong P">PC Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, J" uniqKey="Shen J">J Shen</name></author><author><name sortKey="Liang, Bl" uniqKey="Liang B">BL Liang</name></author><author><name sortKey="Zeng, Qs" uniqKey="Zeng Q">QS Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffith, Jf" uniqKey="Griffith J">JF Griffith</name></author><author><name sortKey="Antonio, Ge" uniqKey="Antonio G">GE Antonio</name></author><author><name sortKey="Kumta, Sm" uniqKey="Kumta S">SM Kumta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author><author><name sortKey="Wang, Sx" uniqKey="Wang S">SX Wang</name></author><author><name sortKey="Gao, Hs" uniqKey="Gao H">HS Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, N" uniqKey="Hong N">N Hong</name></author><author><name sortKey="Du, Xk" uniqKey="Du X">XK Du</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chest</journal-id><journal-id journal-id-type="iso-abbrev">Chest</journal-id><journal-title-group><journal-title>Chest</journal-title></journal-title-group><issn pub-type="ppub">0012-3692</issn><issn pub-type="epub">1931-3543</issn><publisher><publisher-name>The American College of Chest Physicians. Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16778260</article-id><article-id pub-id-type="pmc">7094735</article-id><article-id pub-id-type="publisher-id">S0012-3692(15)50745-9</article-id><article-id pub-id-type="doi">10.1378/chest.129.6.1441</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Treatment of Severe Acute Respiratory Syndrome With Glucosteroids</article-title><subtitle>The Guangzhou Experience</subtitle></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Chen</surname><given-names>Rong-chang</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au20"><name><surname>Tang</surname><given-names>Xiao-ping</given-names></name><degrees>MD</degrees><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au30"><name><surname>Tan</surname><given-names>Shou-yong</given-names></name><degrees>MD</degrees><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au40"><name><surname>Liang</surname><given-names>Bi-ling</given-names></name><degrees>MD</degrees><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au50"><name><surname>Wan</surname><given-names>Zhuo-yue</given-names></name><degrees>MD</degrees><xref rid="aff5" ref-type="aff">e</xref></contrib><contrib contrib-type="author" id="au60"><name><surname>Fang</surname><given-names>Ji-qian</given-names></name><degrees>PhD</degrees><xref rid="aff6" ref-type="aff">f</xref></contrib><contrib contrib-type="author" id="au70"><name><surname>Zhong</surname><given-names>Nanshan</given-names></name><degrees>MD</degrees><email>nanshan@vip.163.com</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou</aff><aff id="aff2"><label>b</label>Guangzhou Municipal Hospital of Infective Disease, Guangzhou</aff><aff id="aff3"><label>c</label>Guangzhou Chest Hospital, Guangzhou</aff><aff id="aff4"><label>d</label>Second Affiliated Hospital of Zhongshan University, Guangzhou</aff><aff id="aff5"><label>e</label>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</aff><aff id="aff6"><label>f</label>Zhongshan University School of Public Health, Guangzhou, China</aff><author-notes><corresp id="cor1"><label>*</label>Guangzhou Institute of Respiratory Diseases, 151 Yanjiang Rd, Guangzhou, China 510120 <email>nanshan@vip.163.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>25</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2015</year></pub-date><volume>129</volume><issue>6</issue><fpage>1441</fpage><lpage>1452</lpage><history><date date-type="received"><day>19</day><month>6</month><year>2005</year></date><date date-type="accepted"><day>19</day><month>6</month><year>2005</year></date></history><permissions><copyright-statement>© 2006 The American College of Chest Physicians</copyright-statement><copyright-year>2006</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ceab10"><sec><title>Study objective</title><p>To investigate the efficacy and safety profiles of corticosteroid therapy in severe acute respiratory syndrome (SARS) patients.</p></sec><sec><title>Design</title><p>Four hundred one of 1,278 SARS cases treated in Guangzhou China between December 2002 and June 2003 fulfilled the diagnostic criteria issued by the World Health Organization for confirmed identification of SARS. Among them, the diagnosis of critical SARS was defined by criteria of SARS guidelines incorporated with a low oxygenation index (OI) [< 300 mm Hg]. Data of these patients retrieved from a database were retrospectively analyzed by logistic regression and Cox regression for the effect of corticosteroid therapy on death, hospitalization days, and complication presentation.</p></sec><sec><title>Results</title><p>Among the 401 SARS patients studied, 147 of 249 noncritical patients (59.0%) received corticosteroids (mean daily dose, 105.3 ± 86.1 mg) [± SD], and all survived the disease; 121 of 152 critical patients (79.6%) received corticosteroids at a mean daily dose of 133.5 ± 102.3 mg, and 25 died. Analysis of these 401 confirmed cases did not show any benefits of corticosteroid on the death rate and hospitalization days. However, when focused on 152 critical SARS cases, factors correlated with these end points indicated by univariate analysis included use of corticosteroid, age, rigor at onset, secondary respiratory infections, pulmonary rales, grading of OI, and use of invasive ventilation. After adjustment for possible confounders, treatment with corticosteroid was shown contributing to lower overall mortality, instant mortality, and shorter hospitalization stay (p < 0.05). Incidence of complications was significantly associated with the need for invasive ventilation but not with use of corticosteroids.</p></sec><sec><title>Conclusion</title><p>This Guangzhou retrospective study revealed that proper use of corticosteroid in confirmed critical SARS resulted in lowered mortality and shorter hospitalization stay, and was not associated with significant secondary lower respiratory infection and other complications.</p></sec></abstract><kwd-group id="cekeyws10"><title>Key words</title><kwd>complication</kwd><kwd>corticosteroid</kwd><kwd>mortality</kwd><kwd>SARS</kwd></kwd-group><kwd-group id="cekeyws20"><title>Abbreviations</title><kwd>ALI, acute lung injury</kwd><kwd>AVN, avascular osteonecrosis</kwd><kwd>CI, confidence interval</kwd><kwd>IL, interleukin</kwd><kwd>IP-10, interferon-inducible protein 10</kwd><kwd>OI, oxygenation index</kwd><kwd>OR, odds ratio</kwd><kwd>PCR, polymerase chain reaction</kwd><kwd>SARS, severe acute respiratory syndrome</kwd><kwd>SARS-CoV, severe acute respiratory syndrome coronavirus</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Chen, Rong Chang" sort="Chen, Rong Chang" uniqKey="Chen R" first="Rong-Chang" last="Chen">Rong-Chang Chen</name></region><name sortKey="Fang, Ji Qian" sort="Fang, Ji Qian" uniqKey="Fang J" first="Ji-Qian" last="Fang">Ji-Qian Fang</name><name sortKey="Liang, Bi Ling" sort="Liang, Bi Ling" uniqKey="Liang B" first="Bi-Ling" last="Liang">Bi-Ling Liang</name><name sortKey="Tan, Shou Yong" sort="Tan, Shou Yong" uniqKey="Tan S" first="Shou-Yong" last="Tan">Shou-Yong Tan</name><name sortKey="Tang, Xiao Ping" sort="Tang, Xiao Ping" uniqKey="Tang X" first="Xiao-Ping" last="Tang">Xiao-Ping Tang</name><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001022 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001022 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7094735
|texte= Treatment of Severe Acute Respiratory Syndrome With Glucosteroids
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:16778260" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |