Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
Identifieur interne : 000F61 ( Pmc/Checkpoint ); précédent : 000F60; suivant : 000F62Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
Auteurs : Seraphin Kuate [Allemagne] ; Jindrich Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne] ; Klaus Überla [Allemagne]Source :
- Virology [ 0042-6822 ] ; 2007.
Abstract
Infection with the SARS-associated coronavirus (SARS-CoV) induces an atypical pulmonary disease with a high lethality rate. Although the initial SARS epidemic was contained, sporadic outbreaks of the disease still occur, suggesting a continuous need for a vaccine against this virus. We therefore explored exosome-based vaccines containing the spike S proteins of SARS-CoV. S-containing exosomes were obtained by replacing the transmembrane and cytoplasmic domains of the S protein by those of VSV-G. The immunogenicity and efficacy of the S-containing exosomes were tested in mice and compared to an adenoviral vector vaccine expressing the S protein. Both, S-containing exosomes and the adenoviral vector vaccine induced neutralizing antibody titers. After priming with the SARS-S exosomal vaccine and boosting with the adenoviral vector the neutralizing antibody titers exceeded those observed in the convalescent serum of a SARS patient. Both approaches were effective in a SARS-S-expressing tumor challenge model and thus warrant further investigation.
Url:
DOI: 10.1016/j.virol.2006.12.011
PubMed: 17258782
PubMed Central: 7103344
Affiliations:
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PMC:7103344Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Infection with the SARS-associated coronavirus (SARS-CoV) induces an atypical pulmonary disease with a high lethality rate. Although the initial SARS epidemic was contained, sporadic outbreaks of the disease still occur, suggesting a continuous need for a vaccine against this virus. We therefore explored exosome-based vaccines containing the spike S proteins of SARS-CoV. S-containing exosomes were obtained by replacing the transmembrane and cytoplasmic domains of the S protein by those of VSV-G. The immunogenicity and efficacy of the S-containing exosomes were tested in mice and compared to an adenoviral vector vaccine expressing the S protein. Both, S-containing exosomes and the adenoviral vector vaccine induced neutralizing antibody titers. After priming with the SARS-S exosomal vaccine and boosting with the adenoviral vector the neutralizing antibody titers exceeded those observed in the convalescent serum of a SARS patient. Both approaches were effective in a SARS-S-expressing tumor challenge model and thus warrant further investigation.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Admyre, C" uniqKey="Admyre C">C. Admyre</name>
</author>
<author><name sortKey="Grunewald, J" uniqKey="Grunewald J">J. Grunewald</name>
</author>
<author><name sortKey="Thyberg, J" uniqKey="Thyberg J">J. Thyberg</name>
</author>
<author><name sortKey="Gripenback, S" uniqKey="Gripenback S">S. Gripenback</name>
</author>
<author><name sortKey="Tornling, G" uniqKey="Tornling G">G. Tornling</name>
</author>
<author><name sortKey="Eklund, A" uniqKey="Eklund A">A. Eklund</name>
</author>
<author><name sortKey="Scheynius, A" uniqKey="Scheynius A">A. Scheynius</name>
</author>
<author><name sortKey="Gabrielsson, S" uniqKey="Gabrielsson S">S. Gabrielsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersson, A M" uniqKey="Andersson A">A.M. Andersson</name>
</author>
<author><name sortKey="Melin, L" uniqKey="Melin L">L. Melin</name>
</author>
<author><name sortKey="Bean, A" uniqKey="Bean A">A. Bean</name>
</author>
<author><name sortKey="Pettersson, R F" uniqKey="Pettersson R">R.F. Pettersson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Andersen, M" uniqKey="Andersen M">M. Andersen</name>
</author>
<author><name sortKey="Wolfers, J" uniqKey="Wolfers J">J. Wolfers</name>
</author>
<author><name sortKey="Lozier, A" uniqKey="Lozier A">A. Lozier</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Serra, V" uniqKey="Serra V">V. Serra</name>
</author>
<author><name sortKey="Ruegg, C" uniqKey="Ruegg C">C. Ruegg</name>
</author>
<author><name sortKey="Flament, C" uniqKey="Flament C">C. Flament</name>
</author>
<author><name sortKey="Angevin, E" uniqKey="Angevin E">E. Angevin</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Schartz, N E" uniqKey="Schartz N">N.E. Schartz</name>
</author>
<author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Flament, C" uniqKey="Flament C">C. Flament</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
<author><name sortKey="Angevin, E" uniqKey="Angevin E">E. Angevin</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Schartz, N E" uniqKey="Schartz N">N.E. Schartz</name>
</author>
<author><name sortKey="Flament, C" uniqKey="Flament C">C. Flament</name>
</author>
<author><name sortKey="Aubert, N" uniqKey="Aubert N">N. Aubert</name>
</author>
<author><name sortKey="Bernard, J" uniqKey="Bernard J">J. Bernard</name>
</author>
<author><name sortKey="Lemonnier, F" uniqKey="Lemonnier F">F. Lemonnier</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Escudier, B" uniqKey="Escudier B">B. Escudier</name>
</author>
<author><name sortKey="Hsu, D H" uniqKey="Hsu D">D.H. Hsu</name>
</author>
<author><name sortKey="Tursz, T" uniqKey="Tursz T">T. Tursz</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
<author><name sortKey="Angevin, E" uniqKey="Angevin E">E. Angevin</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bangari, D S" uniqKey="Bangari D">D.S. Bangari</name>
</author>
<author><name sortKey="Mittal, S K" uniqKey="Mittal S">S.K. Mittal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barouch, D H" uniqKey="Barouch D">D.H. Barouch</name>
</author>
<author><name sortKey="Pau, M G" uniqKey="Pau M">M.G. Pau</name>
</author>
<author><name sortKey="Custers, J H" uniqKey="Custers J">J.H. Custers</name>
</author>
<author><name sortKey="Koudstaal, W" uniqKey="Koudstaal W">W. Koudstaal</name>
</author>
<author><name sortKey="Kostense, S" uniqKey="Kostense S">S. Kostense</name>
</author>
<author><name sortKey="Havenga, M J" uniqKey="Havenga M">M.J. Havenga</name>
</author>
<author><name sortKey="Truitt, D M" uniqKey="Truitt D">D.M. Truitt</name>
</author>
<author><name sortKey="Sumida, S M" uniqKey="Sumida S">S.M. Sumida</name>
</author>
<author><name sortKey="Kishko, M G" uniqKey="Kishko M">M.G. Kishko</name>
</author>
<author><name sortKey="Arthur, J C" uniqKey="Arthur J">J.C. Arthur</name>
</author>
<author><name sortKey="Korioth Schmitz, B" uniqKey="Korioth Schmitz B">B. Korioth-Schmitz</name>
</author>
<author><name sortKey="Newberg, M H" uniqKey="Newberg M">M.H. Newberg</name>
</author>
<author><name sortKey="Gorgone, D A" uniqKey="Gorgone D">D.A. Gorgone</name>
</author>
<author><name sortKey="Lifton, M A" uniqKey="Lifton M">M.A. Lifton</name>
</author>
<author><name sortKey="Panicali, D L" uniqKey="Panicali D">D.L. Panicali</name>
</author>
<author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name>
</author>
<author><name sortKey="Letvin, N L" uniqKey="Letvin N">N.L. Letvin</name>
</author>
<author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J. Goudsmit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonifaz, L C" uniqKey="Bonifaz L">L.C. Bonifaz</name>
</author>
<author><name sortKey="Bonnyay, D P" uniqKey="Bonnyay D">D.P. Bonnyay</name>
</author>
<author><name sortKey="Charalambous, A" uniqKey="Charalambous A">A. Charalambous</name>
</author>
<author><name sortKey="Darguste, D I" uniqKey="Darguste D">D.I. Darguste</name>
</author>
<author><name sortKey="Fujii, S" uniqKey="Fujii S">S. Fujii</name>
</author>
<author><name sortKey="Soares, H" uniqKey="Soares H">H. Soares</name>
</author>
<author><name sortKey="Brimnes, M K" uniqKey="Brimnes M">M.K. Brimnes</name>
</author>
<author><name sortKey="Moltedo, B" uniqKey="Moltedo B">B. Moltedo</name>
</author>
<author><name sortKey="Moran, T M" uniqKey="Moran T">T.M. Moran</name>
</author>
<author><name sortKey="Steinman, R M" uniqKey="Steinman R">R.M. Steinman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, D A" uniqKey="Brown D">D.A. Brown</name>
</author>
<author><name sortKey="Crise, B" uniqKey="Crise B">B. Crise</name>
</author>
<author><name sortKey="Rose, J K" uniqKey="Rose J">J.K. Rose</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M. Chan-Yeung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M. Chan-Yeung</name>
</author>
<author><name sortKey="Yu, W C" uniqKey="Yu W">W.C. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M. Chan-Yeung</name>
</author>
<author><name sortKey="Seto, W H" uniqKey="Seto W">W.H. Seto</name>
</author>
<author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chapple, S D J" uniqKey="Chapple S">S.D.J. Chapple</name>
</author>
<author><name sortKey="Jones, I M" uniqKey="Jones I">I.M. Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Schartz, N E" uniqKey="Schartz N">N.E. Schartz</name>
</author>
<author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Taieb, J" uniqKey="Taieb J">J. Taieb</name>
</author>
<author><name sortKey="Schartz, N" uniqKey="Schartz N">N. Schartz</name>
</author>
<author><name sortKey="Flament, C" uniqKey="Flament C">C. Flament</name>
</author>
<author><name sortKey="Novault, S" uniqKey="Novault S">S. Novault</name>
</author>
<author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Shao, C" uniqKey="Shao C">C. Shao</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y. Yu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X. Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clayton, A" uniqKey="Clayton A">A. Clayton</name>
</author>
<author><name sortKey="Turkes, A" uniqKey="Turkes A">A. Turkes</name>
</author>
<author><name sortKey="Navabi, H" uniqKey="Navabi H">H. Navabi</name>
</author>
<author><name sortKey="Mason, D M" uniqKey="Mason D">D.M. Mason</name>
</author>
<author><name sortKey="Tabi, Z" uniqKey="Tabi Z">Z. Tabi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Compton, T" uniqKey="Compton T">T. Compton</name>
</author>
<author><name sortKey="Ivanov, I E" uniqKey="Ivanov I">I.E. Ivanov</name>
</author>
<author><name sortKey="Gottlieb, T" uniqKey="Gottlieb T">T. Gottlieb</name>
</author>
<author><name sortKey="Rindler, M" uniqKey="Rindler M">M. Rindler</name>
</author>
<author><name sortKey="Adesnik, M" uniqKey="Adesnik M">M. Adesnik</name>
</author>
<author><name sortKey="Sabatini, D D" uniqKey="Sabatini D">D.D. Sabatini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delcayre, A" uniqKey="Delcayre A">A. Delcayre</name>
</author>
<author><name sortKey="Shu, H" uniqKey="Shu H">H. Shu</name>
</author>
<author><name sortKey="Le Pecq, J B" uniqKey="Le Pecq J">J.B. Le Pecq</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Denzer, K" uniqKey="Denzer K">K. Denzer</name>
</author>
<author><name sortKey="Van, E M" uniqKey="Van E">E.M. van</name>
</author>
<author><name sortKey="Kleijmeer, M J" uniqKey="Kleijmeer M">M.J. Kleijmeer</name>
</author>
<author><name sortKey="Jakobson, E" uniqKey="Jakobson E">E. Jakobson</name>
</author>
<author><name sortKey="De, G C" uniqKey="De G">G.C. de</name>
</author>
<author><name sortKey="Geuze, H J" uniqKey="Geuze H">H.J. Geuze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name>
</author>
<author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name>
</author>
<author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name>
</author>
<author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name>
</author>
<author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name>
</author>
<author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name>
</author>
<author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name>
</author>
<author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name>
</author>
<author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name>
</author>
<author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name>
</author>
<author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name>
</author>
<author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name>
</author>
<author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name>
</author>
<author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name>
</author>
<author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name>
</author>
<author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name>
</author>
<author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name>
</author>
<author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name>
</author>
<author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name>
</author>
<author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name>
</author>
<author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name>
</author>
<author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dubridge, R B" uniqKey="Dubridge R">R.B. DuBridge</name>
</author>
<author><name sortKey="Tang, P" uniqKey="Tang P">P. Tang</name>
</author>
<author><name sortKey="Hsia, H C" uniqKey="Hsia H">H.C. Hsia</name>
</author>
<author><name sortKey="Leong, P M" uniqKey="Leong P">P.M. Leong</name>
</author>
<author><name sortKey="Miller, J H" uniqKey="Miller J">J.H. Miller</name>
</author>
<author><name sortKey="Calos, M P" uniqKey="Calos M">M.P. Calos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name>
</author>
<author><name sortKey="Meyer, B E" uniqKey="Meyer B">B.E. Meyer</name>
</author>
<author><name sortKey="Simon, J H M" uniqKey="Simon J">J.H.M. Simon</name>
</author>
<author><name sortKey="Fischer, U" uniqKey="Fischer U">U. Fischer</name>
</author>
<author><name sortKey="Malim, M H" uniqKey="Malim M">M.H. Malim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giroglou, T" uniqKey="Giroglou T">T. Giroglou</name>
</author>
<author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name>
</author>
<author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Schwalbe, H" uniqKey="Schwalbe H">H. Schwalbe</name>
</author>
<author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name>
</author>
<author><name sortKey="Von Laer, D" uniqKey="Von Laer D">D. von Laer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hart, K C" uniqKey="Hart K">K.C. Hart</name>
</author>
<author><name sortKey="Xu, Y F" uniqKey="Xu Y">Y.F. Xu</name>
</author>
<author><name sortKey="Meyer, A N" uniqKey="Meyer A">A.N. Meyer</name>
</author>
<author><name sortKey="Lee, B A" uniqKey="Lee B">B.A. Lee</name>
</author>
<author><name sortKey="Donoghue, D J" uniqKey="Donoghue D">D.J. Donoghue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, T C" uniqKey="He T">T.C. He</name>
</author>
<author><name sortKey="Zhou, S B" uniqKey="Zhou S">S.B. Zhou</name>
</author>
<author><name sortKey="Da Costa, L T" uniqKey="Da Costa L">L.T. da Costa</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name>
</author>
<author><name sortKey="Kinzler, K W" uniqKey="Kinzler K">K.W. Kinzler</name>
</author>
<author><name sortKey="Vogelstein, B" uniqKey="Vogelstein B">B. Vogelstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemler, M E" uniqKey="Hemler M">M.E. Hemler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ho, A S" uniqKey="Ho A">A.S. Ho</name>
</author>
<author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name>
</author>
<author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M. Chan-Yeung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H. Hofmann</name>
</author>
<author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S. Pohlmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H. Hofmann</name>
</author>
<author><name sortKey="Hattermann, K" uniqKey="Hattermann K">K. Hattermann</name>
</author>
<author><name sortKey="Marzi, A" uniqKey="Marzi A">A. Marzi</name>
</author>
<author><name sortKey="Gramberg, T" uniqKey="Gramberg T">T. Gramberg</name>
</author>
<author><name sortKey="Geier, M" uniqKey="Geier M">M. Geier</name>
</author>
<author><name sortKey="Krumbiegel, M" uniqKey="Krumbiegel M">M. Krumbiegel</name>
</author>
<author><name sortKey="Kuate, S" uniqKey="Kuate S">S. Kuate</name>
</author>
<author><name sortKey="Uberla, K" uniqKey="Uberla K">K. Uberla</name>
</author>
<author><name sortKey="Niedrig, M" uniqKey="Niedrig M">M. Niedrig</name>
</author>
<author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S. Pohlmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jeffers, S A" uniqKey="Jeffers S">S.A. Jeffers</name>
</author>
<author><name sortKey="Tusell, S M" uniqKey="Tusell S">S.M. Tusell</name>
</author>
<author><name sortKey="Gillim Ross, L" uniqKey="Gillim Ross L">L. Gillim-Ross</name>
</author>
<author><name sortKey="Hemmila, E M" uniqKey="Hemmila E">E.M. Hemmila</name>
</author>
<author><name sortKey="Achenbach, J E" uniqKey="Achenbach J">J.E. Achenbach</name>
</author>
<author><name sortKey="Babcock, G J" uniqKey="Babcock G">G.J. Babcock</name>
</author>
<author><name sortKey="Thomas, W D" uniqKey="Thomas W">W.D. Thomas</name>
</author>
<author><name sortKey="Thackray, L B" uniqKey="Thackray L">L.B. Thackray</name>
</author>
<author><name sortKey="Young, M D" uniqKey="Young M">M.D. Young</name>
</author>
<author><name sortKey="Mason, R J" uniqKey="Mason R">R.J. Mason</name>
</author>
<author><name sortKey="Ambrosino, D M" uniqKey="Ambrosino D">D.M. Ambrosino</name>
</author>
<author><name sortKey="Wentworth, D E" uniqKey="Wentworth D">D.E. Wentworth</name>
</author>
<author><name sortKey="Demartini, J C" uniqKey="Demartini J">J.C. DeMartini</name>
</author>
<author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y. Jin</name>
</author>
<author><name sortKey="Wright, S E" uniqKey="Wright S">S.E. Wright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Keng, C T" uniqKey="Keng C">C.T. Keng</name>
</author>
<author><name sortKey="Zhang, A" uniqKey="Zhang A">A. Zhang</name>
</author>
<author><name sortKey="Shen, S" uniqKey="Shen S">S. Shen</name>
</author>
<author><name sortKey="Lip, K M" uniqKey="Lip K">K.M. Lip</name>
</author>
<author><name sortKey="Fielding, B C" uniqKey="Fielding B">B.C. Fielding</name>
</author>
<author><name sortKey="Tan, T H P" uniqKey="Tan T">T.H.P. Tan</name>
</author>
<author><name sortKey="Chou, C F" uniqKey="Chou C">C.F. Chou</name>
</author>
<author><name sortKey="Loh, C B" uniqKey="Loh C">C.B. Loh</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Fu, J" uniqKey="Fu J">J. Fu</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Lim, S G" uniqKey="Lim S">S.G. Lim</name>
</author>
<author><name sortKey="Hong, W" uniqKey="Hong W">W. Hong</name>
</author>
<author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuate, S" uniqKey="Kuate S">S. Kuate</name>
</author>
<author><name sortKey="Stefanou, D" uniqKey="Stefanou D">D. Stefanou</name>
</author>
<author><name sortKey="Hoffmann, D" uniqKey="Hoffmann D">D. Hoffmann</name>
</author>
<author><name sortKey="Wildner, O" uniqKey="Wildner O">O. Wildner</name>
</author>
<author><name sortKey="Uberla, K" uniqKey="Uberla K">K. Uberla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuate, S" uniqKey="Kuate S">S. Kuate</name>
</author>
<author><name sortKey="Stahl Hennig, C" uniqKey="Stahl Hennig C">C. Stahl-Hennig</name>
</author>
<author><name sortKey="Stoiber, H" uniqKey="Stoiber H">H. Stoiber</name>
</author>
<author><name sortKey="Nchinda, G" uniqKey="Nchinda G">G. Nchinda</name>
</author>
<author><name sortKey="Floto, A" uniqKey="Floto A">A. Floto</name>
</author>
<author><name sortKey="Franz, M" uniqKey="Franz M">M. Franz</name>
</author>
<author><name sortKey="Sauermann, U" uniqKey="Sauermann U">U. Sauermann</name>
</author>
<author><name sortKey="Bredl, S" uniqKey="Bredl S">S. Bredl</name>
</author>
<author><name sortKey="Deml, L" uniqKey="Deml L">L. Deml</name>
</author>
<author><name sortKey="Ignatius, R" uniqKey="Ignatius R">R. Ignatius</name>
</author>
<author><name sortKey="Norley, S" uniqKey="Norley S">S. Norley</name>
</author>
<author><name sortKey="Racz, P" uniqKey="Racz P">P. Racz</name>
</author>
<author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K. Tenner-Racz</name>
</author>
<author><name sortKey="Steinman, R M" uniqKey="Steinman R">R.M. Steinman</name>
</author>
<author><name sortKey="Wagner, R" uniqKey="Wagner R">R. Wagner</name>
</author>
<author><name sortKey="Uberla, K" uniqKey="Uberla K">K. Uberla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W H" uniqKey="Li W">W.H. Li</name>
</author>
<author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name>
</author>
<author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N. Vasilieva</name>
</author>
<author><name sortKey="Sui, J H" uniqKey="Sui J">J.H. Sui</name>
</author>
<author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name>
</author>
<author><name sortKey="Berne, M A" uniqKey="Berne M">M.A. Berne</name>
</author>
<author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M. Somasundaran</name>
</author>
<author><name sortKey="Sullivan, J L" uniqKey="Sullivan J">J.L. Sullivan</name>
</author>
<author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K. Luzuriaga</name>
</author>
<author><name sortKey="Greenough, T C" uniqKey="Greenough T">T.C. Greenough</name>
</author>
<author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name>
</author>
<author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name>
</author>
<author><name sortKey="Jones, S J M" uniqKey="Jones S">S.J.M. Jones</name>
</author>
<author><name sortKey="Astell, C R" uniqKey="Astell C">C.R. Astell</name>
</author>
<author><name sortKey="Holt, R A" uniqKey="Holt R">R.A. Holt</name>
</author>
<author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A. Brooks-Wilson</name>
</author>
<author><name sortKey="Butterfield, Y S N" uniqKey="Butterfield Y">Y.S.N. Butterfield</name>
</author>
<author><name sortKey="Khattra, J" uniqKey="Khattra J">J. Khattra</name>
</author>
<author><name sortKey="Asano, J K" uniqKey="Asano J">J.K. Asano</name>
</author>
<author><name sortKey="Barber, S A" uniqKey="Barber S">S.A. Barber</name>
</author>
<author><name sortKey="Chan, S Y" uniqKey="Chan S">S.Y. Chan</name>
</author>
<author><name sortKey="Cloutier, A" uniqKey="Cloutier A">A. Cloutier</name>
</author>
<author><name sortKey="Coughlin, S M" uniqKey="Coughlin S">S.M. Coughlin</name>
</author>
<author><name sortKey="Freeman, D" uniqKey="Freeman D">D. Freeman</name>
</author>
<author><name sortKey="Girn, N" uniqKey="Girn N">N. Girn</name>
</author>
<author><name sortKey="Griffin, O L" uniqKey="Griffin O">O.L. Griffin</name>
</author>
<author><name sortKey="Leach, S R" uniqKey="Leach S">S.R. Leach</name>
</author>
<author><name sortKey="Mayo, M" uniqKey="Mayo M">M. Mayo</name>
</author>
<author><name sortKey="Mcdonald, H" uniqKey="Mcdonald H">H. McDonald</name>
</author>
<author><name sortKey="Montgomery, S B" uniqKey="Montgomery S">S.B. Montgomery</name>
</author>
<author><name sortKey="Pandoh, P K" uniqKey="Pandoh P">P.K. Pandoh</name>
</author>
<author><name sortKey="Petrescu, A S" uniqKey="Petrescu A">A.S. Petrescu</name>
</author>
<author><name sortKey="Robertson, A G" uniqKey="Robertson A">A.G. Robertson</name>
</author>
<author><name sortKey="Schein, J E" uniqKey="Schein J">J.E. Schein</name>
</author>
<author><name sortKey="Siddiqui, A" uniqKey="Siddiqui A">A. Siddiqui</name>
</author>
<author><name sortKey="Smailus, D E" uniqKey="Smailus D">D.E. Smailus</name>
</author>
<author><name sortKey="Stott, J E" uniqKey="Stott J">J.E. Stott</name>
</author>
<author><name sortKey="Yang, G S" uniqKey="Yang G">G.S. Yang</name>
</author>
<author><name sortKey="Plummer, F" uniqKey="Plummer F">F. Plummer</name>
</author>
<author><name sortKey="Andonov, A" uniqKey="Andonov A">A. Andonov</name>
</author>
<author><name sortKey="Artsob, H" uniqKey="Artsob H">H. Artsob</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N. Bastien</name>
</author>
<author><name sortKey="Bernard, K" uniqKey="Bernard K">K. Bernard</name>
</author>
<author><name sortKey="Booth, T F" uniqKey="Booth T">T.F. Booth</name>
</author>
<author><name sortKey="Bowness, D" uniqKey="Bowness D">D. Bowness</name>
</author>
<author><name sortKey="Czub, M" uniqKey="Czub M">M. Czub</name>
</author>
<author><name sortKey="Drebot, M" uniqKey="Drebot M">M. Drebot</name>
</author>
<author><name sortKey="Fernando, L" uniqKey="Fernando L">L. Fernando</name>
</author>
<author><name sortKey="Flick, R" uniqKey="Flick R">R. Flick</name>
</author>
<author><name sortKey="Garbutt, M" uniqKey="Garbutt M">M. Garbutt</name>
</author>
<author><name sortKey="Gray, M" uniqKey="Gray M">M. Gray</name>
</author>
<author><name sortKey="Grolla, A" uniqKey="Grolla A">A. Grolla</name>
</author>
<author><name sortKey="Jones, S" uniqKey="Jones S">S. Jones</name>
</author>
<author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name>
</author>
<author><name sortKey="Meyers, A" uniqKey="Meyers A">A. Meyers</name>
</author>
<author><name sortKey="Kabani, A" uniqKey="Kabani A">A. Kabani</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Normand, S" uniqKey="Normand S">S. Normand</name>
</author>
<author><name sortKey="Stroher, U" uniqKey="Stroher U">U. Stroher</name>
</author>
<author><name sortKey="Tipples, G A" uniqKey="Tipples G">G.A. Tipples</name>
</author>
<author><name sortKey="Tyler, S" uniqKey="Tyler S">S. Tyler</name>
</author>
<author><name sortKey="Vogrig, R" uniqKey="Vogrig R">R. Vogrig</name>
</author>
<author><name sortKey="Ward, D" uniqKey="Ward D">D. Ward</name>
</author>
<author><name sortKey="Watson, B" uniqKey="Watson B">B. Watson</name>
</author>
<author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C. Brunham</name>
</author>
<author><name sortKey="Krajden, M" uniqKey="Krajden M">M. Krajden</name>
</author>
<author><name sortKey="Petric, M" uniqKey="Petric M">M. Petric</name>
</author>
<author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name>
</author>
<author><name sortKey="Upton, C" uniqKey="Upton C">C. Upton</name>
</author>
<author><name sortKey="Roper, R L" uniqKey="Roper R">R.L. Roper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsac, D" uniqKey="Marsac D">D. Marsac</name>
</author>
<author><name sortKey="Loirat, D" uniqKey="Loirat D">D. Loirat</name>
</author>
<author><name sortKey="Petit, C" uniqKey="Petit C">C. Petit</name>
</author>
<author><name sortKey="Schwartz, O" uniqKey="Schwartz O">O. Schwartz</name>
</author>
<author><name sortKey="Michel, M L" uniqKey="Michel M">M.L. Michel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcqueen, N" uniqKey="Mcqueen N">N. McQueen</name>
</author>
<author><name sortKey="Nayak, D P" uniqKey="Nayak D">D.P. Nayak</name>
</author>
<author><name sortKey="Stephens, E B" uniqKey="Stephens E">E.B. Stephens</name>
</author>
<author><name sortKey="Compans, R W" uniqKey="Compans R">R.W. Compans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mears, R" uniqKey="Mears R">R. Mears</name>
</author>
<author><name sortKey="Craven, R A" uniqKey="Craven R">R.A. Craven</name>
</author>
<author><name sortKey="Hanrahan, S" uniqKey="Hanrahan S">S. Hanrahan</name>
</author>
<author><name sortKey="Totty, N" uniqKey="Totty N">N. Totty</name>
</author>
<author><name sortKey="Upton, C" uniqKey="Upton C">C. Upton</name>
</author>
<author><name sortKey="Young, S L" uniqKey="Young S">S.L. Young</name>
</author>
<author><name sortKey="Patel, P" uniqKey="Patel P">P. Patel</name>
</author>
<author><name sortKey="Selby, P J" uniqKey="Selby P">P.J. Selby</name>
</author>
<author><name sortKey="Banks, R E" uniqKey="Banks R">R.E. Banks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mittereder, N" uniqKey="Mittereder N">N. Mittereder</name>
</author>
<author><name sortKey="March, K L" uniqKey="March K">K.L. March</name>
</author>
<author><name sortKey="Trapnell, B C" uniqKey="Trapnell B">B.C. Trapnell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miyoshi, H" uniqKey="Miyoshi H">H. Miyoshi</name>
</author>
<author><name sortKey="Blomer, U" uniqKey="Blomer U">U. Blomer</name>
</author>
<author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M. Takahashi</name>
</author>
<author><name sortKey="Gage, F H" uniqKey="Gage F">F.H. Gage</name>
</author>
<author><name sortKey="Verma, I M" uniqKey="Verma I">I.M. Verma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Owens, R J" uniqKey="Owens R">R.J. Owens</name>
</author>
<author><name sortKey="Rose, J K" uniqKey="Rose J">J.K. Rose</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peche, H" uniqKey="Peche H">H. Peche</name>
</author>
<author><name sortKey="Heslan, M" uniqKey="Heslan M">M. Heslan</name>
</author>
<author><name sortKey="Usal, C" uniqKey="Usal C">C. Usal</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
<author><name sortKey="Cuturi, M C" uniqKey="Cuturi M">M.C. Cuturi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name>
</author>
<author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name>
</author>
<author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name>
</author>
<author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name>
</author>
<author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name>
</author>
<author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R. Campagnoli</name>
</author>
<author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name>
</author>
<author><name sortKey="Penaranda, S" uniqKey="Penaranda S">S. Penaranda</name>
</author>
<author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B. Bankamp</name>
</author>
<author><name sortKey="Maher, K" uniqKey="Maher K">K. Maher</name>
</author>
<author><name sortKey="Chen, M H" uniqKey="Chen M">M.H. Chen</name>
</author>
<author><name sortKey="Tong, S X" uniqKey="Tong S">S.X. Tong</name>
</author>
<author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name>
</author>
<author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name>
</author>
<author><name sortKey="Frace, M" uniqKey="Frace M">M. Frace</name>
</author>
<author><name sortKey="Derisi, J L" uniqKey="Derisi J">J.L. Derisi</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name>
</author>
<author><name sortKey="Peret, T C T" uniqKey="Peret T">T.C.T. Peret</name>
</author>
<author><name sortKey="Burns, C" uniqKey="Burns C">C. Burns</name>
</author>
<author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name>
</author>
<author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name>
</author>
<author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name>
</author>
<author><name sortKey="Liffick, S" uniqKey="Liffick S">S. Liffick</name>
</author>
<author><name sortKey="Holloway, B" uniqKey="Holloway B">B. Holloway</name>
</author>
<author><name sortKey="Limor, J" uniqKey="Limor J">J. Limor</name>
</author>
<author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K. McCaustland</name>
</author>
<author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M. Olsen-Rasmussen</name>
</author>
<author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name>
</author>
<author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name>
</author>
<author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name>
</author>
<author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sandrin, V" uniqKey="Sandrin V">V. Sandrin</name>
</author>
<author><name sortKey="Muriaux, D" uniqKey="Muriaux D">D. Muriaux</name>
</author>
<author><name sortKey="Darlix, J L" uniqKey="Darlix J">J.L. Darlix</name>
</author>
<author><name sortKey="Cosset, F L" uniqKey="Cosset F">F.L. Cosset</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schartz, N E" uniqKey="Schartz N">N.E. Schartz</name>
</author>
<author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Andre, F" uniqKey="Andre F">F. Andre</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schnell, T" uniqKey="Schnell T">T. Schnell</name>
</author>
<author><name sortKey="Foley, P" uniqKey="Foley P">P. Foley</name>
</author>
<author><name sortKey="Wirth, M" uniqKey="Wirth M">M. Wirth</name>
</author>
<author><name sortKey="Munch, J" uniqKey="Munch J">J. Munch</name>
</author>
<author><name sortKey="Uberla, K" uniqKey="Uberla K">K. Uberla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Southgate, C" uniqKey="Southgate C">C. Southgate</name>
</author>
<author><name sortKey="Zapp, M L" uniqKey="Zapp M">M.L. Zapp</name>
</author>
<author><name sortKey="Green, M R" uniqKey="Green M">M.R. Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spiga, O" uniqKey="Spiga O">O. Spiga</name>
</author>
<author><name sortKey="Bernini, A" uniqKey="Bernini A">A. Bernini</name>
</author>
<author><name sortKey="Ciutti, A" uniqKey="Ciutti A">A. Ciutti</name>
</author>
<author><name sortKey="Chiellini, S" uniqKey="Chiellini S">S. Chiellini</name>
</author>
<author><name sortKey="Menciassi, N" uniqKey="Menciassi N">N. Menciassi</name>
</author>
<author><name sortKey="Finetti, F" uniqKey="Finetti F">F. Finetti</name>
</author>
<author><name sortKey="Causarono, V" uniqKey="Causarono V">V. Causarono</name>
</author>
<author><name sortKey="Anselmi, F" uniqKey="Anselmi F">F. Anselmi</name>
</author>
<author><name sortKey="Prischi, F" uniqKey="Prischi F">F. Prischi</name>
</author>
<author><name sortKey="Niccolai, N" uniqKey="Niccolai N">N. Niccolai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taieb, J" uniqKey="Taieb J">J. Taieb</name>
</author>
<author><name sortKey="Chaput, N" uniqKey="Chaput N">N. Chaput</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wagner, R" uniqKey="Wagner R">R. Wagner</name>
</author>
<author><name sortKey="Graf, M" uniqKey="Graf M">M. Graf</name>
</author>
<author><name sortKey="Bieler, K" uniqKey="Bieler K">K. Bieler</name>
</author>
<author><name sortKey="Wolf, H" uniqKey="Wolf H">H. Wolf</name>
</author>
<author><name sortKey="Grunwald, T" uniqKey="Grunwald T">T. Grunwald</name>
</author>
<author><name sortKey="Foley, P" uniqKey="Foley P">P. Foley</name>
</author>
<author><name sortKey="Uberla, K" uniqKey="Uberla K">K. Uberla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y D" uniqKey="Wang Y">Y.D. Wang</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Xu, G B" uniqKey="Xu G">G.B. Xu</name>
</author>
<author><name sortKey="Dong, X Y" uniqKey="Dong X">X.Y. Dong</name>
</author>
<author><name sortKey="Yang, X A" uniqKey="Yang X">X.A. Yang</name>
</author>
<author><name sortKey="Feng, Z R" uniqKey="Feng Z">Z.R. Feng</name>
</author>
<author><name sortKey="Tian, C" uniqKey="Tian C">C. Tian</name>
</author>
<author><name sortKey="Chen, W F" uniqKey="Chen W">W.F. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wubbolts, R" uniqKey="Wubbolts R">R. Wubbolts</name>
</author>
<author><name sortKey="Leckie, R S" uniqKey="Leckie R">R.S. Leckie</name>
</author>
<author><name sortKey="Veenhuizen, P T M" uniqKey="Veenhuizen P">P.T.M. Veenhuizen</name>
</author>
<author><name sortKey="Schwarzmann, G" uniqKey="Schwarzmann G">G. Schwarzmann</name>
</author>
<author><name sortKey="Mobius, W" uniqKey="Mobius W">W. Möbius</name>
</author>
<author><name sortKey="Hoernschemeyer, J" uniqKey="Hoernschemeyer J">J. Hoernschemeyer</name>
</author>
<author><name sortKey="Slot, J W" uniqKey="Slot J">J.W. Slot</name>
</author>
<author><name sortKey="Geuze, H J" uniqKey="Geuze H">H.J. Geuze</name>
</author>
<author><name sortKey="Stoorvogel, W" uniqKey="Stoorvogel W">W. Stoorvogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name>
</author>
<author><name sortKey="Wyatt, L S" uniqKey="Wyatt L">L.S. Wyatt</name>
</author>
<author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name>
</author>
<author><name sortKey="Moodie, Z" uniqKey="Moodie Z">Z. Moodie</name>
</author>
<author><name sortKey="Moss, B" uniqKey="Moss B">B. Moss</name>
</author>
<author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name>
</author>
<author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name>
</author>
<author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name>
</author>
<author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name>
</author>
<author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name>
</author>
<author><name sortKey="Chow, K Y C" uniqKey="Chow K">K.Y.C. Chow</name>
</author>
<author><name sortKey="Hon, C C" uniqKey="Hon C">C.C. Hon</name>
</author>
<author><name sortKey="Law, K M" uniqKey="Law K">K.M. Law</name>
</author>
<author><name sortKey="Yip, C W" uniqKey="Yip C">C.W. Yip</name>
</author>
<author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name>
</author>
<author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name>
</author>
<author><name sortKey="Leung, F C C" uniqKey="Leung F">F.C.C. Leung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
<author><name sortKey="Regnault, A" uniqKey="Regnault A">A. Regnault</name>
</author>
<author><name sortKey="Lozier, A" uniqKey="Lozier A">A. Lozier</name>
</author>
<author><name sortKey="Wolfers, J" uniqKey="Wolfers J">J. Wolfers</name>
</author>
<author><name sortKey="Flament, C" uniqKey="Flament C">C. Flament</name>
</author>
<author><name sortKey="Tenza, D" uniqKey="Tenza D">D. Tenza</name>
</author>
<author><name sortKey="Ricciardi Castagnoli, P" uniqKey="Ricciardi Castagnoli P">P. Ricciardi-Castagnoli</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher><publisher-name>Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17258782</article-id>
<article-id pub-id-type="pmc">7103344</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(06)00898-1</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2006.12.011</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kuate</surname>
<given-names>Seraphin</given-names>
</name>
<email>Seraphin.Kuate@rub.de</email>
<email>sekuate@yahoo.com</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cinatl</surname>
<given-names>Jindrich</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Doerr</surname>
<given-names>Hans Wilhelm</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Überla</surname>
<given-names>Klaus</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Department of Molecular and Medical Virology, Ruhr-University Bochum, D-44780 Bochum, Germany</aff>
<aff id="aff2"><label>b</label>
Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. Fax: +49 234 3214352. <email>Seraphin.Kuate@rub.de</email>
<email>sekuate@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>26</day>
<month>1</month>
<year>2007</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>25</day>
<month>5</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub"><day>26</day>
<month>1</month>
<year>2007</year>
</pub-date>
<volume>362</volume>
<issue>1</issue>
<fpage>26</fpage>
<lpage>37</lpage>
<history><date date-type="received"><day>7</day>
<month>7</month>
<year>2006</year>
</date>
<date date-type="rev-recd"><day>5</day>
<month>10</month>
<year>2006</year>
</date>
<date date-type="accepted"><day>8</day>
<month>12</month>
<year>2006</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2007 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract><p>Infection with the SARS-associated coronavirus (SARS-CoV) induces an atypical pulmonary disease with a high lethality rate. Although the initial SARS epidemic was contained, sporadic outbreaks of the disease still occur, suggesting a continuous need for a vaccine against this virus. We therefore explored exosome-based vaccines containing the spike S proteins of SARS-CoV. S-containing exosomes were obtained by replacing the transmembrane and cytoplasmic domains of the S protein by those of VSV-G. The immunogenicity and efficacy of the S-containing exosomes were tested in mice and compared to an adenoviral vector vaccine expressing the S protein. Both, S-containing exosomes and the adenoviral vector vaccine induced neutralizing antibody titers. After priming with the SARS-S exosomal vaccine and boosting with the adenoviral vector the neutralizing antibody titers exceeded those observed in the convalescent serum of a SARS patient. Both approaches were effective in a SARS-S-expressing tumor challenge model and thus warrant further investigation.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>SARS-CoV</kwd>
<kwd>S spike</kwd>
<kwd>Vaccine</kwd>
<kwd>Exosome</kwd>
<kwd>Adenoviral vector</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>District de Darmstadt</li>
<li>Hesse (Land)</li>
</region>
<settlement><li>Francfort-sur-le-Main</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Kuate, Seraphin" sort="Kuate, Seraphin" uniqKey="Kuate S" first="Seraphin" last="Kuate">Seraphin Kuate</name>
</noRegion>
<name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name>
<name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<name sortKey="Uberla, Klaus" sort="Uberla, Klaus" uniqKey="Uberla K" first="Klaus" last="Überla">Klaus Überla</name>
</country>
</tree>
</affiliations>
</record>
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