A Decentralized Molecular Diagnostic Testing Plan for Pandemic Influenza in the Ontario Public Health Laboratory System
Identifieur interne : 000E63 ( Pmc/Checkpoint ); précédent : 000E62; suivant : 000E64A Decentralized Molecular Diagnostic Testing Plan for Pandemic Influenza in the Ontario Public Health Laboratory System
Auteurs : Steven J. Drews [Canada] ; Anna Majury [Canada] ; Frances Jamieson [Canada] ; Garth Riley ; Tony Mazzulli [Canada] ; Donald E. Low [Canada]Source :
- Canadian Journal of Public Health = Revue Canadienne de Santé Publique [ 0008-4263 ] ; 2008.
Abstract
The Ontario Public Health Laboratories system (OPHL) is in the midst of a six-year plan to implement molecular tools for pandemic influenza diagnostics in one central and three regional public health laboratories. This plan has been formulated as a consequence of: 1) experiences gained through severe acute respiratory syndrome (SARS), and comments of the members of the Expert Panel on SARS and Infectious Disease Control (i.e., the Walker report); 2) a review of pandemic preparedness literature; 3) historical and epidemiologic discussions about previous pandemics; and 4) suggestions made by various pandemic working committees. The OPHL plan includes: 1) an aggressive restructuring of the overall molecular microbiology testing capacity of the OPHL; 2) the ability to shift influenza testing of samples between designated OPHL laboratories; and 3) the development of screening tools for pandemic influenza diagnostic tests. The authors believe that investing in increased molecular testing capacity for regional laboratories outside the greater Toronto area will be beneficial to the OPHL system whether or not an influenza pandemic occurs. Well-trained technologists and microbiologists, and the introduction of new technologies, will facilitate the development of a wide variety of molecular tests for other infectious diseases at public health laboratories geographically distant from Toronto, thus enhancing overall laboratory testing capacity in the province of Ontario.
Url:
DOI: 10.1007/BF03405247
PubMed: 19009922
PubMed Central: 6975982
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The Ontario Public Health Laboratories system (OPHL) is in the midst of a six-year plan to implement molecular tools for pandemic influenza diagnostics in one central and three regional public health laboratories. This plan has been formulated as a consequence of: 1) experiences gained through severe acute respiratory syndrome (SARS), and comments of the members of the Expert Panel on SARS and Infectious Disease Control (i.e., the Walker report); 2) a review of pandemic preparedness literature; 3) historical and epidemiologic discussions about previous pandemics; and 4) suggestions made by various pandemic working committees. The OPHL plan includes: 1) an aggressive restructuring of the overall molecular microbiology testing capacity of the OPHL; 2) the ability to shift influenza testing of samples between designated OPHL laboratories; and 3) the development of screening tools for pandemic influenza diagnostic tests. The authors believe that investing in increased molecular testing capacity for regional laboratories outside the greater Toronto area will be beneficial to the OPHL system whether or not an influenza pandemic occurs. Well-trained technologists and microbiologists, and the introduction of new technologies, will facilitate the development of a wide variety of molecular tests for other infectious diseases at public health laboratories geographically distant from Toronto, thus enhancing overall laboratory testing capacity in the province of Ontario.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Can J Public Health</journal-id>
<journal-id journal-id-type="iso-abbrev">Can J Public Health</journal-id>
<journal-title-group><journal-title>Canadian Journal of Public Health = Revue Canadienne de Santé Publique</journal-title>
</journal-title-group>
<issn pub-type="ppub">0008-4263</issn>
<issn pub-type="epub">1920-7476</issn>
<publisher><publisher-name>Springer International Publishing</publisher-name>
<publisher-loc>Cham</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19009922</article-id>
<article-id pub-id-type="pmc">6975982</article-id>
<article-id pub-id-type="publisher-id">BF03405247</article-id>
<article-id pub-id-type="doi">10.1007/BF03405247</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject>
</subj-group>
</article-categories>
<title-group><article-title>A Decentralized Molecular Diagnostic Testing Plan for Pandemic Influenza in the Ontario Public Health Laboratory System</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Drews</surname>
<given-names>Steven J.</given-names>
</name>
<degrees>PhD, FCCM D(ABMM)</degrees>
<address><phone>416-235-5703</phone>
<email>steven.drews@ontario.ca</email>
</address>
<xref ref-type="aff" rid="Aff17">17</xref>
<xref ref-type="aff" rid="Aff27">27</xref>
<xref ref-type="aff" rid="Aff37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Majury</surname>
<given-names>Anna</given-names>
</name>
<degrees>DVM, PhD</degrees>
<xref ref-type="aff" rid="Aff47">47</xref>
<xref ref-type="aff" rid="Aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jamieson</surname>
<given-names>Frances</given-names>
</name>
<degrees>MD, FRCPC</degrees>
<xref ref-type="aff" rid="Aff17">17</xref>
<xref ref-type="aff" rid="Aff37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Riley</surname>
<given-names>Garth</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="Aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mazzulli</surname>
<given-names>Tony</given-names>
</name>
<degrees>MD, FRCPC</degrees>
<xref ref-type="aff" rid="Aff17">17</xref>
<xref ref-type="aff" rid="Aff27">27</xref>
<xref ref-type="aff" rid="Aff37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Low</surname>
<given-names>Donald E.</given-names>
</name>
<degrees>MD, FRCPC</degrees>
<xref ref-type="aff" rid="Aff17">17</xref>
<xref ref-type="aff" rid="Aff27">27</xref>
<xref ref-type="aff" rid="Aff37">37</xref>
</contrib>
<aff id="Aff17"><label>17</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.415822.8</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0500 0405</institution-id>
<institution>Ministry of Health and Long-Term Care,</institution>
<institution>Public Health Laboratories Branch,</institution>
</institution-wrap>
81 Resources Road, Etobicoke, ON M9P 3T1 Canada</aff>
<aff id="Aff27"><label>27</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.416166.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0473 9881</institution-id>
<institution>Department of Microbiology,</institution>
<institution>Mount Sinai Hospital,</institution>
</institution-wrap>
Toronto, ON Canada</aff>
<aff id="Aff37"><label>37</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Department of Laboratory Medicine and Pathobiology,</institution>
<institution>University of Toronto,</institution>
</institution-wrap>
Toronto, Canada</aff>
<aff id="Aff47"><label>47</label>
Ministry of Health and Long-Term Care, Kingston Public Health Laboratory, Kingston, ON Canada</aff>
<aff id="Aff57"><label>57</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.410356.5</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 8331</institution-id>
<institution>Department of Microbiology and Immunology,</institution>
<institution>Queen’s University,</institution>
</institution-wrap>
Kingston, Canada</aff>
</contrib-group>
<pub-date pub-type="epub"><day>1</day>
<month>9</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2008</year>
</pub-date>
<volume>99</volume>
<issue>5</issue>
<fpage>387</fpage>
<lpage>390</lpage>
<history><date date-type="received"><day>9</day>
<month>7</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>14</day>
<month>3</month>
<year>2008</year>
</date>
</history>
<permissions><copyright-statement>© The Canadian Public Health Association 2008</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>The Ontario Public Health Laboratories system (OPHL) is in the midst of a six-year plan to implement molecular tools for pandemic influenza diagnostics in one central and three regional public health laboratories. This plan has been formulated as a consequence of: 1) experiences gained through severe acute respiratory syndrome (SARS), and comments of the members of the Expert Panel on SARS and Infectious Disease Control (i.e., the Walker report); 2) a review of pandemic preparedness literature; 3) historical and epidemiologic discussions about previous pandemics; and 4) suggestions made by various pandemic working committees. The OPHL plan includes: 1) an aggressive restructuring of the overall molecular microbiology testing capacity of the OPHL; 2) the ability to shift influenza testing of samples between designated OPHL laboratories; and 3) the development of screening tools for pandemic influenza diagnostic tests. The authors believe that investing in increased molecular testing capacity for regional laboratories outside the greater Toronto area will be beneficial to the OPHL system whether or not an influenza pandemic occurs. Well-trained technologists and microbiologists, and the introduction of new technologies, will facilitate the development of a wide variety of molecular tests for other infectious diseases at public health laboratories geographically distant from Toronto, thus enhancing overall laboratory testing capacity in the province of Ontario.</p>
</abstract>
<trans-abstract xml:lang="fr" id="Abs2"><title>Résumé</title>
<p>Le système des laboratoires de santé publique de l’Ontario (LSPO) est à mi-parcours d’un plan de six ans visant à mettre en œuvre des outils moléculaires pour le diagnostic de la grippe pandémique dans un laboratoire central et trois laboratoires régionaux de dépistage sanitaire. Le plan en question a été formulé d’après: 1) les leçons de la crise du syndrome respiratoire aigu sévère (SRAS) et les commentaires des membres du Comité d’experts sur le SRAS et la lutte contre les maladies infectieuses (rapport Walker); 2) l’examen de la documentation sur la préparation à une pandémie; 3) les analyses historiques et épidémiologiques des pandémies antérieures; et 4) les suggestions de divers comités de travail sur les pandémies. Le plan des LSPO englobe: 1) une restructuration approfondie de l’ensemble des outils de dépistage basés sur la microbiologie moléculaire dans les laboratoires; 2) la possibilité de transférer d’un LSPO désigné à un autre l’analyse des échantillons grippaux; et 3) l’élaboration d’outils de sérodiagnostic de la grippe pandémique. Selon les auteurs, le fait d’investir davantage dans la capacité de dépistage moléculaire des laboratoires régionaux à l’extérieur du Grand Toronto serait bénéfique pour le système des LSPO, peu importe si une pandémie de grippe survient ou non. Des technologues et des microbiologistes bien formés, ainsi que l’implantation de nouvelles technologies, faciliteront l’élaboration d’un vaste éventail de tests moléculaires pour d’autres maladies infectieuses dans les laboratoires de dépistage sanitaire éloignés de Toronto, ce qui devrait améliorer globalement la capacité de dépistage en laboratoire en Ontario.</p>
</trans-abstract>
<kwd-group xml:lang="fr"><title>Mots clés</title>
<kwd>planification entourant une pandémie</kwd>
<kwd>grippe</kwd>
<kwd>tests moléculaires</kwd>
<kwd>RT-PCR</kwd>
<kwd>diagnostic</kwd>
</kwd-group>
<kwd-group xml:lang="en"><title>Key words</title>
<kwd>Pandemic planning</kwd>
<kwd>influenza</kwd>
<kwd>molecular testing</kwd>
<kwd>RT-PCR</kwd>
<kwd>diagnosis</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Canadian Public Health Association 2008</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Riley, Garth" sort="Riley, Garth" uniqKey="Riley G" first="Garth" last="Riley">Garth Riley</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Drews, Steven J" sort="Drews, Steven J" uniqKey="Drews S" first="Steven J." last="Drews">Steven J. Drews</name>
</noRegion>
<name sortKey="Jamieson, Frances" sort="Jamieson, Frances" uniqKey="Jamieson F" first="Frances" last="Jamieson">Frances Jamieson</name>
<name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E." last="Low">Donald E. Low</name>
<name sortKey="Majury, Anna" sort="Majury, Anna" uniqKey="Majury A" first="Anna" last="Majury">Anna Majury</name>
<name sortKey="Mazzulli, Tony" sort="Mazzulli, Tony" uniqKey="Mazzulli T" first="Tony" last="Mazzulli">Tony Mazzulli</name>
</country>
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</affiliations>
</record>
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