Individual and common inhibitors of coronavirus and picornavirus main proteases
Identifieur interne : 000D14 ( Pmc/Checkpoint ); précédent : 000D13; suivant : 000D15Individual and common inhibitors of coronavirus and picornavirus main proteases
Auteurs : Chih-Jung Kuo ; Hun-Ge Liu ; Yueh-Kuei Lo ; Churl-Min Seong ; Kee-In Lee ; Young-Sik Jung ; Po-Huang LiangSource :
- Febs Letters [ 0014-5793 ] ; 2009.
Abstract
Picornaviruses (PV) and coronaviruses (CoV) are positive‐stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS‐CoV 3CLpro with IC50 of low μM. Interestingly, one of them equally inhibited both 3Cpro and 3CLpro from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti‐viral agents against PV and CoV.
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DOI: 10.1016/j.febslet.2008.12.059
PubMed: 19166843
PubMed Central: 7094298
Affiliations:
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As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS‐CoV 3CL<sup>pro</sup> with IC<sub>50</sub> of low μM. Interestingly, one of them equally inhibited both 3C<sup>pro</sup> and 3CL<sup>pro</sup> from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti‐viral agents against PV and CoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-id journal-id-type="iso-abbrev">FEBS Lett</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1873-3468</journal-id><journal-id journal-id-type="publisher-id">FEB2</journal-id><journal-title-group><journal-title>Febs Letters</journal-title></journal-title-group><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19166843</article-id><article-id pub-id-type="pmc">7094298</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2008.12.059</article-id><article-id pub-id-type="publisher-id">FEB2S0014579309000167</article-id><article-categories><subj-group subj-group-type="overline"><subject>Short Communication</subject></subj-group><subj-group subj-group-type="heading"><subject>Short Communications</subject></subj-group></article-categories><title-group><article-title>Individual and common inhibitors of coronavirus and picornavirus main proteases</article-title></title-group><contrib-group><contrib id="feb2s0014579309000167-cr-0001" contrib-type="author"><name><surname>Kuo</surname><given-names>Chih-Jung</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff1"><sup>1</sup></xref><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff2"><sup>2</sup></xref></contrib><contrib id="feb2s0014579309000167-cr-0002" contrib-type="author"><name><surname>Liu</surname><given-names>Hun-Ge</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff1"><sup>1</sup></xref></contrib><contrib id="feb2s0014579309000167-cr-0003" contrib-type="author"><name><surname>Lo</surname><given-names>Yueh-Kuei</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff1"><sup>1</sup></xref></contrib><contrib id="feb2s0014579309000167-cr-0004" contrib-type="author"><name><surname>Seong</surname><given-names>Churl-Min</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff3"><sup>3</sup></xref></contrib><contrib id="feb2s0014579309000167-cr-0005" contrib-type="author"><name><surname>Lee</surname><given-names>Kee-In</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff3"><sup>3</sup></xref></contrib><contrib id="feb2s0014579309000167-cr-0006" contrib-type="author" corresp="yes"><name><surname>Jung</surname><given-names>Young-Sik</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff3"><sup>3</sup></xref><address><email>ysjung@krict.re.kr</email></address></contrib><contrib id="feb2s0014579309000167-cr-0007" contrib-type="author" corresp="yes"><name><surname>Liang</surname><given-names>Po-Huang</given-names></name><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff1"><sup>1</sup></xref><xref ref-type="aff" rid="feb2s0014579309000167-aff-aff2"><sup>2</sup></xref><address><email>phliang@gate.sinica.edu.tw</email></address></contrib></contrib-group><aff id="feb2s0014579309000167-aff-aff1"><label><sup>1</sup></label>Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan, ROC</aff><aff id="feb2s0014579309000167-aff-aff2"><label><sup>2</sup></label>Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan</aff><aff id="feb2s0014579309000167-aff-aff3"><label><sup>3</sup></label>Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea</aff><author-notes><corresp id="correspondenceTo"><label>*</label>Corresponding authors. Address: Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan, ROC. Fax: +886 2 2788 9759.</corresp></author-notes><pub-date pub-type="ppub"><day>04</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>21</day><month>1</month><year>2009</year></pub-date><volume>583</volume><issue>3</issue><issue-id pub-id-type="doi">10.1002/feb2.2009.583.issue-3</issue-id><fpage>549</fpage><lpage>555</lpage><history><date date-type="received"><day>05</day><month>11</month><year>2008</year></date><date date-type="rev-recd"><day>17</day><month>12</month><year>2008</year></date><date date-type="accepted"><day>23</day><month>12</month><year>2008</year></date></history><permissions><pmc-comment> © 2015 Federation of European Biochemical Societies </pmc-comment>
<copyright-statement content-type="article-copyright">FEBS Letters 583 (2009) 1873-3468 © 2015 Federation of European Biochemical Societies</copyright-statement><license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:FEB2-583-549.pdf"></self-uri><abstract><p>Picornaviruses (PV) and coronaviruses (CoV) are positive‐stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS‐CoV 3CL<sup>pro</sup> with IC<sub>50</sub> of low μM. Interestingly, one of them equally inhibited both 3C<sup>pro</sup> and 3CL<sup>pro</sup> from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti‐viral agents against PV and CoV.</p></abstract><kwd-group><kwd id="feb2s0014579309000167-kwd-0001">Coronavirus</kwd><kwd id="feb2s0014579309000167-kwd-0002">Picornavirus</kwd><kwd id="feb2s0014579309000167-kwd-0003">3C protease</kwd><kwd id="feb2s0014579309000167-kwd-0004">Fluorescence assay</kwd><kwd id="feb2s0014579309000167-kwd-0005">High throughput screening</kwd><kwd id="feb2s0014579309000167-kwd-0006">Computer modeling</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="2"></table-count><ref-count count="21"></ref-count><page-count count="7"></page-count><word-count count="3418"></word-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>February 04, 2009</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020</meta-value></custom-meta></custom-meta-group></article-meta><notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="feb2s0014579309000167-cit-0000"><string-name><surname>Kuo</surname><given-names>Chih-Jung</given-names></string-name>,<string-name><surname>Liu</surname><given-names>Hun-Ge</given-names></string-name>,<string-name><surname>Lo</surname><given-names>Yueh-Kuei</given-names></string-name>,<string-name><surname>Seong</surname><given-names>Churl-Min</given-names></string-name>,<string-name><surname>Lee</surname><given-names>Kee-In</given-names></string-name>,<string-name><surname>Jung</surname><given-names>Young-Sik</given-names></string-name> and <string-name><surname>Liang</surname><given-names>Po-Huang</given-names></string-name>(<year>2009</year>), <article-title>Individual and common inhibitors of coronavirus and picornavirus main proteases</article-title>, <source xml:lang="en">FEBS Letters</source>, <volume>583</volume>, doi: 10.1016/j.febslet.2008.12.059</mixed-citation></p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Jung, Young Sik" sort="Jung, Young Sik" uniqKey="Jung Y" first="Young-Sik" last="Jung">Young-Sik Jung</name><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><name sortKey="Lee, Kee In" sort="Lee, Kee In" uniqKey="Lee K" first="Kee-In" last="Lee">Kee-In Lee</name><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><name sortKey="Liu, Hun Ge" sort="Liu, Hun Ge" uniqKey="Liu H" first="Hun-Ge" last="Liu">Hun-Ge Liu</name><name sortKey="Lo, Yueh Kuei" sort="Lo, Yueh Kuei" uniqKey="Lo Y" first="Yueh-Kuei" last="Lo">Yueh-Kuei Lo</name><name sortKey="Seong, Churl Min" sort="Seong, Churl Min" uniqKey="Seong C" first="Churl-Min" last="Seong">Churl-Min Seong</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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