Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Identifieur interne : 000C37 ( Pmc/Checkpoint ); précédent : 000C36; suivant : 000C38Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Auteurs : Ali Danesh [Canada] ; Cheryl M. Cameron [Canada] ; Alberto J. Le N [République populaire de Chine] ; Longsi Ran [Canada] ; Luoling Xu [Canada] ; Yuan Fang [Canada] ; Alyson A. Kelvin [Canada, Italie] ; Thomas Rowe [Canada] ; Honglin Chen [République populaire de Chine] ; Yi Guan [République populaire de Chine] ; Colleen B. Jonsson [États-Unis] ; Mark J. Cameron [Canada] ; David J. Kelvin [Canada, République populaire de Chine, Italie]Source :
- Virology [ 0042-6822 ] ; 2010.
Abstract
Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection.
Url:
DOI: 10.1016/j.virol.2010.10.002
PubMed: 21035159
PubMed Central: 7111932
Affiliations:
- Canada, Italie, République populaire de Chine, États-Unis
- Kentucky, Ontario
- Toronto
- Université de Toronto
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PMC:7111932Le document en format XML
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Le N</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Ran, Longsi" sort="Ran, Longsi" uniqKey="Ran L" first="Longsi" last="Ran">Longsi Ran</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Luoling" sort="Xu, Luoling" uniqKey="Xu L" first="Luoling" last="Xu">Luoling Xu</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af0010">Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. 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Cameron</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Le N, Alberto J" sort="Le N, Alberto J" uniqKey="Le N A" first="Alberto J." last="Le N">Alberto J. Le N</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Ran, Longsi" sort="Ran, Longsi" uniqKey="Ran L" first="Longsi" last="Ran">Longsi Ran</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Luoling" sort="Xu, Luoling" uniqKey="Xu L" first="Luoling" last="Xu">Luoling Xu</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af0010">Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name><affiliation wicri:level="1"><nlm:aff id="af0015">Immune Diagnostics & Research, IDR , MaRS Centre, 101 College Street, Suite 200, Toronto, ON, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Immune Diagnostics & Research, IDR , MaRS Centre, 101 College Street, Suite 200, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0035">SaRD, Sardinia Research and Development srl, Porto Conte Ricerche Research Centre, S.P. 55 Porto Conte Capo Caccia km 8,400, Loc. Tramariglio, 07041, Alghero (SS), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>SaRD, Sardinia Research and Development srl, Porto Conte Ricerche Research Centre, S.P. 55 Porto Conte Capo Caccia km 8,400, Loc. Tramariglio, 07041, Alghero (SS)</wicri:regionArea><wicri:noRegion>Alghero (SS)</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Jonsson, Colleen B" sort="Jonsson, Colleen B" uniqKey="Jonsson C" first="Colleen B." last="Jonsson">Colleen B. Jonsson</name><affiliation wicri:level="2"><nlm:aff id="af0025">Center for Predictive Medicine, 950 N. Hurstbourne Pkwy, Louisville, KY 40222, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Predictive Medicine, 950 N. Hurstbourne Pkwy, Louisville, KY 40222</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0030">Department of Biomedical Sciences, University of Sassari, Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences, University of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. <italic>In vivo</italic> experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barclay, J L" uniqKey="Barclay J">J.L. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn><publisher><publisher-name>Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21035159</article-id><article-id pub-id-type="pmc">7111932</article-id><article-id pub-id-type="publisher-id">S0042-6822(10)00638-0</article-id><article-id pub-id-type="doi">10.1016/j.virol.2010.10.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Danesh</surname><given-names>Ali</given-names></name><xref rid="af0005" ref-type="aff">a</xref><xref rid="af0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Cameron</surname><given-names>Cheryl M.</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>León</surname><given-names>Alberto J.</given-names></name><xref rid="af0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Ran</surname><given-names>Longsi</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Luoling</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Fang</surname><given-names>Yuan</given-names></name><xref rid="af0005" ref-type="aff">a</xref><xref rid="af0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Kelvin</surname><given-names>Alyson A.</given-names></name><xref rid="af0015" ref-type="aff">c</xref><xref rid="af0035" ref-type="aff">g</xref></contrib><contrib contrib-type="author"><name><surname>Rowe</surname><given-names>Thomas</given-names></name><xref rid="af0005" ref-type="aff">a</xref><xref rid="fn0005" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Honglin</given-names></name><xref rid="af0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Guan</surname><given-names>Yi</given-names></name><xref rid="af0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Jonsson</surname><given-names>Colleen B.</given-names></name><xref rid="af0025" ref-type="aff">e</xref></contrib><contrib contrib-type="author"><name><surname>Cameron</surname><given-names>Mark J.</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Kelvin</surname><given-names>David J.</given-names></name><email>dkelvin@uhnres.utoronto.ca</email><xref rid="af0005" ref-type="aff">a</xref><xref rid="af0020" ref-type="aff">d</xref><xref rid="af0030" ref-type="aff">f</xref><xref rid="cr0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af0005"><label>a</label>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</aff><aff id="af0010"><label>b</label>Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7</aff><aff id="af0015"><label>c</label>Immune Diagnostics & Research, IDR , MaRS Centre, 101 College Street, Suite 200, Toronto, ON, Canada M5G 1L7</aff><aff id="af0020"><label>d</label>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</aff><aff id="af0025"><label>e</label>Center for Predictive Medicine, 950 N. Hurstbourne Pkwy, Louisville, KY 40222, USA</aff><aff id="af0030"><label>f</label>Department of Biomedical Sciences, University of Sassari, Sassari, Italy</aff><aff id="af0035"><label>g</label>SaRD, Sardinia Research and Development srl, Porto Conte Ricerche Research Centre, S.P. 55 Porto Conte Capo Caccia km 8,400, Loc. Tramariglio, 07041, Alghero (SS), Italy</aff><author-notes><corresp id="cr0005"><label>⁎</label>Corresponding author. Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, China, 515041. Fax: + 86 754 88573991. <email>dkelvin@uhnres.utoronto.ca</email></corresp><fn id="fn0005"><label>1</label><p>Present address: Centers for Disease Control and Prevention, Influenza Division, 1600 Clifton Road, MS:G-16, Atlanta, GA 30333, USA.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>28</day><month>10</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>5</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2010</year></pub-date><volume>409</volume><issue>1</issue><fpage>102</fpage><lpage>112</lpage><history><date date-type="received"><day>25</day><month>2</month><year>2010</year></date><date date-type="rev-recd"><day>23</day><month>8</month><year>2010</year></date><date date-type="accepted"><day>1</day><month>10</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. <italic>In vivo</italic> experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.</p></abstract><kwd-group><title>Keywords</title><kwd>Ferret</kwd><kwd>Gene expression</kwd><kwd>SARS</kwd><kwd>Interferon</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>Italie</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Kentucky</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name></noRegion><name sortKey="Cameron, Cheryl M" sort="Cameron, Cheryl M" uniqKey="Cameron C" first="Cheryl M." last="Cameron">Cheryl M. Cameron</name><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name><name sortKey="Ran, Longsi" sort="Ran, Longsi" uniqKey="Ran L" first="Longsi" last="Ran">Longsi Ran</name><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name><name sortKey="Xu, Luoling" sort="Xu, Luoling" uniqKey="Xu L" first="Luoling" last="Xu">Luoling Xu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Le N, Alberto J" sort="Le N, Alberto J" uniqKey="Le N A" first="Alberto J." last="Le N">Alberto J. Le N</name></noRegion><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name></country><country name="Italie"><noRegion><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name></noRegion><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name></country><country name="États-Unis"><region name="Kentucky"><name sortKey="Jonsson, Colleen B" sort="Jonsson, Colleen B" uniqKey="Jonsson C" first="Colleen B." last="Jonsson">Colleen B. Jonsson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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