The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”
Identifieur interne : 000940 ( Pmc/Checkpoint ); précédent : 000939; suivant : 000941The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”
Auteurs : Jasper Fuk-Woo Chan [République populaire de Chine] ; Susanna Kar-Pui Lau [République populaire de Chine] ; Patrick Chiu-Yat Woo [République populaire de Chine]Source :
- Journal of the Formosan Medical Association [ 0929-6646 ] ; 2013.
Abstract
A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to
Url:
DOI: 10.1016/j.jfma.2013.05.010
PubMed: 23883791
PubMed Central: 7125600
Affiliations:
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PMC:7125600Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to <italic>Tylonycteris</italic>
bat coronavirus HKU4 and <italic>Pipistrellus</italic>
bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Formos Med Assoc</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Formos. Med. Assoc</journal-id>
<journal-title-group><journal-title>Journal of the Formosan Medical Association</journal-title>
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<issn pub-type="ppub">0929-6646</issn>
<issn pub-type="epub">0929-6646</issn>
<publisher><publisher-name>Published by Elsevier (Singapore) Pte Ltd.</publisher-name>
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<article-meta><article-id pub-id-type="pmid">23883791</article-id>
<article-id pub-id-type="pmc">7125600</article-id>
<article-id pub-id-type="publisher-id">S0929-6646(13)00177-0</article-id>
<article-id pub-id-type="doi">10.1016/j.jfma.2013.05.010</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”</article-title>
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</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au3"><name><surname>Woo</surname>
<given-names>Patrick Chiu-Yat</given-names>
</name>
<email>pcywoo@hkucc.hku.hk</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China</aff>
<aff id="aff2"><label>b</label>
Department of Microbiology, The University of Hong Kong, Hong Kong, China</aff>
<aff id="aff3"><label>c</label>
Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Corresponding author. Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong, China. <email>pcywoo@hkucc.hku.hk</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>21</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>7</month>
<year>2013</year>
</pub-date>
<volume>112</volume>
<issue>7</issue>
<fpage>372</fpage>
<lpage>381</lpage>
<history><date date-type="received"><day>16</day>
<month>4</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>13</day>
<month>5</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>14</day>
<month>5</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Published by Elsevier (Singapore) Pte Ltd.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder></copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0010"><p>A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to <italic>Tylonycteris</italic>
bat coronavirus HKU4 and <italic>Pipistrellus</italic>
bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.</p>
</abstract>
<kwd-group id="kwrds0010"><title>Keywords</title>
<kwd>coronavirus</kwd>
<kwd>EMC</kwd>
<kwd>human</kwd>
<kwd>Middle East</kwd>
<kwd>SARS</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name>
</noRegion>
<name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name>
<name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name>
<name sortKey="Lau, Susanna Kar Pui" sort="Lau, Susanna Kar Pui" uniqKey="Lau S" first="Susanna Kar-Pui" last="Lau">Susanna Kar-Pui Lau</name>
<name sortKey="Lau, Susanna Kar Pui" sort="Lau, Susanna Kar Pui" uniqKey="Lau S" first="Susanna Kar-Pui" last="Lau">Susanna Kar-Pui Lau</name>
<name sortKey="Lau, Susanna Kar Pui" sort="Lau, Susanna Kar Pui" uniqKey="Lau S" first="Susanna Kar-Pui" last="Lau">Susanna Kar-Pui Lau</name>
<name sortKey="Woo, Patrick Chiu Yat" sort="Woo, Patrick Chiu Yat" uniqKey="Woo P" first="Patrick Chiu-Yat" last="Woo">Patrick Chiu-Yat Woo</name>
<name sortKey="Woo, Patrick Chiu Yat" sort="Woo, Patrick Chiu Yat" uniqKey="Woo P" first="Patrick Chiu-Yat" last="Woo">Patrick Chiu-Yat Woo</name>
<name sortKey="Woo, Patrick Chiu Yat" sort="Woo, Patrick Chiu Yat" uniqKey="Woo P" first="Patrick Chiu-Yat" last="Woo">Patrick Chiu-Yat Woo</name>
</country>
</tree>
</affiliations>
</record>
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