SARS vaccines: where are we?
Identifieur interne : 000857 ( Pmc/Checkpoint ); précédent : 000856; suivant : 000858SARS vaccines: where are we?
Auteurs : Rachel L. Roper ; Kristina E. RehmSource :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Abstract
In this review, the current state of vaccine development against human severe acute respiratory syndrome (SARS) coronavirus, focusing on recently published data is assessed. We discuss which strategies have been assessed immunologically and which have been evaluated in SARS coronavirus challenge models. We discuss inactivated vaccines, virally and bacterially vectored vaccines, recombinant protein and DNA vaccines, as well as the use of attenuated vaccines. Data regarding the correlates of protection, animal models and the available evidence regarding potential vaccine enhancement of SARS disease are discussed. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Current data suggest that intranasal vaccination may be crucial and that new or combination strategies may be required for good protective efficacy against SARS in humans.
Url:
DOI: 10.1586/erv.09.43
PubMed: 19538115
PubMed Central: 7105754
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS vaccines: where are we?</title><author><name sortKey="Roper, Rachel L" sort="Roper, Rachel L" uniqKey="Roper R" first="Rachel L" last="Roper">Rachel L. Roper</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rehm, Kristina E" sort="Rehm, Kristina E" uniqKey="Rehm K" first="Kristina E" last="Rehm">Kristina E. 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Roper</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rehm, Kristina E" sort="Rehm, Kristina E" uniqKey="Rehm K" first="Kristina E" last="Rehm">Kristina E. Rehm</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Expert Review of Vaccines</title><idno type="ISSN">1476-0584</idno><idno type="eISSN">1744-8395</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this review, the current state of vaccine development against human severe acute respiratory syndrome (SARS) coronavirus, focusing on recently published data is assessed. We discuss which strategies have been assessed immunologically and which have been evaluated in SARS coronavirus challenge models. We discuss inactivated vaccines, virally and bacterially vectored vaccines, recombinant protein and DNA vaccines, as well as the use of attenuated vaccines. Data regarding the correlates of protection, animal models and the available evidence regarding potential vaccine enhancement of SARS disease are discussed. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Current data suggest that intranasal vaccination may be crucial and that new or combination strategies may be required for good protective efficacy against SARS in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marra" uniqKey="Marra">Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota" uniqKey="Rota">Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier" uniqKey="Fouchier">Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng" uniqKey="Zheng">Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleck" uniqKey="Fleck">Fleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan" uniqKey="Guan">Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che" uniqKey="Che">Che</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen" uniqKey="Chen">Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina" uniqKey="Martina">Martina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang" uniqKey="Wang">Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan" uniqKey="Guan">Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau" uniqKey="Lau">Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten" uniqKey="Drosten">Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek" uniqKey="Ksiazek">Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris" uniqKey="Peiris">Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris" uniqKey="Peiris">Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yam" uniqKey="Yam">Yam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding" uniqKey="Ding">Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang" uniqKey="Wang">Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knudsen" uniqKey="Knudsen">Knudsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls" uniqKey="Nicholls">Nicholls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee" uniqKey="Lee">Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pearson" uniqKey="Pearson">Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabenau" uniqKey="Rabenau">Rabenau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hon" uniqKey="Hon">Hon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen" uniqKey="Olsen">Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anton" uniqKey="Anton">Anton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh" uniqKey="Cavanagh">Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai" uniqKey="Lai">Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai" uniqKey="Lai">Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong" uniqKey="Wong">Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeffers" uniqKey="Jeffers">Jeffers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes" uniqKey="Holmes">Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navas Martin" uniqKey="Navas Martin">Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo" uniqKey="Guo">Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani" uniqKey="Kamitani">Kamitani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang" uniqKey="Huang">Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito" uniqKey="Ito">Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaecher" uniqKey="Schaecher">Schaecher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen" uniqKey="Shen">Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiong" uniqKey="Xiong">Xiong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsunetsugu Yokota" uniqKey="Tsunetsugu Yokota">Tsunetsugu-Yokota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He" uniqKey="He">He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takasuka" uniqKey="Takasuka">Takasuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang" uniqKey="Tang">Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qu" uniqKey="Qu">Qu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang" uniqKey="Zhang">Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadler" uniqKey="Stadler">Stadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See" uniqKey="See">See</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lokugamage" uniqKey="Lokugamage">Lokugamage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kobinger" uniqKey="Kobinger">Kobinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See" uniqKey="See">See</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darnell" uniqKey="Darnell">Darnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou" uniqKey="Zhou">Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin" uniqKey="Lin">Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rocha" 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uniqKey="Bukreyev">Bukreyev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz" uniqKey="Buchholz">Buchholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du" uniqKey="Du">Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinapoli" uniqKey="Dinapoli">DiNapoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapadia" uniqKey="Kapadia">Kapadia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liniger" uniqKey="Liniger">Liniger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faber" uniqKey="Faber">Faber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai" uniqKey="Bai">Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo" 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uniqKey="Olsen">Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesseling" uniqKey="Wesseling">Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohlman" uniqKey="Stohlman">Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohlman" uniqKey="Stohlman">Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo" uniqKey="Seo">Seo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boots" uniqKey="Boots">Boots</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Collisson" uniqKey="Collisson">Collisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu" uniqKey="Zhu">Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim" uniqKey="Kim">Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du" uniqKey="Du">Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurunathan" uniqKey="Gurunathan">Gurunathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng" uniqKey="Zeng">Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakhartchouk" uniqKey="Zakhartchouk">Zakhartchouk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Callendret" uniqKey="Callendret">Callendret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang" uniqKey="Wang">Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang" uniqKey="Wang">Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao" uniqKey="Zhao">Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta" uniqKey="Gupta">Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung" uniqKey="Cheung">Cheung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada" uniqKey="Okada">Okada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakhartchouk" uniqKey="Zakhartchouk">Zakhartchouk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma" uniqKey="Ma">Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dediego" uniqKey="Dediego">DeDiego</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dediego" uniqKey="Dediego">Dediego</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamirande" uniqKey="Lamirande">Lamirande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zust" uniqKey="Zust">Zust</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount" uniqKey="Yount">Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De" uniqKey="De">de</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enjuanes" uniqKey="Enjuanes">Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken" uniqKey="Kuiken">Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauliffe" uniqKey="Mcauliffe">McAuliffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao" uniqKey="Subbarao">Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass" uniqKey="Glass">Glass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts" uniqKey="Roberts">Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao" uniqKey="Xiao">Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts" uniqKey="Roberts">Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx" uniqKey="Rockx">Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccray" uniqKey="Mccray">McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng" uniqKey="Tseng">Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang" uniqKey="Yang">Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ter" uniqKey="Ter">ter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weingartl" uniqKey="Weingartl">Weingartl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="To" uniqKey="To">To</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski" uniqKey="Skowronski">Skowronski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawler" uniqKey="Lawler">Lawler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss" uniqKey="Weiss">Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kam" uniqKey="Kam">Kam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deming" uniqKey="Deming">Deming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan" uniqKey="Tan">Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo" uniqKey="Woo">Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu" uniqKey="Liu">Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenough" uniqKey="Greenough">Greenough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui" uniqKey="Sui">Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai" uniqKey="Traggiai">Traggiai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roper" uniqKey="Roper">Roper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fogg" uniqKey="Fogg">Fogg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Golden" uniqKey="Golden">Golden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu" uniqKey="Hu">Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang" uniqKey="Yang">Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu" uniqKey="Qiu">Qiu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Rev Vaccines</journal-id><journal-id journal-id-type="iso-abbrev">Expert Rev Vaccines</journal-id><journal-id journal-id-type="publisher-id">IERV</journal-id><journal-id journal-id-type="publisher-id">ierv20</journal-id><journal-title-group><journal-title>Expert Review of Vaccines</journal-title></journal-title-group><issn pub-type="ppub">1476-0584</issn><issn pub-type="epub">1744-8395</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19538115</article-id><article-id pub-id-type="pmc">7105754</article-id><article-id pub-id-type="publisher-id">11218665</article-id><article-id pub-id-type="doi">10.1586/erv.09.43</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>SARS vaccines: where are we?</article-title><alt-title alt-title-type="running-title">SARS vaccines: where are we?</alt-title><alt-title alt-title-type="running-title">Roper & Rehm</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Roper</surname><given-names>Rachel L</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0001"></xref></contrib><contrib contrib-type="author"><name><surname>Rehm</surname><given-names>Kristina E</given-names></name><xref ref-type="aff" rid="AFF0002"></xref></contrib><aff id="AFF0001"><label>1</label>Brody School of Medicine, Department of Microbiology & Immunology, 5E-106A, East Carolina University, Greenville, NC 27834, USA.<email xlink:href="roperr@ecu.edu">roperr@ecu.edu</email></aff><aff id="AFF0002"><label>2</label>Brody School of Medicine, Department of Microbiology & Immunology, 5E-106A, East Carolina University, Greenville, NC 27834, USA.<email xlink:href="ker0312@ecu.edu">ker0312@ecu.edu</email></aff></contrib-group><author-notes><corresp id="AN0001">† <italic>Author for correspondence</italic></corresp></author-notes><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>09</day><month>1</month><year>2014</year></pub-date><volume>8</volume><issue>7</issue><fpage seq="9">887</fpage><lpage>898</lpage><permissions><copyright-statement>© Expert Reviews Ltd</copyright-statement><copyright-year>2009</copyright-year><copyright-holder>Expert Reviews Ltd</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IERV_8_11218665.pdf"></self-uri><abstract><p>In this review, the current state of vaccine development against human severe acute respiratory syndrome (SARS) coronavirus, focusing on recently published data is assessed. We discuss which strategies have been assessed immunologically and which have been evaluated in SARS coronavirus challenge models. We discuss inactivated vaccines, virally and bacterially vectored vaccines, recombinant protein and DNA vaccines, as well as the use of attenuated vaccines. Data regarding the correlates of protection, animal models and the available evidence regarding potential vaccine enhancement of SARS disease are discussed. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Current data suggest that intranasal vaccination may be crucial and that new or combination strategies may be required for good protective efficacy against SARS in humans.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords:</title><kwd>animal model</kwd><kwd>antibody</kwd><kwd>efficacy</kwd><kwd>SARS</kwd><kwd>T lymphocyte</kwd><kwd>vaccine</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><ref-count count="142"></ref-count><page-count count="12"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Rehm, Kristina E" sort="Rehm, Kristina E" uniqKey="Rehm K" first="Kristina E" last="Rehm">Kristina E. Rehm</name><name sortKey="Roper, Rachel L" sort="Roper, Rachel L" uniqKey="Roper R" first="Rachel L" last="Roper">Rachel L. Roper</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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