The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
Identifieur interne : 000750 ( Pmc/Checkpoint ); précédent : 000749; suivant : 000751The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
Auteurs : Inga Patar I [Croatie] ; Andrea Gelemanovi [Croatie] ; Mirna Kirin [Croatie] ; Ivana Kol I [Croatie] ; Evropi Theodoratou [Royaume-Uni] ; Kenneth J. Baillie [Royaume-Uni] ; Menno D. De Jong [Pays-Bas] ; Igor Rudan [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Ozren Polašek [Croatie, Royaume-Uni]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from
The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/srep16119
PubMed: 26524966
PubMed Central: 4630784
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from <italic>IL4</italic>
gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of <italic>TLR2</italic>
gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified <italic>CCL2</italic>
as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The <italic>IL4</italic>
-<italic>TLR2</italic>
-<italic>CCL2</italic>
axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id>
<journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id>
<journal-title-group><journal-title>Scientific Reports</journal-title>
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<issn pub-type="epub">2045-2322</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
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<article-id pub-id-type="pmc">4630784</article-id>
<article-id pub-id-type="publisher-id">BFsrep16119</article-id>
<article-id pub-id-type="doi">10.1038/srep16119</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis</article-title>
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<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
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Split, Croatia</aff>
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Edinburgh, UK</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.482685.5</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 9166 3715</institution-id>
<institution>Roslin Institute, University of Edinburgh,</institution>
</institution-wrap>
Midlothian, UK</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.418716.d</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0709 1919</institution-id>
<institution>Intensive Care Unit, Royal Infirmary of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.5650.6</institution-id>
<institution-id institution-id-type="ISNI">0000000404654431</institution-id>
<institution>Department of Medical Microbiology,</institution>
<institution>Academic Medical Centre, University of Amsterdam,</institution>
</institution-wrap>
Amsterdam, The Netherlands</aff>
</contrib-group>
<pub-date pub-type="epub"><day>3</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>5</volume>
<elocation-id>16119</elocation-id>
<history><date date-type="received"><day>20</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>9</day>
<month>10</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2015</copyright-statement>
<license license-type="OpenAccess"><license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from <italic>IL4</italic>
gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of <italic>TLR2</italic>
gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified <italic>CCL2</italic>
as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The <italic>IL4</italic>
-<italic>TLR2</italic>
-<italic>CCL2</italic>
axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Infectious diseases</kwd>
<kwd>Molecular medicine</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Croatie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Croatie"><noRegion><name sortKey="Patar I, Inga" sort="Patar I, Inga" uniqKey="Patar I I" first="Inga" last="Patar I">Inga Patar I</name>
</noRegion>
<name sortKey="Gelemanovi, Andrea" sort="Gelemanovi, Andrea" uniqKey="Gelemanovi A" first="Andrea" last="Gelemanovi">Andrea Gelemanovi</name>
<name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name>
<name sortKey="Kol I, Ivana" sort="Kol I, Ivana" uniqKey="Kol I I" first="Ivana" last="Kol I">Ivana Kol I</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name>
</noRegion>
<name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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