The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
Identifieur interne : 000750 ( Pmc/Checkpoint ); précédent : 000749; suivant : 000751The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
Auteurs : Inga Patar I [Croatie] ; Andrea Gelemanovi [Croatie] ; Mirna Kirin [Croatie] ; Ivana Kol I [Croatie] ; Evropi Theodoratou [Royaume-Uni] ; Kenneth J. Baillie [Royaume-Uni] ; Menno D. De Jong [Pays-Bas] ; Igor Rudan [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Ozren Polašek [Croatie, Royaume-Uni]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from
The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/srep16119
PubMed: 26524966
PubMed Central: 4630784
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4630784Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis</title>
<author><name sortKey="Patar I, Inga" sort="Patar I, Inga" uniqKey="Patar I I" first="Inga" last="Patar I">Inga Patar I</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gelemanovi, Andrea" sort="Gelemanovi, Andrea" uniqKey="Gelemanovi A" first="Andrea" last="Gelemanovi">Andrea Gelemanovi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kol I, Ivana" sort="Kol I, Ivana" uniqKey="Kol I I" first="Ivana" last="Kol I">Ivana Kol I</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.482685.5</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 9166 3715</institution-id>
<institution>Roslin Institute, University of Edinburgh,</institution>
</institution-wrap>
Midlothian, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Midlothian</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.418716.d</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0709 1919</institution-id>
<institution>Intensive Care Unit, Royal Infirmary of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.5650.6</institution-id>
<institution-id institution-id-type="ISNI">0000000404654431</institution-id>
<institution>Department of Medical Microbiology,</institution>
<institution>Academic Medical Centre, University of Amsterdam,</institution>
</institution-wrap>
Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26524966</idno>
<idno type="pmc">4630784</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630784</idno>
<idno type="RBID">PMC:4630784</idno>
<idno type="doi">10.1038/srep16119</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000470</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000470</idno>
<idno type="wicri:Area/Pmc/Curation">000470</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000470</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000750</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000750</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis</title>
<author><name sortKey="Patar I, Inga" sort="Patar I, Inga" uniqKey="Patar I I" first="Inga" last="Patar I">Inga Patar I</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gelemanovi, Andrea" sort="Gelemanovi, Andrea" uniqKey="Gelemanovi A" first="Andrea" last="Gelemanovi">Andrea Gelemanovi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kol I, Ivana" sort="Kol I, Ivana" uniqKey="Kol I I" first="Ivana" last="Kol I">Ivana Kol I</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.482685.5</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 9166 3715</institution-id>
<institution>Roslin Institute, University of Edinburgh,</institution>
</institution-wrap>
Midlothian, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Midlothian</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.418716.d</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0709 1919</institution-id>
<institution>Intensive Care Unit, Royal Infirmary of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.5650.6</institution-id>
<institution-id institution-id-type="ISNI">0000000404654431</institution-id>
<institution>Department of Medical Microbiology,</institution>
<institution>Academic Medical Centre, University of Amsterdam,</institution>
</institution-wrap>
Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Split</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from <italic>IL4</italic>
gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of <italic>TLR2</italic>
gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified <italic>CCL2</italic>
as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The <italic>IL4</italic>
-<italic>TLR2</italic>
-<italic>CCL2</italic>
axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
<author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fumagalli, M" uniqKey="Fumagalli M">M Fumagalli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Folkers, Gk" uniqKey="Folkers G">GK Folkers</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sorensen, Ti" uniqKey="Sorensen T">TI Sorensen</name>
</author>
<author><name sortKey="Nielsen, Gg" uniqKey="Nielsen G">GG Nielsen</name>
</author>
<author><name sortKey="Andersen, Pk" uniqKey="Andersen P">PK Andersen</name>
</author>
<author><name sortKey="Teasdale, Tw" uniqKey="Teasdale T">TW Teasdale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albright, Fs" uniqKey="Albright F">FS Albright</name>
</author>
<author><name sortKey="Orlando, P" uniqKey="Orlando P">P Orlando</name>
</author>
<author><name sortKey="Pavia, At" uniqKey="Pavia A">AT Pavia</name>
</author>
<author><name sortKey="Jackson, Gg" uniqKey="Jackson G">GG Jackson</name>
</author>
<author><name sortKey="Cannon Albright, La" uniqKey="Cannon Albright L">LA Cannon Albright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooke, Gs" uniqKey="Cooke G">GS Cooke</name>
</author>
<author><name sortKey="Hill, Avs" uniqKey="Hill A">AVS Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgner, D" uniqKey="Burgner D">D Burgner</name>
</author>
<author><name sortKey="Jamieson, Se" uniqKey="Jamieson S">SE Jamieson</name>
</author>
<author><name sortKey="Blackwell, Jm" uniqKey="Blackwell J">JM Blackwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rowell, Jl" uniqKey="Rowell J">JL Rowell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heitzeneder, S" uniqKey="Heitzeneder S">S Heitzeneder</name>
</author>
<author><name sortKey="Seidel, M" uniqKey="Seidel M">M Seidel</name>
</author>
<author><name sortKey="Forster Waldl, E" uniqKey="Forster Waldl E">E Forster-Waldl</name>
</author>
<author><name sortKey="Heitger, A" uniqKey="Heitger A">A Heitger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chapman, Sj" uniqKey="Chapman S">SJ Chapman</name>
</author>
<author><name sortKey="Hill, Avs" uniqKey="Hill A">AVS Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Colhoun, Hm" uniqKey="Colhoun H">HM Colhoun</name>
</author>
<author><name sortKey="Mckeigue, Pm" uniqKey="Mckeigue P">PM McKeigue</name>
</author>
<author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Affandi, Js" uniqKey="Affandi J">JS Affandi</name>
</author>
<author><name sortKey="Price, P" uniqKey="Price P">P Price</name>
</author>
<author><name sortKey="Waterer, G" uniqKey="Waterer G">G Waterer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barry, Ce" uniqKey="Barry C">CE Barry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hill, Avs" uniqKey="Hill A">AVS Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thye, T" uniqKey="Thye T">T Thye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thye, T" uniqKey="Thye T">T Thye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Allen, Ek" uniqKey="Allen E">EK Allen</name>
</author>
<author><name sortKey="Manichaikul, A" uniqKey="Manichaikul A">A Manichaikul</name>
</author>
<author><name sortKey="Sale, Mm" uniqKey="Sale M">MM Sale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quintana Murci, L" uniqKey="Quintana Murci L">L Quintana-Murci</name>
</author>
<author><name sortKey="Alcais, A" uniqKey="Alcais A">A Alcais</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
<author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manry, J" uniqKey="Manry J">J Manry</name>
</author>
<author><name sortKey="Quintana Murci, L" uniqKey="Quintana Murci L">L Quintana-Murci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patterson, Kd" uniqKey="Patterson K">KD Patterson</name>
</author>
<author><name sortKey="Pyle, Gf" uniqKey="Pyle G">GF Pyle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Np" uniqKey="Johnson N">NP Johnson</name>
</author>
<author><name sortKey="Mueller, J" uniqKey="Mueller J">J Mueller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le Chevalier, F" uniqKey="Le Chevalier F">F Le Chevalier</name>
</author>
<author><name sortKey="Cascioferro, A" uniqKey="Cascioferro A">A Cascioferro</name>
</author>
<author><name sortKey="Majlessi, L" uniqKey="Majlessi L">L Majlessi</name>
</author>
<author><name sortKey="Herrmann, Jl" uniqKey="Herrmann J">JL Herrmann</name>
</author>
<author><name sortKey="Brosch, R" uniqKey="Brosch R">R Brosch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagneux, S" uniqKey="Gagneux S">S Gagneux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hershberg, R" uniqKey="Hershberg R">R Hershberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Walker, Cl" uniqKey="Walker C">CL Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nair, H" uniqKey="Nair H">H Nair</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alcais, A" uniqKey="Alcais A">A Alcaïs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alcais, A" uniqKey="Alcais A">A Alcaïs</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
<author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, P" uniqKey="Choi P">P Choi</name>
</author>
<author><name sortKey="Reiser, H" uniqKey="Reiser H">H Reiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hershey, Gk" uniqKey="Hershey G">GK Hershey</name>
</author>
<author><name sortKey="Friedrich, Mf" uniqKey="Friedrich M">MF Friedrich</name>
</author>
<author><name sortKey="Esswein, La" uniqKey="Esswein L">LA Esswein</name>
</author>
<author><name sortKey="Thomas, Ml" uniqKey="Thomas M">ML Thomas</name>
</author>
<author><name sortKey="Chatila, Ta" uniqKey="Chatila T">TA Chatila</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Newton, C" uniqKey="Newton C">C Newton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Bergenhenegouwen, J" uniqKey="Van Bergenhenegouwen J">J Van Bergenhenegouwen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogus, Ac" uniqKey="Ogus A">AC Ogus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saraav, I" uniqKey="Saraav I">I Saraav</name>
</author>
<author><name sortKey="Singh, S" uniqKey="Singh S">S Singh</name>
</author>
<author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Underhill, Dm" uniqKey="Underhill D">DM Underhill</name>
</author>
<author><name sortKey="Ozinsky, A" uniqKey="Ozinsky A">A Ozinsky</name>
</author>
<author><name sortKey="Smith, Kd" uniqKey="Smith K">KD Smith</name>
</author>
<author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oliveira Nascimento, L" uniqKey="Oliveira Nascimento L">L Oliveira-Nascimento</name>
</author>
<author><name sortKey="Massari, P" uniqKey="Massari P">P Massari</name>
</author>
<author><name sortKey="Wetzler, L" uniqKey="Wetzler L">L Wetzler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcbride, A" uniqKey="Mcbride A">A McBride</name>
</author>
<author><name sortKey="Bhatt, K" uniqKey="Bhatt K">K Bhatt</name>
</author>
<author><name sortKey="Salgame, P" uniqKey="Salgame P">P Salgame</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, M" uniqKey="Xia M">M Xia</name>
</author>
<author><name sortKey="Sui, Z" uniqKey="Sui Z">Z Sui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paiva, Cn" uniqKey="Paiva C">CN Paiva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hussain, R" uniqKey="Hussain R">R Hussain</name>
</author>
<author><name sortKey="Ansari, A" uniqKey="Ansari A">A Ansari</name>
</author>
<author><name sortKey="Talat, N" uniqKey="Talat N">N Talat</name>
</author>
<author><name sortKey="Hasan, Z" uniqKey="Hasan Z">Z Hasan</name>
</author>
<author><name sortKey="Dawood, G" uniqKey="Dawood G">G Dawood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deshmane, Sl" uniqKey="Deshmane S">SL Deshmane</name>
</author>
<author><name sortKey="Kremlev, S" uniqKey="Kremlev S">S Kremlev</name>
</author>
<author><name sortKey="Amini, S" uniqKey="Amini S">S Amini</name>
</author>
<author><name sortKey="Sawaya, Be" uniqKey="Sawaya B">BE Sawaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siveke, Jt" uniqKey="Siveke J">JT Siveke</name>
</author>
<author><name sortKey="Hamann, A" uniqKey="Hamann A">A Hamann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, B" uniqKey="Singh B">B Singh</name>
</author>
<author><name sortKey="Chitra, J" uniqKey="Chitra J">J Chitra</name>
</author>
<author><name sortKey="Selvaraj, P" uniqKey="Selvaraj P">P Selvaraj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mishra, G" uniqKey="Mishra G">G Mishra</name>
</author>
<author><name sortKey="Poojary, Ss" uniqKey="Poojary S">SS Poojary</name>
</author>
<author><name sortKey="Raj, P" uniqKey="Raj P">P Raj</name>
</author>
<author><name sortKey="Tiwari, Pk" uniqKey="Tiwari P">PK Tiwari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, Wx" uniqKey="Feng W">WX Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenwood, Cm" uniqKey="Greenwood C">CM Greenwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cervino, Ac" uniqKey="Cervino A">AC Cervino</name>
</author>
<author><name sortKey="Lakiss, S" uniqKey="Lakiss S">S Lakiss</name>
</author>
<author><name sortKey="Sow, O" uniqKey="Sow O">O Sow</name>
</author>
<author><name sortKey="Hill, Av" uniqKey="Hill A">AV Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Baghdadi, J" uniqKey="El Baghdadi J">J El Baghdadi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlsson, Ek" uniqKey="Karlsson E">EK Karlsson</name>
</author>
<author><name sortKey="Kwiatkowski, Dp" uniqKey="Kwiatkowski D">DP Kwiatkowski</name>
</author>
<author><name sortKey="Sabeti, Pc" uniqKey="Sabeti P">PC Sabeti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chimusa, Er" uniqKey="Chimusa E">ER Chimusa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curtis, J" uniqKey="Curtis J">J Curtis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Picard, C" uniqKey="Picard C">C Picard</name>
</author>
<author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brouwer, Mc" uniqKey="Brouwer M">MC Brouwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szymczak, Wa" uniqKey="Szymczak W">WA Szymczak</name>
</author>
<author><name sortKey="Deepe, Gs" uniqKey="Deepe G">GS Deepe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ladinig, A" uniqKey="Ladinig A">A Ladinig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walch, L" uniqKey="Walch L">L Walch</name>
</author>
<author><name sortKey="Massade, L" uniqKey="Massade L">L Massade</name>
</author>
<author><name sortKey="Dufilho, M" uniqKey="Dufilho M">M Dufilho</name>
</author>
<author><name sortKey="Brunet, A" uniqKey="Brunet A">A Brunet</name>
</author>
<author><name sortKey="Rendu, F" uniqKey="Rendu F">F Rendu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Nemoto Sasaki, Y" uniqKey="Nemoto Sasaki Y">Y Nemoto-Sasaki</name>
</author>
<author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name>
</author>
<author><name sortKey="Akiyama, M" uniqKey="Akiyama M">M Akiyama</name>
</author>
<author><name sortKey="Mukaida, N" uniqKey="Mukaida N">N Mukaida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fiorina, P" uniqKey="Fiorina P">P Fiorina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Asai, H" uniqKey="Asai H">H Asai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Martel, C" uniqKey="De Martel C">C de Martel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
<author><name sortKey="El Baghdadi, J" uniqKey="El Baghdadi J">J El-Baghdadi</name>
</author>
<author><name sortKey="Bousfiha, Aa" uniqKey="Bousfiha A">AA Bousfiha</name>
</author>
<author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
<author><name sortKey="Schurr, E" uniqKey="Schurr E">E Schurr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Manen, D" uniqKey="Van Manen D">D van Manen</name>
</author>
<author><name sortKey="Van Wout, Ab" uniqKey="Van Wout A">AB van ‘t Wout</name>
</author>
<author><name sortKey="Schuitemaker, H" uniqKey="Schuitemaker H">H Schuitemaker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aouizerat, Be" uniqKey="Aouizerat B">BE Aouizerat</name>
</author>
<author><name sortKey="Pearce, Cl" uniqKey="Pearce C">CL Pearce</name>
</author>
<author><name sortKey="Miaskowski, C" uniqKey="Miaskowski C">C Miaskowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, P" uniqKey="An P">P An</name>
</author>
<author><name sortKey="Winkler, Ca" uniqKey="Winkler C">CA Winkler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rietveld, Ca" uniqKey="Rietveld C">CA Rietveld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wakefield, J" uniqKey="Wakefield J">J Wakefield</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polasek, O" uniqKey="Polasek O">O Polasek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Little, J" uniqKey="Little J">J Little</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gallo, V" uniqKey="Gallo V">V Gallo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hollenbach, Ja" uniqKey="Hollenbach J">JA Hollenbach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kodaman, N" uniqKey="Kodaman N">N Kodaman</name>
</author>
<author><name sortKey="Sobota, Rs" uniqKey="Sobota R">RS Sobota</name>
</author>
<author><name sortKey="Mera, R" uniqKey="Mera R">R Mera</name>
</author>
<author><name sortKey="Schneider, Bg" uniqKey="Schneider B">BG Schneider</name>
</author>
<author><name sortKey="Williams, Sm" uniqKey="Williams S">SM Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsland, Bj" uniqKey="Marsland B">BJ Marsland</name>
</author>
<author><name sortKey="Gollwitzer, Es" uniqKey="Gollwitzer E">ES Gollwitzer</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sagoo, Gs" uniqKey="Sagoo G">GS Sagoo</name>
</author>
<author><name sortKey="Little, J" uniqKey="Little J">J Little</name>
</author>
<author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bogardus, St" uniqKey="Bogardus S">ST Bogardus</name>
</author>
<author><name sortKey="Concato, J" uniqKey="Concato J">J Concato</name>
</author>
<author><name sortKey="Feinstein, Ar" uniqKey="Feinstein A">AR Feinstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Vsf" uniqKey="Chan V">VSF Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prugnolle, F" uniqKey="Prugnolle F">F Prugnolle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fumagalli, M" uniqKey="Fumagalli M">M Fumagalli</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lucke, Jf" uniqKey="Lucke J">JF Lucke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name>
</author>
<author><name sortKey="Trikalinos, Ta" uniqKey="Trikalinos T">TA Trikalinos</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id>
<journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id>
<journal-title-group><journal-title>Scientific Reports</journal-title>
</journal-title-group>
<issn pub-type="epub">2045-2322</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26524966</article-id>
<article-id pub-id-type="pmc">4630784</article-id>
<article-id pub-id-type="publisher-id">BFsrep16119</article-id>
<article-id pub-id-type="doi">10.1038/srep16119</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Patarčić</surname>
<given-names>Inga</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Gelemanović</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kirin</surname>
<given-names>Mirna</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kolčić</surname>
<given-names>Ivana</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Theodoratou</surname>
<given-names>Evropi</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baillie</surname>
<given-names>Kenneth J.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Jong</surname>
<given-names>Menno D.</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudan</surname>
<given-names>Igor</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Campbell</surname>
<given-names>Harry</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Polašek</surname>
<given-names>Ozren</given-names>
</name>
<address><email>ozren.polasek@mefst.hr</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.38603.3e</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0644 1675</institution-id>
<institution>Department of Public Health,</institution>
<institution>University of Split School of Medicine,</institution>
</institution-wrap>
Split, Croatia</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics , University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.482685.5</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 9166 3715</institution-id>
<institution>Roslin Institute, University of Edinburgh,</institution>
</institution-wrap>
Midlothian, UK</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.418716.d</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0709 1919</institution-id>
<institution>Intensive Care Unit, Royal Infirmary of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.5650.6</institution-id>
<institution-id institution-id-type="ISNI">0000000404654431</institution-id>
<institution>Department of Medical Microbiology,</institution>
<institution>Academic Medical Centre, University of Amsterdam,</institution>
</institution-wrap>
Amsterdam, The Netherlands</aff>
</contrib-group>
<pub-date pub-type="epub"><day>3</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>5</volume>
<elocation-id>16119</elocation-id>
<history><date date-type="received"><day>20</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>9</day>
<month>10</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2015</copyright-statement>
<license license-type="OpenAccess"><license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from <italic>IL4</italic>
gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of <italic>TLR2</italic>
gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified <italic>CCL2</italic>
as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The <italic>IL4</italic>
-<italic>TLR2</italic>
-<italic>CCL2</italic>
axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1038/srep16119) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Infectious diseases</kwd>
<kwd>Molecular medicine</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Croatie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Croatie"><noRegion><name sortKey="Patar I, Inga" sort="Patar I, Inga" uniqKey="Patar I I" first="Inga" last="Patar I">Inga Patar I</name>
</noRegion>
<name sortKey="Gelemanovi, Andrea" sort="Gelemanovi, Andrea" uniqKey="Gelemanovi A" first="Andrea" last="Gelemanovi">Andrea Gelemanovi</name>
<name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name>
<name sortKey="Kol I, Ivana" sort="Kol I, Ivana" uniqKey="Kol I I" first="Ivana" last="Kol I">Ivana Kol I</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Theodoratou, Evropi" sort="Theodoratou, Evropi" uniqKey="Theodoratou E" first="Evropi" last="Theodoratou">Evropi Theodoratou</name>
</noRegion>
<name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<name sortKey="Baillie, Kenneth J" sort="Baillie, Kenneth J" uniqKey="Baillie K" first="Kenneth J." last="Baillie">Kenneth J. Baillie</name>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000750 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000750 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:4630784 |texte= The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:26524966" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |