Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)
Identifieur interne : 000659 ( Pmc/Checkpoint ); précédent : 000658; suivant : 000660Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)
Auteurs : Xiaohua Wu [République populaire de Chine] ; Dawei Dong [République populaire de Chine] ; Daqing Ma [République populaire de Chine]Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research [ 1234-1010 ] ; 2016.
Abstract
SARS is not only an acute disease, but also leads to long-term impaired lung diffusing capacity in some survivors. However, there is a paucity of data regarding long-term CT findings in survivors after SARS. The aim of this study was to assess the changes in lung function and lung thin-section computed tomography (CT) features in patients recovering from severe acute respiratory syndrome (SARS), especially the dynamic changes in ground-glass opacity (GGO).
Clinical and radiological data from 11 patients with SARS were collected. The serial follow-up thin-section CTs were evaluated at 3, 6, and 84 months after SARS presentation. The distribution and predominant thin-section CT findings of lesions were evaluated.
The extent of the lesions on the CT scans of the 11 patients decreased at 6 and 84 months compared to 3 months. The number of segments involved on 84-month follow-up CTs was less than those at 6 months (P<0.05). The predominant thin-section CT manifestation at 84 months (intralobular and interlobular septal thickening) was different than that at 6 months, at which GGO was predominant.
During convalescence after SARS, GGO and intralobular and interlobular septal thickening were the main thin-section CT manifestation. Intralobular and interlobular septal thickening predominated over GGO at 84 months.
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DOI: 10.12659/MSM.896985
PubMed: 27501327
PubMed Central: 4982531
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)</title><author><name sortKey="Wu, Xiaohua" sort="Wu, Xiaohua" uniqKey="Wu X" first="Xiaohua" last="Wu">Xiaohua Wu</name><affiliation wicri:level="3"><nlm:aff id="af1-medscimonit-22-2793">Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dong, Dawei" sort="Dong, Dawei" uniqKey="Dong D" first="Dawei" last="Dong">Dawei Dong</name><affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-22-2793">Department of Radiology, Beijng Xiaotangshan Hospital, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Xiaotangshan Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Daqing" sort="Ma, Daqing" uniqKey="Ma D" first="Daqing" last="Ma">Daqing Ma</name><affiliation wicri:level="3"><nlm:aff id="af1-medscimonit-22-2793">Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27501327</idno><idno type="pmc">4982531</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982531</idno><idno type="RBID">PMC:4982531</idno><idno type="doi">10.12659/MSM.896985</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001283</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001283</idno><idno type="wicri:Area/Pmc/Curation">001283</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001283</idno><idno type="wicri:Area/Pmc/Checkpoint">000659</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000659</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)</title><author><name sortKey="Wu, Xiaohua" sort="Wu, Xiaohua" uniqKey="Wu X" first="Xiaohua" last="Wu">Xiaohua Wu</name><affiliation wicri:level="3"><nlm:aff id="af1-medscimonit-22-2793">Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dong, Dawei" sort="Dong, Dawei" uniqKey="Dong D" first="Dawei" last="Dong">Dawei Dong</name><affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-22-2793">Department of Radiology, Beijng Xiaotangshan Hospital, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Xiaotangshan Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Daqing" sort="Ma, Daqing" uniqKey="Ma D" first="Daqing" last="Ma">Daqing Ma</name><affiliation wicri:level="3"><nlm:aff id="af1-medscimonit-22-2793">Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Medical Science Monitor : International Medical Journal of Experimental and Clinical Research</title><idno type="ISSN">1234-1010</idno><idno type="eISSN">1643-3750</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>SARS is not only an acute disease, but also leads to long-term impaired lung diffusing capacity in some survivors. However, there is a paucity of data regarding long-term CT findings in survivors after SARS. The aim of this study was to assess the changes in lung function and lung thin-section computed tomography (CT) features in patients recovering from severe acute respiratory syndrome (SARS), especially the dynamic changes in ground-glass opacity (GGO).</p></sec><sec><title>Material/Methods</title><p>Clinical and radiological data from 11 patients with SARS were collected. The serial follow-up thin-section CTs were evaluated at 3, 6, and 84 months after SARS presentation. The distribution and predominant thin-section CT findings of lesions were evaluated.</p></sec><sec><title>Results</title><p>The extent of the lesions on the CT scans of the 11 patients decreased at 6 and 84 months compared to 3 months. The number of segments involved on 84-month follow-up CTs was less than those at 6 months (P<0.05). The predominant thin-section CT manifestation at 84 months (intralobular and interlobular septal thickening) was different than that at 6 months, at which GGO was predominant.</p></sec><sec><title>Conclusions</title><p>During convalescence after SARS, GGO and intralobular and interlobular septal thickening were the main thin-section CT manifestation. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Sci Monit</journal-id><journal-id journal-id-type="iso-abbrev">Med. Sci. Monit</journal-id><journal-id journal-id-type="publisher-id">Medical Science Monitor</journal-id><journal-title-group><journal-title>Medical Science Monitor : International Medical Journal of Experimental and Clinical Research</journal-title></journal-title-group><issn pub-type="ppub">1234-1010</issn><issn pub-type="epub">1643-3750</issn><publisher><publisher-name>International Scientific Literature, Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27501327</article-id><article-id pub-id-type="pmc">4982531</article-id><article-id pub-id-type="doi">10.12659/MSM.896985</article-id><article-id pub-id-type="publisher-id">896985</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject></subj-group></article-categories><title-group><article-title>Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Xiaohua</given-names></name><xref ref-type="aff" rid="af1-medscimonit-22-2793">1</xref><xref ref-type="author-notes" rid="fn1-medscimonit-22-2793">A</xref><xref ref-type="author-notes" rid="fn2-medscimonit-22-2793">B</xref><xref ref-type="author-notes" rid="fn3-medscimonit-22-2793">C</xref></contrib><contrib contrib-type="author"><name><surname>Dong</surname><given-names>Dawei</given-names></name><xref ref-type="aff" rid="af2-medscimonit-22-2793">2</xref><xref ref-type="author-notes" rid="fn3-medscimonit-22-2793">C</xref><xref ref-type="author-notes" rid="fn4-medscimonit-22-2793">D</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Daqing</given-names></name><xref ref-type="aff" rid="af1-medscimonit-22-2793">1</xref><xref ref-type="author-notes" rid="fn4-medscimonit-22-2793">D</xref><xref ref-type="author-notes" rid="fn5-medscimonit-22-2793">E</xref><xref ref-type="corresp" rid="c1-medscimonit-22-2793"></xref></contrib></contrib-group><aff id="af1-medscimonit-22-2793"><label>1</label>Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijing, P.R. China</aff><aff id="af2-medscimonit-22-2793"><label>2</label>Department of Radiology, Beijng Xiaotangshan Hospital, Beijing, P.R. China</aff><author-notes><corresp id="c1-medscimonit-22-2793">Corresponding Author: Daqing Ma, e-mail: <email>cjr.madaqing@vip.163.com</email></corresp><fn id="fn1-medscimonit-22-2793"><label>A</label><p>Study Design</p></fn><fn id="fn2-medscimonit-22-2793"><label>B</label><p>Data Collection</p></fn><fn id="fn3-medscimonit-22-2793"><label>C</label><p>Statistical Analysis</p></fn><fn id="fn4-medscimonit-22-2793"><label>D</label><p>Data Interpretation</p></fn><fn id="fn5-medscimonit-22-2793"><label>E</label><p>Manuscript Preparation</p></fn><fn id="fn6-medscimonit-22-2793"><label>F</label><p>Literature Search</p></fn><fn id="fn7-medscimonit-22-2793"><label>G</label><p>Funds Collection</p></fn></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>08</day><month>8</month><year>2016</year></pub-date><volume>22</volume><fpage>2793</fpage><lpage>2799</lpage><history><date date-type="received"><day>04</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>12</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>© Med Sci Monit, 2016</copyright-statement><copyright-year>2016</copyright-year><license><license-p>This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)</license-p></license></permissions><abstract><sec><title>Background</title><p>SARS is not only an acute disease, but also leads to long-term impaired lung diffusing capacity in some survivors. However, there is a paucity of data regarding long-term CT findings in survivors after SARS. The aim of this study was to assess the changes in lung function and lung thin-section computed tomography (CT) features in patients recovering from severe acute respiratory syndrome (SARS), especially the dynamic changes in ground-glass opacity (GGO).</p></sec><sec><title>Material/Methods</title><p>Clinical and radiological data from 11 patients with SARS were collected. The serial follow-up thin-section CTs were evaluated at 3, 6, and 84 months after SARS presentation. The distribution and predominant thin-section CT findings of lesions were evaluated.</p></sec><sec><title>Results</title><p>The extent of the lesions on the CT scans of the 11 patients decreased at 6 and 84 months compared to 3 months. The number of segments involved on 84-month follow-up CTs was less than those at 6 months (P<0.05). The predominant thin-section CT manifestation at 84 months (intralobular and interlobular septal thickening) was different than that at 6 months, at which GGO was predominant.</p></sec><sec><title>Conclusions</title><p>During convalescence after SARS, GGO and intralobular and interlobular septal thickening were the main thin-section CT manifestation. Intralobular and interlobular septal thickening predominated over GGO at 84 months.</p></sec></abstract><kwd-group><title>MeSH Keywords</title><kwd>Pneumonia, Viral</kwd><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Tomography Scanners, X-Ray Computed</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-medscimonit-22-2793" position="float"><label>Figure 1</label><caption><p>Case 1, SARS survivor, female, 30 years old. (<bold>A</bold>) The CT scan at 3 months showed diffuse bilateral GGO (arrow). (<bold>B</bold>) Six months later, GGO was reduced. (<bold>C</bold>) At 84 months, GGO was greatly reduced and fine reticulation (intralobular and interlobular septal thickening) predominated (arrow). Patchy decreased attenuation was seen at 3-, 6-, and 84-month CT (triangle).</p></caption><graphic xlink:href="medscimonit-22-2793-g001"></graphic></fig><fig id="f2-medscimonit-22-2793" position="float"><label>Figure 2</label><caption><p>Case 7, SARS survivor, male, 31 years old. (<bold>A</bold>) Chest radiography showed consolidation in the lower lobes of both lungs in acute phase. (<bold>B</bold>) Six months later, GGO (triangle) and reticulation (arrow) were observed in both lungs. (<bold>C</bold>) Fine reticulation (arrow) still persisted but GGO could not be found at 84-month CT.</p></caption><graphic xlink:href="medscimonit-22-2793-g002"></graphic></fig><fig id="f3-medscimonit-22-2793" position="float"><label>Figure 3</label><caption><p>Case 6, SARS survivor, female, 32 years old. (<bold>A</bold>) X-ray radiography showed a large consolidation in the lower lobes of both lungs in acute phase. (<bold>B</bold>) Six months later, X-ray revealed GGO, septal thickening, and fine-mesh shadows (white arrow). Traction bronchiectasis was found in the left lower lobe. (<bold>C</bold>) At 84 months, GGO was reduced and interlobular thickening predominated. Traction bronchiectasis was still present.</p></caption><graphic xlink:href="medscimonit-22-2793-g003"></graphic></fig><table-wrap id="t1-medscimonit-22-2793" position="float"><label>Table 1</label><caption><p>Characteristics of the patients.</p></caption><table frame="hsides" rules="rows"><thead><tr><th valign="middle" rowspan="2" align="center" colspan="1">Case number</th><th valign="middle" rowspan="2" align="center" colspan="1">Gender</th><th valign="middle" rowspan="2" align="center" colspan="1">Age at onset</th><th colspan="2" valign="middle" align="center" rowspan="1">3 months</th><th colspan="2" valign="middle" align="center" rowspan="1">6 months</th><th colspan="3" valign="middle" align="center" rowspan="1">84 months</th></tr><tr><th valign="middle" align="center" rowspan="1" colspan="1">Predominant HRCT findings</th><th valign="middle" align="center" rowspan="1" colspan="1">Segments involved</th><th valign="middle" align="center" rowspan="1" colspan="1">Predominant HRCT findings</th><th valign="middle" align="center" rowspan="1" colspan="1">Segments involved</th><th valign="middle" align="center" rowspan="1" colspan="1">Predominant HRCT findings</th><th valign="middle" align="center" rowspan="1" colspan="1">Segments involved</th><th valign="middle" align="center" rowspan="1" colspan="1">PFT</th></tr></thead><tbody><tr><td valign="middle" align="center" rowspan="1" colspan="1">1</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">30</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">15</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">15</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">15</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">2</td><td valign="middle" align="center" rowspan="1" colspan="1">M</td><td valign="middle" align="center" rowspan="1" colspan="1">35</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">3</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">2</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">1</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">3</td><td valign="middle" align="center" rowspan="1" colspan="1">M</td><td valign="middle" align="center" rowspan="1" colspan="1">54</td><td valign="middle" align="left" rowspan="1" colspan="1">Consolidation and GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">8</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">6</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">4</td><td valign="middle" align="left" rowspan="1" colspan="1">N</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">4</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">38</td><td valign="middle" align="left" rowspan="1" colspan="1">Diffuse GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">9</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">3</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">3</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">5</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">42</td><td valign="middle" align="left" rowspan="1" colspan="1">Consolidation and GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">13</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">7</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">5</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">6</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">32</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">14</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">11.5</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">7</td><td valign="middle" align="center" rowspan="1" colspan="1">M</td><td valign="middle" align="center" rowspan="1" colspan="1">31</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">18</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">9.5</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">8</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">31</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">5</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">3.5</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">9</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">40</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">9</td><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation and interlobular thickening</td><td valign="middle" align="center" rowspan="1" colspan="1">6.5</td><td valign="middle" align="left" rowspan="1" colspan="1">Moderate</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">10</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">48</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">18</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">16</td><td valign="middle" align="left" rowspan="1" colspan="1">Mild</td></tr><tr><td valign="middle" align="center" rowspan="1" colspan="1">11</td><td valign="middle" align="center" rowspan="1" colspan="1">F</td><td valign="middle" align="center" rowspan="1" colspan="1">36</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="center" rowspan="1" colspan="1">–</td><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">9</td><td valign="middle" align="left" rowspan="1" colspan="1">Normal</td><td valign="middle" align="center" rowspan="1" colspan="1">0</td><td valign="middle" align="left" rowspan="1" colspan="1">N</td></tr></tbody></table></table-wrap><table-wrap id="t2-medscimonit-22-2793" position="float"><label>Table 2</label><caption><p>CT findings during follow-up.</p></caption><table frame="hsides" rules="rows"><thead><tr><th valign="bottom" align="center" rowspan="1" colspan="1">CT findings</th><th valign="bottom" align="center" rowspan="1" colspan="1">3 months (n=5)</th><th valign="bottom" align="center" rowspan="1" colspan="1">6 months (n=11)</th><th valign="bottom" align="center" rowspan="1" colspan="1">84 months (n=11)</th></tr></thead><tbody><tr><td valign="middle" align="left" rowspan="1" colspan="1">GGO</td><td valign="middle" align="center" rowspan="1" colspan="1">5 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">11 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">10 (90.9%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Consolidation</td><td valign="middle" align="center" rowspan="1" colspan="1">5 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">0</td><td valign="middle" align="center" rowspan="1" colspan="1">0</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation</td><td valign="middle" align="center" rowspan="1" colspan="1">5 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">9 (81.7%)</td><td valign="middle" align="center" rowspan="1" colspan="1">10 (90.9%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Subpleural line</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (20.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (9.1%)</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (9.1%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Traction brochiectasis</td><td valign="middle" align="center" rowspan="1" colspan="1">0</td><td valign="middle" align="center" rowspan="1" colspan="1">2 (18.2%)</td><td valign="middle" align="center" rowspan="1" colspan="1">2 (18.2%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Air trapping</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (20.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (9.1%)</td><td valign="middle" align="center" rowspan="1" colspan="1">1 (9.1%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Small nodule</td><td valign="middle" align="center" rowspan="1" colspan="1">2 (40.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">2 (18.2%)</td><td valign="middle" align="center" rowspan="1" colspan="1">2 (9.1%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">GGO predominance</td><td valign="middle" align="center" rowspan="1" colspan="1">5 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1"></td><td valign="middle" align="center" rowspan="1" colspan="1">2 (18.2%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Reticulation predominance</td><td valign="middle" align="center" rowspan="1" colspan="1">0</td><td valign="middle" align="center" rowspan="1" colspan="1">3 (27.3%)</td><td valign="middle" align="center" rowspan="1" colspan="1">8 (72.7%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Distribution of peripheral</td><td valign="middle" align="center" rowspan="1" colspan="1">3 (60.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">9 (81.7%)</td><td valign="middle" align="center" rowspan="1" colspan="1">9 (81.7%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Distribution on axial section (anterior and posterior)</td><td valign="middle" align="center" rowspan="1" colspan="1">5 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">11 (100.0%)</td><td valign="middle" align="center" rowspan="1" colspan="1">10 (90.9%)</td></tr><tr><td valign="middle" align="left" rowspan="1" colspan="1">Segments involved</td><td valign="middle" align="center" rowspan="1" colspan="1">48 (48/500)</td><td valign="middle" align="center" rowspan="1" colspan="1">106 (106/2200)</td><td valign="middle" align="center" rowspan="1" colspan="1">75 (75/2200)</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Xiaohua" sort="Wu, Xiaohua" uniqKey="Wu X" first="Xiaohua" last="Wu">Xiaohua Wu</name></noRegion><name sortKey="Dong, Dawei" sort="Dong, Dawei" uniqKey="Dong D" first="Dawei" last="Dong">Dawei Dong</name><name sortKey="Ma, Daqing" sort="Ma, Daqing" uniqKey="Ma D" first="Daqing" last="Ma">Daqing Ma</name></country></tree></affiliations></record>Pour 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